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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
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| 15 | An index of patient reported out- comes (PRO-index) discriminates effectively between active and control treatment in 4 clinical trials of adalimumab in rheumatoid arthritis显示文摘 | Pincus T Chung C Segurado OG | 2006 | J Rheumato12006，33，11： | 1 |
| 16 | Imatinib compared with chemotherapy as frontline treatment of elderly patients with Philadelphia chromosomepositive acute lymphoblastic leukemia (Ph+ALL) 显示文摘 | Ottmann OG Wassmann B Pfeifer H | 2007 | Cancer2007，109，10： | 1 |
| 17 | Transparent Conductive Al Doped ZnO Thin Films Produced by Pulsed Laser Deposition显示文摘 | A OG Ikovska P A Atanasov I G Dimitrov | 2009 | Journal of Optoelectronics and Advanced Materials2009，11，10： | 1 |
| 18 | Correlation betweenmotor performance and cognitive functions in childrenborn<1250g at school age显示文摘 | Seitz J Jenni OG Molinari L | 2006 | Neuropediatrics2006，37，1： | 1 |
| 19 | Quantitative pro- moter methylation analysis of hepatccellular carcinoma, cirrhotic and normal liver显示文摘 | Harder J Opitz OG Brabender J | 2008 | Int J Cancer2008，122，12： | 1 |
| 20 | Dysregulated stem- ness-related genes in gynecological malignancies显示文摘 | Mak VC Siu MK Wong OG | 2012 | His- tol Histopathol2012，27，9： | 1 |
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