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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats显示文摘INTRODUCTIONLiver fibrosis is a dynamic course leading tocirrhosis from a various chronic liver diseases. Thepathological basis of fibrosis is the disturbance ofproduction and degradation of the extracellularmatrix (ECM), which causes accumulation of ECMin the liver[1,2]. | Ji Yao Wang Qi Sheng Zhang Ji Sheng Guo Mei Yu Hu Department of Gastroenterology, Zhongshan Hospital, Medical Center, Fu Dan University Shanghai Medical University), Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，1： | 29 |
| 3 | Clinicopathological analysis of patients with gastric cancer in 1200 cases显示文摘INTRODUCTIONGastric cancer is one of the most common fatal malignancies in the world. The prognosis is generally poor in advanced gastric cancer .The low survival is related to delayed diagnosis, metastasis and recurrence after operation .The aim of this paper was to find correlation between clinical factors was to find correlation between clinical factors and biologic behavior of gastric cancer in a series of 1200 patients undergoing surgical resection. | Wei Xin Niu Xin Yu Qin Han Liu Cheng Pei Wang Surgical Department, Zhongshan Hospital, Fu Dan University Medical Center, Shanghai 200032, China | 2001 | World Journal of Gastroenterology2001，7，2： | 29 |
| 4 | A mouse model for HBV immunotolerance and immunotherapy显示文摘一个适当小动物模型的缺乏仍然是一个主要障碍因为学习 immunotolerance 和 immunopathogenesis 由肝炎 B 病毒(HBV ) 导致了感染。在这研究,我们与 recombinant 在感染以后与持续 HBV viremia 报导一个老鼠模型带一个可复制的 HBV 染色体(AAV/HBV ) 的联系 adeno 的病毒(AAV ) 。类似于临床的 HBV 搬运人,感染 AAV/HBV 的老鼠为对 HBV 表面抗原(HBsAg ) 的抗体是 sero 否定的。有面对铝助手疫苗的常规 HBV 的免疫没能在这些老鼠对 HBV 得到有免疫力的回答。为了识别一支疫苗,那能潜在地围绕这忍耐, TLR9 收缩筋 CpG 作为一个助手被加到 HBsAg。有 HBsAg/CpG 的老鼠的种痘导致了 viremia,而且强壮的抗体生产和 T 房间回答的不仅清理。而且, DNA 复制和 HBV 的蛋白质表示显著地在 AAV/HBV-infected 鼠标的肝被减少。因此, AAV/HBV-infected 老鼠可以作为一个柔韧的模型被使用调查 HBV immunotolerance 并且为开发新奇免疫疗法根除的内在的机制 HBV 感染。 | Dan Yang Longchao Liu Danming Zhu Hua Peng Lishan Su Yang-Xin Fu Liguo Zhang | 2014 | Cellular & Molecular Immunology2014，11，1： | 25 |
| 5 | Correlation Between the Clinical Severity, Bacterial Load, and Inflammatory Reaction in Children with Mycoplasma Pneumoniae Pneumonia显示文摘Given the lack of defining features in the clinical manifestations and radiographic findings for children with mycoplasma pneumoniae pneumonia(MPP),quantitative polymerase chain reaction(qPCR)has become a useful diagnostic method.This study was performed to explore the relationship between the qPCR findings,clinical symptoms,and inflammatory markers in children with MPP.Four hundred children with MPP have been enrolled in this retrospective analysis.All clinical and analytical information,including mycoplasma pneumoniae(MP)PCR results,has been collected.Based on the PCR results,the patients were divided into groups with load values(copy number)<105(54 cases),2105 and<106(71 cases),2106 and<107(112 cases),>107 and<108(114 cases),and>108(49 cases).The clinical features(including symptoms and signs)and inflammatory indicators were compared among the groups.The incidence of high fever(above 39℃),thermal peak during the entire hospitalization period,fever duration,days of hospitalization,and plasma lactate dehydrogenase(LDH)levels were statistically correlated with the MP PCR load value in children with MPP.The analysis of relevance degree showed the correlative order as a thermal peak of hospitalization>duration of fever>period of hospitalization>LDH value>C-reactive protein value.The host immune response was significantly greater in the complication group than in the non-complication group. | Chen ZHANG Qiao ZHANG Jie-lin DU Dan DENG Ye-lei GAO Cheng-lin WANG Hong-jie ZHAO Qian GUO Zhou FU Dai-yin TIAN | 2020 | Current Medical Science2020，40，5： | 19 |
| 6 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 7 | Screening of QHF formula for effective ingredients from Chinese herbs and its anti-hepatic cell cancer effect in combination with chemotherapy显示文摘背景:最近的研究证明了中国植物的有效成分在治疗越来越广泛地被使用或然而,他们通常是的癌症的合作处理独立使用了并且在那里被限制了关于在多模式的治疗的中国植物的联合申请的研究。这研究的目的是屏蔽 QHF (Q:Qingrejiedu, H:Huoxuehuayu 和 F:Fuzhengguben ) 为从中国药的有效成分的公式并且估计它癌症(HCC ) 与化疗在联合完成的反肝的房间。方法:从中国药的六有效成分基于以前的文学被选择并且在学习使用了。QHF 公式和成分的最好的比率在老鼠(千米;公里) 由一致设计和肿瘤生长和幸存的监视抑制与稳固的肿瘤和腹水肿瘤建模的 H (22 ) 被评估。当在老鼠(Balb/c ) 与稳固的肿瘤和腹水肿瘤建模的 H (22 ) 与 cisplatin (DDP ) 结合了时,我们然后观察了 QHF 的反肝的房间癌症(HCC ) 效果。治疗学的效果评估包括了老鼠,肿瘤生长的抑制,幸存,在体重的变化,胸腺索引,怒气索引和白血球计数的一般条件。结果:为反肝的房间癌症治疗的最佳的 QHF 剂量比率是:800 mg/kg Cinobufotalin, 14 mg/kg 人参皂甙 Rg3, 5.5 mg/kg PNS 和 100 mg/kg Lentinan。治疗在当比用使用 QHF 公式(55.91%) 时,在 H (22 ) 老鼠禁止移植肿瘤的生长是更有效的 Cinobufotalin (33.25%) ,人参皂甙 Rg3 (35.11%) , PNS (27.12%) 或 Lentinan (4.97%) 独立。QHF 也延长了 H (22 ) 腹水的生活肝的癌症老鼠更高效地(38.13%) 比 Cinobufotalin (25.00%) ,人参皂甙 Rg3 (27.27%) , PNS (23.30%) 或 Lentinan (24.43%) 。与 DDP 相结合的 QHF 能减少导致 DDP 的白血球减少症,怒气和胸腺萎缩和另外的有毒的反应。有 DDP 的联合 QHF 肿瘤生长抑制随幸存的 66.83% 增加到达了 82.54% 。结论:QHF 比组成公式的单个药在反肝的房间癌症治疗是更有效的。与 DDP 相结合的 QHF 能稀释肿瘤生长并且压制导致 DDP 的有毒的反应。 | CHEN Tao LI Dan FU Ya-ling HU Wei | 2008 | Chinese Medical Journal2008，，4： | 17 |
| 8 | Adsorption–desorption behavior of atrazine on agricultural soils in China显示文摘Adsorption and desorption are important processes that affect atrazine transport,transformation,and bioavailability in soils.In this study,the adsorption–desorption characteristics of atrazine in three soils(laterite,paddy soil and alluvial soil) were evaluated using the batch equilibrium method.The results showed that the kinetics of atrazine in soils was completed in two steps:a'fast' adsorption and a 'slow' adsorption and could be well described by pseudo-second-order model.In addition,the adsorption equilibrium isotherms were nonlinear and were well fitted by Freundlich and Langmuir models.It was found that the adsorption data on laterite,and paddy soil were better fitted by the Freundlich model;as for alluvial soil,the Langmuir model described it better.The maximum atrazine sorption capacities ranked as follows:paddy soil > alluvial soil > laterite.Results of thermodynamic calculations indicated that atrazine adsorption on three tested soils was spontaneous and endothermic.The desorption data showed that negative hysteresis occurred.Furthermore,lower solution pH value was conducive to the adsorption of atrazine in soils.The atrazine adsorption in these three tested soils was controlled by physical adsorption,including partition and surface adsorption.At lower equilibrium concentration,the atrazine adsorption process in soils was dominated by surface adsorption;while with the increase of equilibrium concentration,partition was predominant. | Lin Yue ChengJun Ge Dan Feng Huamei Yu Hui Deng Bomin Fu | 2017 | Journal of Environmental Sciences2017，29，7： | 16 |
| 9 | Comparisons in finite element analysis of minimally invasive, locking,and non-locking plates systems used in treating calcaneal fractures of Sanders type Ⅱ and type Ⅲ显示文摘 | He Kai Fu Su Liu Song Wang Zhifa Jin Dan | 2014 | Chinese Medical Journal2014，，22： | 13 |
| 10 | Expression of exogenous rat collagenase in vitro and in a rat model of liver fibrosis显示文摘AIM: The present study was conducted to test thehypothesis that the introduction of the collagenase geneinto tissue culture cells and into a rat model of liver fibrosiswould result in the expression of enzymatically active product.METHODS: FLAG-tagged full-length rat collagenase cDNAwas PCR amplified and cloned into a mammalian expressionvector. NIH3T3 cells were then transiently transfected withthis construct. Expression of exogenous collagenase mRNAwas assessed by RT-PCR, and the exogenous collagenasedetected by Western blotting using anti-FLAG monoclonalantibodyEnzymatic activity was detected by gelatinzymography. To determine the effects of exogenouscollagenase production in vivo, the construct was boundto glycosyl-poly-L-lysine and then transduced into rats thathad developed liver fibrosis as a result of CCI4 plus ethanoltreatment. The hepatic expression of the construct and itseffect on the formation of liver fibrosis were demonstratedusing RT-PCR and immunohistochemistry.RESULTS: It was found that exogenously expressed ratcollagenase mRNA could be detected in NTH3T3 cellsfollowing transfection. Enzymatic ally active collagenase couldalso be detected in the culture medium. The recombinantplasmid was also expressed in rat liver after in vivo genetransfer. Expression of exogenous rat collagenase correlatedwith decreased deposition of collagen types I and Ⅲ in thelivers of rats with experimentally induced liver fibrosis.CONCLUSION: The expression of active exogenous ratcollagenase could be achieved in vitro and in vivo. It wassuggested that in vivo expression of active exogenouscollagenase may have therapeutic effects on the formationof liver fibrosis. | Ji-Yao Wang Jin-Sheng Guo Chang-Qing Yang Division of Gastroenterology,Zhongshan Hospital,Fu Dan University,Shanghai 200032,China | 2002 | World Journal of Gastroenterology2002，8，5： | 12 |
| 11 | Effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients显示文摘AIM: To evaluate the effects of bowel rehabilitation and combined trophic therapy on intestinal adaptation in short bowel patients.METHODS: Thirty-eight patients with severe short-bowel syndrome (SBS) were employed in the present study, whose average length of jejunum-ileum was 35.8±21.2 cm. The TPN treatment was initiated early to attain positive nitrogen balance and prevent severe weight loss. The TPN composition was designated to be individualized and altered when necessary. Enteral feeding was given as soon as possible after resection and increased gradually. Meals were distributed throughout the day. Eight patients received treatment of growth hormone (0.14 mg/kg.day) and glutamine (0.3 g/kg.day) for 3 weeks. D-xylose test, 15N-Gly trace test and 13C-palmitic acid breath test were done to determine the patients' absorption capability.RESULTS: Thirty-three patients maintained well body weight and serum albumin concentration. The average time of follow-up for 33 survival patients was 5.9±4.3 years.Twenty-two patients weaned from TPN with an average TPN time of 9.5±6.6 months. Two patients, whose whole small bowel, ascending and transverse colon were resected received home TPN. An other 9 patients received parenteral or enteral nutritional support partly as well as oral diet. Three week rhGH+GLN therapy increased nutrients absorption but the effects were transient.CONCLUSION: By rehabilitation therapy, most short bowel patients could wean from parenteral nutrition. Dietary manipulation is an integral part of the treatment of SBS.Treatment with growth hormone and glutamine may increase nutrients absorption but the effects are not sustained beyond the treatment period. | Guo-Hao Wu Zhao-Han Wu Zhao-Guang Wu, Department of General Surgery, Zhongshan Hospital, Fu Dan University, Shanghai, 200032, China | 2003 | World Journal of Gastroenterology2003，9，11： | 12 |
| 12 | Advances and disputes of posterior malleolus fracture显示文摘 | Fu Su Zou Zhen-yu Mei Gang Jin Dan | 2013 | Chinese Medical Journal2013，，20： | 11 |
| 13 | Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3显示文摘Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective of this study is to determine the effects of emodin on cardiac fibrosis and the underlying molecular mechanisms. Intragastric administration of emodin markedly decreased left ventricular wall thickness in a mouse model of pathological cardiac hypertrophy with excess fibrosis induced by transaortic constriction(TAC) and suppressed activation of cardiac fibroblasts induced by angiotensin II(AngII). Emodin upregulated expression of metastasis associated protein 3(MTA3) and restored the MTA3 expression in the setting of cardiac fibrosis. Moreover, overexpression of MTA3 promoted cardiac fibrosis;in contrast, silence of MTA3 abrogated the inhibitory effect of emodin on fibroblast activation. Our findings unraveled the potential of emodin to alleviate cardiac fibrosis via upregulating MTA3 and highlight the regulatory role of MTA3 in the development of cardiac fibrosis. | Dan Xiao Yue Zhang Rui Wang Yujie Fu Tong Zhou Hongtao Diao Zhixia Wang Yuan Lin Zhange Li Lin Wen Xujuan Kang Philipp Kopylov Dmitri Shchekochikhin Yong Zhang Baofeng Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 11 |
| 14 | Characteristics of interior noise of a Chinese high-speed train under a variety of conditions显示文摘目的:研究高速列车在不同速度(260~385 km/h)、无砟和有砟轨道以及明线和隧道运行时的车内噪声特性,为高速列车车内减振降噪和车体低噪声设计提供科学依据。创新点:系统分析高速列车在不同运行条件下的车内噪声总值变化、空间分布、频谱特性和声源贡献,掌握车内噪声随列车运行速度的变化规律、轨道型式和隧道混响对车内噪声的影响,研究轮轨噪声、气动噪声和弓网噪声对车内噪声的作用。方法:1.根据不同的列车运行速度,分析车内噪声的变化规律;通过进一步对比头尾车运行时,不同测点位置的噪声总值、显著频率和声源贡献,研究气动作用对车内噪声的影响。2.针对不同轨道型式,分析车内噪声的差异特性;通过进一步对比不同速度下的前、后转向架上方车内噪声测点(其中一个还位于受电弓下方)的噪声总值、显著频率和声源贡献,研究有砟和无砟轨道、弓网噪声对车内噪声的影响以及速度因素的作用。3.对于隧道运行,分析不同速度下在明线和隧道运行时的车内噪声总值和显著频率,研究隧道混响对车内噪声的影响以及速度因素的作用。结论:1.TC01车无论作为头车或尾车运行,车内观光区的噪声均主要受气动作用影响。2.随着列车运行速度的提高,轨道型式的不同对车内噪声的影响有所降低。3.隧道混响对中间车的影响要高于头车。 | Jie ZHANG Xin-biao XIAO Xiao-zhen SHENG Rong FU Dan YAO Xue-song JIN | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，8： | 10 |
| 15 | MicroTom Metabolic Network: Rewiring Tomato Metabolic Regulatory Network throughout the Growth Cycle显示文摘Tomato(Solanum lycopersicum)is a major horticultural crop worldwide and has emerged as a preeminent model for metabolic research.Although many research efforts have focused on the analysis of metabolite differences between varieties and species,the dynamics of metabolic changes during the tomato growth cycle and the regulatory networks that underlie these changes are poorly understood.In this study,we integrated high-resolution spatio-temporal metabolome and transcriptome data to systematically explore the metabolic landscape across 20 major tomato tissues and growth stages.In the resulting MicroTom Metabolic Network,the 540 detected metabolites and their co-expressed genes could be divided into 10 distinct clusters based on their biological functions.Using this dataset,we constructed a global map of the major metabolic changes that occur throughout the tomato growth cycle and dissected the underlying regulatory network.In addition to verifying previously well-established regulatory networks for important metabolites,we identified novel transcription factors that regulate the biosynthesis of important secondary metabolites such as steroidal glycoalkaloids and flavonoids.Our findings provide insights into spatiotemporal changes in tomato metabolism and generate a valuable resource for the study of metabolic regulatory processes in model plants. | Yan Li Yang Chen Lu Zhou Shengjie You Heng Deng Ya Chen Saleh Alseekh Yong Yuan Rao Fu Zixin Zhang Dan Su Alisdair R.Fernie Mondher Bouzayen Tao Ma Mingchun Liu Yang Zhang | 2020 | Molecular Plant2020，13，8： | 10 |
| 16 | Generation of GGTA1 biallelic knockout pigs via zinc-finger nucleases and somatic cell nuclear transfer显示文摘Genetically modified pigs are valuable models of human disease and donors of xenotransplanted organs.Conventional gene targeting in pig somatic cells is extremely inefficient.Zinc-finger nuclease(ZFN)technology has been shown to be a powerful tool for efficiently inducing mutations in the genome.However,ZFN-mediated targeting in pigs has rarely been achieved.Here,we used ZFNs to knock out the porcineα-1,3-galactosyl-transferase(GGTA1)gene,which generates Gal epitopes that trigger hyperacute immune rejection in pig-to-human transplantation.Primary pig fibroblasts were transfected with ZFNs targeting the coding region of GGTA1.Eighteen mono-allelic and four biallelic knockout cell clones were obtained after drug selection with efficiencies of 23.4%and 5.2%,respectively.The biallelic cells were used to produce cloned pigs via somatic cell nuclear transfer(SCNT).Three GGTA1 null piglets were born,and one knockout primary fibroblast cell line was established from a cloned fetus.Gal epitopes on GGTA1 null pig cells were completely eliminated from the cell membrane.Functionally,GGTA1 knockout cells were protected from complement-mediated immune attacks when incubated with human serum.This study demonstrated that ZFN is an efficient tool in creating gene-modified pigs.GGTA1 null pigs and GGTA1 null fetal fibroblasts would benefit research and pig-to-human transplantation. | BAO Lei CHEN HaiDe JONG UiMyong RIM CholHo LI WenLing LIN XiJuan ZHANG Dan LUO Qiong CUI Chun HUANG HeFeng ZHANG Yan XIAO Lei FU ZhiXin | 2014 | Science China(Life Sciences)2014，57，2： | 9 |
| 17 | MicroRNA-132 suppresses cell proliferation in human breast cancer by directly targeting FOXA1显示文摘microRNAs (miRNAs ) 的 Dysregulation 在癌症被含有。最近, miR-132 被报导了是在有乳癌的病人的纸巾的 downregulated。在这研究,我们在乳癌房间调查了 miR-132 和它的直接目标 FOXA1 的功能的角色。在 30 人的乳癌纸巾, FOXA1 是显著地 overexpressed 并且否定地与 miR-132 相关表示。生物信息学分析建议 FOXA1 是 miR-132 的一个潜在的目标。而且,双酶记者试金表明 miR-132 dose-dependently 在人的 MDA-MB-468 和 SK-BR3 乳癌房间禁止了 FOXA1 的 wt 3UTR 而非 FOXA1 的傻瓜 3UTR 的酶活动。而且,宫外的 miR-132 表示显著地禁止了 FOXA1 蛋白质表示,而 miR-132 在乳癌房间的击倒的支持的 FOXA1 表示。,宫外的 miR-132 表示也压制了乳癌房间的增长 miR-132 击倒支持了乳癌房间的增长,它被颠倒由 FOXA1 击倒表示。我们断定 MiR-132 不过部分至少压制乳癌房间的增长 FOXA1 的抑制。这些结果建议 miR-132 和 FOXA1 可以在乳癌是潜在的 biomarkers 或治疗学的目标。 | Dan WANG Jin REN Hui REN Jin-ling FU Dan YU | 2018 | Acta Pharmacologica Sinica2018，39，1： | 9 |
| 18 | Trends in the Different Grades of Precipitation over South China during 1960–2010 and the Possible Link with Anthropogenic Aerosols显示文摘Using observed daily precipitation data to classify five levels of rainy days by strength in South China(SC), with an emphasis on the Pearl River Delta(PRD) region, the spatiotemporal variation of different grades of precipitation during the period 1960–2010 was analyzed and the possible link with anthropogenic aerosols examined. Statistical analysis showed that drizzle and small precipitation has significantly decreased, whereas medium to heavy precipitation has increased slightly over the past 50 years(although not statistically significant). Further data analysis suggested that the decline in drizzle and small precipitation probably has a strong link to increased concentrations of anthropogenic aerosols produced by large-scale human activities related to the rapid socioeconomic development of the PRD region. These aerosols may also have led to the obvious decreasing trend in horizontal visibility and sunshine duration in SC, which is statistically significant according to the t-test. | FU Chuanbo DAN Li | 2014 | Advances in Atmospheric Sciences2014，31，2： | 9 |
| 19 | XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells显示文摘Autophagy 被激活响应滋养的饥饿维持细胞的精力动态平衡。然而, autophagy 固执地没被激活,它糟糕在机械学的水平被理解。这里,我们报导 FoxO1 的那周转涉及夫酸安饥饿引起的动态 autophagic 过程。X-box-binding protein-1u (XBP-1u ) 由招募在 FoxO1 降级有一个关键角色 FoxO1 到 20S proteasome。另外,由 Ser61 和 Ser176 上的细胞外的调整蛋白质 kinases1/2 (ERK1/2 ) 的 XBP-1u 的 phosphorylation 被发现在夫酸安饥饿之上为在 XBP-1u 和 FoxO1 之间的增加的相互作用批评。而且,引起 FoxO1 的持续水平和 autophagy 的坚持的激活的 XBP-1u 击倒,在房间生存能力导致重要减少。最后,在 XBP-1u 之间的反的关联和 FoxO1 表示同意很好,表示侧面在许多人的癌症纸巾观察了。因此,我们的调查结果连接到 XBP-1u-induced FoxO1 的 autophagy 的动态过程降级。 | Ying Zhao Xue Li Mu-Yan Cai Ke Ma Jing Yang Jingyi Zhou Wan Fu Fu-Zheng Wei Lina Wang Dan Xie Wei-Guo Zhu | 2013 | Cell Research2013，23，4： | 8 |
| 20 | SIMULATIONS OF THE THREE-DIMENSIONAL TOTAL DISSOLVED GAS SATURATION DOWNSTREAM OF SPILLWAYS UNDER UNSTEADY CONDITIONS显示文摘Dams are often operated in a way to discharge over the spillways,which would cause a high dissolved concentration of air and be harmful to fish.The bubble transfer and the water surface transfer play an important role in affecting the concentration of the Total Dissolved Gas(TDG).Based on recent numerical simulations of the total dissolved gas saturation,in this article,a two-phase TDG transport equation is adopted to develop an unsteady three-dimensional(3-D) two-phase flow Computational Fluid Dynamics(CFD) model,including a number of parameters such as water depth,pressure and air volume entrained.This model is used to predict the hydrodynamics and the TDG distribution under unsteady discharge conditions.Good agreement between measured and numerical results is obtained for a case study. | FU Xiao-li LI Dan ZHANG Xiao-feng | 2010 | Journal of Hydrodynamics2010，22，4： | 8 |
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