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| 1 | Normal and abnormal spine and thoracic cage development显示文摘Development of the spine and thoracic cage consists of a complex series of events involving multiple metabolic processes, genes and signaling pathways. During growth, complex phenomena occur in rapid succession. This succession of events, this establishment of elements, is programmed according to a hierarchy. These events are well synchronized to maintain harmonious limb, spine and thoracic cage relationships, as growth in the various body segments does not occur simultaneously at the same magnitude or rate. In most severe cases of untreated progressive earlyonset spinal deformities, respiratory insufficiency and pulmonary and cardiac hypertension(cor pulmonale), which characterize thoracic insufficiency syndrome(TIS), can develop, sometimes leading to death. TIS is the inability of the thorax to ensure normal breathing. This clinical condition can be linked to costo-vertebral malformations(e.g., fused ribs, hemivertebrae, congenital bars), neuromuscular diseases(e.g., expiratory congenital hypotonia), Jeune or Jarcho-Levin syndromes or to 50% to 75% fusion of the thoracic spine before seven years of age. Complex spinal deformities alter normal growth plate development, and vertebral bodies become progressively distorted, perpetuating the disorder. Therefore, many scoliotic deformities can become growth plate disorders over time. This review aims to provide a comprehensive review of how spinal deformities can affect normal spine and thoracic cage growth. Previous conceptualizations are integrated with more recent scientific data to provide a better understanding of both normal and abnormal spine and thoracic cage growth. | Federico Canavese Alain Dimeglio | 2013 | World Journal of Orthopedics2013，4，4： | 12 |
| 2 | Serial elongation-derotation-flexion casting for children with early-onset scoliosis显示文摘Various early-onset spinal deformities, particularly infantile and juvenile scoliosis(JS), still pose challenges to pediatric orthopedic surgeons. The ideal treatment of these deformities has yet to emerge, as both clinicians and surgeons still face multiple challenges including preservation of thoracic motion, spine and cage, and protection of cardiac and lung growth and function. Elongation-derotation-flexion(EDF) casting is a technique that uses a custom-made thoracolumbar cast based on a three-dimensional correction concept. EDF can control progression of the deformity and- in some cases-coax the initially-curved spine to grow straighter by acting simultaneously in the frontal, sagittal and coronal planes. Here we provide a comprehensive review of how infantile and JS can affect normal spine and thorax and how serial EDF casting can be used to manage these spinal deformities. A fresh review of the literature helps fully understand the principles of the serial EDF casting technique and the effectiveness of conservative treatment in patients with early-onset spinal deformities, particularly infantile and juvenile scolisois. | Federico Canavese Antoine Samba Alain Dimeglio Mounira Mansour Marie Rousset | 2015 | World Journal of Orthopedics2015，6，11： | 2 |
| 3 | Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants显示文摘 | George K. Siberry Paige L. Williams Hermann Mendez George R. Seage Denise L. Jacobson Rohan Hazra Kenneth C. Rich Raymond Griner Katherine Tassiopoulos Deborah Kacanek Lynne M. Mofenson Tracie Miller Linda A. DiMeglio D. Heather Watts | 2012 | AIDS2012，，9： | 2 |
| 4 | 用Sauvegrain法测定青春期骨龄准确性的研究显示文摘背景:Sauvegrain方法是通过分析肘部X线片来评估骨龄,常用于青春期生长发育最为迅速的两年间的骨龄测定。本文旨在研究该方法的准确性以及在小儿骨科中的应用价值。
方法:Sauvegrmn法主要评估肘部的4个解剖标志点:外髁、肱骨滑车、尺骨鹰嘴突以及桡骨近端骨骺。它是一个27分制的评分系统。对上述结构所得的评分进行合计而得出一个总分,然后使用标准图表确定骨龄。让三位观察者分别利用该方法进行骨龄评估。三位观察者通过分析60个男孩和60个女孩样本左肘部的前后位和侧位X线片来测定骨龄,并将该结果与通过分析左手和腕部后前位X线片的Greulich和Pyle图谱而得出的骨龄结果进行比较。间隔4周后每个观察者再测定骨龄一次。
结果:通过分析肘部X线片的方法测定骨龄更为精确,因为采用该方法测定骨龄可以精确到半岁。根据观察者的评定,Sauvegrain法显示出很好的观察者之间的相关性(r=0.93)和可重复性(r=0.96)。Sauvegrain法与Greulich和Pyle图谱之间有很好的相关性(r=0.85)。然而,一些肘部生长中心显示出一种中间的发育形态,这种形态学不适合Sauvegrain法的评分。这就导致了数据分析时出现误差。我们建议对于这些样本设定中间评分,并且通过修改原始图表而使评分更为精确。
结论:改良的Sauvegrain法简单、可靠而且可重复性高,它补充了Greulich和Pyle图谱的不足。在临床实践中,骨骼成熟度可以通过骨龄、年生长率以及第二性征而得以很准确的评估。因此,当青春期需要进行骨骺或脊柱关节融合术时,这种方法对于确定手术时间具有重要意义。
可信水平:诊断性研究,Ⅱ级,进一步可信度参见作者介绍。 | ALAIN DIMEGLIO YANN PHILIPPE CHARLES JEAN-PIERRE DAURES VINCENZO DE ROSA BONIFACE KABORE 韩岳(译) 胡永成(译) | 2006 | 骨科动态2006，2，1： | 2 |
| 5 | Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase deficiency : a meta-analysis 显示文摘 | Eugster E A Dimeglio L A Wright J C | 2001 | J Pediatr2001，138，1： | 1 |
| 6 | Presentation and clinical pro- gression of pseudohypoparathyroidism with multi-hormone resistance and Albright hereditary osteodystrophy : a case series 显示文摘 | Gelfand IM Eugster EA DiMeglio LA | 2006 | J Pediatr2006，149，6： | 1 |
| 7 | Classification of club-foot显示文摘 | Dimeglio H Bensahel Souchet | 1995 | J Pediatr Orthop B1995，4，： | 1 |
| 8 | The Duct-Occlud device:design, clinical results, and future directions 显示文摘 | Moore JW Schneider DJ Dimeglio D | 2001 | J Interv Cardiol2001，14，2： | 1 |
| 9 | Biomechanical activity of the growth plate: clinical incidences显示文摘 | Bonnel F Dimeglio A Baldet P | 1984 | Anat Clin1984，6，1： | 1 |
| 10 | Growth of the spine before age 5 years 显示文摘 | Dimeglio A | 1993 | J Pediatr Orthop B1993，1，： | 1 |
| 11 | Growth in pediatric orthopaedics显示文摘 | Dimeglio A | 2001 | J Pediatr Orthop2001，21，4： | 1 |
| 12 | Two - year clinical trial of oral alendr- onate versus intravenous pamidronate in children with osteogenesis imperfecta 显示文摘 | Dimeglio LA Peacock M | 2006 | Journal of Bone and Mineral Research2006，21，1： | 1 |
| 13 | Height outcome in congenital adrenal hyperplasia caused by 21-hydroxylase defi- ciency: a meta-analysis 显示文摘 | Eugster EA Dimeglio LA Wright JC | 2001 | J Pediatr2001，138，1： | 1 |
| 14 | The IL-23/th17 axis in the immunopathogenesis of psoriasis显示文摘 | Dicesare A Dimeglio P Nestle PO | 2009 | J Invest Dermatol2009，129，13： | 1 |
| 15 | Classification of clubfoot显示文摘 | Dimeglio A Bensahel H Souchet P | 1995 | J Pediatr Orthop B1995，4，2： | 1 |
| 16 | A randomized, controlled study of insulin pump therapy in diabetic preschoolers 显示文摘 | Dimeglio LA Pottorff TM Boyd SR | 2004 | J Pediatr2004，145，3： | 1 |
| 17 | Surgical advances in the treatment of neuromuscular scoliosis显示文摘Neuromuscular disorders are a group of diseases affecting the neuro-musculo-skeletal system. Children with neuromuscular disorders frequently develop progressive spinal deformities with cardio-respiratory compromise in the most severe cases. The incidence of neuromuscular scoliosis is variable, inversely correlated with ambulatory abilities and with a reported risk ranging from 80% to 100% in non-ambulatory patients. As surgical and peri-operative techniques have improved, more severely affected children with complex neuromuscular deformities and considerable co-morbidities are now believed to be candidates for extensive surgery for spinal deformity. This article aimed to provide a comprehensive review of how neuromuscular spinal deformities can affect normal spine balance and how these deformities can be treated with segmental instrumentation and sub-laminar devices. Older concepts have been integrated with newer scientific data to provide the reader with a basis for better understanding of how treatment of neuromuscular scoliosis has evolvedover the past few decades. Recent advances, as well as challenges that remain to be overcome, in the surgical treatment of neuromuscular curves with sub-laminar devices and in the management of post-operative infections are outlined. | Federico Canavese Marie Rousset Benoit Le Gledic Antoine Samba Alain Dimeglio | 2014 | World Journal of Orthopedics2014，5，2： | 1 |
| 18 | The growing spine: how spinal de- formities influence normal spine and thoracic cage growth显示文摘 | Dimeglio A Canavese F | 2012 | Eur Spine J2012，21，1： | 1 |
| 19 | Skeletal agedetermination from the elbow during pubertal growth显示文摘 | Charles Y P Canavese F Dimeglio A | 2005 | Orthopade2005，34，10： | 1 |
| 20 | The Evolution of the Just War Tradition:Defining Jus Post Bellum显示文摘 | RICHARD E DIMEGLIO | 2005 | Military Law Review2005，，186： | 1 |
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