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| 1 | Effects of low-frequency repetitive transcranial magnetic stimulation on electroencephalogram and seizure frequency in 15 patients with temporal lobe epilepsy following dipole source localization显示文摘BACKGROUND:Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to significantly reduce epileptiform discharges and control clinical seizures in intractable epilepsy patients. The location of epileptic foci and magnetic stimulation sites remain uncertain. The effects of rTMS on electroencephalogram and seizure remain unclear in epileptic patients following dipole source localization. OBJECTIVE: To investigate the effects of low-frequency rTMS on electroencephalogram and seizure in temporal lobe epilepsy patients after dipole source localization. DESIGN,TIME AND SETTING: The randomized,controlled study was performed at the outpatient clinic,Department of Neurology,Hospital Affiliated to North Sichuan Medical College from December 2003 to February 2007. PARTICIPANTS: A total of 30 temporal lobe epilepsy patients,comprising 19 males and 11 females,aged 17-49 years,presented with epileptiform discharges and were enrolled for this study. Disease course ranged between 1-6 years,with 1-5 seizures per month. Imaging examinations revealed 11 patients with structural changes in the brain. The patients were randomly and equally assigned into drug treatment and transcranial magnetic stimulation (TMS) groups. METHODS: Patients in the drug treatment group were orally treated with carbamazepine. Patients in the TMS group received oral carbamazepine treatment of and TMS. A Maglite-r25 magnetic stimulator (Dantec Dynamics,Denmark) was used to stimulate epileptic foci in the temporal lobe following electroencephalogram dipole localization (1 Hz,90% threshold intensity,at a stimulation frequency of 500 times,once a day,for 7 days). MAIN OUTCOME MEASURES: At 30 days after TMS,seizure frequency and rate of epileptiform discharges were observed in patients from both groups. Therapeutic safety was investigated during treatment. RESULTS: Within 30 days of treatment,there were no significant differences in seizure frequency between the TMS group (1.5 ± 0.3) seizures and the drug treatment group [(1.9 ± 0.4) seizures] (P > 0.05). The rate of epileptiform discharges [27% (4/15)] was significantly less in the TMS group than in the drug treatment group [73% (11/15)] (P<0.05). During TMS,five patients suffered from transient mild headache,but were completely relieved within 2 hours. CONCLUSION: Low-frequency rTMS exhibited inhibitory effects on epileptiform discharges over a short period of time,and decreased seizure frequency to some degree. Results from the present study suggested that low-frequency rTMS is safe. | Xiaoming Wang Deben Yang Shunxian Wang Xiaoqiong Zhao Lilan Zhang Zhiqiong Chen Xiangrong Sun | 2008 | Neural Regeneration Research2008，3，11： | 8 |
| 2 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 3 | In the name of the rose:a roadmap for rose research in the genome era显示文摘The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting activities.Next to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in polyploids.Rose cultivars are highly heterogeneous and diverse.This vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical breeders.We can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding community.This paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be addressed.We outline possible approaches for a number of these questions. | Marinus J.M.Smulders Paul Arens Peter M.Bourke Thomas Debener Marcus Linde Jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant Jeremy Clotault Fabrice Foucher | 2019 | Horticulture Research2019，6，1： | 2 |
| 4 | Identification of molecular markers linked to Rdrl,a gene conferring resistance to blackspot in roses显示文摘 | Von Malek B Weber W E Debener T | 2000 | Theor Appl Genet2000，101，： | 1 |
| 5 | RFLP maps of potato and their alignment with the homoeologous tomato genome显示文摘 | C. Gebhardt E. Ritter A. Barone T. Debener B. Walkemeier U. Schachtschabel H. Kaufmann R. D. Thompson M. W. Bonierbale M. W. Ganal S. D. Tanksley F. Salamini | 1991 | Theoretical and Applied Genetics1991，，1： | 1 |
| 6 | Sports and seedlings of 10 rose varieties analysed with molecular markers显示文摘 | Debener T Janakiram T Mattiesch L | 2000 | Plant Breeding2000，119，： | 1 |
| 7 | Single-trial EEG-fMRI reveals the dynamics of cognitive function显示文摘 | Debener S Ullsperger M Siegel M | 2006 | TRENDS in Cognitive Sciences2006，10，12： | 1 |
| 8 | Morphological characterization of the interaction between Diplocarpon rosae and various rose species 显示文摘 | Blechert O Debener T | 2005 | Plant Pathology2005，54，： | 1 |
| 9 | The best of both worlds: Phase-reset of human EEG Alpha activity and additive power contribute to ERP generation 显示文摘 | Min BK Busch NA Debener S | 2007 | International Journal of Psychophysiology2007，65，1： | 1 |
| 10 | De- fault-mode brain dysfunction in mental disorders: a systematic review 显示文摘 | BROYD SJ DEMANUELE C DEBENER S | 2009 | Neurosci Biobehav Rev2009，33，： | 1 |
| 11 | Defensin-like ZmES4 mediates pollen tube burst in maize via opening of the potassium channel KZM1显示文摘 | Amien S Kliwer I Marton M L Debener T Geiger D Becker D Dresselhaus T | 2010 | PLoS Biology2010，8，6： | 1 |
| 12 | Genetic analysis of horticulturally important morphological and physiological characters in diploid roses显示文摘 | Debener T | 1999 | Gartenbauwissenschaft1999，，64： | 1 |
| 13 | Analysis of genetic relationships among Rosa damascene plants grown in Turkey by using AFLP and mierosatellite markers显示文摘 | Bardar N G Baydar H Debener T | 2004 | Journal of Bioteehnology2004，111，3： | 1 |
| 14 | Is restinganterior eeg alpha asymmetry a trait marker for depression 显示文摘 | DEBENER S BEAUDUCEL A NESSLER D | 2000 | Neuropsychobiology2000，41，1： | 1 |
| 15 | Mining Eventrelated Brain Dynamics显示文摘 | Makeig S S Debener J Onton | 2004 | Trends in Cognitive Sciences2004，8，5： | 1 |
| 16 | Systemic antibiotic prophylaxis after gastro intestinal hemorrhage in cirrhotic patients with high risk of infection 显示文摘 | PAUWELS A MO STEFA KARA N DEBENES B et a l | 1996 | Hepatology1996，24，4： | 1 |
| 17 | Default-mode brain dysfunction in mental disorders: A systematic review显示文摘 | Samantha J. Broyd Charmaine Demanuele Stefan Debener Suzannah K. Helps Christopher J. James Edmund J.S. Sonuga-Barke | 2008 | Neuroscience and Biobehavioral Reviews2008，，3： | 1 |
| 18 | Defauh-mode brain dysfunction in mental disorders: a systematic review 显示文摘 | Broyd SJ Demanuele C Debener S | 2009 | Neurosci Biobehav Rev2009，33，： | 1 |
| 19 | Analytic study of non-ionic surfactants used in enhanced oil recovery optimization of an alytical conditions in reversed-phase partition chromatog- raphy 显示文摘 | DEBENE P L ESMAZIERES B D BASSELIER J J | 1989 | Journal of Chromatography A1989，461，： | 1 |
| 20 | Faster evaluation of induced floral sterility in transgenie early flowering poplar显示文摘 | Hoenicka H -Now-itzki O Debener O | 2006 | Silvae Genetlca2006，55，6： | 1 |
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