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| 1 | Prognosis and weaning of elderly multiple organ dysfunction syndrome patients with invasive mechanical ventilation显示文摘 | Xiao Kun Su Longxiang Han Bingchao Guo Chao Feng Lin Jiang Zhaoxu Wang Huijuan Lin Yong Jia Yanhong She Danyang Xie Lixin | 2014 | Chinese Medical Journal2014，，1： | 7 |
| 2 | Multifunctional dextran micelles as drug delivery carriers and magnetic resonance imaging probes显示文摘Multifunctional nanoparticles combining diagnostic and therapeutic agents into a single platform make cancer theranostics possible and have attracted wide interests in the field. In this study, a multifunctional nanocomposite based on dextran and superparamagnetic iron oxide nanoparticles(SPIO) was prepared for drug delivery and magnetic resonance imaging(MRI). Amphiphilic dextran was synthesized by grafting stearyl acid onto the carbohydrate backbone, and micelle was formed by the resulted amphiphilic dextran with low critical micelle concentration at 1.8 mg L-1. Doxorubicin(DOX) and a cluster of the manganese-doped iron oxide nanoparticles(Mn-SPIO)nanocrystals were then coencapsulated successfully inside the core of dextran micelles, resulting in nanocomposites with diameter at about 100 nm. Cell culture experiments demonstrated the potential of these Mn-SPIO/DOX nanocomposites as an effective multifunctional nanoplatform for the delivery of anticancer drug DOX with a loading content(DLC) of 16 %. Confocal laser scanning microscopyreveals that the Mn-SPIO/DOX had excellent internalization ability against MCF-7/Adr cells after 2-h labeling compared with free DOXáHCl. Under a 3.0-T MRI scanner, Mn-SPIO/DOX nanocomposite-labeled cells in gelatin phantom show much darker images than the control. Their transverse relaxation(T2) rate is also significantly higher than that of the control cells(33.9 versus 2.3 s-1). Our result offers an effective strategy to treat MCF-7/Adr at optimized low dosages with imaging capability. | Bingbing Lin Hongying Su Rongrong Jin Danyang Li Changqiang Wu Xin Jiang Chunchao Xia Qiyong Gong Bin Song Hua Ai | 2015 | Science Bulletin2015，60，14： | 6 |
| 3 | Parametrization of woods-saxon potential for heavy-ion systems显示文摘Several elastic scattering angular distributions of ^(12)C from target nuclei of A ≥39 are analyzed to extract the Woods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters.Using the best fitted diffuseness parameters,the correlations of the real part parameters with A_1^(1/3)+ A_2^(1/3) and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction.The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by ^(12)C,but also many elastic scattering angular distributions induced by the projectiles other than ^(12)C,thus providing important inputs for the study of nuclear reactions of heavy-ion systems. | Lin Gan ZhiHong Li HuiBin Sun DanYang Pang Bing Guo YunJu Li Jun Su ShengQuan Yan ErTao Li YouBao Wang Gang Lian ZhiYu Han XinYue Li DongHui Li TianLi Ma ChangJin Pei YangPing Shen Yi Su Sheng Zeng Yong Zhou WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 2 |
| 4 | Improving tensile-shear properties of friction stir lap welded dissimilar Al/Mg joints by eliminating hook defect and controlling interfacial reaction显示文摘To improve tensile-shear properties of fiction stir lap welded(FSLW) dissimilar Al/Mg joints, pin-tip profiles were innovatively designed and welding speed was optimized, and effects of them on formation, interface microstructure and mechanical properties of different FSLW joints were investigated. With increasing the welding speed, the tensile-shear load of FSLW joints produced by three pins presents an increasing firstly and then decreasing trend. Compared with Rpin, the hook and hole defect in the joints made by S-pin and T-pin are eliminated owing to additional eccentric force. Moreover, the joints obtained by T-pin at 75 mm/min have the highest tensile-shear load, and a maximum value of 3.425 kN is produced, which increases by 96.8%.Meanwhile, the pin-tip profile improves significantly the interface reaction depending on the welding temperature. For R-pin, thick brittle intermetallic compounds of about 6.9 μm Al3Mg2and 13.3 μm Al12Mg17layers at the welding interface derived from diffusion reaction are formed, resulting in continuous cracks. However, using T-pin can raise the interface temperature, and which makes the interface liquefy locally to generate only 2.2 μm Al3Mg2layer and dispersive(Al12-Mg17+Mg) eutectic structure. This can release high residual stress and remove welding crack, consequently enhancing the interface properties of T-pin joints. | Yuqing MAO Ping YANG Wenyan ZHANG Ning LI Hao NIE Danyang LIN Liming KE | 2023 | Chinese Journal of Aeronautics2023，36，7： | 1 |
| 5 | Research on Low Energy Consumption Distributed Fault Detection Mechanism in Wireless Sensor Network显示文摘Wireless sensor network is an important technical support for ubiquitous communication. For the serious impacts of network failure caused by the unbalanced energy consumption of sensor nodes, hardware failure and attacker intrusion on data transmission, a low energy consumption distributed fault detection mechanism in wireless sensor network(LEFD) is proposed in this paper. Firstly, the time correlation information of nodes is used to detect fault nodes in LEFD, and then the spatial correlation information is adopted to detect the remaining fault nodes, so as to check the states of nodes comprehensively and improve the efficiency of data transmission. In addition, the nodes do not need to exchange information with their neighbor nodes in the initial detection process since LEFD adopts the data sensed by node itself to detect some types of faults, thus reducing the energy consumption of nodes effectively. Finally, LEFD also considers the nodes that may have transient faults. Performance analysis and simulation results show that the proposed detection mechanism can improve the transmission performance and reduce the energy consumption of network effectively. | Shuang Jia Lin Ma Danyang Qin | 2019 | China Communications2019，16，3： | 1 |
| 6 | Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARδ/SGLT2/STAT3 signaling pathway显示文摘Mounting evidence demonstrates that hydrogen sulfide(H2S)promotes anti-inflammatory molecules and inhibits pro-inflammatory cytokines in endothelial cells(ECs).This study aims to investigate the favorable action of H2S on endothelial function in senescence by inhibiting the production of inflammatory molecules.Senescent ECs exhibit a reduction in H2S,endothelial nitric oxide synthase(eNOS)and peroxisome proliferator-activated receptorδ(PPARδ),coupled with increased inflammatory molecules,sodium glucose transporter type 2(SGLT2)and phosphorylation of STAT3,which could be reversed by the administration of a slow but sustained release agent of H2S,GYY4137.Decreased production of eNOS and upregulated p-STAT3 and SGLT2 levels in senescent ECs are reversed by replenishment of the SGLT2 inhibitor EMPA and the PPARδagonist GW501516.The PPARδantagonist GSK0660 attenuates eNOS expression and increases the production of p-STAT3 and SGLT2.However,supplementation with GYY4137 has no beneficial effect on GSK0660-treated ECs.GYY4137,GW501516 and EMPA preserve endothelialdependent relaxation(EDR)in D-gal-treated aortae,while GSK0660 destroys aortic relaxation even with GYY4137 supplementation.In summary,senescent ECs manifest aggravated the expressions of the inflammatory molecules SGLT2 and p-STAT3 and decreased the productions of PPARδ,eNOS and CSE.H2S ameliorates endothelial dysfunction through the anti-inflammatory effect of the PPARδ/SGLT2/p-STAT3 signaling pathway in senescent ECs and may be a potential therapeutic target for anti-ageing treatment. | Danyang Tian Jinqi Meng Lin Li Hongmei Xue Qi Geng Yuxin Miao Meng Xu Ru Wang Xiangjian Zhang Yuming Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，9： | 1 |
| 7 | Effect of grain structure on fatigue crack propagation behavior of Al-Cu-Li alloys显示文摘Recrystallization behavior during optimized heat treatments provides a potential to obtain desirable grain structure,which significantly improves the mechanical properties of aluminum alloys.The influence of grain structures on fatigue crack propagation(FCP)behaviors of Al-Cu-Li alloy with hot-rolled(HR)and cold-rolled(CR)was investigated.Subgrain boundaries have a significant impact on small crack growth rates,which is reflected in the pronounced fluctuation of fatigue crack growth of HR specimens after solution treatment.Moreover,the specific cellular structure within grains can improve the deformation capacity of alloys due to their accommodation of plastic deformation,which contributes to the lower fatigue crack growth rates and higher threshold values in HR specimens.The intragranular deflection also decelerates the FCP rate and occurs in these regions of large grain without subgrain boundaries.Recrystallization occurs in the CR specimens,resulting in small anisotropy on the fatigue resistance for the different orientations in the Paris stage due to the recrystallization texture.Fatigue cracks can be deflected and tend to propagate along the grain boundaries when it goes into the grain with a relatively low Schmidt factor value. | Dingding Lu Ben Lin Tianle Liu Sanxi Deng Youjie Guo Jinfeng Li Danyang Liu | 2023 | Journal of Materials Science & Technology2023，，17： | 1 |
| 8 | Process-microstructure-properties of CuAlNi shape memory alloys fabricated by laser powder bed fusion显示文摘Cu-based shape memory alloys(SMAs)show great potential in the application of high temperature,but their performance improvement combining with additive manufacturing is still challenging.In this paper,nearly defect-free(99.7%relative density)CuAlNi SMAs with two types of thermal-induced martensites,18R and 2H,were successfully fabricated by laser powder bed fusion(LPBF).The remelting printing strat-egy with systematic optimization framework including densification and printability analysis was used to get optimal process window.The twin-related self-accommodation structure with long period stacking order substructure was formed during additive manufacturing process.The as-build samples show excel-lent mechanical properties(ultimate compressive strength of 1593±10 MPa and large fracture strain of 23.0%±0.1%)with double-yielding,and outstanding shape memory effect,with maximum recoverable strain of 3.39% and nearly 100%recovery rate under compressive strain not exceeding 6%.Furthermore,the microstructural evolution in LPBF involving remelting,martensitic transformation,and 2H marten-site was discussed.This result not only builds the microstructure framework involving high reflectivity alloys and martensitic transformation but also provides insight into the applicability of LPBF process in producing Cu-based SMAs. | Yankun Zhang Lianyong Xu Lei Zhao Danyang Lin Minqian Liu Xueyan Qi Yongdian Han | 2023 | Journal of Materials Science & Technology2023，，21： | 0 |
| 9 | Enhanced monopole transition strength from the cluster decay of ^(13)C显示文摘The inelastic excitations and cluster decay of ^(13)C have been measured using the reaction,9Be(^(13)C, ^(13)C* →~9Be + α)~9Be. We observe strong excitation to the 14.3-MeV(1/2-) resonant state from the cluster-decay channel, leading to an enhanced monopole matrix element of(6.3 ± 0.6) fm^2. This large cluster-related monopole strength is a clear indication of the cluster-structure domination of this state and is consistent with the recent prediction of the orthogonality condition model(OCM). It would be interesting to further explore the three-center molecular rotational band that is initiated from the observed band-head. | Jun Feng YanLin Ye Biao Yang ChengJian Lin HuiMin Jia DanYang Pang ZhiHuan Li JianLing Lou QiTe Li XiaoFei Yang Jing Li HongLiang Zang Qiang Liu Wei Jiang ChenGuang Li Yang Liu ZhiQiang Chen HongYi Wu ChunGuang Wang Wei Liu Xiang Wang JingJing Li DiWen Luo Ying Jiang ShiWei Bai JinYan Xu NanRu Ma LiJie Sun DongXi Wang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 0 |
| 10 | Composition,function,and timing:exploring the early‑life gut microbiota in piglets for probiotic interventions显示文摘Background The establishment of a robust gut microbiota in piglets during their early developmental stage holds the potential for long-term advantageous effects.However,the optimal timeframe for introducing probiotics to achieve this outcome remains uncertain.Results In the context of this investigation,we conducted a longitudinal assessment of the fecal microbiota of 63 piglets at three distinct pre-weaning time points.Simultaneously,we gathered vaginal and fecal samples from 23 sows.Employing 16S rRNA gene and metagenomic sequencing methodologies,we conducted a comprehensive analysis of the fluctuation patterns in microbial composition,functional capacity,interaction networks,and colonization resistance within the gut microbiota of piglets.As the piglets progressed in age,discernible modifications in intestinal microbial diversity,composition,and function were observed.A source-tracking analysis unveiled the pivotal role of fecal and vaginal microbiota derived from sows in populating the gut microbiota of neonatal piglets.By D21,the microbial interaction network displayed a more concise and efficient configuration,accompanied by enhanced colonization resistance relative to the other two time points.Moreover,we identified three strains of Ruminococcus sp.at D10 as potential candidates for improving piglets’weight gain during the weaning phase.Conclusions The findings of this study propose that D10 represents the most opportune juncture for the introduction of external probiotic interventions during the early stages of piglet development.This investigation augments our comprehension of the microbiota dynamics in early-life of piglets and offers valuable insights for guiding forthcoming probiotic interventions. | Jianping Quan Cineng Xu Donglin Ruan Yong Ye Yibin Qiu Jie Wu Shenping Zhou Menghao Luan Xiang Zhao Yue Chen Danyang Lin Ying Sun Jifei Yang Enqin Zheng Gengyuan Cai Zhenfang Wu Jie Yang | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 11 | Combinatory action of VEGFR2 and MAP kinase pathways maintains endothelial-cell integrity显示文摘血容器通常坚持说 stereotyped 腔直径和他们的稳定的结构为脉管的功能是关键的。然而,很,很少对控制容器直径的维护和 endothelial 房间的正直的分子的机制被知道。我们由一条化学遗传途径在 zebrafish 胚胎调查了这个问题。小分子图书馆用实时 Tg 被屏蔽(kdrl : GRCFP ) endothelial 房间是的转基因的在胚胎明确地用 GFP 标记的 zn1 。由在腔形成以后在胚胎的血容器的形态学和功能上分析混合物的效果, PP1,一个通常认为的 Src kinase 禁止者,明确地由打断 endothelial 房间正直减少脉管的腔尺寸作为有能力被识别。禁止的效果不由于因为象几个 VEGFR 禁止者一样的另一 Src 禁止者和 Src morpholino 没能生产类似的显型,表明抑制的 Src 或一般 VEGF。在介绍 22 代表性的哺乳动物的 kinases 的一块面板并且调查出版数据以后,我们选择了一些可能的新候选人。这些候选人 kinase 禁止者的 Combinational 分析证实 PP1 由禁止 VEGFR2 和地图 kinase 小径导致了 endothelial 倒塌。更重要地,二临床上同意的药 Dasatinib 和 Sunitinib 的组合使用生产了一样的显型。这是第一研究阐明用化学遗传控制 endothelial 完整的维护的小径来临,显示那 endothelial 正直被 VEGFR2 和地图 kinase 小径的联合行动控制。我们的结果也在循环系统上建议二 anticancer 药的联合的可能的副作用。 | Hanbing Zhong Danyang Wang Nan Wang Yesenia Rios Haigen Huang Song Li Xinrong Wu Shuo Lin | 2011 | Cell Research2011，21，7： | 0 |
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