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58篇 您的检索式：作者名="DeRijk"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Single nucleotide polymorphisms related to HPA ax- is reactivity 显示文摘	DERIJK RH	2009	Neuroirnmunomodulat2009，16，5：	1
3	The association between antidepressant use and disturbances in glucose homeostasis:evidence from spontaneous reports显示文摘	Derijks HJ Meyboom RH Heerdink ER	2008	Eur J Clin Pharmacol2008，64，5：	1
4	Dental arch dimensions in unoperated adult cleft-palate patients: an analysis of 37 cases显示文摘	Derijke A Kuijpers-Jagtman AM Lekkas G	1994	J Craniofac Genet Dev Biol1994，14，：	1
5	The role of xanthine oxi- dase in thiopufine metabolism: a case report显示文摘	Wang DR Derijks LJ den Dulk MO	2007	Ther Drug Monit2007，29，6：	1
6	The adult unoperated cleft patient:Absence of maxillary teeth outside the cleft area显示文摘	Lekkas G Derijke A Kuijpers-Jagtman AM	2000	Cleft Palate Craniofac J2000，37，：	1
7	6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: Dose or level dependent?显示文摘	Luc J.J. Derijks Lennard P.L. Gilissen Nanne K.H. de Boer Chris J.J. Mulder	2006	Journal of Hepatology2006，，：	1
8	Glucocorticoid receptor variants:clinical implications显示文摘	Derijk RH Schaaf M de-kloet ER	2002	Journal of Steriod Biochemistry and Molecular Biology2002，81，2：	1
9	Exercise and circadian rhythm-induced variation in plasma cortisol differentially regulate interleukin-1β, IL-6, and tumor necrosis factor-production in humans:high sensitivity of TNF and resistance of IL-6 显示文摘	Derijk R Michelson D Karp B	1997	J Clin Endocrinol Metab1997，82，：	1
10	Pharmacogenetics of Thiopurines in Inflammato- ry Bowel Disease 显示文摘	Derijks LI Wong DR	2010	Curr Pharm Des2010，16，2：	1
11	Simplified Therapeutic Intervention Scoring System The Tiss~28 items-Results from a multicenter study显示文摘	Miranda DR deRijk A Sehaufeli w	1996	Crit Care Med1996，24，：	1
12	Cytokine release and its modulation by dexamethasone in whole blood following exercise显示文摘	HH Smits K Grunberg RH Derijk	1998	Clin Exp Immunol1998，，2：	1
13	Nursing activities score显示文摘	Miranda DR Nap R deRijk A	2003	Ctit Cme Med2003，31，2：	1
14	Glucocortieoid re- ceptor variants: clinical implications显示文摘	DeRijk R H Schaaf M De Kloet E R	2002	J Steroid Bio- chem2002，81，2：	1
15	The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports显示文摘	Derijks HJ Meyboom RH Heerdink ER	2008	Eur J Clin Pharmaeol2008，64，5：	1
16	Cytokine release and its modulation by dexamethasone in whole blood following exercise 显示文摘	Smits HH Grunberg K Derijk RH	1998	Clin Exp Immunol1998，，2：	1
17	Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression? Nature Clinical Practice 显示文摘	De Kloet ER Derijk RH Meijer OC	2007	Endocrinology & Metabolism2007，3，2：	1
18	Rapamycin coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model显示文摘	CAGIANNOS C ABUL-KHOUDOUD O R DERIJK W	2005	J Vasc Surg2005，42，5：	1
19	Promising treatment of autoimmune hepatitis with 6-thioguanine after adverse events on azathioprine显示文摘	Nanne K.H. de Boer Carin M.J. van Nieuwkerk M. Nieves Aparicio Pages Sybrand Y. de Boer Luc J.J. Derijks Chris J.J. Mulder	2005	European Journal of Gastroenterology & Hepatology2005，，4：	1
20	Preliminary results with laser Doppler velocimetry in gingival tissues显示文摘	Derijk WG Bowen PD Bonner RF	1980	J Dent Res1980，59，232：	1

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