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| 1 | Soil Heavy Metal Pollution Around the Dabaoshan Mine,Guangdong Province,China显示文摘在 Dabaoshan 矿的附近的土壤污染,广东省,中国,通过全部的集中的决心和有毒的金属, Cu, Zn, Cd,和 Pb 的化学种形成被学习,用诱导地联合的血浆质谱法。结果证明在过去的十年,公害被 Cu, Zn, Cd,和 Pb 的联合引起,与跟踪和是的酸矿排水影响土壤的主要污染来源。显著地高级(P ≤ 0.05 ) 作为与稻,花园,和控制土壤相比在跟踪 Cu, Zn, Cd,和 Pb 被发现,与一般水准 1 486, 2 516, 6.42,和 429 mg kg ? 1 分别地。这些金属连续地从跟踪和废水下游地被驱散,并且因此他们在水稻土的集中象 567 一样高, 1 140 , 2.48 ,和 191 mg kg ? 1 ,分别地显著地更高( P ≤ 0.05 )作为与那些相比在花园土壤。从所有土壤类形的上述金属的顺序的抽取的结果证明剩余部分是主导的形式。然而, Fe-Mn 氧化物和有机物一定的金属的数量比那些跳到在可交换的形式存在的碳酸盐或那些相对高。当金属能从一个惰性的状态被转变到一个活跃状态,潜在的环境风险将与时间由于这些金属增加。 | ZHOU Jian-Min DANG Zhi CAI Mei-Fang LIU Cong-Qiang | 2007 | Pedosphere2007，17，5： | 66 |
| 2 | Inhibitory effects of saikosaponin-d on CCl_4-induced hepatic fibrogenesis in rats显示文摘AIM: To investigate the suppressive effect of saikosaponin-d (SSd) on hepatic fibrosis in rats induced by CCl4 injections in combination with alcohol and high fat, low protein feeding and its relationship with the expression of nuclear factor-κB (NF-κB), tumor necrosis factor-alpha (TNF-α) and interleukins-6 (IL-6). METHODS: Hepatic fibrosis models were induced by subcutaneous injection of CCl4 at a dosage of 3 mL/kg in rats. At the same time, rats in treatment groups were injected intraperitoneally with SSd at different doses (1.0, 1.5 and 2.0 mg/kg) once daily for 6 wk in combination with CCl4, while the control group received olive oil instead of CCl4. At the end of the experiment, rats were anesthetized and killed (except for 8 rats which died during the experiment; 2 from the model group, 3 in high-dose group, 1 in medium-dose group and 2 in low- dose group). Hematoxylin and eosin (HE) staining and Van Gieson staining were used to examine the changes in liver pathology. The levels of alanine aminotransferase (ALT), triglyeride (TG), albumin (ALB), globulin (GLB), hyaluronic acid (HA) and laminin (LN) in serum and the content of hydroxyproline (HYP) in liver were measured by biochemical examinations and radioimmuneoassay, respectively. In addition, the expression of TNF-α and IL-6 in liver homogenate was evaluated by enzyme- linked immunosorbent assay (ELISA) and the levels of NF-κBp65 and I-κBα in liver tissue were analyzed by Western blotting. RESULTS: Both histological examination and Van Gieson staining demonstrated that SSd could attenuate the area and extent of necrosis and reduce the scores of liver fibrosis. Similarly, the levels of ALT, TG, GLB, HA, andLN in serum, and the contents of HYP, TNF-α and IL-6 in liver were all significantly increased in model group in comparison with those in control group. Whereas, the treatment with SSd markedly reduced all the above parameters compared with the model group, especially in the medium group (ALT: 412 ± 94.5 IU/L vs 113.76 ± 14.91 IU/L, TG: 0.95 ± 0.16 mmol/L vs 0.51 ± 0.06 mmol/L, GLB: 35.62 ± 3.28 g/L vs 24.82 ± 2.73 g/L, HA: 42.15 ± 8.25 ng/mL vs 19.83 ± 3.12 ng/mL, LN: 27.56 ± 4.21 ng/mL vs 13.78 ± 2.57 ng/mL, HYP: 27.32 ± 4.32 μg/mg vs 16.20 ± 3.12 μg/mg, TNF-α: 4.38 ± 0.76 ng/L vs 1.94 ± 0.27 ng/L, IL-6: 28.24 ± 6.37 pg/g vs 12.72 ± 5.26 pg/g, respectively, P < 0.01). SSd also decreased ALB in serum (28.49 ± 4.93 g/L vs 37.51 ± 3.17 g/L, P < 0.05). Moreover, the expression of NF-κB p65 in the liver of treated groups was lower than that in model groups while the expression of I-κBα was higher in treated group than in model group (P < 0.01). The expression of NF-κBp65 and TNF-α had a positive correlation with the level of HA in serum of rats after treatment with CCl4 (r = 0.862, P < 0.01; r = 0.928, P < 0.01, respectively). CONCLUSION: SSd attenuates CCl4-induced hepatic fibrosis in rats, which may be related to its effects of hepato-protective and anti-inflammation properties, the down-regulation of liver TNF-α, IL-6 and NF-κBp65 expression and the increased I-κBα activity in liver. | Shuang-Suo Dang Bao-Feng Wang Yan-An Cheng Ping Song Zhen-Guo Liu Zong-Fang Li | 2007 | World Journal of Gastroenterology2007，13，4： | 41 |
| 3 | Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2显示文摘背景 lcariine 是从繁体中文药 Epimedium pubescens 孤立的 flavonoid 并且是它的主要活跃混合物。最近, Epimedium pubescens 被发现在骨质疏松症上有治疗学的效果。但是机制是不清楚的。学习的目的是在增长上研究 lcariine 的效果间充质的,人的 osteoblasts.Methods 人造骨细胞的区别是获得的 byinducing 人髓干细胞(hMSCs ) 方向性地并且面对 lcariine 的各种各样的集中是有教养的。3-(4,5-dimethylthiazol-2-yl )-2,5-diphenyltetrazolium 溴化物(MTT ) 测试被用来在房间增长上观察 lcariine 的效果。碱的磷酸酶(高山) 和钙化的小瘤的数量的活动是 assayed 在骨头的房间 differentiation.The 表示上观察效果形态基因的蛋白质 2 (BMP-2 ) mRNA 被 .Results Icariine (20 g/ml ) 显著地增加了的反向的 transcriptase 聚合酶链反应(RT-PCR ) 检测人的造骨细胞的增长。并且, lcariine ( 10 g/ml 和 20g/ml )显著地增加了高山的活动和人的造骨细胞的钙化的小瘤的数量( P0.05 ) .BMP-2 mRNA 合成响应 .Conclusions lcariine 有的 lcariine ( 20 g/ml )显著地被提高有教养的人的 osteoblastcells 的增长和区别上的直接 stimulatory 效果在里面 vitro ,它可以被在造骨细胞增加 BMP-2 的生产调停。 | YIN Xiao-xue CHEN Zhong-qiang LIU Zhong-jun MA Qing-jun DANG Geng-ting | 2007 | Chinese Medical Journal2007，，3： | 47 |
| 4 | A Review on Lithium-ion Power Battery Thermal Management Technologies and Thermal Safety显示文摘Lithium-ion power battery has become one of the main power sources for electric vehicles and hybrid electric vehicles because of superior performance compared with other power sources. In order to ensure the safety and improve the performance, the maximum operating temperature and local temperature difference of batteries must be maintained in an appropriate range. The effect of temperature on the capacity fade and aging are simply investigated. The electrode structure, including electrode thickness, particle size and porosity, are analyzed. It is found that all of them have significant influences on the heat generation of battery. Details of various thermal management technologies, namely air based, phase change material based, heat pipe based and liquid based, are discussed and compared from the perspective of improving the external heat dissipation. The selection of different battery thermal management(BTM) technologies should be based on the cooling demand and applications, and liquid cooling is suggested being the most suitable method for large-scale battery pack charged/discharged at higher C-rate and in high-temperature environment. The thermal safety in the respect of propagation and suppression of thermal runaway is analyzed. | AN Zhoujian JIA Li DING Yong DANG Chao LI Xuejiao | 2017 | Journal of Thermal Science2017，26，5： | 41 |
| 5 | Phosphorus Changes and Sorption Characteristics in a Calcareous Soil Under Long-Term Fertilization显示文摘Knowledge of phosphorus(P)behavior in long-term fertilized soils is essential for programming fertilization practices and for sustaining environmental quality.The long-term(1984-1997)effects of various fertilization treatments on P changes and sorption isotherms as well as the relationship of soil properties to P sorption and P forms were evaluated in an Ustic Isohumisol,a calcareous soil,on the Loess Plateau,China.Compared to 1984,after 13 years of crop production,total soil P in the no-P treatments(control and N treatment)decreased by 5%-7%,but in the phosphorus fertilizer alone(P), nitrogen and phosphorus fertilizers in combination(NP),manure alone(M),and nitrogen and phosphorus fertilizers and manure in combination(NPM)treatments,it increased by 22%,19%,28%,and 58%,respectively.Residual fertilizer P was found mainly in NH_4Ac-soluble P(Ca_8-P),followed by NaHCO_3-soluble P(NaHCO_3-P),and NH_4F-soluble P (A1-P).Phosphorus sorption in the soils with different fertilization practices fit the Langmuir equations.Phosphorus sorption capacity in the no-P treatments increased,whereas it decreased in the P-included treatments(P,NP,and NPM treatments).Phosphorus sorption maximum(Q_m)was significantly and negatively correlated to inorganic P including NaHCO_3-P,Ca_8-P,NaOH-Na_2CO_3-soluble P(Fe-P),and Al-P(P≤0.01).Moreover,long-term fertilization increased soil organic carbon in the NP,M,and NPM treatments and decreased pH in the NP and NPM treatments.Thus,the ability of the soil to release sorbed P to the environment increased under long-term P fertilization. | GUO Sheng-Li DANG Ting-Hui HAO Ming-De | 2008 | Pedosphere2008，18，2： | 36 |
| 6 | Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats显示文摘背景中国药在 hepatoprotective 治疗起一个重要作用。这研究被进行在长期的肝的 injury.Methods 的一个老鼠模型调查 emodin 和距骨多糖( APS )的保护的效果长期的肝的损害被一个星期包含40%碳四氯化物( CCI4 )两次的一个橄榄油答案的皮下注射的注射导致,除了在为 12 个星期的喝的水广告 libitum 的79.5% maizena ,20%脂肪,0.5%胆固醇,和10%酒精的一本食谱。同时,老鼠暴露于 emodin 的不同集中(40 mg ????????????????????? 洠汥楬畴 ??????????????瀠敲業浵刮獥汵獴 吗?? | DANG Shuang-suo ZHANG Xin JIA Xiao-li CHENG Yan-an SONG Ping LIU En-qi HE Qian LI Zong-fang | 2008 | Chinese Medical Journal2008，，11： | 34 |
| 7 | Effects of Traditional Chinese Medicine Shensong Yangxin Capsules on Heart Rhythm and Function in Congestive Heart Failure Patients with Frequent Ventricular Premature Complexes:A Randomized, Double-blind, Multicenter Clinical Trial显示文摘 | Xi Wang Dan HU Song Dang He Huang Cong-Xin Huang Ming-Jie Yuan Yan-Hong Tang Qing-Shan Zheng Fang Yin Shu Zhang Bo-Li Zhang Run-Lin Gao | 2017 | Chinese Medical Journal2017，，14： | 33 |
| 8 | Wheat Grain Yield and Yield Stability in a Long-Term Fertilization Experiment on the Loess Plateau显示文摘To provide a scientific basis for sustainable land management, a 20-year fertility experiment was conducted in Changwu County, Shaanxi Province, China to investigate the effects of long-term application of chemical fertilizers on wheat grain yield and yield stability on the Loess Plateau using regression and stability analysis. The experiment consisted of 17 fertilizer treatments, containing the combinations of different N and P levels, with three replications arranged in a randomized complete block design. Nitrogen fertilizer was applied as urea, and P was applied as calcium superphosphate. Fertilizer rates had a large effect on the response of wheat yield to fertilization. Phosphorus, combined with N, increased yield significantly (P < 0.01). In the unfertilized control and the N or P sole application treatments, wheat yield had a declining trend although it was not statistically significant. Stability analysts combined with the trend analysis indicated that integrated use of fertilizer N and P was better than their sole application in increasing and sustaining the productivity of rainfed winter wheat. | HAO Ming-De FAN Jun WANG Quan-Jiu DANG Ting-Hui GUO Sheng-Li WANG Ji-Jun | 2007 | Pedosphere2007，17，2： | 28 |
| 9 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 10 | Add-on pegylated interferon augments hepatitis B surface antigen clearance vs continuous nucleos(t)ide analog monotherapy in Chinese patients with chronic hepatitis B and hepatitis B surface antigen≤1500 IU/mL:An observational study显示文摘BACKGROUND Nucleos(t)ide analog(NA)has shown limited effectiveness against hepatitis B surface antigen(HBsAg)clearance in chronic hepatitis B(CHB)patients.AIM To evaluate the efficacy and safety of add-on peginterferonα-2a(peg-IFNα-2a)to an ongoing NA regimen in CHB patients.METHODS In this observational study,195 CHB patients with HBsAg≤1500 IU/m L,hepatitis B e antigen(HBeAg)-negative(including HBeAg-negative patients or HBeAg-positive patients who achieved HBeAg-negative after antiviral treatment with NA)and hepatitis B virus-deoxyribonucleic acid<1.0×10^2 IU/mL after over 1 year of NA therapy were enrolled between November 2015 and December2018 at the Second Affiliated Hospital of Xi'an Jiaotong University,China.Patients were given the choice between receiving either peg-IFNα-2a add-on therapy to an ongoing NA regimen(add-on group,n=91)or continuous NA monotherapy(monotherapy group,n=104)after being informed of the benefits and risks of the peg-IFNα-2a therapy.Total therapy duration of peg-IFNα-2a was 48 wk.All patients were followed-up to week 72(24 wk after discontinuation of peg-IFNα-2a).The primary endpoint was the proportion of patients with HBsAg clearance at week 72.RESULTS Demographic and baseline characteristics were comparable between the two groups.Intention-to-treatment analysis showed that the HBsAg clearance rate in the add-on group and monotherapy group was 37.4%(34/91)and 1.9%(2/104)at week 72,respectively.The HBsAg seroconversion rate in the add-on group was 29.7%(27/91)at week 72,and no patient in the monotherapy group achieved HBsAg seroconversion at week 72.The HBsAg clearance and seroconversion rates in the add-on group were significantly higher than in the monotherapy group at week 72(P<0.001).Younger patients,lower baseline HBsAg concentration,lower HBsAg concentrations at weeks 12 and 24,greater HBsAg decline from baseline to weeks 12 and 24 and the alanine aminotransferase≥2×upper limit of normal during the first 12 wk of therapy were strong predictors of HBsAg clearance in patients with peg-IFNα-2a add-on treatment.Regarding the safety of the treatment,4.4%(4/91)of patients in the add-on group discontinued peg-IFNα-2a due to adverse events.No severe adverse events were noted.CONCLUSION Peg-IFNα-2a as an add-on therapy augments HBsAg clearance in HBeAg-negative CHB patients with HBsAg≤1500 IU/m L after over 1 year of NA therapy. | Feng-Ping Wu Ying Yang Mei Li Yi-Xin Liu Ya-Ping Li Wen-Jun Wang Juan-Juan Shi Xin Zhang Xiao-Li Jia Shuang-Suo Dang | 2020 | World Journal of Gastroenterology2020，26，13： | 27 |
| 11 | Effect of Nitrogen Management on Yield and Water Use Efficiency of Rainfed Wheat and Maize in Northwest China显示文摘A field experiment with four treatments and four replicates in a randomized complete block design was conducted at the Changwu Experimental Station in Changwu County, Shaanxi Province, of Northwest China from 1998 to 2002. The local cropping sequence of wheat, wheat-beans, maize, and wheat over the 4-year period was adopted. A micro-plot study using 15N-labelled fertilizer was carried out to determine the fate of applied N fertilizer in the first year. When N fertilizer was applied wheat (years 1, 2 and 4) and maize (year 3) grain yield increased significantly (P<0.05) (>30%), with no significant yield differences in normal rainfall years (Years 1, 2 and 3) for N application at the commonly application rate and at 2/3 of this rate. Grain yield of wheat varied greatly between years, mainly due to variation in annual rainfall. Results of 15N studies on wheat showed that plants recovered 36.6%-38.4% of the N applied, the N remained in soil (0-40 cm) ranged from 29.2% to 33.6%, and unaccounted-for N was 29.5%-34.2%. The following crop (wheat) recovered 2.1%-2.8% of the residual N from N applied to the previous wheat crop with recovery generally decreasing in the subsequent three crops (beans, maize and wheat). | DANG Ting-Hui CAI Gui-Xin GUO Sheng-Li HAO Ming-De L. K. HENG | 2006 | Pedosphere2006，16，4： | 25 |
| 12 | Treatment of cervical dislocation with locked facets显示文摘有锁的方面的背景更低的颈的脱臼在颈的损害是普通的。锁的方面包括单方、双边的类型。不同成功的关上的减小率被使用快速的颅骨拖拉在单方、双边的类型之间完成了,它通常被用来减少颈的脱臼。由于快速的颅骨拖拉对待的颈的损害与锁的方面与颈的脱臼与 38 个病人全部的颈的锁的 facets.Methods A 的不同类型调查对病人特定的一个合适的管理是重要的,从 1988 ~ 2005 的操作被考察。快速的颅骨拖拉在所有病人被使用。成功的关上的减小率在有双边的颈的锁的方面的病人是 88.0% ,那在有单方的颈的锁的方面的那些是 15.4% 。这些数据然后被 Chi 平方测试统计上比较。成功地被减少的病人在受伤水平经历了前面的颈的 discectomy 和熔化,并且在关上的减小失败了的那些在这个系列收到了以后的开的减小和 fixation.Results ,处于在单方、双边的锁的方面脱臼之间的成功的关上的颅骨拖拉减小的率有统计上重要的差别( P0.05 )。单方的颈的锁的方面脱臼没被对双边的颈的锁的方面脱臼的减小合适的颅骨拖拉容易减少。然而,单方的颈的锁的方面脱臼能被以后的开的 reduction.Conclusions 减少单方的颈的锁的方面脱臼应该与以后的开的减小和乐器学立即被对待。双边的颈的锁的方面脱臼能被快速的颅骨拖拉第一减少并且前面的颈的 discectomy 和 interbody 熔化以后。 | YU Ze-sheng James J.Yue WEI Feng LIU Zhong-jun CHEN Zhong-qiang DANG Geng-ting | 2007 | Chinese Medical Journal2007，，3： | 24 |
| 13 | Inhibitory effect of emodin and Astragalus polysaccharide on the replication of HBV显示文摘AIM: To evaluate the anti-viral effect of emodin plus Astragalus polysaccharide (APS) in hepatitis B virus (HBV) transgenic mice.METHODS: Sixty HBV transgenic mice (HBV TGM) whose weight varied between 18 and 24 g were randomly divided into 3 groups, with 20 mice in each group. Group A was the normal control, where the mice were treated with physiological saline; group B was the positive control where the mice were treated with lamivudine solution (100 mL/kg per day). Group C was the experimental group where the mice were treated with physiological saline containing emodin and APS (57.59 mg/kg per day and 287.95 mg/kg per day, respectively). The mice were treated daily for 3 wk. After 1 wk recovery time, the mice were sacrifi ced and serum as well as liver tissues were collected for ELISA and histological examination.RESULTS: After 21 d treatment, HBV DNA levels in group B and group C significantly declined when compared with group A (P < 0.05). However, a signif icant increase in HBV DNA content was observed in group B, whereas this phenomenon was not observed in group C. A reduction in the contents of HBsAg, HBeAg and HBcAg in the mice from group B and C was observed when compared with group A.CONCLUSION: Emodin and APS have a weak but persistent inhibitory effect on HBV replication in vivo, which may function as a supplementary modality in the treatment of hepatitis B infection. | Shuang-Suo Dang Xiao-Li Jia Ping Song Yan-An Cheng Xin Zhang Ming-Zhu Sun En-Qi Liu | 2009 | World Journal of Gastroenterology2009，15，45： | 21 |
| 14 | Deep soil water infiltration and its dynamic variation in the shifting sandy land of typical deserts in China显示文摘Soil moisture is the key resource constraint in arid ecosystems, and has been a focus of research on restoration. However, quantitative studies on the contribution of rainfall to deep soil rainfall infiltration are lacking. In this study, we used the YWB-01 Deep Soil Infiltration Water Recorder which had been invented by ourselves to measure the quantity of rain infiltration into deep soil, 150 cm below ground, in four locations in China: Mu Us Sandy Land and Ulan Buh, Tengger, and Badan Jilin deserts over a 2-year period. We found:(1) Deep soil rainfall infiltration decreased progressively from east to west and from semiarid to arid areas, with two locations completely lacking rainfall infiltration. Heavy rain was important to deep soil infiltration in shifting sandy land of arid and semiarid areas.(2) Seasonal variation of infiltration was correlated with rainfall, with a time lag that was less apparent in areas with more rainfall.(3) For single intense rainfall events, infiltration maximums occurred 40–55 h after the rainfall, during which the infiltration rates increased rapidly before reaching a peak, and then decreased slowly. Continuous infiltration could last about 150 h. Rainfall infiltration was determined by the combined action of intensity, quantity and duration. Rainfall with low intensity, long duration, and large quantity was most favorable for deep soil infiltration. Our results can be used in water resource assessments and protection during eco-restoration in the arid and semiarid areas in China. | YANG WenBin TANG JinNian LIANG HaiRong DANG HongZhong LI Wei | 2014 | Science China Earth Sciences2014，57，8： | 21 |
| 15 | Angiopoiesis and bone regeneration via co expression of the hVEGF and hBMP genes from an adeno-associated viral vector in vitro and in vivo显示文摘 | Chen ZHANG Kun-zheng WANG Hui QIANG Yi-lun TANG Qian LI Miao LI Xiao-qian DANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 20 |
| 16 | Surveillance-based evidence:elimination of schistosomiasis as a public health problem in the Peoples’Republic of China显示文摘Background:A steady progress on schistosomiasis control in the Peoples’Republic of China(P.R.China)was achieved and broadened into the twelve-year medium and long term national plan(MLNP)which marled the implementation of an integrated control strategy across all endemic areas in P.R.China in 2004.To understand the endemic trends of schistosomiasis to assess the effectiveness of an integrated strategy,we conducted an analysis of schistosomiasis surveillance data spanned from 2005 to 2015.Methods:The schistosomiasis sentinel surveillance data from sentinel sites were collected and analyzed from 2005 to 2015.In these sentinel sites,residents aged 6 years or above were screened annually by indirect hemagglutination assay(IHA),while only antibody positives were followed by stool examination either Kato-katz method(KK)and/or hatching technique(HT).Domestic animals raised in sentinel sites were examined by HT for confirming the infection of schistosomes.Snail investigation was conducted each year through systematic sampling method combined with environmental sampling method.The snails collected from field were tested by microscopic dissection method.The infection rates of schistosomes in residents,domestic animals and snails,as well as the indicators reflecting the snails’distribution were calculated and analyzed.ANOVA analysis was used to examine the changes of the number of eggs per gram feces in population and Chi-square test was used to examine any change in proportions among groups.Results:A total of 148902 residents from sentinel sites attended this study and 631676 blood samples were examined by IHA test during the 11 covered years.The annual average antibody positive rates presented a significant decrease trends,from 17.48%(95%CI:17.20–17.75%)in 2005 to 5.93%(95%CI:5.71–6.15%)(χ2=8890.47,P<0.001)in 2015.During 2005–2015,the average infection rate of schistosomes in residents declined from 2.07%(95%CI:1.96–2.17%)to 0.13%(95%CI:0.09–0.16%),accompanied by significant decrease of infection intensity in population.In 2015,the stool positives were only found in farmers,fishermen and boatmen with infection rate of 0.16%(95%CI:0.11–0.20%),0.17%(95%CI:0–0.50%)respectively.The infection rate of schistosomes in domestic animals dropped from 9.42%(538/5711,95%CI:8.66–10.18%)to 0.08%(2/2360,95%CI:0–0.20%)from 2005 to 2015.Infections were found in eight species of domestic animals at the beginning of surveillance while only two cattle were infected in 2015.Totally 98 ha of new snail habitats were found,while 94.90%(93/98)distributed in lake and marshland regions.The percentage of frames with snails decreased from 16.96%(56884/335391,95%CI:16.83–17.09%)in 2005 to 4.28%(18121/423755,95%CI:4.22–4.34%)in 2014,with a slightly increase in 2015.Meanwhile,the infection rate of schistosomes in snails was decreased from 0.26%(663/256531,95%CI:0.24–0.28%)to zero during 2005–2015.Conclusions:The infection rate of schistosomes declined significantly,providing evidence that the goal of the MLNP was achieved.Elimination of schistosomiasis as a public health problem defined as WHO was also reached in P.R.China nationwide.Surveillance-response system should be improved and strengthened to realize the final goal of schistosomiasis elimination. | Jing Xu Shi-Zhu Li Li-Juan Zhang Robert Bergquist Hui Dang Qiang Wang Shan Lv Tian-Ping Wang Dan-Dan Lin Jian-Bing Liu Guang-Hui Ren Kun Yang Yang Liu Yi Dong Shi-Qing Zhang Xiao-Nong Zhou | 2020 | Infectious Diseases of Poverty2020，9，3： | 20 |
| 17 | Effectiveness of urban construction boundaries in Beijing:an assessment显示文摘Based on the remote sensing (RS) and geographic information system (GIS) analysis of the Landsat multispectral scanner (MSS) and thematic mapper (TM) satellite images of 1983, 1993, and 2005, the present research examined the effectiveness of the urban construction boundaries (UCBs) in containing urban growth within the 6th Ring Road of Beijing Municipality. Three indicators on boundary control were proposed, through which the effectiveness of boundary containment, land inventory sufficiency and illegal adjacent development to the UCBs were explored. The results suggested that, first, the UCBs were limited in effectiveness in containing urban growth; second, the area encompassed by the UCBs might not be designed large enough to accommodate new development. The frustration of the urban growth control through the UCBs mainly resulted from the lack of a transparent system for urban land use planning and control to provide sufficient information, the limitation of the traditional land use prediction method to consider contingencies, and the absence of a mechanism to monitor and adjust the UCBs to respond just in time to urban change. | Hao-ying HAN Shih-Kung LAI An-rong DANG Zong-bo TAN Ci-fang WU | 2009 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2009，10，9： | 20 |
| 18 | Impact of co-infections with enteric pathogens on children suffering from acute diarrhea in southwest China显示文摘Background:Acute diarrhea is a global health problem,resulting in high morbidity and mortality in children.It has been suggested that enteric pathogen co-infections play an important role in gastroenteritis,but most research efforts have only focused on a small range of species belonging to a few pathogen groups.This study aimed to assess the impact of co-infections with a broad range of enteric pathogens on children aged below five years who suffer from acute diarrhea in southwest China.Method:A total of 1020 subjects(850 diarrhea cases and 170 healthy controls)were selected from four sentinel hospitals in Kunming,Yunnan province,southwest China,from June 2014 to July 2015.Stool specimens were collected to detect five virus(rotavirus group A,RVA;norovirus,NoV;Sapovirus,SaV;astrovirus,As;and adenovirus,Ad),seven bacterial(diarrheagenic Escherichia coli,DEC;non-typhoidal Salmonella,NTS;Shigella spp.;Vibrio cholera;Vibrio parahaemolyticus;Aeromonas spp.;and Plesiomonas spp.),and three protozoan(Cryptosporidium spp.,Giardia lamblia,and Blastocystis hominis,B.hominis)species using standard microbiologic and molecular methods.Data were analyzed using the partial least square regression technique and chi-square test.Results:At least one enteric pathogen was detected in 46.7%(n=397)of acute gastroenteritis cases and 13.5%(n=23)of healthy controls(χ^(2)=64.4,P<0.05).Single infection with RVA was associated with acute diarrhea(26.5%vs.5.8%,P<0.05).The prevalence of a single infection with B.hominis in diarrhea cases was higher than in healthy controls(3.1%vs.0.5%,OR=4.7,95%CI:1.01–112.0).Single infection with NoV GII was not associated with diarrhea(4.4%vs.3.5%,OR=1.2,95%CI:0.5–3.3).Single infections with bacterial species were not observed.The prevalence of co-infections with two enteric pathogens in diarrhea cases was higher than in asymptomatic children(20.1%vs.5.3%,P<0.05).RVA-NoV GII was the most common co-infection in symptomatic children(4.4%),with it aggravating the severity of diarrhea.Conclusions:Although it is clear that RVA has an overwhelming impact on diarrhea illnesses in children,co-infection with other enteric pathogens appears to also aggravate diarrhea severity.These findings should serve as evidence for public health services when planning and developing intervention programs. | Shun-Xian Zhang Yong-Ming Zhou Wen Xu Li-Guang Tian Jia-Xu Chen Shao-Hong Chen Zhi-Sheng Dang Wen-Peng Gu Jian-Wen Yin Emmanuel Serrano Xiao-Nong Zhou | 2016 | Infectious Diseases of Poverty2016，5，1： | 19 |
| 19 | Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis显示文摘AIM: To evaluate the role of microcirculatory disorder (MCD) and the therapeutic effectiveness of tetramethyl- pyrazine (TMP) on intestinal mucosa injury in rats with acute necrotizing pancreatitis (ANP). METHODS: A total of 192 Sprague-Dawley rats were randomly divided into three groups: normal control group (C group), ANP group not treated with TMP (P group), ANP group treated with TMP (T group). An ANP model was induced by injection of 50 g/L sodium tau- rocholate under the pancreatic membrane (4 mL/kg). C group received isovolumetric injection of 9 g/L physi- ological saline solution using the same method. T group received injection of TMP (10 mL/kg) via portal vein. Ra- dioactive biomicrosphere technique was used to measure the blood flow at 0.5, 2, 6 and 12 h after the induction of ANP. Samples of pancreas, distal ileum were collected to observe pathological changes using a validated histol- ogy score. Intestinal tissues were also used for examina- tion of myeloperoxidase (MPO) expressed intracellularly in azurophilic granules of neutrophils. RESULTS: The blood flow was significantly lower in P group than in C group (P < 0.01). The pathological changes were aggravated significantly in P group. The longer the time, the severer the pathological changes. The intestinal MPO activities were significantly higher in P group than in C group (P < 0.01). The blood flow of intestine was significantly higher in T group than in P group after 2 h (P < 0.01). The pathological changes were alleviated significantly in T group. MPO activities were significantly lower in T group than in P group (P < 0.01 or P < 0.05). There was a negative correlation be- tween intestinal blood flow and MPO activity (r = -0.981, P < 0.01) as well as between intestinal blood flow and pathologic scores (r = -0.922, P < 0.05).CONCLUSION: MCD is an important factor for intestinal injury in ANP. TMP can ameliorate the condition of MCD and the damage to pancreas and intestine. | Jian-Xin Zhang Sheng-Chun Dang Jian-Guo Qu Xue-Qing Wang | 2006 | World Journal of Gastroenterology2006，12，39： | 19 |
| 20 | Alkaloid from Dicranostigma leptopodum(Maxim) Fedde显示文摘Fedde 有的 Dicranostigma leptopodum (格言) 的整个植物的 Phytochemical 调查导致五碱的隔离:dicranostigmine (1 ) , isocorydine (2 ) , corydine (3 ) , protopine (4 ) 和 sinoacutine (5 ) 。Oxomorphine 碱(5 ) 第一次从类 Dicranostigma 被孤立,新复合结构(1 ) 被各种各样的分光镜的方法包括 2D NMR 技术(gCOSY, HMQC, HMBC 和 NOESY ) 和 HRESIMS 阐明。 | Yan Dang Hong Fei Gong Jun Xi Liu Si Jiu Yu | 2009 | Chinese Chemical Letters2009，20，10： | 19 |
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