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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 3 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 4 | Polymerization of L, L - lactide initiated by aluminum isopropoxide trimer or tetramer 显示文摘 | Kowalski A Duda A Penczek S | 1998 | Macromolecules1998，31，： | 1 |
| 5 | A riverscape per- spective of Pacific salmonids and aquatic habitats prior to large-scale dam removal in the Elwha River, Washington, USA 显示文摘 | Brenkman S J Duda J J Torgersen C E | 2012 | Fisheries Management and Ecology2012，19，1： | 1 |
| 6 | Enhancing and tuning pho- non transport at vibrationally mismatched solid-solid interfhces显示文摘 | English T S Duda J C Smoyer J L | 2012 | Physics Review B2012，85，03： | 1 |
| 7 | Supercritical Devolatilization of Polymers显示文摘 | ALSOY S DUDA J L | 1998 | AIChE J1998，44，3： | 1 |
| 8 | Utility of CT whirl sign in guiding management of small-bowel obstruction 显示文摘 | Duda J B Bhatt S Dogra V S | 2008 | A JR Am J Roentgenol2008，191，3： | 1 |
| 9 | Utility of CT whirl sign in guiding management of small-bowel obstruction显示文摘 | Duda JB Bhatt S Dogra VS | 2008 | AJR Am J Roentgenol2008，191，3： | 1 |
| 10 | Normalization of the vasculature for treatment of cancer and other diseases显示文摘 | Goel S Duda DG Xu L | 2011 | Physiol Rev2011，91，： | 1 |
| 11 | Normal,blue and red earthquakes A new way of earthquake classification on the basis of body-wave magnitudes显示文摘 | Duda S J Nortmann R | 1983 | Tectonophysics1983，93，： | 1 |
| 12 | Sexualy transmited infections and prostate cancer risk: A systematic review and meta- analysis显示文摘 | Caini S Gandini S Dudas M | 2014 | Cancer Epidemiol2014，28，14： | 1 |
| 13 | Molecular diffusion in polymer solutions显示文摘 | VRENTAS J S DUDA J L | 1979 | AIChE Journal1979，25，1： | 1 |
| 14 | Adenosine Antagonist Theophylline Prevents the Reduction of Glomerular Filtration Rateafter Contrast Media Application 显示文摘 | Erley C M Duda S H Schlepckow S | 1994 | Kidney Int1994，45，14： | 1 |
| 15 | Increased BMP expression in arthrofibrosis after TKA显示文摘 | Pfitzner T Geissler S Duda G | 2012 | Knee Surg Sports Traumatnl Arthrosc2012，20，9： | 1 |
| 16 | Utility of CT whirl sign in guiding management of small-bowel obstruction 显示文摘 | Duda JB Bhatt S Dogra VS | 2008 | AJR2008，191，3： | 1 |
| 17 | Skin-sparing mastectomy and immediate reconstruction: oncologic risks and aesthetic results in patients with early-stage breast cancer显示文摘 | Slavin SA Schnitt S J Duda RB | 1998 | Plast Reconstr Surg1998，102，1： | 1 |
| 18 | Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma 显示文摘 | Rempel SA Dudas S Ge S | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 19 | Cross-correlation of polarity curves to predict partition coefficients of nonionic organic contaminants显示文摘 | Xing B S McGill W B Dudas M J | 1994 | Environ Sci Technol1994，28，11： | 1 |
| 20 | Montreal cognitive assessment performance in patients with Parkinson's disease with'normal'global cognition according to mini-mental state examination score显示文摘 | Nazem S Sidcrowf AD Duda JE | 2009 | J Am Geriatr Soc2009，57，： | 1 |
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