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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 3 | Caveolin-1 is down-regulated in alveolarrhabdomyosarcomas and negatively regulatestumor growth显示文摘 | Juan HM Santiago RV David HM | 2014 | Oncotarget2014，5，20： | 1 |
| 4 | RNAstructure: software for RNA secondary structure prediction and analysis 显示文摘 | Jessica SR David HM | 2010 | BMC Bioin formaties2010，3，15： | 1 |
| 5 | IDO and tolerance to tumors显示文摘 | David HM Andrew LM | 2004 | Trends Mol Med2004，10，1： | 1 |
| 6 | Evidence for preconditioning by isoflurane in coronary artery bypass graft surgery 显示文摘 | Peynet J Louzy M David HM | 2000 | Circulation2000，01，11： | 1 |
| 7 | Caveolin-1 is down-regulated in alveolarrhabdomyosarcomas and negatively regulatestumor growth显示文摘 | Juan HM Santiago RV David HM | 2014 | Oncotarget2014，5，20： | 1 |
| 8 | A fresh look atreperfusioninjury 显示文摘 | David GD | 1998 | Cardiovascular Research1998，38，2： | 1 |
| 9 | Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction显示文摘 | Elliott MA David MA Carolyn HM | 2006 | New Eng J Med2006，354，14： | 1 |
| 10 | Target converage for head and neck cancers treated with IMRT: review of clinical experiences 显示文摘 | Adam SG William HM David IR | 2004 | Semin Radiat Oncol2004，14，2： | 1 |
| 11 | Simultaneous PCR Detection of Haemophilus ducreyi,Treponema pallidum,and Herpes Simplex Virus Types 1 and 2 from Genital Ulcers显示文摘 | Carol AG David HM | 1996 | J Clin Microbiol1996，34，1： | 1 |
| 12 | Evaluating Electronic Referrals for Specialty Care at a Public Hospital显示文摘 | Judy E. Kim-Hwang Alice Hm Chen Douglas S. Bell David Guzman Hal F. Yee Margot B. Kushel | 2010 | Journal of General Internal Medicine2010，，10： | 1 |
| 13 | The Microbiota of the vaginal and its influence on women's health and disease显示文摘 | David HM | 2012 | Am J Med Sei2012，343，1： | 1 |
| 14 | Statins and risk of inci- dent diabetes: a collaborative recta-analysis of randomised statin trials显示文摘 | Naveed S David P Murray HM | 2010 | Lancet2010，375，9716： | 1 |
| 15 | Technical report: ethical and policy issues in genetic testing and screening of children 显示文摘 | Ross LF Saal HM David KL | 2013 | Genet Med2013，15，3： | 1 |
| 16 | Hepatic lesion characterization in cirrhosis: significance of arterial hypervascularity on dual-phase helical CT 显示文摘 | David S K L Krasny RM | 1997 | AJR1997，169，： | 1 |
| 17 | The tentorial notch:anatomical variation,morphometric analysis,and classification in 100 humen autopsy cases显示文摘 | THOMAS HM | 2002 | J Neurosurg2002，96，6： | 1 |
| 18 | Indoleamine 2,3-dioxygenase and tumor-induced tolerance显示文摘 | David HM Mellor AL | 2007 | J Clin Invest2007，117，5： | 1 |
| 19 | Health' systems' accountability for patient safety显示文摘 | David K Pamela HM | 2010 | OJIN2010，8，9： | 1 |
| 20 | Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase显示文摘 | David HM Madhav DS Jeffrey RL | 2002 | Science2002，297，： | 1 |
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