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| 1 | How the Bcl-2 family of proteins interact to regulate apoptosis显示文摘到 apoptosis 的房间的承诺主要被在 Bcl-2 蛋白质家庭的成员之间的蛋白质蛋白质相互作用管理。它的三个亚科有不同角色:BH3 仅仅,蛋白质经由他们的 BH3 领域由绑定触发 apoptosis 到支持幸存的亲戚,当 pro-apoptotic Bax 和 Bak 有一个必要下游的角色包含 organellar 膜和 caspase 激活的正式就职的混乱时。BH3 仅仅,蛋白质充当损坏传感器,由压力信号保持惰性直到他们的激活。一旦激活,他们被认为杂乱地绑在支持幸存的蛋白质目标,但是意外选择最近从他们的相互作用的分析出现了。BH3 仅仅,蛋白质也绑在 Bax 和 Bak 的一些。Bax 和 Bak 是否被这些 BH3 仅仅直接激活蛋白质,或间接地作为后果 BH3 仅仅蛋白质抵销他们的支持幸存的目标是强烈争论的题目。不管这,在家庭成员之间的相互作用的详细理解,经常选择,为设计反癌症药指向 Bcl-2 家庭有著名含意。 | Mark F van Delft David CS Huang | 2006 | Cell Research2006，16，2： | 38 |
| 2 | Machine-learned multi-system surrogate models for materials prediction显示文摘Surrogate machine-learning models are transforming computational materials science by predicting properties of materials with the accuracy of ab initio methods at a fraction of the computational cost.We demonstrate surrogate models that simultaneously interpolate energies of different materials on a dataset of 10 binary alloys(AgCu,AlFe,AlMg,AlNi,AlTi,CoNi,CuFe,CuNi,FeV,and NbNi)with 10 different species and all possible fcc,bcc,and hcp structures up to eight atoms in the unit cell,15,950 structures in total.We find that the deviation of prediction errors when increasing the number of simultaneously modeled alloys is<1 meV/atom.Several state-of-the-art materials representations and learning algorithms were found to qualitatively agree on the prediction errors of formation enthalpy with relative errors of<2.5% for all systems. | Chandramouli Nyshadham Matthias Rupp Brayden Bekker Alexander V.Shapeev Tim Mueller Conrad W.Rosenbrock Gábor Csányi David W.Wingate Gus L.W.Hart | 2019 | npj Computational Materials2019，，1： | 8 |
| 3 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 4 | Specific amplification with PCR of a refractory segment of genomic DNA显示文摘 | HAQQI TM SARKAR G DAVID CS | 1998 | Nucleic Acids Res1998，16，11： | 1 |
| 5 | Commensal bac- teria-derived signals regulate basophil hematopoiesis and allergic inflammation显示文摘 | David AH Mark CS michael CA | 2008 | Nature Medicine2008，3，12： | 1 |
| 6 | Authenticity and Consumer Value Ratings: Empirical Tests from the Restaurant Domain显示文摘 | Balázs Kovács Glenn R. Carroll David W. Lehman | 2014 | Organization Science2014，，2： | 1 |
| 7 | 显示文摘 | Kong YC David CS | 2000 | Int Roy Immunol2000，19，： | 1 |
| 8 | Early hepatocellular carcinoma:transplantation versus resection:the case for liver resection显示文摘 | Merchant N David CS Cunningham SC | | 0，，： | 1 |
| 9 | Acetylcholine receptor peptide recognition in HLA DR3-transgenic mice: in vivo responses correlation with MHC-peptide binding显示文摘 | Spack EG David CS | 2001 | J Immunol2001，167，： | 1 |
| 10 | Molecular analysis and repair of a defective Ef alpha gene显示文摘 | Donovan KA Singh SK David CS | 1989 | Immunol1989，142，11： | 1 |
| 11 | HLA transgenic mice as humanized mouse models of disease and immunity显示文摘 | Taneja V David CS | 1998 | J Clin Invest1998，101，： | 1 |
| 12 | Role of HLA-B27 in spondyloarthropathies 显示文摘 | Khare SD Luthra HS David CS | 1996 | Curt Top Microbiol Immunol1996，206，： | 1 |
| 13 | Esophageal leiomyomato- sis presenting as achalasia diagnosed by high-resolution manometry and endoscopic core biopsy显示文摘 | David AK Thomas CS Heather JC | 2012 | Gastrointestinal Endoscopy2012，76，1： | 1 |
| 14 | Spontaneous inflammatory arthritis in HLA-B27 transgeic mice lacking beta 2-microglobulin : a model of human spondyloarthropathies 显示文摘 | Khare SD Luthra HS David CS | 1995 | J Exp Med1995，182，： | 1 |
| 15 | H2A- and H2E-derived CD4+CD25+regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis显示文摘 | Morris GP Yan Y David CS | 2005 | J Immunol2005，174，5： | 1 |
| 16 | Prospects for targeting the Bcl-2 family of proteins to develop novel cytotoxic drugs显示文摘 | Jonathan B David CS | 2002 | Biochemical Pharmacology2002，64，： | 1 |
| 17 | Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin,a model of human spondyloarthropathies显示文摘 | Khare SD Luthra HS David CS | 1995 | J Exp Med1995，182，4： | 1 |
| 18 | You can run, but you can't hide:An effective methodology to traceback DDoS attackers显示文摘 | Law KT John CS Lui David KY Yau | 2005 | IEEE Transactions On Parallel and Distributed Systems2005，16，9： | 1 |
| 19 | A non-linear fuzzy regression for estimating reliability in a degradation process显示文摘 | SG David JPA Rolando CS Mario | 2014 | Applied Soft Computing2014，16，： | 1 |
| 20 | Statin therapy may be associated with lower mortality in patients with diastolic heart failure:a preliminary report显示文摘 | Hidekatsu F David CS Stefen B | 2005 | Circulation2005，111，2： | 1 |
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