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| 1 | 围产期低能饲粮添加过瘤胃赖氨酸对初乳质量、断奶前犊牛生长性能的影响显示文摘本试验旨在研究围产期低能饲粮添加过瘤胃赖氨酸(RPL)对初乳质量、断奶前犊牛生长性能和瘤胃发酵的影响。试验采用2×2析因试验设计,即能量(产奶净能)水平设为6.40、5.73 M J/kg DM和RPL添加水平设为0、40 g/(d·头)。选取体况和预产期相近的52头第3胎荷斯坦奶牛,分为4组,分别为基础饲粮(B)组、低能饲粮(L)组、基础饲粮+RPL(BL)组和低能饲粮+RPL(LL)组,每组13头牛。试验从预产期前21天至产后犊牛断奶结束。奶牛产后第1次泌乳时采集初乳,测定初乳中总固形物、蛋白质、脂肪和乳糖、免疫球蛋白(Ig) G、IgM和IgA含量;犊牛出生当天(1日龄)、60日龄测定体重和体尺;犊牛60日龄采集瘤胃液,测定pH、氨态氮(NH3-N)和挥发性脂肪酸(VFA)浓度。结果表明:1)围产期低能饲粮显著降低了初乳总固形物、乳糖和IgM含量(P<0.05);围产母牛饲粮添加RPL对初乳乳糖含量有提高的趋势(P=0.068 2),对其他初乳指标无显著影响(P> 0.05)。2)围产期低能饲粮显著降低了母犊60日龄体重、体高、体斜长和胸围(P<0.05),显著降低了公犊60日龄体斜长和初生胸围(P<0.05)。围产母牛饲粮添加RPL有降低公犊60日龄体重的趋势(P=0.073 0)。3)围产期低能饲粮显著降低了母犊初生体躯指数(P<0.05),对母犊60日龄体躯指数有升高的趋势(P=0.059 6),对公犊初生体躯指数有降低的趋势(P=0.099 1),提高了公犊60日龄体躯指数(P<0.05),降低了公犊60日龄体长指数(P<0.05)。围产母牛饲粮添加RPL对公、母犊体尺指数没有显著影响(P>0.05)。4)围产期低能饲粮显著降低了犊牛瘤胃液中总挥发性脂肪酸、乙酸、丙酸、异丁酸、丁酸、异戊酸和戊酸浓度(P<0.05)。围产母牛饲粮添加RPL对犊牛瘤胃发酵指标无显著影响(P>0.05)。5)围产母牛饲粮能量水平与添加RPL对奶牛初乳质量指标、断奶前犊牛体重、体尺指标、体尺指数和瘤胃发酵指标均不存在交互作用(P>0.05)。综上所述,围产期低能饲粮降低了奶牛初乳质量、断奶前犊牛体重、体尺及体尺指数和瘤胃发酵指标;围产期母牛饲粮添加RPL对奶牛初乳质量和断奶前犊牛体重、体尺及体尺指数和瘤胃发酵无不利影响;围产期低能饲粮中添加RPL并不能替代正常标准能量水平饲粮。 | 蒋青荣 DELELESSE Debele Girma 顾鲲涛 杜超 马露 吴鹏 王建平 卜登攀 | 2019 | 动物营养学报2019，31，7： | 5 |
| 2 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 3 | Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation显示文摘 | P0ZDZIK A SALMON U DEBELLE FD | 2008 | Kidney Int2008，73，5： | 1 |
| 4 | Application of the needle optimization technique to the design of optical coatings 显示文摘 | TIKHONRAVOV A V TRUBETSKOV M K DEBELL G W | 1996 | Applied Optics1996，35，28： | 1 |
| 5 | Human bone morphogenetic protein-7 does not counteract aristo|oebic acid-induced renal toxicity显示文摘 | Antoine MH Debelle F Piecirilli J | 2015 | J Appl Toxicol2015，35，： | 1 |
| 6 | A hybrid scatter sear-ch/electromagnetism meta-heuristic for the resource-constrained project scheduling problem显示文摘 | DEBELS D DE REYCK B LEUS R | 2006 | European Journal of Operational Research2006，169，3： | 1 |
| 7 | A decomposition-based genetic algorithm for the resource-constrained project-scheduling problem显示文摘 | DEBELS D VANHOUCKE M | 2007 | Operations Research2007，55，3： | 1 |
| 8 | Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy显示文摘 | Debelle F Nortier J Arlt VM | 2003 | Arch Toxicol2003，77，： | 1 |
| 9 | Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies 显示文摘 | LEBEAU C DEBELLE FD ARLT VM | 2005 | Nephrol Dial Transplant2005，20，11： | 1 |
| 10 | ltow to simulate wear? Overview of existing methods 显示文摘 | Lambrechts P Debels F Van l anduyt K | | Dent Mater0，22，8： | 1 |
| 11 | Evaluation of Water Quality in the Chillán River (Central Chile) Using Physicochemical Parameters and a Modified Water Quality Index显示文摘 | Patrick Debels Ricardo Figueroa Roberto Urrutia Ricardo Barra Xavier Niell | 2005 | Environmental Monitoring and Assessment (-)2005，，1： | 1 |
| 12 | A hybrid scatter search/electromagnetism meta- heuristic for project scheduling显示文摘 | Debels D Reyck B D Leus R Vanhoucke M | 2006 | European Journal of Operation Research2006，169，： | 1 |
| 13 | Thixoforming of an automotive part in A390 hypereutectic Al-Si alloy显示文摘 | KAPRANOS P KIRKWOOD D H ATKINSON H V RHEINLANDER J T BENTZEN J J TOFT P T DEBEL C P LASLAZ G MAENNER L BLAIS S RODRIGUEZ-IBABE J M LASA L GIORDANO P CHIARMETTA G GIESE A | 2003 | J Mater Process Tech2003，135，23： | 1 |
| 14 | An Evaluation of the Adequacy of Project Network Generators with Systematically Sampled Networks 显示文摘 | Mario V Coelho J Debels D Macnhout B | 2008 | European Journal of Operational Research (S0377-2217)2008，187，2： | 1 |
| 15 | Aristolochic acid nephropathy : a worldwide problem 显示文摘 | Debelle F D Vanherweghem J-L Nortier J L | 2008 | Kidney Inter2008，74，2： | 1 |
| 16 | A hybrid scatter search electromagnetism meta-heuristic for project sched- uling显示文摘 | Debels D Reyck B D Leus R | 2006 | European Journal of Operational Research2006，169，2： | 1 |
| 17 | Dermal matrices and bioengi- neered skin substitutes: a critical review of current options显示文摘 | Debels H Hamdi M Abberton K | 2015 | Plast Reconstr Surg Glob Open2015，3，： | 1 |
| 18 | Analytical solution for solute transport resulting from instantanenas injection in streams with transient storage显示文摘 | DE SMEDT F BREVIS W DEBELS P | 2005 | J Hydrol2005，315，1234： | 1 |
| 19 | Coupling up- land watershed and downstream waterbody hydrodynamic and water quality models (SWAT and CE-QUAL-W2) for better water resources management in complex river basins显示文摘 | DEBELE B SRINIVASAN R PARLANGE J Y | 2008 | En- vironmental Modeling and Assessment2008，13，1： | 1 |
| 20 | The medicago genome provides insight into the evolution of rhizobial symbiose 显示文摘 | YONG N D DEBELLE F OLDROYD G E | 2011 | Nature2011，480，： | 1 |
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