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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Single-nucleotide polymorphisms of matrix metalloproteinases and their inhibitors in gastrointestinal cancer显示文摘Matrix metalloproteinases(MMPs) are implicated in cancer development and progression and are associated with prognosis.Single-nucleotide polymorphisms(SNPs) of MMPs,most frequently located in the promoter region of the genes,have been shown to influence cancer susceptibility and/or progression.SNPs of MMP-1,-2,-3,-7,-8,-9,-12,-13 and-21 and of the tissue inhibitor of metalloproteinases(TIMPs) TIMP-1 and TIMP-2 have been studied in digestive tract tumors.The contribution of these polymorphisms to the cancer risk and prognosis of gastrointestinal tumors are reviewed in this paper. | Alexandra MJ Langers Hein W Verspaget Daniel W Hommes Cornelis FM Sier | 2011 | World Journal of Gastrointestinal Oncology2011，3，6： | 4 |
| 3 | Estrogenic activity removal of 1713-estradiol by ozonation and identification of by-products显示文摘 | Daniele B Antonio FM D6bora de AA | 2007 | Chemosphere2007，69，5： | 1 |
| 4 | Pali{ermin for the protection and regeneration o{ epithelial tissues following injury: new findings in basic research and pre-clinical models显示文摘 | Paul WF Lawrence J Daniel FM | 2013 | J Cell Mol Med2013，17，9： | 1 |
| 5 | Effect of Methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation显示文摘 | Daniel FM Colm GH Colm MG | 1999 | Clin Toxicol1999，37，4： | 1 |
| 6 | Effect of methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation 显示文摘 | Daniel FM Colm GH Colm MG | 1999 | Clin Toxicol1999，37，4： | 1 |
| 7 | Scedosporium apiospermum soft tissue infection successfully treated with voriconazole:potential pitfalls in the transition from intravenous to oral tberapy显示文摘 | Joanna MS Daniel BD Laurence FM | 2005 | Journal of Clinical Microbiology2005，4，2： | 1 |
| 8 | Dermcidin exerts itsoncogenic effects in breast cancer via modulation of ERBBsignaling显示文摘 | Jasna B Dayson FM Daniel C | 2015 | Bmc Cancer2015，15，70： | 1 |
| 9 | Effect of Methionine supplementation on endothelial function, plasma homocysteine, and lipid peroxidation显示文摘 | Daniel FM Colm GH Colm MG | 1999 | Clinical Toxicology1999，37，4： | 1 |
| 10 | Antioxidant activity and total phenolic content of Agaricus brasiliensis (Agaricus blazei Murri ) in two stages of maturity显示文摘 | Soares AA Souza CGMD Daniel FM | 2009 | Food Chemistry2009，112，： | 1 |
| 11 | Antioxidant activity and total phenolic content of Agaricus brasiliensis (Agaricus blazei Murri) in two stages of maturity显示文摘 | Soares AA De Souza CGM Daniel FM | 2009 | Food Chem2009，112，： | 1 |
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