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| 1 | Effects of different amino acid levels and a carvacrol-thymol blend on growth performance and intestinal health of weaned pigs显示文摘Background:Over the past years,antibiotic growth promoter had been restricted in animal husbandry production in many countries because of antimicrobial resistance and foodborne antibiotic residues.However,the problems of poor intestinal health and low growth efficiency of piglets have not been solved completely in an antibiotic-free diet,and it is urgent to explore alternatives to antimicrobial growth promoters.Methods:Here,a total of 532 weaned pigs were assigned to one of 4 treatments,the low amino acid(AA)level diet(d 1 to d 14 is 1.35%,d 15 to d 42 is 1.25%)(Low AA),the low AA level diet supplementation with a carvacrol-thymol blend(50 mg carvacrol and 50 mg thymol/kg of diet)(CB)(Low AA+CB),the high AA level diet(d 1 to d 14 is 1.50%,d 15 to d 42 is 1.40%)(High AA),and the high AA level diet supplementation with a CB(High AA+CB),respectively.Then we measured growth performance and intestinal health indicators of weaned pigs.Results:Results showed that high AA level significantly reduced plasma urea nitrogen,plasma Interleukin-6(IL-6)and fecal lipocalin-2 contents(P<0.05),significantly increased the relative abundance of fecal Lactobacillus and Enterococcus,and had a trend to increase the fecal secretory immunoglobulin A(sIgA)and mucin 2(MUC 2)contents(P<0.05)in piglets,thereby alleviating the diarrhea of piglets and reducing the feed conversion ratio(FCR)of piglets during d 1~14 after weaning.Dietary supplementation with CB significantly increased the activity of plasma antioxidant enzymes T-SOD and GSH-px(P<0.05),while significantly reduced plasma malondialdehyde(MDA),plasma interleukin-1β(IL-1β),plasma endotoxin and D-lactic acid contents(P<0.05).Meanwhile,CB significantly decreased fecal lipocalin-2 contents and the abundance of fecal Escherichia coli(P<0.05).Thus,we hypothesis that dietary supplementation with CB significantly increased the average daily gain(ADG)of piglets(P<0.05)during d 1~14 after weaning through promoting intestinal health.Conclusion:These results suggest that high AA level and dietary supplementation with CB improved the growth performance of weaned pigs in an antibiotic-free diet by improving AA metabolism and intestinal antioxidant capacity. | Yanan Wang Zhipeng Yang Yuanfei Zhou Jiajian Tan Haiqing Sun Defa Sun Yuyun Mu Jian Peng Hongkui Wei | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 2 |
| 2 | In situ carrier tuning in high temperature superconductor Bi2Sr2CaCu2O(8+δ)by potassium deposition显示文摘We report a successful tuning of the hole doping level over a wide range in high temperature superconductor Bi_2Sr_2CaCu_2O_(8+δ)(Bi2212) through successive in situ potassium(K) deposition. By taking high resolution angleresolved photoemission measurements on the Fermi surface and band structure of an overdoped Bi2212(T_c= 76 K) at different stages of K deposition, we found that the area of the hole-like Fermi surface around the Brillouin zone corner(p,p) shrinks with increasing K deposition. This indicates a continuous hole concentration change from initial 0.26 to eventual 0.09 after extensive K deposition, a net doping level change of 0.17 that makes it possible to bring Bi2212 from being originally overdoped, to optimally-doped, and eventually becoming heavily underdoped. The electronic behaviors with K deposition are consistent with those of Bi2212 samples with different hole doping levels. These results demonstrate that K deposition is an effective way of in situ controlling the hole concentration in Bi2212. This work opens a good way of studying the doping evolution of electronic structure and establishing the electronic phase diagram in Bi2212 that can be extended to other cuprate superconductors. | Yuxiao Zhang Cheng Hu Yong Hu Lin Zhao Ying Ding Xuan Sun Aiji Liang Yan Zhang Shaolong He Defa Liu Li Yu Guodong Liu Xiaoli Dong Genda Gu Chuangtian Chen Zuyan Xu Xingjiang Zhou | 2016 | Science Bulletin2016，61，13： | 1 |
| 3 | A novel method using immuno- affinity chromatography for isolating β-conglycinin fromsoybeanproteins 显示文摘 | YOU Jiaming SUN Peng Li Defa | 2009 | Food Chemistry2009，117，2： | 1 |
| 4 | Effects of gtycinin on lgE-mediated increase of mast cen numbers and histamine release in the small intestine 显示文摘 | SUN Peng LI Defa LI Zheji | 2008 | J Nutr Biochem2008，19，9： | 1 |
| 5 | Effects of glycinin on IgE-mediated increase of mast cell numbers and histamine release in the small intestine显示文摘 | SUN Peng LI Defa LI Zheji | | 0，，9： | 1 |
| 6 | Small molecules targeting protein-protein interactions for cancer therapy显示文摘Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases,especially tumours.Encouragingly,selective PPI-based therapeutic agents have been rapidly advancing over the past decade,providing promising perspectives for novel therapies for patients with cancer.In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects,focusing on PPIs in disease,drug design and discovery strategies,structure-activity relationships,inherent dilemmas,and future directions. | Defa Wu Yang Li Lang Zheng Huan Xiao Liang Ouyang Guan Wang Qiu Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 1 |
| 7 | Effects of glycinin on IgE-mediated increase of mast cell numbers and histamine release in the small intestine 显示文摘 | SUN Peng LI Defa LI Zheji | 2008 | The Journal of Nutritional Biochemistry2008，19，9： | 1 |
| 8 | Prediction of Traffic Volume of Motor Vehicles Based on Mobile Phone Signaling Technology显示文摘Urban traffic volume detection is an essential part of trafficplanning in terms of urban planning in China. To improve the statisticsefficiency of road traffic volume, this thesis proposes a method for predictingmotor vehicle traffic volume on urban roads in small and medium-sizedcities during the traffic peak hour by using mobile signal technology. Themethod is verified through simulation experiments, and the limitations andthe improvement methods are discussed. This research can be divided intothree parts: Firstly, the traffic patterns of small and medium-sized cities areobtained through a questionnaire survey. A total of 19745 residents weresurveyed in Luohe, a medium-sized city in China and five travel modes oflocal people were obtained. Secondly, after the characteristics of residents’rest and working time are investigated, a method is proposed in this studyfor the distribution of urban residential and working places based on mobilephone signaling technology. Finally, methods for predicting traffic volume ofthese travel modes are proposed after the characteristics of these travel modesand methods for the distribution of urban residential and working placesare analyzed. Based on the actual traffic volume data observed at offlineintersections, the project team takes Luohe city as the research object and itverifies the accuracy of the prediction method by comparing the predictiondata. The prediction simulation results of traffic volume show that the averageerror rate of traffic volume is unstable. The error rate ranges from 10% to 30%.In this thesis, simulation experiments and field investigations are adopted toanalyze why these errors occur. | Jin Shang Hailong Su Kai Hu Xin Guo Defa Sun | 2023 | Computers, Materials & Continua2023，，4： | 0 |
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