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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | An overview of fractal anten-na engineering research 显示文摘 | DOUGLAS H W SUMAN G | 2003 | IEEE Antennas and Propaga- tion2003，，3： | 1 |
| 3 | Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains显示文摘 | Terrill T H Rowan A M Douglas G B | 1992 | Journal of the Science of Food and Agriculture1992，58，3： | 1 |
| 4 | Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study显示文摘 | Douglas S Berkman Andres G Lescano Robert H Gilman Sonia L Lopez Maureen M Black | 2002 | The Lancet2002，，9306： | 1 |
| 5 | Human RhoGAP domain- containing proteins: structure, function and evolutionary relation- ships显示文摘 | Peck J Douglas G 4th Wu C H | 2002 | FEBS Lett2002，528，13： | 1 |
| 6 | Multicriteria optimization with a multiobjective golden section line search显示文摘 | Douglas A G V Ricardo H C T Rodney R S | 2012 | Mathematical Programming2012，131，12： | 1 |
| 7 | Exaggerated heart rate oscillations during two meditation techniques 显示文摘 | Peng C-K and Mietus J E and Liu Y and Khalsa G and Douglas P S and Benson H and Goldberger A L | 1999 | Int J Cardiol:1999，70，： | 1 |
| 8 | Haman umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells 显示文摘 | Broxmeyer H E Douglas G W Hangoc G | 1989 | Proc Natl Acad Csi U S A1989，86，38： | 1 |
| 9 | Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice显示文摘 | Lucas R J Douglas R H Foster R G | 2001 | Behav Brain Res2001，125，： | 1 |
| 10 | Multiresidue pesticide analysis of wines by dispersive solid-phase extraction and ultrahigh-performance liquid chromatography? tandem mass spectrometry显示文摘 | ZHANG K WONG J W DOUGLAS G H | 2009 | J AgricFood Chem2009，57，10： | 1 |
| 11 | Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium 显示文摘 | MORBIDELLI L CHANG C H DOUGLAS J G | 1996 | Am J1996，270，： | 1 |
| 12 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 13 | Patterns of Gene Expression in Swine Macrophages Infected with Classical Swine Fever Virus Detected by Microarray显示文摘 | Douglas P G James Zhu Lauren G H | 2010 | Virus Research2010，151，1： | 1 |
| 14 | A Delphi evaluation of the factors influencing length of stay in Australian hospitals显示文摘 | Xiao J G Douglas D Lee A H | 1997 | International Journal of Health Planning and Management1997，，17： | 1 |
| 15 | Overexpression of AtCpNifS enhances selenium tolerance and accumulation in Arabidopsis显示文摘 | Douglas V H Gulnara F G Ashley R A | 2005 | Plant Physiol2005，139，： | 1 |
| 16 | Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells显示文摘 | BROXMEYER H E DOUGLAS G W HANGOC G | 1989 | Proc Natl Acad Sci USA1989，86，10： | 1 |
| 17 | The OSSA lI Pipeline Oil Spill: the Character and Weathering of the Spilled Oil显示文摘 | Douglas G S Owens E H Hardenstine J | 2002 | Spill Sci Tech Bull2002，，7： | 1 |
| 18 | Glycine in broiler nutrition 显示文摘 | DOUGLAS C R HOCHREICH H G HARMS R H | 1958 | Poultry Science1958，37，3： | 1 |
| 19 | Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains显示文摘 | Terrill T H Rowan A M Douglas G B | 1992 | Journal of the Science of Food and Agriculture1992，58，3： | 1 |
| 20 | Urea complexation for the rapid, ecologically responsible fractionation of fatty acids from seed oil显示文摘 | DOUGLAS G H YLVA C B JAMES M V | 1998 | American Oil Chemists'' Society1998，75，10： | 1 |
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