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| 1 | Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions显示文摘AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic diseases.METHODS Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow cytometry.Serum levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by ELISA.RESULTS Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other groups.Inactive p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC patients.There was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC patients.There was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC. | Abdel-Rahman N Zekri Somaya El Deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Role of soluble P - se- lectin and methylenetetrahydrofolate reductase gene polymorphisms (677C > T) in Egyptian patients with venous thromboembolism 显示文摘 | TAWFIK N M DEEB M E NASR A S | 2012 | Blood Coagul Fibrinolysis2012，23，6： | 1 |
| 3 | Gastroesophageal reflux in children with refractory asthma显示文摘 | Deeb AS Al-Hakeem A Dib GS | | 0，，03： | 1 |
| 4 | Hepatic lipase as a focal point for the development and treatment of coronary artery disease显示文摘 | ZAMBON A BROWN B G DEEB S S | | J0，，： | 1 |
| 5 | Hepatic lipase: a marker for cardiovascular disease risk and response to therapy显示文摘 | ZAMBON A DEEB S S PAULEITO P | 2003 | Curr Opin Lipidol2003，14，2： | 1 |
| 6 | Sources and fate of nitrosodimethylamine and its precursors in municipal wastewater treatment plants显示文摘 | SEDLAK D L DEEB R A MITCH W A | 2005 | Water Environment Research2005，77，1： | 1 |
| 7 | Sources and fate of nitrosodimethylamine and its precursors in municipal wastewater treatment plants显示文摘 | Sedlak D L Deeb R A Hawley E L | 2005 | Water Environment Research2005，77，1： | 1 |
| 8 | Role of soluble P-selectin and methylenetetrahydrofolate reductase gene polymorphisms (677C>T) in Egyptian patients with venous thromboembolism显示文摘 | Tawfik N M Deeb M E Nasr A S | 2012 | Blood Coagul Fibrinolysis2012，23，6： | 1 |
| 9 | Genelype by envirmment interaction with broihr genqlyps diflring in growlh rate uflcler ntn'mal and high amble,hi temperature显示文摘 | Deeb N Cahaner A | 2002 | Poultry Science2002，81，： | 1 |
| 10 | Common hepatic lipa gene promoter variant determines clinical response to intensive lipid-lowering treatment显示文摘 | Zambon A Deeb SS Brown BG | 2011 | Circulation2011，103，6： | 1 |
| 11 | Bioremediation of MTBE:A review from a practical perspective显示文摘 | Stocking A J Deeb R A Flores A E | 2000 | Biodegradation2000，11，23： | 1 |
| 12 | Formation of nitrosodimethylamine(NDMA)during chlorine disinfection of wastewater effluents prior to use in irrigation systems显示文摘 | Pehlivanoglu-Mantas E Hawley E L Deeb R A | 2006 | Water Research2006，40，2： | 1 |
| 13 | Permanent neonatal diabetes : different aetiology in Arabs compared to Europeans显示文摘 | Habeb AM Flanagan SE Deeb A | 2012 | Arch Dis Child2012，97，8： | 1 |
| 14 | In vivo evidence of a rolefor hepatic lipase in human apoB-containing lipoprotein metabolism,independent of its lipolytic activity显示文摘 | Zambon A Deeb SS Bensadoun A | 2000 | J Lipid Res2000，41，： | 1 |
| 15 | Genomic breedingvalue prediction using three Bayesian methods and application to re-duced density marker panels 显示文摘 | CLEVELAND M A FORNI S DEEB N | 2010 | BMC Proc2010，4，113： | 1 |
| 16 | Impaired expression of peroxisome proliferator - activated receptor γ in ulcerative colitis 显示文摘 | DUBUQUOY L JANSSON E A DEEB S | 2003 | Gastroenterology2003，124，： | 1 |
| 17 | A longitudinal assessment of the effect of inhaled fluticasone propiohate therapy on adrenal function and growth in young children with asthma显示文摘 | Iles R Williams RM Deeb A Ross-Russell R Acefini CL | 2008 | Pediatr Pulmonol2008，43，4： | 1 |
| 18 | Impact of the peroxisome proliferators activated receptor gamma2 Pro12Ala polymorphis on adiposity, lipids and noninsulin- dependent diabetes mellitus 显示文摘 | Meirhaeghe A Fajas L Heibecque N Cottel D Auwerx J Deeb SS and Amouyel P | 2000 | lnt J Obes Relat Metab Disord2000，24，2： | 1 |
| 19 | 显示文摘 | Zambon A Deeb SS Panleho P | 2003 | Curr Opin Lipidol2003，14，2： | 1 |
| 20 | Relationship between Basal insulin requirement and body mass index in children and adults with type 1 dia- betes on insulin pump therapy显示文摘 | Deeb A Abu-Awad S Tomy M | 2015 | J Diabetes Sci Techno12015，9，3： | 1 |
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