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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis 显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2004 | Eur J Pharmacol2004，486，1： | 1 |
| 4 | Mesenchymal stem cells: potential precursors for tumors stroma and targeted delivery vehicles for anticancer agents显示文摘 | Studeny M Marini FC Dembinski JL | 2004 | J Natl Cancer Inst2004，96，21： | 1 |
| 5 | Neurodevelopmental outcome after intrauterine red cell transfusion for parvovirus B19 induced fetal hydrops 显示文摘 | Dembinski J Haverkamp F Maara H | 2002 | BJOG2002，109，11： | 1 |
| 6 | Progress in gas atomization of liquid metals by means of a De Laval nozzle显示文摘 | ALLIMANT A PLANCHE M P BAILLY Y DEMBINSKI L CODDET C | 2009 | Powder Technology2009，190，： | 1 |
| 7 | Mesenehymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents显示文摘 | Studeny M Marini FC Dembinski JL | 2004 | J Natl Cancer Inst2004，96，21： | 1 |
| 8 | Deleterious effect of helicobacter pylori infection on the course of acute pancreatitis in rats显示文摘 | Warzecha Z Dembinski A Ceranovioz P | 2002 | Pancreatology2002，2，： | 1 |
| 9 | Calcitonin gene related peptide can attenuate or augment pancreatic damage in caerulein-induced pancreatitis in rats显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 1999 | J Physiol Pharmacoi1999，50，1： | 1 |
| 10 | Mesenchy-real stem eells: potential precursors for lumor slroma and targeted-delivery vehicles for antieaneer agents 显示文摘 | Studeny M Marini FC Dembinski JL | 2004 | J Natl Cancer Inst2004，96，： | 1 |
| 11 | Evaluation of Laryngopharyngeal Reflux in Pediatric Patients with Ashma Using a New Technique of Pharyngeal pH-Monitoring显示文摘 | Banaszkjewicz A Dembinski L Zawadzka-Krajewska A | | 0，，： | 1 |
| 12 | Epidermal growth factor, polyamines, and prostaglandins in healing of stress-induced gastric lesions in rats显示文摘 | T. Brzozowski PhD Prof. Dr. S. J. Konturek MD J. Majka MD A. Dembinski MD D. Drozdowicz PhD | 1993 | Digestive Diseases and Sciences1993，，2： | 1 |
| 13 | Thyrdid function in healthy and sick very - low - birth - weight infants thyrotropin and free thy- roxine levels until the sixth week of age 显示文摘 | Dembinski J Arpe V Kroll M | 2001 | BiolNeonate2001，80，3： | 1 |
| 14 | Role of growth hormone and insulin-like growth factor-1 in the protective effect of ghrelin in ischemia/reperfusion-induced acute pancreatitis 显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2006 | Growth Horm IGF Res2006，16，56： | 1 |
| 15 | Stimulation of c - myc oncogene expression associated with estrogen - induced proliferation of hu- man breast eancer cells显示文摘 | Dubik D Dembinski TC Shiu RP | 1987 | Cancer Res1987，47，241： | 1 |
| 16 | Respiratory compliance but not gas exchange correlates with changes in lung aeration after a recruitment maneuver:an experimental study in pigs with saline lavage lung injury 显示文摘 | Henzler D Pelosi P Dembinski R | 2005 | Crit Care2005，9，5： | 1 |
| 17 | Morphometry of the ciliary body using ultrasound biomicroscopy 显示文摘 | Frieling E Dembinsky B | 1995 | Ophthalmologe1995，92，5： | 1 |
| 18 | Temperature dependence of microstrucmre and hardness of vacuum plasma sprayed Cu-Mo composite coatings显示文摘 | CHWA S O KLEIN D LIAO H DEMBINSKI L CODDET C | 2006 | Surface & Coatings Technology2006，200，： | 1 |
| 19 | Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents 显示文摘 | Studeny M Marini F C Dembinski J L | 2004 | J Natl Cancer Inst2004，96，21： | 1 |
| 20 | Long term follow up of serostatus after maternofetal parvovirus B19 infection显示文摘 | Eis-Hubinger AM Maar J | 2003 | Arch Dis Child2003，88，3： | 1 |
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