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| 1 | A new method for improving the accuracy of miRNA detection with NaYF4:Yb,Er upconversion nanoparticles显示文摘MicroRNAs(miRNAs)are small noncoding RNAs,which play a central role in gene expression regulation and have been considered as excellent biomarker candidates for clinical diagnosis and prognosis.So far,many miRNAs detection methods require polymerase chain reaction(PCR)amplification following reverse transcription of miRNAs.These processes are complicated and time-consuming.In this work,we have developed a simpler method for miRNA detection based on base stacking hybridization happening on the surface of NaYF_4:Yb,Er upconversion nanoparticles.In this method,the fluorescence of NaYF_4:Yb,Er upconversion nanoparticles were functionalized as a reference standard,which can improve the accuracy of miRNA detection.On the basis of these findings,we suggest this novel approach for miRNA detection could be applied as an accurate and specific technique for miRNAs detection. | Lanlan Mao Zhuoxuan Lu Nongyue He Liming Zhang Yan Deng Deming Duan | 2017 | Science China Chemistry2017，60，1： | 0 |
| 2 | Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022显示文摘Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics. | Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang | 2024 | China CDC weekly2024，6，4： | 0 |
| 3 | Identification of Novel Bartonella washoensis Sequence Type 22 in Marmota himalayana-Jiuquan City,Gansu Province,China,2021–2022显示文摘Summary What is already known about this topic?The prevalence of rodent-adapted Bartonella species has been increasing significantly.However,the specific Bartonella species carried by Marmota himalayana(M.himalayana),a large rodent species,and the potential risk it poses to human populations remain unknown.What is added by this report?Bartonella washoensis(B.washoensis),associated with human endocarditis,was initially identified in M.himalayana,exhibiting a detection rate of approximately one-third and demonstrating a predilection for the heart and lungs.The discovery of the novel Sequence Type 22 has expanded both the isolation source and genetic lineage of B.washoensis.What are the implications for public health practice?Individuals residing within the M.himalayana plague focus are at an elevated risk for B.washoensis infection.Consequently,there is a pressing need for public health warnings and efficient clinical case identification in this population. | Ran Duan Xiaojin Zheng Qun Duan Asaiti Bukai Peng Zhang Shuai Qin Xinmin Lu Dongyue Lyu Haonan Han Dan Zhang Zhaokai He Junrong Liang Deming Tang Jinxiao Xi Huaiqi Jing Xin Wang | 2023 | China CDC weekly2023，5，20： | 0 |
| 4 | Rayleigh backscattering noise in single-fiber Ioopback duplex WDM-PON architecture显示文摘 | Duan LIU Songnian FU Ming TANG Ping SHUM Deming LIU | 2012 | Frontiers of Optoelectronics2012，5，4： | 0 |
| 5 | Built-in ESD Protection for RFID Tag ICs显示文摘The built-in Electro-Static discharge(ESD) protection circuits for Radio frequency identification(RFID) tag ICs are proposed. The ESD protection function is built into the rectifier and amplitude limiter.The rectifier and limiter are connected directly to the RF interface, and some transistors can discharge the larger current. These transistors can be used to build ESD protection circuits, through the redesign and optimization. The built-in ESD protection circuits can improve the ESD protection level and reduce the layout area. The circuits have been fabricated in 0.18μm CMOS process. The test results show that the built-in ESD protection circuits work well under 4kV ESD pressure and save as much as 72% of the layout area compare with foundry standard ESD protection cells. | DING Yi HU Jianguo DUAN Zhikui WANG Deming DING Yanyu TAN Hongzhou | 2016 | Chinese Journal of Electronics2016，25，6： | 0 |
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