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| 1 | IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis显示文摘Viral hepatitis is still a public health problem affecting several million people around the world.Neutrophils are polymorphonuclear cells that have a critical role in antibacterial infection.However,the role of neutrophils in viral infection is not fully understood.By using a mouse model of lymphocytic choriomeningitis virus infection-induced viral hepatitis,we observed increased neutrophil recruitment in the liver accompanied by enhanced CD8+T-cell responses.Liver neutrophils expressed high levels of immunomodulatory cytokines,such as C-X-C chemokine ligand 2,arginase-1,inducible nitric oxide synthase and interleukin(IL)-10,demonstrating immunosuppressive properties.Depletion of neutrophils in vivo by a neutralizing antibody resulted in the exacerbation of liver injury and the promotion of T-cell responses at the immune contraction stage.IL-33 significantly induced neutrophil recruitment in the liver and attenuated liver injury by limiting effector T-cell accumulation.Mechanistically,we found that IL-33 promoted the expression of arginase-1 in neutrophils through the type 2 innate lymphoid cell(ILC2)-derived IL-13.Additionally,IL-13 increased the inhibitory effect of neutrophils on CD8+T-cell proliferation in vitro,partially through arginase-1.Finally,we found that IL-13 induced arginase-1 expression,depending on signal transducer and activator of transcription factor 6(STAT6)signaling.Therefore,IL-33 induced immunosuppressive neutrophils via an ILC2/IL-13/STAT6 axis.Collectively,our findings shed new light on the mechanisms associated with IL-33-triggered neutrophils in the liver and suggest potential targets for therapeutic investigation in viral hepatitis. | Yuejin Liang Panpan Yi Denley Ming Kee Yuan Zuliang Jie Zakari Kwota Lynn Soong Yingzi Cong Jiaren Sun | 2019 | Cellular & Molecular Immunology2019，16，2： | 7 |
| 2 | Excision biopsy findings of patients with breast needle core biopsies reported as suspicious of malignancy(B4) or lesion of uncertain malignant potential ( B3 ) 显示文摘 | Lee AH Denley HE Pinder SE | 2003 | Histopathology2003，42，4： | 1 |
| 3 | Molecular interactions of the IGF system 显示文摘 | Denley A Cosgrove L J Booker G W | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 4 | Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors显示文摘 | Denley A Carroll J M Brierley G V | | 0，，10： | 1 |
| 5 | Phenotypic similarities in bilateral breast cancer显示文摘 | Kiollias J Pinder SE Denley HE | 2004 | Breast Cancer Res Treat2004，85，3： | 1 |
| 6 | Mofecular interactions of the IGF system显示文摘 | Denley A Cosgrove LJ Booker GW | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 7 | Oncogenic transformation induced by the p110β,γ and δ isoforms of class Ⅰ phosphoinositide 3-kinase显示文摘 | Kang S Denley A Vanhaesebroeck B | 2006 | PNAS USA2006，103，5： | 1 |
| 8 | A prospective comparison of the prognostic value of tumor- and patient-related factors in patients undergoing potentially curative surgery for pancreatic ductal adenocarcinoma 显示文摘 | Jamieson NB Denley SM Logne J | 2011 | Ann Surg Oncol2011，18，8： | 1 |
| 9 | Excision biopsy findings of patients with breast needle core biopsies reported as suspicious of malignancy(B4) or lesion of uncertain malignant potential (B3)显示文摘 | Lee AH Denley HE Pinder SE | 2003 | Histopathology2003，42，4： | 1 |
| 10 | Phenotypic similarities in bilateral breast cancer显示文摘 | J. Kollias S.E. Pinder H.E. Denley I.O. Ellis P. Wencyk J.A. Bell C.W. Elston R.W. Blamey | 2004 | Breast Cancer Research and Treatment2004，，3： | 1 |
| 11 | Correlation of histologic prognostic factors in core biopsies and therapeutic excisions of invasive breast carcinoma显示文摘 | Harris GC Denley HE Pinder SE | 2003 | Am J Surg Pathol2003，27，1： | 1 |
| 12 | Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors显示文摘 | Denley A Carroll JM Brierley GV | | 0，，10： | 1 |
| 13 | IUCD induced abdomino-pelvic actinomycosis presenting as acute large bowel obstruction 显示文摘 | Biyani DK Denley H Hill J | 2007 | J Obstet Gynaecot2007，27，8： | 1 |
| 14 | Molecular interactions of the IGF system显示文摘 | Denley A Cosgrove L J Booker G W | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 15 | Requirement of phosphatidylinositol(3,4,5)trisphosphate in phosphatidylinositol 3-kinase-inducedoncogenic transformation显示文摘 | Denley A Gymnopoulos M Kang S | 2009 | Mol Cancer Res2009，7，7： | 1 |
| 16 | Structural and functional characteristics of the Va144Met insulin-like growth factor I missense mutation: correlation with effects on growth and development显示文摘 | Denley A Wang C C McNeil K A | 2005 | Mol Endocrinol2005，19，3： | 1 |
| 17 | Recent Studies on Italian Universities of the Middle Ages and Ren-aissance显示文摘 | Denley Peter | 1981 | History of Universities1981，，： | 1 |
| 18 | Molecular interactions of the IGF system 显示文摘 | Denley A Cosgrove LJ Booker GW | 2005 | Cytokine Growth Factor Rev2005，16，： | 1 |
| 19 | Phenotypic similarities in bilateral breast cancer显示文摘 | Kollias J Pinder SE Denley HE | 2004 | Breast Cancer Res Treat2004，85，3： | 1 |
| 20 | Computational model for the IGF-Ⅱ/IGF2r complex that is predictive of mutational and surface plasmon resonance data 显示文摘 | Roche P Brown J Denley A | 2006 | Proteins2006，64，3： | 1 |
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