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2篇 您的检索式：作者名="David Liska"

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		题名	作者	年代	出处	被引量
	1	Pulmonary Recurrence Predominates After Combined Modality Therapy for Rectal Cancer: An Original Retrospective Study显示文摘	Peirong Ding David Liska Peter Tang Jinru Shia Leonard Saltz Karyn Goodman Robert J. Downey Garrett M. Nash Larissa K. Temple Philip B. Paty José G. Guillem W. Douglas Wong Martin R. Weiser	2012	Annals of Surgery2012，，1：	1
	2	Association of cancer with comorbid inflammatory conditions and treatment in patients with Lynch syndrome显示文摘BACKGROUND Individuals with Lynch syndrome(LS)and hereditary non-polyposis colorectal cancer(HNPCC)are at increased risk of both colorectal cancer and other cancers.The interplay between immunosuppression,a comorbid inflammatory condition(CID),and HNPCC on cancer risk is unclear.AIM To evaluate the impact of CIDs,and exposure to monoclonal antibodies and immunomodulators,on cancer risk in individuals with HNPCC.METHODS Individuals prospectively followed in a hereditary cancer registry with LS/HNPCC with the diagnosis of inflammatory bowel disease or rheumatic disease were identified.We compared the proportion of patients with cancer in LS/HNPCC group with and without a CID.We also compared the proportion of patients who developed cancer following a CID diagnosis based upon exposure to immunosuppressive medications.RESULTS A total of 21 patients with LS/HNPCC and a CID were compared to 43 patients with LS/HNPCC but no CID.Cancer occurred in 84.2% with a CID compared to 76.7% without a CID(P=0.74)with no difference in age at first cancer diagnosis 45.5±14.6 vs 43.8±7.1 years(P=0.67).LS specific cancers were diagnosed in 52.4% with a CID vs 44.2% without a CID(P=0.54).Nine of 21(42.9%)patients were exposed to biologics or immunomodulators for the treatment of their CID.Cancer after diagnosis of CID was seen in 7(77.8%)of exposed individuals vs 5(41.7%)individuals unexposed to biologics/immunomodulators(P=0.18).All 7 exposed compared to 3/5 unexposed developed a LS specific cancer.The exposed and unexposed groups were followed for a median 10 years and 8.5 years,respectively.The hazard ratio for cancer with medication exposure was 1.59(P=0.43,95%CI:0.5-5.1).CONCLUSION In patients with LS/HNPCC,the presence of a concurrent inflammatory condition,or use of immunosuppressive medication to treat the inflammatory condition,might not increase the rate of cancer occurrence in this limited study.	Muhammad S Faisal Carol A Burke David Liska Amy L Lightner Brandie Leach Margaret O’Malley Lisa LaGuardia Benjamin Click JP Achkar Matthew Kalady JM Church Gautam Mankaney	2022	World Journal of Clinical Oncology2022，13，1：	0

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