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| 1 | 高效抗病毒治疗促使艾滋病患者免疫功能重建显示文摘The characteristics of AIDS is that HIV infection induces CD4+ T cell defects that includes a quantitave CD4+ T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4+ and CD8+ T cells followed by a slower CD4+ T cell increase; (2) a rapid rise in memory CD4+ T cells during the first three months of treatment by late increase in naive T cells coexpressing CD45RA and CD62L molecules after 3 months of efficient antiviral treatment;(3) a significant reduction of CD4 and CD8 activation markers in parallel to plasma virus load reduction;(4) a restoration in CD4+ T cell reactivity to recall antigens. These observations open new perspectives for the understanding of CD4+ T cells deficiency and therapeutic strategies of HIV infection. In the present review we will address some of the questions raised by immune restoration with HAART when administered at advanced stages of the disease. | 李太生 Guislaine Carcelaine Patrice Debre Brigitte Autran | 2001 | 基础医学与临床2001，21，1： | 14 |
| 2 | Effects of the Molecular Weight of Peg Molecules (8, 20 and 35 KDA) on Cell Function and Allograft Survival Prolongation in Pancreatic Islets Transplantation显示文摘 | Y. Neuzillet S. Giraud L. Lagorce M. Eugene P. Debre F. Richard B. Barrou | 2006 | Transplantation Proceedings2006，，7： | 2 |
| 3 | Management of prostate cancer in China:a multicenter report of 6 institutions显示文摘 | Peyrornaure M Debre B Mao K | 2005 | J Urol2005，174，5： | 1 |
| 4 | Management of prostate cancer in China: a multicenter report of 6 institutions显示文摘 | PEYROMAURE M DEBRe B MAO K | 2005 | J Urol2005，174，5： | 1 |
| 5 | Management of prostate cancer in China: a multicenter report of 6 institutions 显示文摘 | PEYROMAURE M DEBRE B MAO K | 2005 | J Urol2005，174，5： | 1 |
| 6 | Management of prostate cancer in China: a multicenter report of 6 institutions 显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，5： | 1 |
| 7 | T cell receptor gamma/delta+lymphocyte subsets during HIV infection显示文摘 | Autran B Triebel F Katlama C Rozenbaum W Hercend T Debre P | 1989 | Clin Exp Immunol1989，75，2： | 1 |
| 8 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in HIV-1 infected individuals显示文摘 | Magdalena M Theodorou L Debre P | 1999 | Blood1999，93，3： | 1 |
| 9 | Management of prostate cancer in China:a multicenter report of 6 institutions显示文摘 | Peyromaure M Debre B Mao K | | 0，，05： | 1 |
| 10 | Management of prostate cancer in China: a multicenter report of 6 institutions显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，9： | 1 |
| 11 | Therapeuie vaeeines a- gainst HIV need international partnerships显示文摘 | Autran B Debre P Walker B | 2003 | Nat Revimmu- nol2003，3，6： | 1 |
| 12 | Management of prosatecanncer in China:a muhicenter report of 6 institutions 显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，9： | 1 |
| 13 | Management of prostate cancer in China:a multicenter report of 6 institutions显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，： | 1 |
| 14 | NK cytotoxicity against CD4^+ T cells during HIV-1 infection: a gp41 peptide induces the expression of an NKp44 ligand显示文摘 | Vieillard V Strominger JL Debre P | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 15 | Management of prostate cancer in China: a muhicenter report of 6 institutions 显示文摘 | Peyromanre M Debre B Man K | 2005 | J Urol2005，174，5： | 1 |
| 16 | Management of prostate cancer in China:a multicenter report of 6 institutions显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，5： | 1 |
| 17 | Surgical management of infiltrating bladder cancer in elderly patients 显示文摘 | Peyromaure M Guerin F Debre B | 2004 | Eur Urol2004，45，2： | 1 |
| 18 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in human immunodeficiency virus-1-infected individuals显示文摘 | Magierowska M Theodorou I Debre P | 1999 | Blood1999，93，： | 1 |
| 19 | The Value of a Second Transurethral Resection in Evaluating Patients with Bladder Tumours显示文摘 | Makram Miladi Micha?l Peyromaure Marc Zerbib Djillali Sa??ghi Bernard Debré | 2003 | European Urology2003，，3： | 1 |
| 20 | Management of prostate cancer in China:a multicenter report of 6 institutions显示文摘 | Peyromaure M Debre B Mao K | 2005 | J Urol2005，174，5： | 1 |
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