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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Optical disassembly of cellular clusters by tunable ‘tug-of-war’ tweezers显示文摘Bacterial biofilms underlie many persistent infections,posing major hurdles in antibiotic treatment.Here we design and demonstrate‘tug-of-war’optical tweezers that can facilitate the assessment of cell–cell adhesion—a key contributing factor to biofilm development,thanks to the combined actions of optical scattering and gradient forces.With a customized optical landscape distinct from that of conventional tweezers,not only can such‘tug-of-war’tweezers stably trap and stretch a rod-shaped bacterium in the observing plane,but,more importantly,they can also impose a tunable lateral force that pulls apart cellular clusters without any tethering or mechanical movement.As a proof of principle,we examined a Sinorhizobium meliloti strain that forms robust biofilms and found that the strength of intercellular adhesion depends on the growth medium.This technique may herald new photonic tools for optical manipulation and biofilm study,as well as other biological applications. | Anna S Bezryadina Daryl C Preece Joseph C Chen Zhigang Chen | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 3 | 1-Methylcyclopropene treatment affects strawberry fruit decay显示文摘 | Yueming Jiang Daryl C Joyce Leon A Terry | 2001 | Postharvest Biology and Technology2001，，3： | 2 |
| 4 | An investigation of self reinforced poly denture base acrylic resin using scanning electron and atomic force microscopy显示文摘 | Daryll C | 2000 | Int J Prosthodont2000，13，6： | 1 |
| 5 | Extension of the shelf life ofbanana fruit by 1-methylcyclopropene in combination with polyethylene bags显示文摘 | JIANG Y M DARYL C JOYCE | 1999 | Postharvest Biology and Technology1999，16，2： | 1 |
| 6 | Extension of the shelf life of banana fruit by 1-methylcyclopropene in combination with polyethylene bags显示文摘 | Jiang Y M Daryl C Joyce | 1999 | Postharvest Biology and Technology1999，16，： | 1 |
| 7 | Effects of salt concentration and freezing on mozzarella cheese texture显示文摘 | MIGUEL A C DARYL B L | 1983 | J Dairy Sci1983，66，： | 1 |
| 8 | Optimizing liposomes for delivery of chemotherapeutic agents to solid tumors 显示文摘 | DARYL C D OLIVIER M KEELUNG H | 1999 | Pharmacol Rev1999，51，3： | 1 |
| 9 | Responses of banana fruit treatment with 1-methylcyclopropenes 显示文摘 | Jiang Y M Daryl C J Andrew J M | 1999 | Plant Growth Regulation1999，28，： | 1 |
| 10 | Physiology and quality response of harvested banana fruit to cold shock显示文摘 | Zhang Haiyan Yang Shaoyu Daryl C J | 2010 | Postharvest Biology and Technology2010，55，3： | 1 |
| 11 | Effects of Salt Concentration and Freezing on Mozzarella Cheese Texture显示文摘 | MIGUEL A C DARYL B L NORMAN F O | 1983 | J Dairy Sci1983，66，： | 1 |
| 12 | An investigation of se1f reinforced po1y denture base acrylic resin using scanning electron and atomic force microscopy 显示文摘 | Daryll C | 2000 | Int J Prosthodont2000，13，6： | 1 |
| 13 | Perfeetionism and psychological dis- tress:evidence of the mediating effects of rumination显示文摘 | Daryl B Rory C Rachel M | 2007 | Euro- pean Journal of Personality2007，21，4： | 1 |
| 14 | Physiology and quality response of harvested banana fruit to cold shock 显示文摘 | Zhang Haiyan Yang Shaoyu Daryl C J | 2010 | Postharvest Biology and Technology2010，55，3： | 1 |
| 15 | An investigation of self reinforced poly denture base acrylic resin using scanning electron and atomic force microscopy 显示文摘 | Daryll C | 2000 | Int J Prosthodont2000，13，6： | 1 |
| 16 | Physiology and quality response of harvested banana fruit to cold shock显示文摘 | Zhang Haiyan Yang Shaoyu Daryl C J | | 0，，03： | 1 |
| 17 | The cosmetic appearance of the biceps muscle after long-head Tenotomy Versus Tenodesis显示文摘 | Daryl C Osbahr BS Alex B | | 0，，： | 1 |
| 18 | Localized genetic algorithm for vehicle routing problem with time windows显示文摘 | Ziauddin U Daryl E David C | 2011 | Applied Soft Compu- ting2011，11，8： | 1 |
| 19 | The efficacy of continuous cryother- apy on the postoperative shoulder: A prospective, randomized in- vestigation显示文摘 | Singh H Daryl C Osbahr BS | 2001 | J Shoulder Elbow Surg2001，10，6： | 1 |
| 20 | Scale factor non-linearity of a body dither laser gyro显示文摘 | THOMAS J H DARYL C S | 1978 | J IEEE1978，66，5： | 1 |
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