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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Is social acceptance aproblem for noise control and active silencers显示文摘 | Hirschom M Duda J | 2000 | Sound and Vibration2000，34，8： | 1 |
| 3 | Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway显示文摘 | DUDAS M NAGY A LAPING N J | 2004 | Dev Biol2004，266，1： | 1 |
| 4 | Immunohistochemical localization of androgen receptor and aromatase in the ovary of the pregnam pig显示文摘 | Duda M Burek M Galas J | 2004 | Biol Reprod2004，114，3： | 1 |
| 5 | Design, scale up and safe piloting of thymol hydro- genation and menthol racemisation显示文摘 | Dudas J Hanika J | 2009 | Chemical Engineering Research and Design2009，87，1： | 1 |
| 6 | Modified MacNeille cube polarizer for a wide angular field显示文摘 | Mouchart J Begel J Duda E | 1989 | Appl Opt1989，28，14： | 1 |
| 7 | Quantitative NMR Spectroscopy for the Prediction of Base Oil Properties显示文摘 | Adhvaryu A Perez J M Duda J L | 2000 | Tribol T2000，43，2： | 1 |
| 8 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 9 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 10 | Differences in native soil ecology associated with invasion of the exotic annual chenopod,Halogeton glomeratus显示文摘 | Duda J J Freeman D C Emlen J M | 2003 | Biol FertilSoils2003，38，2： | 1 |
| 11 | Continuum structural topology design with genetic algorithms 显示文摘 | Jakiela M J Chapman C Duda J Adewuya A | 2000 | Computer Methods in Applied Mechanics and Engineering2000，186，： | 1 |
| 12 | Differences in native soil ecology associated with invasion of the exotic annual chenopod,Halogeton glomeratus显示文摘 | Duda J J Freeman D C Emlen J M | 2003 | Biology and Fertility of Soils2003，38，： | 1 |
| 13 | A riverscape per- spective of Pacific salmonids and aquatic habitats prior to large-scale dam removal in the Elwha River, Washington, USA 显示文摘 | Brenkman S J Duda J J Torgersen C E | 2012 | Fisheries Management and Ecology2012，19，1： | 1 |
| 14 | Internal tide and nonlinear internal wave behavior at the continental slope in the northern South China Sea显示文摘 | Duda T F Lynch J F Irish J D | 2004 | IEEE Journal of Oceanic Engineering2004，29，4： | 1 |
| 15 | A test of Self-Determination Theory in School Physical Education 显示文摘 | STANDAGE M DUDA J L NTOUMANIS N | 2005 | British Journal of Educational Psychology2005，75，3： | 1 |
| 16 | Enhancing and tuning pho- non transport at vibrationally mismatched solid-solid interfhces显示文摘 | English T S Duda J C Smoyer J L | 2012 | Physics Review B2012，85，03： | 1 |
| 17 | Goal orientations and moral identity as predictors of prosocial and antisocial functioning in male association football players显示文摘 | SAGE L KAVUSSANU M DUDA J | 2006 | Journal of Sports Sciences2006，24，5： | 1 |
| 18 | Immunohistoehemical localization of androgen receptor and aromatase in the ovary of the pregnaat pig显示文摘 | Duda M Burek M Galas J | 2004 | Repro Biol2004，4，3： | 1 |
| 19 | Sputtered molybdenum bilayer back contact for copper Indium diselenide-based polyerystalline thin-film solar cells显示文摘 | Scofieldl J H Duda A Albin D | 1995 | Thin Solid Films1995，260，1： | 1 |
| 20 | Correlates of Goal Orientations among Young Athletes 显示文摘 | Horn H Duda J L Miller A | 1993 | Pediatric Exercise Science1993，5，： | 1 |
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