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| 1 | Effect of pegylated interferon alpha 2b plus ribavirin treatment on plasma transforming growth factor-β1,metalloproteinase-1,and tissue metalloproteinase inhibitor-1 in patients with chronic hepatitis C显示文摘AIM: To evaluate the effect of antiviral treatment on plasma levels of transforming growth factor-β1 (TGF-β1),metalloproteinase 1 (MMP-1), and tissue inhibitor of metalloproteinase-1 (TIMP-1) in patients with chronic hepatitis C.METHODS: TGF-β1, MMP-1, and TIMP-1 plasma concentrations were measured by an enzyme immunoassay in 28 patients, during 48 wk of treatment with pegylated interferon-alpha 2b (PEG-IFN-α2b) plus ribavirin (RBV)and after 24 wk of follow-up. Patients were divided into two groups: responders (R) and non-responders (NR)related to achieved sustained virologic response. Normal values were evaluated in plasma samples of 13 healthy volunteers.RESULTS: Baseline plasma concentrations of TGF-β1and TIMP-1 (30.9±3.7 and 1506±61 ng/mL respectively)measured in all subjects significantly exceeded the normal values (TGF-β1:18.3±1.6 ng/mL and TIMP-1:1102±67 ng/mL). In contrast, pretreatment MMP-1mean level (6.5±0.9 ng/mL) was significantly lower than normal values (11.9±0.9 ng/mL). Response to the treatment was observed in 12 patients (43%). TGF-β1mean concentration measured during the treatment phase decreased to the control level in both groups.However at wk 72, values of NR patients increased and became significantly higher than in R group.TIMP-1 concentrations in R group decreased during the treatment to the level similar to normal. In NR group,TIMP-1 remained significantly elevated during treatment and follow-up phase and significant difference between both groups was demonstrated at wk 48 and 72. MMP-1levels were significantly decreased in both groups at baseline. Treatment caused rise of its concentration only in the R group, whereas values in NR group remained on the level similar to baseline. Statistically significant difference between groups was noted at wk 48 and 72.CONCLUSION: These findings support the usefulness of TGF-β1, TIMP-1, and MMP-1 in the management of chronic hepatitis C. Elevated TIMP-1 and low MMP-1plasma concentrations during antiviral therapy may indicate medication failure. | Robert Flisiak Jerzy Jaroszewicz Tadeusz W Lapiski Iwona Flisiak Danuta Prokopowiczi | 2005 | World Journal of Gastroenterology2005，11，43： | 7 |
| 2 | Geotrlehum hydrolytic activity in milled malt and barley medium 显示文摘 | Michal P Danuta W Regina S | 2005 | Journal of Biotechnology2005，8，1： | 1 |
| 3 | Metal contamination of farming soils affected by industry显示文摘 | Krzysztof L Danuta W Irena K | 2004 | Environment International2004，30，： | 1 |
| 4 | Application of principal component analysis for the estimation of source of heavy metal contamination in surface sediments from the Rybnik Reservoir 显示文摘 | KRZYSZTOF L DANUTA W | 2003 | Chemosphere2003，51，： | 1 |
| 5 | Metal contamination of farming soils affected by industry显示文摘 | Krzysztof L Danuta W Irena K | 2004 | Environment International2004，30，： | 1 |
| 6 | Application of principalcomponent analysis for the estimation of source of heavy metalcontamination in surface sediments from the Rybnik Reservoir显示文摘 | Krzysztof L Danuta W | 2003 | Chemosphere2003，51，： | 1 |
| 7 | Oilfield solids and water-in-oil emulsion stability 显示文摘 | DANUTA M S HARVEY W Y | 2005 | J Colloid Interface Sci2005，285，： | 1 |
| 8 | Isolation and characteriza- tion of a novel strain of Stenotrophomonas maltophilia possessing various dioxygenases for monocyclic hydrocarbon degradation 显示文摘 | Urszula G Izabela G Danuta W | 2009 | Brazilian Journal of Microbiology2009，，2： | 1 |
| 9 | Geotrichum hydrolytic activity in milled malt and barley medium 显示文摘 | MICHAL P DANUTA W REGINA S | 2005 | J Biotechnol2005，8，1： | 1 |
| 10 | 患家族性高胆固醇血症男性和女性颈动脉斑块形成的危险因素是否相同?显示文摘低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)水平升高是家族性高胆固醇血症(familial hypercholesterolemia,FH)患者早期冠状动脉性心脏病(coronary heart disease,CHD)和死亡的主要原因。然而其对男性和女性的影响是否相同尚不确定。为了比较男性和女性FH患者颈动脉斑块(作为冠状动脉粥样硬化可靠的替代指标)的危险因素, | 刘莉 叶鹏 Malgorzata WM Danuta C Malgorzata KB Wiktoria W Maria K Maciej T | 2017 | 中华高血压杂志2017，25，8： | 1 |
| 11 | Species abundance distribution of collembolan communities in forest soils polluted with heavy metals显示文摘 | DANUTA S WANDA M W MAREK W | 2006 | Applied Soil Ecology2006，31，3： | 1 |
| 12 | Molecular anatomy of interendothelial junctions in human blood-brainbarrier microvessels显示文摘 | Andrzej W Vorbrodt Danuta H Dobrogowska | 2004 | Folia Histochemica et Cytobiologica2004，42，2： | 1 |
| 13 | In vitro activities of the beta-lactamase inhibitors clavulanic acid, sulbactam, and tazobactam alone or in combination with-lactams against epidemiologically characterized multidmg-resistant Acinetobacter bau- mannii strains显示文摘 | PAUL G HILMAR W DANUTA S | 2004 | Antimicrobial Agents and Chemotherapy2004，48，5： | 1 |
| 14 | The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways显示文摘 | Danuta Jantas S Krawczyk W Lason | 2014 | Neurotox Res2014，25，2： | 1 |
| 15 | Yarranton oil field sol- ids and water-in-oilemusion stability 显示文摘 | Danuta M Sztukowski Harvey W | 2005 | Journal of Colloid and Interface Science2005，82，5： | 1 |
| 16 | Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii显示文摘 | Paul G Hilmar W Danuta S | 2004 | J Antimicrob Chemther2004，54，： | 1 |
| 17 | Fluorescence quenching and ESR spectroscopy of metallic porphyrins in the presence of an electron acceptor显示文摘 | Danuta W Je D U Manikowski H | 2003 | Dyes and Pigments2003，58，1： | 1 |
| 18 | Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways显示文摘AIM: Grapefruit-seed extract (GSE) containing flavonoids, possesses antibacterial and antioxidative properties but whether it influences the gastric defense mechanism and gastroprotection against ethanol- and stress-induced gastric lesions remains unknown. METHODS: We compared the effects of GSE on gastric mucosal lesions induced in rats by topical application of 100% ethanol or 3.5 h of water immersion and restraint stress (WRS) with or without (A) inhibition of cyclooxygenase (COX)-1 activity by indomethacin and rofecoxib, the selective COX-2 inhibitor, (B) suppression of NO-synthase with L-NNA (20 mg/kg ip), and (C) inactivation by capsaicin (125 mg/kg sc) of sensory nerves with or without intragastric (ig) pretreatment with GSE applied 30 min prior to ethanol or WRS. One hour after ethanol and 3.5 h after the end of WRS, the number and area of gastric lesions were measured by planimetry, the gastric blood flow (GBF) was assessed by H2-gas clearance technique and plasma gastrin levels and the gastric mucosal generation of PGE2, superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) concentration, as an index of lipid peroxidation were determined. RESULTS: Ethanol and WRS caused gastric lesions accompanied by the significant fall in the GBF and SOD activity and the rise in the mucosal MDA content. Pretreatment with GSE (8-64 mg/kg i g) dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) was 25 and 36 mg/kg, respectively, and this protective effect was similar to that obtained with methyl PGE2 analog (5 μg/kg i g). GSE significantly raised the GBF, mucosal generation of PGE2, SOD activity and plasma gastrin levels while attenuating MDA content. Inhibition of PGE2 generation with indomethacin or rofecoxib and suppression of NO synthase by L-NNA or capsaicin denervation reversed the GSE-induced protection and the accompanying hyperemia. Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation. CONCLUSION: GSE exerts a potent gastroprotective activity against ethanol and WRS-induced gastric lesions via an increase in endogenous PG generation, suppression of lipid peroxidation and hyperemia possibly mediated by NO and CGRP released from sensory nerves. | Tomasz Brzozowski Peter C Konturek Danuta Drozdowicz Stanislaw J Konturek Oxana Zayachivska Robert Pajdo Slawomir Kwiecien Wieslaw W Pawlik Eckhart G Hahn | 2005 | World Journal of Gastroenterology2005，11，41： | 1 |
| 19 | Yarranton Oilfield solids and water-in-oilemusion stability显示文摘 | Danuta M Sztukowski Harvey W | 2005 | Journalof Colloid and Interface Science2005，82，5： | 1 |
| 20 | Isolation and characterization of a novel strain of Stenotrophomonas maltophilia possessing various dioxygenases for monocyclic hydrocarbon degradation显示文摘 | Urszula G Izabela G Danuta W | 2009 | Braz J Microbiol2009，40，2： | 1 |
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