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| 1 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Deep carbon cycle in subduction zones显示文摘The carbon cycle between the deep Earth and the atmosphere(i.e., the deep carbon cycle) can significantly affect the global climate on both long and short time scales. Although carbon in the deep Earth can be released to the atmosphere in many ways, plate subduction is the only pathway for the return of carbon from the surface to the deep Earth. Owing to diversity in the forms of carbon and the special physicochemical property of carbonates, the behavior of carbon and carbonates in subduction zones significantly affects the products of subduction processes, the oxygen fugacity in subduction zones, and the activation and migration of elements during the crust-mantle interaction. Therefore, the carbon cycle in subduction zones plays an important role in maintaining a habitable climate by regulating the atmospheric CO_2 concentration, which significantly affects the global climate, and in causing fundamental changes in the physical and chemical properties of the mantle that result in a heterogeneous mantle. In this study, we review and discuss previous studies and scientific problems regarding the carbon cycle in subduction zones from four aspects: observation and tracing of the carbon cycle, migration and variation of carbon during subduction,carbon flux, and the effect of the carbon cycle. | Yongsheng LIU Chunfei CHEN Detao HE Wei CHEN | 2019 | Science China Earth Sciences2019，62，11： | 7 |
| 3 | Characteristics of size distributions and sources of water-soluble ions in Lhasa during monsoon and non-monsoon seasons显示文摘To understand the physical and chemical characteristics, particle size distribution and sources of size-separated aerosols in Lhasa, which is located on the Tibetan Plateau(TP), six sizes of aerosol samples were collected in Lhasa in 2014. Ca^(2+), NH_4^+, NO_3^-,SO_4^(2-)and Cl-were the dominant ions. The ratio of cation equivalents(CE) to anion equivalents(AE) for each particle size segment indicated that the atmospheric aerosols in Lhasa were alkaline. SO_4^(2-)and NO_3^-could be neutralized by Ca^(2+), but could not be neutralized by NH_4^+, according to the [NH_4^+]/[NO_3^-+ SO_4^(2-)] and [Ca^(2+)]/[NO_3^-+ SO_4^(2-)] ratios. Mobile sources were dominant in PM_(0.95-1.5),PM_(1.5-3) and PM_(3-7.2), while stationary sources were dominant in the other three size fractions according to the [NO_3^-]/[SO_4^(2-)] ratios. The particle size distribution of all watersoluble ions during monsoon and non-monsoon periods was characterized by a bimodal distribution due to the different sources and formation mechanisms, and it was revealed that different ions had different sources in different seasons and different particle size segments by combining particle size distribution with correlation analysis. Source analysis of aerosols in Lhasa was performed using the Principal component analysis(PCA) for the first time, which revealed that combustion sources, motor vehicle exhaust, photochemical reaction sources and various types of dust were the main sources of Lhasa aerosols.Furthermore, Lhasa's air quality was also affected by long-distance transmission, expressed as pollutants from South Asia and West Asia, which were transmitted to Lhasa according to backward trajectory analysis. | Nannan Wei Zhiyou Xu Junwen Liu Guanghua Wang Wei Liu Deqing Zhuoga Detao Xiao Jian Yao | 2019 | Journal of Environmental Sciences2019，31，8： | 7 |
| 4 | Interface engineering of high efficiency perovskite solar cells based on ZnO nanorods using atomic layer deposition显示文摘尽管有无机器官的金属混血儿 perovskite 太阳能电池(PSC ) 的更加改进的效率,电子运输仍然是一个挑战性的问题。在这份报纸,我们报导 ZnO nanorods 的使用准备了由热水象在 perovskite 的电子运输层自己组装太阳能电池。perovskite 太阳能电池的效率被使钝化显著地提高经由艾尔 2 ZnO nanorods 上的 O 3 单层。由采用艾尔 2 O 3 单层, methylammonium 铅碘化物 PSC 的平均力量变换效率从 10.33% ~ 15.06% 被增加,并且获得的最高的效率是 16.08% 。我们建议用单层的原子层免职的缺点的钝化可能为 PSC 的所有类型的改进提供一条新小径…… | Shibin Li Peng Zhang Yafei Wang Hojjatollah Sarvari Detao Liu Jiang Wu Yajie Yang Zhiming Wang Zhi David Chen | 2017 | Nano Research2017，10，3： | 6 |
| 5 | Protein adsorption onto diethylaminoethyl dextran modified anion exchanger:Effect of ionic strength and column behavior显示文摘Our previous studies on bovine serum albumin(BSA) adsorption to diethylaminoethyl dextran(DEAE dextran,DexD, grafting-ligand) and DEAE(D, surface-ligand) modified Sepharose FF resins found that all the grafted resins(FF-DexD and FF-D-DexD) exhibited extremely fast uptake rate(effective diffusivity, D_e, D_e/D_O> 1.4),which was six times greater than the ungrafted resins(D_e/D_O < 0.3). In this work, the influence of ionic strength(IS) on 6 typical DEAE dextran-grafted resins was investigated. Bath adsorption equilibria and kinetics, breakthrough, and linear gradient elution experiments were conducted. Commercial DEAE Sepharose FF was used for comparison. It is found that protein adsorption capacities on DEAE dextran-FF resins and the commercial resin decreased with increasing IS, but DEAE dextran-FF resins exhibited much higher capacity sensitivity to salt concentration. Besides, steeper decrease of adsorption capacities could be obtained at higher graftingligand or surface-ligand density. It is worth noting that the facilitating role of surface-ligand to the 'chain delivery' effect was weakened after adding salt, leading to the less improvement in uptake rate by increasing surface-ligand density at higher IS. Although the uptake rates of the DEAE dextran-FF resins increased first and then decreased with increasing IS, they kept the extremely high level of De values(D_e/D_O > 1.1) at the their working/binding IS range. Moreover, the DEAE dextran-FF resin displayed much higher adsorption capacities and De values than commercial ungrafted resin in their working condition. Furthermore, the column results of DEAE dextran-FF resins presented higher dynamic binding capacities than and similar elution ISs with DEAE Sepharose FF to achieve similar(or even higher) recoveries suggest the excellent chromatographic column performance of the DEAE dextran-FF resins. Finally, both high recovery and purity of BSA and γ-globulin could be easily achieved using the typical DEAE dextran-FF column, FF-D60-DexD160, to separate their binary mixtures,by step gradient elution. The research has provided new insights into the practical application of the series of DEAE-dextran grafted resins in protein chromatography and proved their superiority. | Shu Bai Lingli Gong Detao Han Yutong Li Linling Yu Yan Sun | 2018 | Chinese Journal of Chemical Engineering2018，26，2： | 5 |
| 6 | ADAPTIVE REPAIR APPROACH FOR RECOVERING COMPONENTS FROM DEFECTS显示文摘The geometry of each worn part is unique,so that a repair has to be tailored to each part individually. To ensure that a high quality repair is carried out,tool paths have to be generated adaptively for the unique geometry and pose of the part being repaired. A polygonal modelling approach is introduced to rapidly construct a geometric model of the part to be repaired,together with a defect-free model with identical geometry and poise. The two models are compared so that the defects are identified for direct use by the laser cladding,machining and inspection processes. | GAO Jian CHEN Xin ZHENG Detao GINDY Nabil | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 3 |
| 7 | Flexible optoelectronic devices based on metal halide perovskites显示文摘The unique physical and chemical properties of metal halide perovskites predestine the devices to achieve high performance in optoelectronic field.Among the numerous high qualities of perovskites,their different low-temperature synthesis methods and preparation processes make them impressive and popular materials for flexible optoelectronic devices.Mainstream perovskite devices,for instance,solar cells,photodetectors and light-emitting diodes,have been fabricated on flexible substrates and show outstanding flexibility as well as high performance.For soft wearable electronic systems,mechanical flexibility is the premier condition.Compared to common devices based on rigid substrates,flexible perovskite devices are more practical and see widespread applications in energy,detection,display,and other fields.This review summarizes the recent progress of flexible perovskite solar cells,photodetectors and light-emitting diodes.The design and fabrication of different high-performance flexible perovskite devices are introduced.Various low-dimensional perovskite materials and configurations for flexible perovskite devices are presented.In addition,the limitations and challenges for further application are also briefly discussed. | Hao Chen Hao Wang Jiang Wu Feng Wang Ting Zhang Yafei Wang Detao Liu Shibin Li Richard V.Penty Ian H.White | 2020 | Nano Research2020，13，8： | 2 |
| 8 | Advantage of dual wavelength light-emitting diodes with dip-shaped quantum wells显示文摘Dual-wavelength light-emitting diodes (DW-LEDs) with dip-shaped quantum wells have been studied by numerical simulation.The emission spectra,light output power,carrier concentration in the quantum wells and internal quantum efficiency are investigated.The simulation results indicate that the DW-LEDs with dip-shaped quantum wells perform better than conventional LEDs with rectangular quantum wells in terms of light output power,leakage current and efficiency droop.These improvements in the electrical and optical characteristics are mainly attributed to the alleviation of the electrostatic field in the dip-shaped quantum wells. | XU YiQin FAN GuangHan ZHOU DeTao LI Xin LU TaiPing ZHAO Fang ZHANG YunYan ZHENG ShuWen GONG ChangChun | 2012 | Chinese Science Bulletin2012，57，20： | 2 |
| 9 | Natural rubber/nitrile butadiene rubber/hindered phenol composites with high-damping properties显示文摘New natural rubber(NR)/nitrile butadiene rubber(NBR)/hindered phenol(AO-80)composites with high-damping properties were prepared in this study.The morpholo-gical,structural,and mechanical properties were characterized by atomic force micro-scopy(AFM),polarized Fourier transform infrared spectrometer(FTIR),dynamic mechanical thermal analyzer(DMTA),and a tensile tester.Each composite consisted of two phases:the NR phase and the NBR/AO-80 phase.There was partial compat-ibility between the NR phase and the NBR/AO-80 phase,and the NR/NBR/AO-80(50/50/20)composite exhibited a co-continuous morphology.Strain-induced crystal-lization occurred in the NR phase at strains higher than 200%,and strain-induced orientation appeared in the NBR/AO-80 phase with the increase of strain from 100%to 500%.The composites had a special stress–strain behavior and mechanical properties because of the simultaneous strain-induced orientation and strain-induced crystalliza-tion.In the working temperature range of a seismic isolation bearing,the composites(especially the NR/NBR/AO-80(50/50/20)composite)presented a high loss factor,high area of loss peak(TA),and high hysteresis energy.Therefore,the NR/NBR/AO-80 rubber composites are expected to have important application as a high-perfor-mance damping material for rubber bearing. | Xiuying Zhao Jingna Yang Detao Zhao Yonglai Lu Wencai Wang Liqun Zhang Toshio Nishi | 2015 | International Journal of Smart and Nano Materials2015，6，4： | 2 |
| 10 | The near-optimal maximum principle of impulse control for stochastic recursive system显示文摘Here, we discuss the near-optimality for a class of stochastic impulse control problems. The state process in our problem is given by forward-backward stochastic differential equations(FBSDEs) with two control components involved: the regular and impulse control. More specially, the impulse control is defined on a sequence of prescribed stopping times. A recursive cost functional is introduced and the maximum principle for its near-optimality(both necessary and sufficient conditions) is derived with the help of Ekeland's principle and variational analysis. For illustration, one concrete example is studied with our maximum principle and the corresponding near-optimal control is characterized. | Jianhui HUANG Detao ZHANG | 2016 | Science China(Information Sciences)2016，59，11： | 2 |
| 11 | Revision for Measuringthe Radon Exhalation Rate from the Medium Surface显示文摘 | Yanliang Tan Detao Xiao | 2011 | IEEE Transactions on Nuclear Science2011，58，1： | 1 |
| 12 | Adaptive restoration of complex geometry parts through reverse engineering application显示文摘 | Gao Jian Chen Xin Zheng Detao | 2006 | Advances in Engineering Software2006，37，9： | 1 |
| 13 | Adaptive restoration of complex geometry parts through reverse engineering application显示文摘 | Jian Gao Xin Chen Detao Zheng Oguzhan Yilmaz Nabil Gindy | 2006 | Advances in Engineering Software2006，，9： | 1 |
| 14 | An Ex-traction and purification of 227 Ac and development ofsolid 219Rn source 显示文摘 | Quan Tang Shoukang Qiu Detao Xiao | 2014 | Radiochimica Acta2014，102，12： | 1 |
| 15 | Revision for Measuring the Radon Exhalation Rate From the Medium Surface 显示文摘 | Tan Yanliang Xiao Detao | 2011 | IEEE Transactions on Nuclear Science2011，58，： | 1 |
| 16 | Adaptive restora- tion of complex geometry parts through reverse engineering application 显示文摘 | Gao Jian Chen Xin Zheng Detao | 2006 | Advances in Engineering Software2006，，1： | 1 |
| 17 | A simple model for automatically measuring radon exhalation rate from medium surface 显示文摘 | TAN Yanliang XIAO Detao | 2014 | Radiation Measure- ments2014，64，： | 1 |
| 18 | Measuring radon exhalation rate by tracing the radon concentration of ventilation-type accu mulation chamber显示文摘 | TAN Yanliang XIAO Detao LIU Xiaosong | 2013 | Radiation Measurements2013，58，： | 1 |
| 19 | A novel algorithm for quick and continuous tracing the change of ra don concentration in environment显示文摘 | TAN Yanliang XIAO Detao | 2011 | Review of Scientific Instruments2011，82，04： | 1 |
| 20 | Mathematical Representation of Feature Conversion for CAD/CAM System Integration显示文摘 | Gao Jian Zheng Detao Gindy N | 2004 | Robotics and Computer- Integrated Manufacturing2004，20，5： | 1 |
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