5篇
您的检索式：作者名="Denys Simard"
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| 1 | Influence of cardiac nerve status on cardiovascular regulation and cardioprotection显示文摘Neural elements of the intrinsic cardiac nervous system transduce sensory inputs from the heart, blood vessels and other organs to ensure adequate cardiac function on a beat-to-beat basis. This inter-organ crosstalk is critical for normal function of the heart and other organs; derangements within the nervous system hierarchy contribute to pathogenesis of organ dysfunction. The role of intact cardiac nerves in development of, as well as protection against, ischemic injury is of current interest since it may involve recruitment of intrinsic cardiac ganglia. For instance, ischemic conditioning, a novel protection strategy against organ injury, and in particular remote conditioning, is likely mediated by activation of neural pathways or by endogenous cytoprotective bloodborne substances that stimulate different signalling pathways. This discovery reinforces the concept that inter-organ communication, and maintenance thereof, is key. As such, greater understanding of mechanisms and elucidation of treatment strategies is imperative to improve clinical outcomes particularly in patients with comorbidities. For instance, autonomic imbalance between sympathetic and parasympathetic nervous system regulation can initiate cardiovascular autonomic neuropathy that compromises cardiac stability and function. Neuromodulation therapies that directly target the intrinsic cardiac nervous system or other elements of the nervous system hierarchy are currently being investigated for treatment of different maladies in animal and human studies. | John G Kingma Denys Simard Jacques R Rouleau | 2017 | World Journal of Cardiology2017，9，6： | 6 |
| 2 | Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer's Disease显示文摘 | Alain R Simard Denis Soulet Genevieve Gowing | 2006 | Neuron2006，49，4： | 1 |
| 3 | Low-dose and high-dose acetylsalicylic acid for patients undergoing carotid endarterectomy: a randomised controlled trial显示文摘 | D Wayne Taylor Henry JM Barnett R Brian Haynes Gary G Ferguson David L Sackett Kevin E Thorpe Denis Simard Frank L Silver Vladimir Hachinski G Patrick Clagett R Barnes J David Spence | 1999 | The Lancet1999，，9171： | 1 |
| 4 | Dynamics of soluble organic C and C mineralization in cultivated soils with varying N fertilization显示文摘 | Martin H Chantigny Denis A Angers Danielle Prévost Régis R Simard Fran?ois-P Chalifour | 1999 | Soil Biology and Biochemistry1999，，4： | 1 |
| 5 | Bone Marrow-Derived Microglia Play a Critical Role in Restricting Senile Plaque Formation in Alzheimer’s Disease显示文摘 | Alain R. Simard Denis Soulet Genevieve Gowing Jean-Pierre Julien Serge Rivest | 2006 | Neuron2006，，4： | 1 |
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