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| 1 | Lx2-32c,a novel semi-synthetic taxane,exerts antitumor activity against prostate cancer cells in vitro and in vivo显示文摘Tubulin has been shown to be an effective target for the development of cytotoxic agents against prostate cancer. Previously, we reported that Lx2-32 c is an anti-tubulin agent with high binding affinity to tubulin. In this study, we investigated the potential of Lx2-32 c to act as an effective cytotoxic agent in the treatment of prostate cancer. MTT assays showed that Lx2-32 c was cytotoxic to all tested prostate cancer cell lines. The Lx2-32c-treated cells typically exhibited a rounded morphology associated with the onset of apoptosis, as evidenced by immunocytochemical staining. Human prostate cancer cell lines treated with Lx2-32 c arrest in the G2/M phase of the cell cycle and the treatment is associated with an increased ratio of cells in the sub-G0/G1 phase as determined by flow cytometry. Furthermore, expression of the cleaved form of poly(ADP-ribose) polymerase in prostate cancer cell lines treated with Lx2-32 c was shown by Western blotting assay. Xenograft implants of LNCa P and PC3-derived tumors in nude mice showed that Lx2-32 c treatment significant inhibited tumor growth with effects equivalent to those of docetaxel. These findings demonstrate the potential of Lx2-32 c as a candidate antitumor agent for the treatment of prostate cancer. | Guangyao Lv Dengjun Sun Jingwen Zhang Xiaoxia Xie Xiaoqiong Wu Weishuo Fang Jingwei Tian Chunhong Yan Hongbo Wang Fenghua Fu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 6 |
| 2 | Facilitated transport of Cu with hydroxyapatite nanoparticles in saturated sand: Effects of solution ionic strength and composition显示文摘 | Dengjun Wang Marcos Paradelo Scott A. Bradford Willie J.G.M. Peijnenburg Lingyang Chu Dongmei Zhou | 2011 | Water Research2011，，18： | 2 |
| 3 | Preparation and electrochemical performance of In-doped ZnO as anode material for Ni–Zn secondary cells显示文摘 | Dongqing Zeng Zhanhong Yang Shengwei Wang Xia Ni Dengjun Ai Qingqing Zhang | 2011 | Electrochimica Acta2011，，11： | 1 |
| 4 | Preparation and electrochemical performance of In-doped ZnO as anode material for Ni–Zn secondary cells显示文摘 | Dongqing Zeng Zhanhong Yang Shengwei Wang Xia Ni Dengjun Ai Qingqing Zhang | 2011 | Electrochimica Acta2011，，11： | 1 |
| 5 | Long-term biochar addition significantly decreases rice rhizosphere available phosphorus and its release risk to the environment显示文摘Phosphorus(P)availability,diffusion,and resupply processes can be altered by biochar addition in flooded rice rhizosphere,which controls the risk of P release to the environment.However,there are few in-situ investigations of these rhizospheric processes and effects.To explore the effects of biochar addition on soil P availability,high-resolution dialysis(HR-Peeper),diffusive gradients in thin films(DGT),and zymography techniques were used to provide direct evidence in the rice rhizosphere at the sub-millimeter scale.Long-term(9-years)field and greenhouse pot experiments demonstrated that biochar addition notably decreased the soluble/labile P and Fe concentrations in rice rhizosphere(vs.no biochar addition;CK)based on the results of Peeper,DGT,and two-dimensional imaging of labile P fluxes.DGT-induced fluxes in the soil/sediment(DIFS)model and sediment P release risk index(SPRRI)further indicated that biochar addition decreased the diffusion and resupply capacity of P from soil solid to the solution,thereby decreasing P release risk to the environment.These processes were dominated by Fe redox cycling and the hydrolysis of Al(hydro)oxides that greatly increased the unavailable P(Ca-P and residual-P).Additionally,greenhouse pot experiments(without additional biochar)showed that the previous long-term biochar addition significantly increased soil phosphatase activity,due to an adaptive-enhancing response to P decrease in the rhizosphere zone.The in-situ study on the biogeochemical reactions of P in the rice rhizosphere may provide a new and direct perspective to better evaluate the biochar addition and potential benefits to agricultural soils. | Hao Chen Jiahui Yuan Guanglei Chen Xu Zhao Shenqiang Wang Dengjun Wang Lei Wang Yujun Wang Yu Wang | 2022 | Biochar2022，4，1： | 1 |
| 6 | Hyperexponential and Nonmonotonic Retention of Polyvinylpyrrolidone-Coated Silver Nanoparticles in an Ultisol显示文摘 | Dengjun Wang Liqiang Ge Jianzhou He Wei Zhang Deb P. Jaisi Dongmei Zhou | 2014 | Journal of Contaminant Hydrology2014，，： | 1 |
| 7 | Transport of hiochar particles in saturated granular media: effects of pyrolysis temperature and particle size 显示文摘 | Wang Dengjun Zhang Wei Hao Xxiuzhen | 2013 | Environmental Science & Technology2013，47，2： | 1 |
| 8 | A mechanistic study of ciprofloxacin adsorption by goethite in the presence of silver and titanium dioxide nanoparticles显示文摘The adsorption behaviors of ciprofloxacin(CIP),a fluoroquinolone antibiotic,onto goethite(Gt)in the presence of silver and titanium dioxide nanoparticles(AgNPs and TiO_(2)NPs)were investigated.Results showed that CIP adsorption kinetics in Gt with or without NPs both followed the pseudo-second-order kinetic model.The presence of AgNPs or TiO_(2)NPs inhibited the adsorption of CIP by Gt.The amount of inhibition of CIP sorption due to AgNPs was decreased with an increase of solution pH from 5.0 to 9.0.In contrast,in the presence of TiO_(2)NPs,CIP adsorption by Gt was almost unchanged at pHs of 5.0∼6.5 but was decreased with an increase of pH from 6.5 to 9.0.The mechanisms of AgNPs and TiO_(2)NPs in inhibiting CIP adsorption by Gt were different,which was attributed to citrate coating of AgNPs resulting in competition with CIP for adsorption sites on Gt,while TiO_(2)NPs could compete with Gt for CIP adsorption.Additionally,CIP was adsorbed by Gt or TiO_(2)NPs through a tridentate complex involving the bidentate inner-sphere coordination of the deprotonated carboxylic group and hydrogen bonding through the adjacent carbonyl group on the quinoline ring.These findings advance our understanding of the environmental behavior and fate of fluoroquinolone antibiotics in the presence of NPs. | Jie Tang Yun Wang Qiang Xue Fei Liu Kenneth CCarroll Xiaohua Lu Taogeng Zhou Dengjun Wang | 2022 | Journal of Environmental Sciences2022，34，8： | 0 |
| 9 | Quantification of the redox properties of microplastics and their effect on arsenite oxidation显示文摘Microplastics have attracted global concern.The environmental-weathering processes control their fate,transport,transformation,and toxicity to wildlife and human health,but their impacts on biogeochemical redox processes remain largely unknown.Herein,multiple spectroscopic and electrochemical approaches in concert with wet-chemistry analyses were employed to characterize the redox properties of weathered microplastics.The spectroscopic results indicated that weathering of phenol-formaldehyde resins(PFs)by hydrogen peroxide(H2O2)led to a slight decrease in the content of phenol functional groups,accompanied by an increase in semiquinone radicals,quinone,and carboxylic groups.Electrochemical and wet-chemistry quantifications,coupled with microbial-chemical characterizations,demonstrated that the PFs exhibited appreciable electron-donating capacity(0.264-1.15 mmol e-g^(-1))and electron-accepting capacity(0.120-0.300 mmol e-g^(-1)).Specifically,the phenol groups and semiquinone radicals were responsible for the electron-donating capacity,whereas the quinone groups dominated the electron-accepting capacity.The reversible redox peaks in the cyclic voltammograms and the enhanced electron-donating capacity after accepting electrons from microbial reduction demonstrated the reversibility of the electron-donating and-accepting reactions.More importantly,the electron-donating phenol groups and weathering-induced semiquinone radicals were found to mediate the production of H2O2 from oxygen for arsenite oxidation.In addition to the H2O2-weathered PFs,the ozone-aged PF and polystyrene were also found to have electron-donating and arsenite-oxidation capacity.This study reports important redox properties of microplastics and their effect in mediating contaminant transformation.These findings will help to better understand the fate,transformation,and biogeochemical roles of microplastics on element cycling and contaminant fate. | Lin Chen Dengjun Wang Tianran Sun Tingting Fan Song Wu Guodong Fang Min Yang Dongmei Zhou | 2023 | Fundamental Research2023，3，5： | 0 |
| 10 | Interactions of extracellular DNA with aromatized biochar and protection against degradation by DNaseⅠ显示文摘With increasing environmental application,biochar(BC)will inevitably interact with and impact environmental behaviors of widely distributed extracellular DNA(eDNA),which however still remains to be studied.Herein,the adsorption/desorption and the degradation by nucleases of eDNA on three aromatized BCs pyrolyzed at 700℃were firstly investigated.The results show that the eDNA was irreversibly adsorbed by aromatized BCs and the pseudo-second-order and Freundlich models accurately described the adsorption process.Increasing solution ionic strength or decreasing pH below 5.0 significantly increased the eDNA adsorption on BCs.However,increasing pH from 5.0 to 10.0 faintly decreased eDNA adsorption.Electrostatic interaction,Ca ion bridge interaction,andπ-πinteraction between eDNA and BC could dominate the eDNA adsorption,while ligand exchange and hydrophobic interactions were minor contributors.The presence of BCs provided a certain protection to eDNA against degradation by DNase I.BC-bound eDNA could be partly degraded by nuclease,while BC-bound nuclease completely lost its degradability.These findings are of fundamental significance for the potential application of biochar in eDNA dissemination management and evaluating the environmental fate of eDNA. | Jing Fang Liang Jin Qingkang Meng Dengjun Wang Daohui Lin | 2021 | Journal of Environmental Sciences2021，33，3： | 0 |
| 11 | Soil and microbial C:N:P stoichiometries play vital roles in regulating P transformation in agricultural ecosystems:A review显示文摘Stoichiometry plays a crucial role in biogeochemical cycles and can modulate soil nutrient availability and functions. In agricultural ecosystems,phosphorus(P) fertilizers(organic or chemical) are often applied to achieve high crop yields. However, P is readily fixed by soil particles, leading to low P use efficiency. Therefore, understanding the role of carbon:nitrogen:P stoichiometries of soil and microorganisms in soil P transformation is of great significance for P management in agriculture. This paper provides a comprehensive review of the recent research on stoichiometry effect on soil P transformation in agricultural ecosystems. Soil microorganisms play an important role in the transformation of soil non-labile inorganic P to microbial biomass P by regulating microbial biomass stoichiometry. They also mobilize soil unavailable organic P into available P by changing ecoenzyme stoichiometry. Organic materials, such as manure and straw, play an important role in promoting the transformation of insoluble P into available P as well. Additionally, periphytic biofilms can reduce P loss from rice field ecosystems. Agricultural stoichiometries are different from those of natural ecosystems and thereby should receive more attention due to the influences of anthropogenic factors. Therefore, it is necessary to conduct further stoichiometry research on the soil biochemical mechanisms underlying P transformation in agricultural ecosystems. In conclusion, understanding stoichiometry impact on soil P transformation is crucial for P management in agricultural ecosystems. | Guanglei CHEN Jiahui YUAN Shenqiang WANG Yuting LIANG Dengjun WANG Yiyong ZHU Yu WANG | 2024 | Pedosphere2024，34，1： | 0 |
| 12 | Expression Pattern of IGF-I Gene and Correlation between Its SNPs and Growth Traits in Sheep显示文摘This study was to investigate the expression pattern of IGF-I gene and correlation between its SNPs and growth traits in sheep.The expression patterns of IGF-I gene in brain,muscle,skin,liver and heart of Liangshan semi-wool sheep were detected at six growth stages(15,60,105,195,240 days) by employing qRT-PCR approach,and the correlation between SNPs of IGF-I gene and growth traits via SSCP method.The first inflection point of IGF-I gene expression was observed at day 105 in all five tissues.From 15-105 days IGF-I gene gave a decline-ascending trend in muscle,brain and liver,while it did not vary significantly during day 15-day 60 and was up-regulated in heart and liver at day 105.Whenafter,the expression level was down-regulated in liver,while that in muscle,heart,brain and skin assumed the second inflection point.The expression levels of IGF-I gene in brain and skin at day 195 were significantly higher than that at day 150 and day 240.These suggest the synchronous expression of IGF-I gene in all five tissues.Two SNPs located at the leader region and exon 3 of IGF-I gene were middle or low polymorphic.The SNP locus detected with primer P-1 was significantly correlated with birth weight of Liangshan semi-wool sheep(P <0.05),while that detected with primer P-2 was significantly correlated with weaning weight and the weaning daily gain(P < 0.05).The expression of IGF-I in all tissues had the similar developmental patterns,and strong correlation of the SNPs of IGF-I gene was confirmed with the eary growth traits to provide theoretical basis for the growth regulation and applying to assisted selective breeding with the SNPs in liangshan semi-wool sheep. | Zhou Mingliang Zhang Xiangyu Qi Songzhi Wang Qi Wu Dengjun Yang Pinggui | 2015 | Animal Husbandry and Feed Science2015，7，1： | 0 |
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