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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Piezoelectric and piezomagnetic materials and their function in transducer显示文摘 | Berlincourt DA Curran DR Jaffe H | 1964 | Physical Acoustics1964，，： | 7 |
| 3 | Biliary complications after pediatric liver transplantation: Risk factors, diagnosis and management显示文摘The expanded indications of partial grafts in pediatric liver transplantation have reduced waiting list mortality. However, a higher morbidity is observed, including an increased rate of biliary complications(BCs). Factors such as the type of graft, the preservation methods applied, the donor characteristics, the type of biliary reconstruction, and the number of bile ducts in the liver graft influences the occurrence of these complications. Bile leaks and strictures comprise the majority of posttransplant BCs. Biliary strictures require a high grade of suspicion, and because most children have a bileoenteric anastomosis, its diagnosis and management rely on percutaneous hepatic cholangiography and percutaneous biliary interventions(PBI). The success rates with PBI range from 70% to 90%. Surgery is reserved for patients who have failed PBI. BCs in children after liver transplantation have a prolonged treatment and are associated with a longer length of stay and higher hospital costs. However, with early diagnosis and aggressive treatment, patient and graft survival are not significantly compromised. | Flavia H Feier Eduardo A da Fonseca Joao Seda-Neto Paulo Chapchap | 2015 | World Journal of Hepatology2015，7，18： | 4 |
| 4 | Evolution of the social network of scientific collaborations显示文摘 | A.L Barabási H Jeong Z Néda E Ravasz A Schubert T Vicsek | 2002 | Physica A: Statistical Mechanics and its Applications2002，，3： | 3 |
| 5 | Histological analysis of pollen-pistil interactions in sour passion fruit plants (Passiflora edulis Sims)显示文摘The success of sexual plant reproduction is directly influenced by specific interactions between the pollen and pistil.Light,fluorescence and scanning electron microscopy techniques were used to evaluate the steps of pollination in sour passion fruit plants(Passiflora edulis Sims).In the compatible interaction,pollen tubes grow through stigma projections towards the ovary.The pollen grain surface was found to be spheroidal and to consist of heteroreticulate exine with six colpi.Furthermore,analysis in vivo of pollenpistil interactions indicated that stigmas of flowers 24 hours before anthesis are unable to discriminate compatible(genetically unrelated)and incompatible(genetically related)pollen grains.Taken together,these results provide insight into the cellular mechanisms underlying pollination in passion fruit plants. | HÉRIKA CHAGAS MADUREIRA TELMA NAIR SANTANA PEREIRA MAURA DA CUNHA DENISE ESPELLET KLEIN | 2012 | BIOCELL2012，36，2： | 2 |
| 6 | An acridinium sulphonyl amide as a new chemiluminescent label for the determination of carboxylie acids in liquid chromatography 显示文摘 | Steijger OM Kainga DA Lingeman H | 1998 | J Biolumin Chemilumin1998，13，1： | 2 |
| 7 | The corpus cavernosum after treatment with dutasteride or finasteride: a histomorphometric study in a benign prostatic hyperplasia rodent model显示文摘 | Marcello H A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De Souza | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
| 8 | Indirect printing of hierarchical patient-specific scaffolds for meniscus tissue engineering显示文摘The complex meniscus tissue plays a critical role in the knee. The high susceptibility to injury has led to an intense pursuit for better tissue engineering regenerative strategies, where scaffolds play a major role. In this study, indirect printed hierarchical multilayered sca ffolds composed by a silk fibroin (SF) upper layer and an 80/20 (w/w) ratio of SF/ionic-doped β-tricalcium phosphate (TCP) bottom layer were developed. Furthermore, a comparative analysis between two types of sca ffolds pro- duced using di fferent SF concentrations, i.e., 8% (w/v) (Hi8) and 16% (w/v) (Hi16) was performed. In terms of architecture and morphology, the produced sca ffolds presented homogeneous porosity in both layers and no di fferences were observed when comparing both sca ffolds. A decrease in terms of mechanical performance of the sca ffolds was observed when SF concentration decreased from 16 to 8% (w/v). Hi16 revealed a static compressive modulus of 0.66 ± 0.05 MPa and dynamical mechanical properties ranging from 2.17 ± 0.25 to 3.19 ± 0.38 MPa. By its turn, Hi8 presented a compressive modulus of 0.27 ± 0.08 MPa and dynamical mechanical properties ranging from 1.03 ± 0.08 MPa to 1.56 ± 0.13 MPa. In vitro bioactivity studies showed formation of apatite crystals onto the surface of Hi8 and Hi16 bottom layers. Human meniscus cells (hMCs) and human primary osteoblasts were cultured separately onto the top layer (SF8 and SF16) and bottom layer (SF8/TCP and SF16/TCP) of the hierarchical sca ffolds Hi8 and Hi16, respectively. Both cell types showed good adhesion and proliferation as denoted by the live/dead staining, Alamar Blue assay and DNA quanti fication analysis. Subcutaneous implantation in mice revealed weak in flammation and sca ffold’s integrity. The hierarchical indirect printed SF sca ffolds can be promising candidate for meniscus TE sca ffolding applications due their suitable mechanical properties, good biological performance and possibility of being applied in a patient-speci fic approach. | Joao BCosta Joana Silva-Correia Sandra Pina Alain da Silva Morais Sílvia Vieira Hélder Pereira Joao Espregueira-Mendes Rui LReis Joaquim M.Oliveira | 2019 | Bio-Design and Manufacturing2019，2，4： | 2 |
| 9 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infaretion显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 10 | A New class of polymers:starburst-dendritic macromolecules显示文摘 | Tomalia DA Baker H Dewald J | 1985 | Polymer J1985，17，： | 1 |
| 11 | Comparative study of propylene polymerization using Me2Si(Rind)2ZrCl2/SiO2-SMAO/AlR3 and Me2Si(RInd)2ZrCl2/MAO(R=Me, H)显示文摘 | Franceschini F C da R Tavares T T dos Santos J H Z | 2007 | Polymer2007，48，7： | 1 |
| 12 | Repeated allergen exposure of semitized Brown-Norway rats induces airway cell DNA synthesis and remodelling 显示文摘 | Salmon M Walsh DA Koto H | 1999 | Eur Respir J1999，14，3： | 1 |
| 13 | Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M Dersimonian H Brenner DA | 2001 | Circulation2001，103，： | 1 |
| 14 | BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer显示文摘 | Bochar DA Wang L Beniya H | 2000 | Cell2000，102，2： | 1 |
| 15 | Cell therapy anenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction显示文摘 | Jain M DerSimonian H Brenner DA | 2001 | Circulation2001，103，14： | 1 |
| 16 | Alpha(1)-antitrypsin deficiency, liver disease and emphysema显示文摘 | Parfrey H Mahadeva R Lomas DA | 2003 | Int J Biochem Cell Biol2003，35，7： | 1 |
| 17 | Validity and reliability of the Obserer's Assessment of Alertness/Sedation Scale:study with intravenous midazolam 显示文摘 | Chernik DA Gillings D Laine H | 1990 | J Clin Psychopharmacol1990，10，： | 1 |
| 18 | Massive and disproportionate elevation of blood urea nitrogen in acute azotemia显示文摘 | Feinfeld DA Bargouthi H Niaz Q | 2002 | Int Urol Nephrol2002，34，1： | 1 |
| 19 | Posterior reversibleencephalopathy syndrome (PRES):Features on CT and MRimaging显示文摘 | Hugonnet E Da Ines D Boby H | 2012 | Diagn Interv Imaging2012，94，1： | 1 |
| 20 | Chagas disease : clinical over view and implications for nursing显示文摘 | Lennox HA Karcz DA Tales H | 2007 | Medsurg Nurs2007，16，4： | 1 |
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