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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 3 | Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains显示文摘 | Terrill T H Rowan A M Douglas G B | 1992 | Journal of the Science of Food and Agriculture1992，58，3： | 1 |
| 4 | Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study显示文摘 | Douglas S Berkman Andres G Lescano Robert H Gilman Sonia L Lopez Maureen M Black | 2002 | The Lancet2002，，9306： | 1 |
| 5 | Air-water gas transfer in uniform channel flow显示文摘 | Douglas B M Gerhard H J | 1999 | Journal of hydraulic engineering1999，125，1： | 1 |
| 6 | Unbundling the Voting Rights and Profit ChiIlls of Common Shares显示文摘 | Douglas H Blair D L M James | 1989 | Journal of Political Economy1989，97，： | 1 |
| 7 | Compliance with CPAP therapy in patients with the sleep apnoea/hypopnoea syndrome显示文摘 | ENGLEMAN H M MARTIN S E DOUGLAS NJ | 1994 | Thorax1994，49，： | 1 |
| 8 | Myocardial disease:hemodynamic and renal excretory effects of human brain natriuretic peptide infusion in patients with congestive heart failure:A double-blind,placebo-controlled,randomized crossover trial显示文摘 | Lee M Douglas H Micton P | 1996 | Circulation1996，94，12： | 1 |
| 9 | Spatio - temporal fastICA algorithms for the blind separation of convo- lutive mixtures 显示文摘 | DOUGLAS S C GUlrI'A M SAWADA H | 2007 | IEEE Transactions on Audio Speech and I-anguage Processing2007，2007，15： | 1 |
| 10 | Segmenting Consumers Using Multiple -category Purchase Data 显示文摘 | CARRIE M H DOUGLAS B | 2002 | International Journal of Research in Marketing2002，19，3： | 1 |
| 11 | Numerical investigation of oxy-coal combustion to evaluate burner and combustor design concepts 显示文摘 | Chui E H Majeski A J Douglas M A | 2004 | Energy2004，29，： | 1 |
| 12 | The Corporate Competitive Intelligence/Counterintelligence Team: a Symbiotic Design for the Future 显示文摘 | Clough H D Margulies R A Douglas M | 1994 | Competitive Intelligence Review1994，5，3： | 1 |
| 13 | Self-Assembly of DNA into Nanoscale Three-Dimensional Shapes显示文摘 | Douglas S M Dietz H Liedl T | | Nature0，459，： | 1 |
| 14 | Distinguishing the dark triad:Evidence from the Five-Factor Model and the Hogan DevelopmentSurvey显示文摘 | Douglas H Bore M Munro D | 2012 | Psychology2012，3，3： | 1 |
| 15 | Stoking the fires? CO2 emissions and economic growth 显示文摘 | DOUGLAS H E THOMAS M S | 1995 | Journal of Public Economics1995，57，1： | 1 |
| 16 | Modeling of oxy-fuel combustion for a western canadian sub-bituminous coal显示文摘 | Chui E H Douglas M A Yewan T | 2003 | Fuel2003，82，10： | 1 |
| 17 | The health impacts of khat: a qualitative study among Somali-Australians显示文摘 | Douglas H M Boyle N Lintzeris | 2011 | Med J Aust2011，195，1112： | 1 |
| 18 | Progress in semiconducting oxide-based thin-film transistors for displays显示文摘 | LI Y J KWON Y W JONES M HEO Y W ZHOU J LUO S C HOLLOWAY P H DOUGLAS E NORTON D P PARK Z LI S | | 0，，08： | 1 |
| 19 | The longer the shifts for hospital nurses,the higher the levels of burnout and patient dissatisfaction显示文摘 | Amy Witkoski Stimpfel Douglas M Sloane Linda H Aiken | 2012 | Health Aff(Millwood)2012，31，11： | 1 |
| 20 | 显示文摘 | Nick B Patrick C H Douglas R M | 2007 | Surf Coat Technol2007，201，： | 1 |
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