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| 1 | A preliminary evaluation of VEGF-A, VEGFR1 and VEGFR2 in patients with well-controlled type 2 diabetes mellitus显示文摘 | Barbara Ruszkowska-Ciastek Alina Sokup Maciej W. Socha Zofia Ruprecht Lidia Ha?as Barbara Góralczyk Krzysztof Góralczyk Gra?yna Gadomska Danuta Ro?? | 2014 | Journal of Zhejiang University SCIENCE B2014，，6： | 1 |
| 2 | 未受控制的高血糖对2型糖尿病患者粘附分子的影响(英文)显示文摘目的:评估可溶性血管细胞间黏附分子(s VCAM-1)、可溶性细胞间黏附分子(s ICAM-1)、可溶性选择素E和可溶性血栓调节蛋白在血糖控制良好和不受控制的2型糖尿病患者中的水平。创新点:对2型糖尿病患者的血管内皮炎症标记物进行评估。方法:62例糖尿病患者分成两组:第一组包括35个血糖控制良好的糖尿病患者,第二组包括27个未控制血糖并伴有微蛋白尿的糖尿病患者。对照组由25名健康志愿者组成。测定血浆中s VCAM-1、s ICAM-1、可溶性选择素E和可溶性血栓调节蛋白的浓度,同时测定血清肌酐及血浆中空腹血糖和糖化血红蛋白(Hb A1c)的浓度。结论:与血糖控制良好的糖尿病组相比,未控制血糖组具有相对低的ICAM-1水平和更高的VCAM-1水平。未控制血糖组中患者的糖化血红蛋白和ICAM-1之间呈正相关,肾小球滤过率和可溶性选择素E之间呈正相关,而肌酐和ICAM-1之间呈负相关。研究证实2型糖尿病的发病机理中炎症过程的出现与血管内皮功能受损有关。未受控制的高血糖对粘附分子的反向作用表明,在糖尿病的并发症中VCAM-1和ICAM-1具有不同功能。 | Barbara RUSZKOWSKA-CIASTEK Alina SOKUP Tomasz WERNIK Zofia RUPRECHT Barbara GóRALCZYK Krzysztof GóRALCZYK Grazyna GADOMSKA Danuta RO | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
| 3 | 病态肥胖患者在接受治疗体重减少后C反应蛋白、肿瘤坏死因子α和白细胞介素-6的水平变化(英文)显示文摘目的:评估病态肥胖患者在低热量饮食和浸浴治疗前后,C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素-6(IL-6)以及胰岛素抵抗指数(HOMA-IR)的水平变化。创新点:研究炎症反应对病态肥胖的影响。方法:本研究包括33个病例和20个正常对照,对治疗前后的CRP、IL-6、TNF-α、血脂谱、HOMA-IR以及空腹血糖水平进行评估。结论:与对照组相比,低热量饮食和浸浴治疗后,病态肥胖患者的CRP水平显著降低,而TNF-α和IL-6的水平却没有显著变化,这表明脂肪细胞的正常功能恢复之前必须先去除一定量的脂肪组织。HOMA-IR水平的降低说明对胰岛素的敏感性有所提高,这有利于肥胖患者的治疗。 | Danuta RO Przemyslaw ADAMCZYK Joanna BOINSKA Robert SZAFKOWSKI Irena PONIKOWSKA Katarzyna STANKOWSKA Barbara GóRALCZYK Barbara RUSZKOWSKA-CIASTEK | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 0 |
| 4 | Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy显示文摘Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone,the combination of doses,the time of taking HRT,and the route of administration (oral,transdermal,implanted).The aim of the current study was to assess some parameters of coagulation,especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal HRT.Methods: The study was conducted on 76 healthy women,including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT,and 30 women aged 44–54 years who did not take HRT as the control group.Plasma concentrations of TF,TFPI,thrombin-antithrombin complex (TAT),and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA).Moreover,the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric methods.Results: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control group.We also found a significantly lower concentration of fibrinogen in women taking oral HRT vs.the control group.Moreover,no statistically significant changes in concentrations of TAT and D-dimer,or activity of protein C were noted.Conclusions: In this study,the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates hypercoagulability.No significant modification of TAT or D-dimer occurred,and thus there may not be increased risk of thrombosis. | Barbara RUSZKOWSKA GraZyna GADOMSKA Liliana BIELIS Marzena GRUSZKA Barbara GóRALCZYK Danuta RO GraZyna ODROWAZ-SYPNIEWSKA | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，1： | 0 |
| 5 | 2型糖尿病对外周动脉疾病患者血浆内的血管内皮生长因子及其可溶性受体浓度的影响(英文)显示文摘目的:研究2型糖尿病对外周动脉疾病患者血浆内的血管内皮生长因子(VEGF-A)及其水溶性受体(s VEGFR-1和s VEGFR-2)浓度的影响。创新点:首次研究了2型糖尿病对外周动脉疾病患者血浆内s VEGFR-1和s VEGFR-2浓度的影响。方法:选取46个外周动脉疾病患者,根据有无2型糖尿病分为糖尿病组(15例)和无糖尿病组(31例),另选30个健康志愿者为正常对照组。采用酶联免疫吸附法(ELISA)检测他们血浆中VEGF-A及s VEGFR-1和s VEGFR-2的浓度,然后通过对比各组浓度研究2型糖尿病的影响。结论:与正常对照组相比,外周动脉疾病患者具有较高的VEGF-A浓度(2型糖尿病组P=0.000007,非糖尿病组P=0.0000001)以及较低的s VEGFR-2浓度(2型糖尿病组P=0.02,非糖尿病组P=0.00001)。同时,2型糖尿病组比非糖尿病组具有较低的VEGF-A浓度及较高的s VEGFR-1和s VEGFR-2浓度。研究结果表明:无论2型糖尿病是否共存,缺氧是导致血管生成的一个关键的刺激因素;同时,高血糖状态对下肢的血管生成有抑制作用。 | Rados?aw WIECZóR Gra?yna GADOMSKA Barbara RUSZKOWSKA-CIASTEK Katarzyna STANKOWSKA Jacek BUDZY?SKI Jacek FABISIAK Karol SUPPAN Grzegorz PULKOWSKI Danuta RO?? | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，11： | 0 |
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