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| 1 | A Review on Metal-and Metal Oxide-Based Nanozymes:Properties,Mechanisms,and Applications显示文摘Since the ferromagnetic(Fe_(3)O_(4))nanoparticles were firstly reported to exert enzyme-like activity in 2007,extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies.As promising alterna-tives for natural enzymes,nanozymes have broadened the way toward clinical medicine,food safety,environmental monitoring,and chemical production.The past decade has witnessed the rapid development of metal-and metal oxide-based nanozymes owing to their remarkable physicochemical proper-ties in parallel with low cost,high stability,and easy storage.It is widely known that the deep study of catalytic activities and mechanism sheds sig-nificant influence on the applications of nanozymes.This review digs into the characteristics and intrinsic properties of metal-and metal oxide-based nanozymes,especially emphasizing their catalytic mechanism and recent applications in biological analysis,relieving inflammation,antibacterial,and cancer therapy.We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials. | Qianwen Liu Amin Zhang Ruhao Wang Qian Zhang Daxiang Cui | 2021 | Nano-Micro Letters2021，13，10： | 15 |
| 2 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 3 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 4 | Chemistry and health beneficial effects of oolong tea and theasinensins显示文摘Among six major types of tea(white,green,oolong,yellow,black,and dark teas)from Camellia sinensis,oolong tea,a semi-fermented tea,with its own unique aroma and taste,has become a popular consumption as indicated by the increasing production.Representing the characteristic flavonoids of oolong tea,theasinensins are dimeric flavan-3-ols.Many recent studies have indicated that oolong tea and theasinensins possess several health benefit properties.We consider it significant and necessary to have a comprehensive review in the recent advances of oolong tea.Therefore,the aim of the present review is to provide a new perspective on oolong tea and its characteristic phytochemicals,theasinensins associated with health benefits,molecular action pathway,and chemical mechanism of theasinensin formation from scientific evidences available on the literature.Furthermore,the chemical characterization of the oxidation products and the model oxidation system to the chemical changes of theasinensins are also discussed. | Monthana Weerawatanakorn Wei-Lun Hung Min-Hsiung Pan Shiming Li Daxiang Li Xiaochun Chi-Tang Ho | 2015 | Food Science and Human Wellness2015，4，4： | 8 |
| 5 | Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy显示文摘Objective:To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars(GNSs)with Chlorin e6 molecules(Ce6)into human peripheral blood mononuclear cells(PBMCs)-derived NK cells for tumor targeted therapy.Methods:GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis.The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry(FCM)and ELISA.Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8.Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic(CLSM)and FCM at different time points.Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM.The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging.The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice.Results:The coated CaC03 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging.The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy.Conclusions:The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice.Through fully utilizing the features of GNSs and NK cells,this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future. | Bin Liu Wen Cao Jin Cheng Sisi Fan Shaojun Pan Lirui Wang Jiaqi Niu Yunxiang Pan Yanlei Liu Xiyang Sun Lijun Ma Jie Song Jian Ni Daxiang Cui | 2019 | Cancer Biology & Medicine2019，16，4： | 7 |
| 6 | Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘 | Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang | 2016 | Cellular & Molecular Immunology2016，13，5： | 6 |
| 7 | Oligomeric proanthocyanidin protects retinal ganglion cells against oxidative stress-induced apoptosis显示文摘The death of retinal ganglion cells is a hallmark of many optic neurodegenerative diseases such as glaucoma and retinopathy.Oxidative stress is one of the major reasons to cause the cell death Oligomeric proanthocyanidin has many health beneficial effects including antioxidative and neuroprotective actions.Here we tested whether oligomeric proanthocyanidin may protect retina ganglion cells against oxidative stress induced-apoptosis in vitro.Retinal ganglion cells were treated with hydrogen peroxide with or without oligomeric proanthocyanidin3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay showed that treating retinal ganglion cell line RGC-5 cells with 20μmol/L oligomeric proanthocyanidin significantly decreased the hydrogen peroxide(H2O2)induced death.Results of flow cytometry and Hoechst staining demonstrated that the death of RGC-5 cells was mainly caused by cell apoptosis.We further found that expression of pro-apoptotic Bax and caspase-3 were significantly decreased while anti-apoptotic Bcl-2 was greatly increased in H2O2damaged RGC-5 cells with oligomeric proanthocyanidin by western blot assay.Furthermore,in retinal explant culture,the number of surviving retinal ganglion cells in H2O2-damaged retinal ganglion cells with oligomeric proanthocyanidin was significantly increased.Our studies thus demonstrate that oligomeric proanthocyanidin can protect oxidative stress-injured retinal ganglion cells by inhibiting apoptotic process. | Hui Wang Chanjuan Zhang Dan Lu Xiaoming Shu Lihong Zhu Renbing Qi Kwok-Fai So Daxiang Lu Ying Xu | 2013 | Neural Regeneration Research2013，8，25： | 5 |
| 8 | One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip显示文摘RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiF e-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiF e-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin.Cell lines such as Calu3, Hela, A549, CaF br, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost,easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition. | Chenchen Bao Lei Chen Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou | 2013 | Nano-Micro Letters2013，5，3： | 5 |
| 9 | Bioinspired MXene-Based User-Interactive Electronic Skin for Digital and Visual Dual-Channel Sensing显示文摘User-interactive electronic skin(e-skin) that could convert mechanical stimuli into distinguishable outputs displays tremendous potential for wearable devices and health care applications. However, the existing devices have the disadvantages such as complex integration procedure and lack of the intuitive signal display function. Here, we present a bioinspired user-interactive e-skin, which is simple in structure and can synchronously achieve digital electrical response and optical visualization upon external mechanical stimulus. The e-skin comprises a conductive layer with a carbon nanotubes/cellulose nanofibers/MXene nanohybrid network featuring remarkable electromechanical behaviors, and a stretchable elastomer layer, which is composed of silicone rubber and thermochromic pigments. Furthermore, the conductive nanohybrid network with outstanding Joule heating performance can generate controllable thermal energy under voltage input and then achieve the dynamic coloration of silicone-based elastomer. Especially, such an innovative fusion strategy of digital data and visual images enables the e-skin to monitor human activities with evermore intuition and accuracy. The simple design philosophy and reliable operation of the demonstrated e-skin are expected to provide an ideal platform for next-generation flexible electronics. | Wentao Cao Zheng Wang Xiaohao Liu Zhi Zhou Yue Zhang Shisheng He Daxiang Cui Feng Chen | 2022 | Nano-Micro Letters2022，14，7： | 4 |
| 10 | GSH-triggered sequential catalysis for tumor imaging and eradication based on star-like Au/Pt enzyme carrier system显示文摘Distinctively different metabolism between tumor cells and normal cells endows tumor tissues unique microenvironment.In this regard,we have successfully prepared a sequential catalytic platform based on Au/Pt star for tumor theragnostic.The multifunctional probes consisted of a gold/platinum star-shaped core(Au/Pt star)conjugated with a GSH-sensitive disulfide bond(S–S),a targeting ligand(rHSA-FA),a near-infrared fluorophore(IR780)and glucose oxidase(GOx).When systemically administered in a xenografted murine model,the probes specifically targeted the tumor sites.As the disulfide linker was cleaved by intracellular GSH,the IR780 molecules could be released for photo-thermal therapy&photodynamic therapy(PTT&PDT)and imaging.Subsequently,the Pt nanolayer of the Au/Pt star and the GOx formed a sequential catalytic system:GOx effectively catalyzed intracellular glucose by consuming oxygen to generate H2O2 and enhance the local acidity,and the Pt layer exhibited peroxidase-like property to catalyze H2O2 producing toxic·OH for tumor oxidative damage.Here we demonstrated that our probes simultaneously possessed a GSH-sensitive release,real-time imaging ability,and synergetic cancer starving-like therapy/enzyme oxidative therapy/PTT/PDT features,which provides a potential strategy for effective tumor theragnostic. | Amin Zhang Qian Zhang Gabriel Alfranca Shaojun Pan Zhicheng Huang Jin Cheng Qiang Ma Jie Song Yunxiang Pan Jian Ni Lijun Ma Daxiang Cui | 2020 | Nano Research2020，13，1： | 4 |
| 11 | Preparation of porous structures on copper microchannel surfaces by laser writing显示文摘A laser writing method is developed to fabricate porous structures on copper microchannel wall surfaces for enhanced microchannel heat sinks(MHSs). The formation feasibility together with its mechanism of such porous structures is explored by the comparison of dry and wet laser writing process, i.e., in both air atmosphere and under de-ionized water. Rectangular microchannels with ripples-like porous structures on the wall surfaces, which consisted of numerous micro-holes and micro-cavities,have been successfully formed in the dry laser writing process. Nevertheless, the microchannel wall surfaces were hardly altered in wet conditions. Besides, the effect of laser fluence on the formation of porous structures on the microchannels was also assessed in both dry and wet conditions. In dry laser writing process, the microchannel depth and surface roughness of wall surface increased monotonically, whereas the microchannel bottom width decreased continuously with increasing the laser fluence. On the other hand, the microchannel wall kept almost unchanged with smooth surfaces with increasing laser fluence in wet conditions. | DENG DaXiang CHEN XiaoLong CHEN Liang LIAN YunSong FU Ting | 2019 | Science China(Technological Sciences)2019，62，12： | 4 |
| 12 | Advances in isolation and detection of circulating tumor cells based on microfluidics显示文摘Circulating tumor cells(CTCs) are the cancer cells that circulate in the peripheral blood after escaping from the original or metastatic tumors. CTCs could be used as non-invasive source of clinical information in early diagnosis of cancer and evaluation of cancer development. In recent years, CTC research has become a hotspot field wherein many novel CTC detection technologies based on microfluidics have been developed. Great advances have been made that exhibit obvious technical advantages, but cannot yet satisfy the current clinical requirements. In this study, we review the main advances in isolation and detection methods of CTC based on microfluidics research over several years, propose five technical indicators for evaluating these methods, and explore the application prospects. We also discuss the concepts, issues, approaches, advantages, limitations, and challenges with an aim of stimulating a broader interest in developing microfluidics-based CTC detection technology. | Dan Zou Daxiang Cui | 2018 | Cancer Biology & Medicine2018，15，4： | 4 |
| 13 | Functional characterization of the NF-kB binding site in the human NOD2 promoter显示文摘Nucleotide-binding and oligomerization domain 2(NOD2),a member of the NOD protein family,plays an important role in innate immunity.In response to pathogen attack,NOD2 stimulates cytokine and defensin production by activating nuclear factor(NF)-kB,a key transcription factor responsible for mediating downstream reactions.However,the mechanism linking NOD2 regulation and NF-kB activation is poorly understood.Using bioinformatics,we found a completely preserved canonical NF-kB binding site in the NOD2 core promoter(216 to 225 bp)in both humans and chimpanzees.The functional role of this NF-kB binding site was investigated using the enhanced green fluorescent protein(EGFP)reporter system,site-directed mutagenesis,the NF-kB activation inhibitor(JSH-23)and the chromatin immunoprecipitation(ChIP)assay.The results show that the NF-kB binding site is critical for regulation of the NOD2 gene.Either deletion of the NF-kB binding elements within the NOD2 promoter or treatment with an NF-kB activation inhibitor could lead to a significant loss of NOD2 promoter activity as detected by reporter gene assay.The canonical NF-kB binding site was bound by NF-kB as determined by the ChIP method.Based on these results,we suggest a positive feedback regulation between NF-kB and NOD2,which may represent an efficient mechanism in response to pathogen invasion. | Chaofeng Hu Liping Sun Yiling Hu Daxiang Lu Huadong Wang Suisheng Tang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 14 | Microstructure and Tribological Properties of PlasmaSprayed Ni/MoS_2 Solid Lubrication Coating显示文摘A composite Ni based MoS2 solid lubrication coating was prepared using the plasma spraying technology with optimized process parameters.The tribological properties of the composite Ni/MoS2 coatings in air and vacuum were studied with a ball-on-disk friction and wear tester under dry sliding condition,respectively.XRD,SEM and EDS were adopted to analyze the microstructures of the coating before and after wear tests.Results showed that the deposition quality of the coating was good.The content of lubricant MoS2 was high.But the compactability of the coating with many superficial micrometersized defects such as pores and cracks was relatively low.The composite Ni/MoS2 coating exhibited excellent friction-reduction properties both in air and in vacuum conditions.In vacuum,the wear loss was greater because the severe spalling of top layer resulted from breakthrough of the adjacent defects.In air condition,the wear loss of the coating was relatively low but its friction-reduction ability may be weakened for the oxidation of MoS2. | Ma Guozheng,Xu Binshi,Wang Haidou,Yang Daxiang National Key Laboratory for Remanufacturing,Academy of Armored Forces Engineering,Beijing 100072,China | 2012 | 稀有金属材料与工程2012，41，S1： | 3 |
| 15 | Synthesis of ceramic precursor polycarbosi-lane (PCS) under supercritical fluids (SCFs) state显示文摘Using xylene as supercritical fluids (SCFs) media and polydimethylsilane (PDMS) as raw material, the ceramic precursor polycarbosilane (PCS) with moderate mo-lecular weight and narrow molecular weights distribution was synthesized under high pressure and temperature in autoclave. Softening-point test, Fourier transform infrared spectroscopy (FT-IR), gel permeation chromatography (GPC), element analysis and the yield test of PCS were adopted to characterize the SCFs-method and compared with two other PCS synthesis methods named normal-pressure high-temperature (NP) method and high-pressure hith-temperature (HP) method. The results indicate that the PCS maintains a high Si-H content and its chemical formula is SiC1.91H7.27O0.05. The yield is 63.5 wt% which has been improved by about 20 wt%, the softening-point is 180―220 ℃, the number average molecular weight is 1477 and the molecular weights distribution index is 1.61. The synthesis method via supercritical fluids with good diathermancy and reaction uniformity is a new feasi-ble method of synthesizing PCS with good qualities. | YANG DaXiang SONG YongCai LI ZongYuan | 2008 | Science China(Technological Sciences)2008，51，9： | 3 |
| 16 | Machine Learning Approach to Enhance the Performance of MNP?Labeled Lateral Flow Immunoassay显示文摘The use of magnetic nanoparticle(MNP)-labeled immunochromatography test strips(ICTSs) is very important for point-ofcare testing(POCT). However, common diagnostic methods cannot accurately analyze the weak magnetic signal from ICTSs, limiting the applications of POCT. In this study, an ultrasensitive multiplex biosensor was designed to overcome the limitations of capturing and normalization of the weak magnetic signal from MNPs on ICTSs. A machine learning model for sandwich assays was constructed and used to classify weakly positive and negative samples, which significantly enhanced the specificity and sensitivity. The potential clinical application was evaluated by detecting 50 human chorionic gonadotropin(HCG) samples and 59 myocardial infarction serum samples. The quantitative range for HCG was 1–1000 mIU mL^(-1) and the ideal detection limit was 0.014 mIU mL^(-1), which was well below the clinical threshold. Quantitative detection results of multiplex cardiac markers showed good linear correlations with standard values. The proposed multiplex assay can be readily adapted for identifying other biomolecules and also be used in other applications such as environmental monitoring, food analysis, and national security. | Wenqiang Yan Kan Wang Hao Xu Xuyang Huo Qinghui Jin Daxiang Cui | 2019 | Nano-Micro Letters2019，11，1： | 2 |
| 17 | Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection显示文摘Metal-organic frameworks(MOFs)have attracted widespread interest due to their unique and unprecedented advantages in microstructures and properties.Besides,surface-enhanced Raman scattering(SERS)technology has also rapidly developed into a powerful fingerprint spectroscopic technique that can provide rapid,non-invasive,non-destructive,and ultra-sensitive detection,even down to single molecular level.Consequently,a considerable amount of researchers combined MOFs with the SERS technique to further improve the sensing performance and broaden the applications of SERS substrates.Herein,representative synthesis strategies of MOFs to fabricate SERS-active substrates are summarized and their applications in ultra-sensitive biomedical trace detection are also reviewed.Besides,relative barriers,advantages,disadvantages,future trends,and prospects are particularly discussed to give guidance to relevant researchers. | Yuna Zhang Cuili Xue Yuli Xu Shengsheng Cui Alexander A.Ganeev Kistenev Yury V Anna Gubal Victoria Chuchina Han Jin Daxiang Cui | 2023 | Nano Research2023，16，2： | 2 |
| 18 | A novel HBV genotypes detecting system combined with microfluidic chip, loop-mediated isothermal amplification and GMR sensors显示文摘 | Xiao Zhi Min Deng Hao Yang Guo Gao Kan Wang Hualin Fu Yixia Zhang Di Chen Daxiang Cui | 2014 | Biosensors and Bioelectronics2014，，： | 2 |
| 19 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 20 | N-doped coaxial CNTs@a-Fe_2O_3@C nanofibers as anode material for high performance lithium ion battery显示文摘N-doped coaxial CNTs@α-Fe_2O_3@C nanofibers have been successfully synthesized according to a facile solvothermal/hydrothermal method.The obtained CNTs@α-Fe_2O_3@C nanofibers composites exhibited special three-dimensional(3-D)network structure,which endows they promising candidate for anode materials of lithium ion battery.The coaxial property of CNTs@α-Fe_2O_3@C nanofibers could significantly improve the cycling and rate performance owing to the acceleration of charge/electron transfer,improvement of conductivity,maintaining of structural integrity and inhibiting the aggregation.Theα-Fe_2O_3nanoparticles with small size and high percentage of N-doped amount could further improve the electrochemical performance.As for the CNT@α-Fe_2O_3@C nanofibers,the capacity presented a high value of1255.4 mAh/g at 0.1 C,and retained at 1213.4 mAh/g after 60 cycles.Even at high rate of 5 C,the capacity still exhibited as high as 319 mAh/g.The results indicated that the synthesized N-doped coaxial CNTs@α-Fe_2O_3@C nanofibers exhibited high cycling and rate performance. | Peng Huang Wei Tao Haixia Wu Xiaogang Li Ting Yin Qian Zhang Wen Qi Guo Gao Daxiang Cui | 2018 | Journal of Energy Chemistry2018，27，5： | 2 |
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