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| 1 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 2 | Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells显示文摘AIM:To investigate the role of reactive oxygen species(ROS) in ethanol-mediated cell death of polarized hepatic(WIF-B) cells.METHODS:In this work,WIF-B cultures were treated with pyrazole(inducer of cytochrome P4502E1,CYP2E1) and/or L-buthionine sulfoximine(BSO),a known inhibitor of hepatic glutathione(GSH),followed by evaluation of ROS production,antioxidant levels,and measures of cell injury(apoptosis and necrosis).RESULTS:The results revealed that ethanol treatment alone caused a significant two-fold increase in the activation of caspase-3 as well as a similar doubling in ROS.When the activity of the CYP2E1 was increased by pyrazole pretreatment,an additional two-fold elevation in ROS was detected.However,the CYP2E1-related ROS elevation was not accompanied with a correlative increase in apoptotic cell injury,but rather was found to be associated with an increase in necrotic cell death.Interestingly,when the thiol status of the cells was manipulated using BSO,the ethanol-induced activation of caspase-3 was abrogated.Additionally,ethanol-treated cells displayed enhanced susceptibility to Fas-mediated apoptosis that was blocked by GSH depletion as a result of diminished caspase-8 activity.CONCLUSION:Apoptotic cell death induced as a consequence of ethanol metabolism is not completely dependent upon ROS status but is dependent on sustained GSH levels. | Benita L McVicker Pamela L Tuma Kusum K Kharbanda Serene ML Lee Dean J Tuma | 2009 | World Journal of Gastroenterology2009，15，21： | 5 |
| 3 | The Importance of Medial Support in Locked Plating of Proximal Humerus Fractures显示文摘 | Michael J Gardner Yoram Weil Joseph U Barker Bryan T Kelly David L Helfet Dean G Lorich | 2007 | Journal of Orthopaedic Trauma2007，，3： | 2 |
| 4 | Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells显示文摘Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system. | Benita L McVicker Dean J Tuma Carol A Casey | 2007 | World Journal of Gastroenterology2007，13，37： | 2 |
| 5 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 6 | Non-ionlc, poly(ethylene oxide)-based surfactants as intercalants/dispersants/exfoliants for poly(propylene)-clay nanocomposites 显示文摘 | Mead G Dean K Edmond L | 2006 | Macromol Mater Eng2006，291，1： | 1 |
| 7 | Ap38 MAP kinase inhinitor regulates stability of interleukin-1-induced eyclooxygenase-2 mRNA 显示文摘 | Mueckler S H Dean J L Sarsfield S J | 2006 | FEBS Lett2006，439，12： | 1 |
| 8 | Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of prote in kinase C-α expression显示文摘 | Mckay R Miraglia L | 1996 | Cancer Res1996，56，10： | 1 |
| 9 | Epigenetie modification is central to genome reprogramming in somatic cell nuclear transfer显示文摘 | Lako M Dean W | 2006 | Stem Cells2006，24，4： | 1 |
| 10 | Web search for a planet: The Google cluster architecture显示文摘 | Barroso L A Dean J Holzle U | 2003 | IEEE Micro2003，23，2： | 1 |
| 11 | Boundary condition sensi- tivity analysis of the stochastic flow equation显示文摘 | L Dean O Liver George Christakos | 1996 | Advances in Water Resources1996，，2： | 1 |
| 12 | The importance of advancing technology to America's energy goals显示文摘 | GREENE D L BOUDREAUX P R DEAN D J | 2010 | Energy Policy2010，38，8： | 1 |
| 13 | Inhibition of growth of human tumor cell lines in nude mice by an antisense oligonucleotide inhibitor of protein kinase C-α expression显示文摘 | Mckay R Miraglia L | 1996 | Cancer Res1996，56，10： | 1 |
| 14 | Geochemical and climatic effects of increased marine organic carbon burial at the Cenomanian/Turonian boundary显示文摘 | ARTHUR M A DEAN W PRATT L M | 1988 | Nature1988，335，： | 1 |
| 15 | Altered imprinted gene methylation and expression in completely ES cell derived mouse fetuses: association with aberrant phenotypes 显示文摘 | Dean W Bowden L Aitchison A | 1998 | Development1998，125，12： | 1 |
| 16 | Team-based Learning in a Medical Gross Anatomy and Embryology Course显示文摘 | GARY L NIEDER DEAN X PARMEI EE ADRIENNE STOLFI | 2005 | Clinical Anatomy2005，18，1： | 1 |
| 17 | Retrogade Intramedullarry Nailing of Supracondylar Femoral Fracture显示文摘 | David L Heffct Dean G Lorch | 1998 | Clin Orthop1998，350，： | 1 |
| 18 | A new era in the diagnosis of breast cancer显示文摘 | Tabar L Dean PB Kaufman CS | 2000 | Surg Oncol Clin N Am2000，9，2： | 1 |
| 19 | Laccase and the deposition of lignin in vascular plants 显示文摘 | Dean J F D Eriksson K-E L | 1994 | Holzforschung1994，48，： | 1 |
| 20 | Removing heavy metals from waste water 显示文摘 | Dean J G Bosqui F L Bermond A | 1972 | Environ Sci Technol1972，6，6： | 1 |
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