|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Neurodevelopmental outcome after intrauterine red cell transfusion for parvovirus B19 induced fetal hydrops 显示文摘 | Dembinski J Haverkamp F Maara H | 2002 | BJOG2002，109，11： | 1 |
| 4 | Thyrdid function in healthy and sick very - low - birth - weight infants thyrotropin and free thy- roxine levels until the sixth week of age 显示文摘 | Dembinski J Arpe V Kroll M | 2001 | BiolNeonate2001，80，3： | 1 |
| 5 | Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents 显示文摘 | Studeny M Marini F C Dembinski J L | 2004 | J Natl Cancer Inst2004，96，21： | 1 |
| 6 | Long term follow up of serostatus after maternofetal parvovirus B19 infection显示文摘 | Eis-Hubinger AM Maar J | 2003 | Arch Dis Child2003，88，3： | 1 |
| 7 | Inflammation and tumour microenvironments : defining the migratory itinerary of mesenchy- mal stem cells显示文摘 | Spaeth E Klopp A Dembinski J | 2008 | Gene Ther2008，15，10： | 1 |
| 8 | Direct evidence of mesenchynml stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging 显示文摘 | Kidd S Spaeth E Dembinski J L | 2009 | Stem Cells2009，27，10： | 1 |
| 9 | Direct Evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging显示文摘 | Kidd S Spaeth E Dembinski J L | 2009 | Stem Cells2009，27，10： | 1 |
| 10 | Mesenchymal stem cells as delivery systems for cancer and leukemia gene therapy显示文摘 | ANDREEFF M STUDENY M DEMBINSKI J | 2004 | J Clin Oncol2004，22，14： | 1 |
| 11 | Inflammation and tumor microenvironments: defining the migratory itinerary of mesenchymal stem cells 显示文摘 | Spaeth E Klopp A Dembinski J | 2008 | Gene Ther2008，15，10： | 1 |
| 12 | Mesenchymal stem cells:Potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents显示文摘 | STUDENY M MARINI F C DEMBINSKI J L | 2004 | J Natl Cancer Inst2004，96，21： | 1 |
| 13 | Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma显示文摘 | AMBRUS J L DEMBINSKI W AMBRUS J L | 2003 | Hepatology Cancer2003，98，12： | 1 |
| 14 | Thyroglobulin and anti-thyro-globulin assays in thyroid cancer monitoring显示文摘 | KRAHN J DEMBINSKI T | 2009 | Clin Bio-chem2009，42，45： | 1 |
| 15 | Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression显示文摘 | SPAETH E L DEMBINSKI J L SASSER A K | 2009 | PLoS One2009，4，4： | 1 |
| 16 | Inflammation and tumor microenvironments: defining the migratory itinerary of mes- enchymal stem cells显示文摘 | SPAETH E KLOPP A DEMBINSKI J | 2008 | Gene Ther2008，15，10： | 1 |
| 17 | Mesenchymal stem cells in cancer: tumor-associated fibroblasts and cell-based delivery vehicles显示文摘 | Hall B Dembinski J Sasser AK | 2007 | Int J Hematol2007，86，1： | 1 |
| 18 | Low vitamin D status is associated with low cord blood levels of the immunosuppressive cytokine interleukin-10 显示文摘 | Zittermann A Dembinski J Stehle P | 2004 | Pediatr Allergy Immunol2004，15，3： | 1 |
| 19 | Inflammation and tumor mi-croenvironments :defining the migratory itinerary of mesenchymalstem cells显示文摘 | Spaeth E Klopp A Dembinski J | 2008 | Gene Ther2008，15，10： | 1 |
| 20 | Mesenchymal Stem Cells as Delivery Systems for Cancer Therapy:Evaluation of Tropism and Efficacy显示文摘 | Marini F Dembinski J Studeny M | 2005 | Molecular Therapy2005，11，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员