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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | The Relationship Between Attenuated Plaque Identified by Intravascular Ultrasound and No-Reflow After Stenting in Acute Myocardial Infarction显示文摘 | Xiaofan Wu Gary S. Mintz Kai Xu Alexandra J. Lansky Bernhard Witzenbichler Giulio Guagliumi Bruce Brodie Mirle A. Kellett Ovidiu Dressler Helen Parise Roxana Mehran Gregg W. Stone Akiko Maehara | 2011 | JACC: Cardiovascular Interventions2011，，5： | 3 |
| 3 | PAX-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor显示文摘 | Dressler GR Douglass EC | 1992 | PNAS1992，89，： | 1 |
| 4 | Less nocturnal hypoglycemia and better post-dinner glucose control with bedtime insulin glargine compared with bedtime NPH insulin during insulin combination therapy in type 2 diabetes显示文摘 | Yki-Jrvinen H Dressler A Ziemen M | 2000 | Diabetes Care2000，23，8： | 1 |
| 5 | Biology of the orchid bees(Euglossini)显示文摘 | Dressler R | 1982 | Annual Review of Ecology and Systematics1982，13，1： | 1 |
| 6 | History - high Speed Network Monitoring and Analysis 显示文摘 | DRESSLER F CARLE G | 2005 | In Proceedings of the 24th IEEE Conference on Computer Communications (IEEE INFOCOM 2005)2005，，： | 1 |
| 7 | Mutations in the transketolase-like gene TKTL1 : clinical implications for neurodegenerative diseases, diabetes and cancer显示文摘 | Coy JF Dressler D Wilde J | 2005 | Clin Lab2005，51，56： | 1 |
| 8 | Digestion of biological materials using the microwave-assisted sample combustion technique 显示文摘 | Mesko M F Moraes D P Barin J S Dressler V L Knapp G Flores E M M | 2006 | Microchem Journal2006，82，： | 1 |
| 9 | The cellular basis of kidney development显示文摘 | Dressler GR | | 0，，： | 1 |
| 10 | Application of microwave induced combustion in closed vessels for carbon black-containing elastomers decomposition 显示文摘 | Moraes D P Mesko M F Mello P A Paniz J N G Dressler V L Knapp G Flores E M M | 2007 | Spectrochim Acta : Part B2007，62，： | 1 |
| 11 | Botulinum toxin type B de novo ther-apy of cervical dystonia:frequency of antibody induced thera-py failure显示文摘 | Dressler D Bigalke H | 2005 | J Neurol2005，252，： | 1 |
| 12 | DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens显示文摘 | Owens M | 1988 | Cancer1988，61，1： | 1 |
| 13 | Accuracy of Kinematic and Dynamic Models of a Gantry-Tau Parallel Kinematic Robot显示文摘 | Isolde Dressler Anders Robertsson Rolf Johan sson | 2007 | IEEE International Conference on Robotics and Automation2007，，： | 1 |
| 14 | Repair of patellar tendon injuries using a cell collagen composite显示文摘 | Awad H A Boivin G P Dressler MR | | 0，，03： | 1 |
| 15 | Expression of the PAX2 oncogene in human breast cancer and its role in progesterone-dependent mammary growth显示文摘 | Silberstein GB Dressler GR Van Horn K | 2002 | Oncogene2002，21，7： | 1 |
| 16 | PAX-2, a new paired-box-containing gene and its expression in the developing excretory system显示文摘 | Dressler GR Deutsch U Chowdhury K | 1990 | Development1990，109，： | 1 |
| 17 | Tumor characteristics in African American and white women显示文摘 | Furberg H Millikan R Dressler L | 2001 | Breast Cancer Res Treat2001，68，： | 1 |
| 18 | Determination of Hg in seawater by inductively coupled plasma wass spectrometry after on-line pre-concentration,Spectrochim显示文摘 | Seibert Edson Luiz Seibert Edson htiz Dressler Valderi Luiz | 2001 | Acta Part B2001，56，10： | 1 |
| 19 | Satellite tracking by combined optimal estimation and control techniques显示文摘 | Dressler R M Tabak D | 1971 | IEEE Transactions on Automatic Control1971，16，6： | 1 |
| 20 | Botulinum toxin:mechanisms of action显示文摘 | Dressler D Saberi FA Barbosa ER | | 0，，： | 1 |
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