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| 1 | Synthesis and biological evaluation of 8-substituted berberine derivatives as novel anti-mycobacterial agents显示文摘Tuberculosis(TB)is a disease which kills two million people every year and infects over one-third of the world's population.Eighteen new 8-substituted berberine derivatives were synthesized and evaluated for their anti-mycobacterial activities against M ycobacterium tuberculosis(M.tuberculosis)strain H_(37)Rv.Among these compounds,compound 6i was the most effective antitubercular agent with an MIC of 1.0μg/mL.Most importantly,compound 6i also exhibited a potent effect against clinically isolated rifampicin-and isoniazid-resistant M.tuberculosis strains,suggesting a different mode of action from the current drugs.Therefore,it shows potential for the development of new anti-TB agents. | Yanxiang Wang Haigen Fu Yinghong Li Jiandong Jiang Danqing Song | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 4 |
| 2 | Evolution and development of potent monobactam sulfonate candidate IMBZ18g as a dual inhibitor against MDR Gram-negative bacteria producing ESBLs显示文摘A series of new monobactam sulfonates is continuously synthesized and evaluated for their antimicrobial efficacies against Gram-negative bacteria.Compound 33a(IMBZ18G)is highly effective in vitro and in vivo against clinically intractable multi-drug-resistant(MDR)Gram-negative strains,with a highly druglike nature.The checkerboard assay reveals its significant synergistic effect withβ-lactamase inhibitor avibactam,and the MIC values against MDR enterobacteria were reduced up to 4—512folds.X-ray co-crystal and chemoproteomic assays indicate that the anti-MDR bacteria effect of 33a results from the dual inhibition of the common PBP3 and some class A and Cβ-lactamases.Accordingly,preclinical studies of 33a alone and 33a-avibactam combination as potential innovative candidates are actively going on,in the treatment ofβ-lactamase-producing MDR Gram-negative bacterial infections. | Zhiwen Li Zhihao Guo Xi Lu Xican Ma Xiukun Wang Rui Zhang Xinxin Hu Yanxiang Wang Jing Pang Tianyun Fan Yonghua Liu Sheng Tang Haigen Fu Jingpu Zhang Yinghong Li Xuefu You Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 3 | Research on Route Optimization of Battlefield Collection Equipment Based on Improved Ant Algorithm显示文摘Accurate battlefield collection plays a crucial role in the end of thewar. How to effectively improve the ability of accurate battlefield collection hasbecome a hot issue of research. However, the existing support force is limited. Tosolve the problem, an improved ant algorithm is applied to the path optimizationproblem of battlefield collection equipment. A model for solving the collectionpath optimization problem of battlefield collection vehicles was designed, andan example was used to simulate calculations. The final results show that thealgorithm is effective and practical,which improves the army’s ability to accuratelycollect equipment in the modern battlefield. | Haigen Yang Wang Sun Xiao Fu Gang Li Luyang Li | 2021 | 国际计算机前沿大会会议论文集2021，，1： | 0 |
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