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| 1 | Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis显示文摘骨头转移从疾病是乳癌的经常的复杂并发症和病态和死亡的一个普通原因。在转移期间,分泌蛋白质在在癌症房间和主人基质之间的相互作用起关键作用。为了描绘分泌蛋白质,那与乳癌骨头转移被联系,我们比较四个 MDA-MB-231 (MDA231 ) 衍生物房间的 secretomes 的没有标签的 proteomic 分析与骨头转移的改变的能力衬里的 preformed。128 蛋白质的一个总数被发现是一致地在骨头回归线癌症房间的调节媒介的 up-/down-regulated。改变的蛋白质的充实的分子的函数包括了受体绑定和 peptidase 抑制。通过乳癌房间的另外的 transcriptomic 分析,我们选择了 cystatin E/M (CST6 ) ,在骨头变形的房间下面调整的一个半胱氨酸朊酶禁止者,为进一步功能的研究。我们的结果证明 CST6 压制了乳癌房间的增长,殖民地形成,迁居和侵略。对癌症房间活动性的镇压功能被癌症执行导出房间的可溶的 CST6。更重要地,在癌症房间的 CST6 的宫外的表示在动物学习救了老鼠免于公开 osteolytic 转移和死亡,当时 CST6 击倒的显著地提高的癌症房间骨头转移和弄短的动物幸存。总的来说,我们的学习提供了乳癌骨头向性的全身的 secretome 分析并且作为乳癌 osteolytic 转移的真正的 suppressor 建立了分泌 CST6。 | Lei Jin Yan Zhang Hui Li Ling Yao Da Fu Xuebiao Yao Lisa X Xu Xiaofang Hu Guohong Hu | 2012 | Cell Research2012，22，9： | 15 |
| 2 | FAILURE ANALYSIS OF PEELING PROCESS FOR TITANIUM ANODES COATINGS显示文摘FAILUREANALYSISOFPEELINGPROCESSFORTITANIUMANODESCOATINGSTangDian;ChenShiren(InstituteforMaterialsResearch,FuzhouUniversity,Fu... | Tang, DA Chen, SR Lin, XA Cui, X Yan, Q | 1995 | 中国有色金属学会会刊:英文版1995，5，4： | 3 |
| 3 | Adenovirus-mediated heme oxygenase-1 gene delivery inhibits injury-induced vascular neointima formation显示文摘 | Tulis DA Durante W Liu X | 2001 | Circulation2001，104，22： | 1 |
| 4 | In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment 显示文摘 | Sipkins DA We i X Wu JW | 2005 | Nature2005，435，7044： | 1 |
| 5 | Synthesis of 1-aryloxyacetyl-4- ( 5-( 4-chlorophenyl )-2-furoyl ) - semicarbazides显示文摘 | Li Z Wang X C Da Y X | 2001 | Synth Commun2001，31，9： | 1 |
| 6 | Measurement and prediction of peak shivering intensity in humans 显示文摘 | Eyolfson DA Tikuisis P Xu X | 2001 | Eur J Appl Physiol2001，84，12： | 1 |
| 7 | Pixel arrangement of autostereoscopic liquid crystal displays based on parallax barriers显示文摘 | Zhao W X Wang Q H Da H L | 2009 | Molecular Crystals and Liquid Crystals2009，507，1： | 1 |
| 8 | Inte- gration and relative value of biomarkers for prediction of MCI to AD progression: spatial patterns of brain atrophy, cognitive scores, APOE genotype and CSF biomarkers 显示文摘 | Da X Toledo JB Zee J | 2014 | Neuroimage Clin2014，4，： | 1 |
| 9 | Effects of Survivin on cell proliferation and apoptosis in MG-63 cells in vitro显示文摘 | Liang X Da M Zhuang Z | 2009 | Cell Biol Int2009，33，1： | 1 |
| 10 | Karyotypic stability, genotyping, differentiation, feeder-free maintenance, and gene expression sampling in three human embryonic stem cell lines derived prior to August 9, 2001显示文摘 | Brimble SN Zeng X Weiler DA | 2004 | Stem Cells Dev2004，13，6： | 1 |
| 11 | Toll-like receptor 4 mediates oxidized LDL-induced macrophage differentiation to foam cells显示文摘 | Howell KW Meng X Fullerton DA | | 0，，： | 1 |
| 12 | 查看详情显示文摘 | Wang X F da Cunha Lima I C Lei X L | | 0，，： | 1 |
| 13 | Active learning paradigms for CBIR systems based on optimum-path forest classification 显示文摘 | da SILVA A T FALC?O A X MAGALH?ES L P | 2011 | Pattern Recognition2011，44，12： | 1 |
| 14 | Interleukin-11: review of molecular cell biology, and clinical use 显示文摘 | Du X Williams DA | 1997 | Blood1997，89，11： | 1 |
| 15 | Assessment of endotracheal cuff pressure by continuous monitoring a pilot study显示文摘 | Sole ML Penoyer DA Su X | 2009 | Am J Crit Care2009，18，2： | 1 |
| 16 | What drives stock price movements? 显示文摘 | Chen L Da Z Zhao X | 2013 | Review of Financial Studies2013，26，4： | 1 |
| 17 | Microstructure evolution of underconling iron-copper hypopefitectic alloys显示文摘 | Da X Y Cao C D | 2001 | Materials Science and Engineering A2001，313，： | 1 |
| 18 | Antisurvivin oligonucleotides inhibit growth and induce apoptosis in human medullary thyroid carcinoma cells 显示文摘 | Du ZX Zhang HY Gao da X | 2006 | Exp Mol Med2006，38，3： | 1 |
| 19 | Effects of Survivin on cell pro- liferation and apoptosis in MG - 63 cells in vitro显示文摘 | Liang X Da M Zhuang Z | 2009 | Cell Biol Int2009，33，1： | 1 |
| 20 | Relationship between expression of Bcl-2 genes and growth factors in ischemic acute renal failure in the rat显示文摘 | Zhang X J Wiugoss DA | 2000 | J Am Soc Nephrol2000，11，3： | 1 |
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