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| 1 | Enteral stents for the management of malignant colorectal obstruction显示文摘Colorectal cancer(CRC) is the 3rd most common cancer in the United States with more than 10000 new cases diagnosed annually. Approximately 20% of patients with CRC will have distant metastasis at time of diagnosis, making them poor candidates for primary surgical resection. Similarly, 8%-25% of patients with CRC will present with bowel obstruction and will require palliative therapy. Emergent surgical decompression has a high mortality and morbidity, and often leads to a colostomy which impairs the patient's quality of life. In the last decade, there has been an increasing use of colonic stents for palliative therapy to relieve malignant colonic obstruction. Colonic stents have been shown to be effective and safe to treat obstruction from CRC, and are now the therapy of choice in this scenario. In the setting of an acute bowel obstruction in patients with potentially resectable colon cancer, stents may beused to delay surgery and thus allow for decompression, adequate bowel preparation, and optimization of the patient's condition for curative surgical intervention. An overall complication rate(major and minor) of up to 25% has been associated with the procedure. Long term failure of stents may result from stent migration and tumor ingrowth. In the majority of cases, repeat stenting or surgical intervention can successfully overcome these adverse effects. | Jeremy Kaplan Anna Strongin Douglas G Adler Ali A Siddiqui | 2014 | World Journal of Gastroenterology2014，20，37： | 13 |
| 2 | Endoscopic retrograde cholangiopancreatography in cirrhosis-a systematic review and meta-analysis focused on adverse events显示文摘AIM To investigate indications and outcomes of endoscopic retrograde cholangiopancreatography(ERCP) in cirrhotics, especially adverse events. Patients with cirrhosis undergoing ERCP are believed to have increased risk. However, there is a paucity of literature describing the indications and outcomes of ERCP procedures in patients with cirrhosis, especially focusing on adverse events.METHODS We performed a systematic appraisal of major literature databases, including PubMed and EMBASE, with a manual search of literature from their inception until April 2017.RESULTS A total of 6,505 patients from 15 studies were analyzed(male ratio 59%, mean age 59 years), 11% with alcoholic and 89% with non-alcoholic cirrhosis, with 56.2% Child-Pugh class A, and 43.8% class B or C. Indications for ERCP included choledocholithiasis 60.9%, biliary strictures 26.2%, gallstone pancreatitis 21.1% and cholangitis 15.5%. Types of interventions included endoscopic sphincterotomy 52.7%, biliary stenting 16.7% and biliary dilation 4.6%. Individual adverse events included hemorrhage in 4.58%(95%CI: 2.77-6.75%, I^2 = 85.9%), post-ERCP pancreatitis(PEP) in 3.68%(95%CI: 1.83-6.00%, I^2 = 89.5%), cholangitis in 1.93%(95%CI: 0.63-3.71%, I^2 = 87.1%) and perforation in 0.00%(95%CI: 0.00-0.23%, I^2 = 37.8%). Six studies were used for comparison of ERCPrelated complications in cirrhosis vs non-cirrhosis, which showed higher overall rates of complications in cirrhosis patients with pooled OR of 1.63(95%CI: 1.27-2.09, I2 = 65%): higher rates of hemorrhage with OR of 2.05(95%CI: 1.62-2.58, I^2 = 2.1%) and PEP with OR of 1.33(95%CI: 1.04-1.70, I2=65%), but similar cholangitis rates with OR of 1.23(95%CI: 0.67-2.26, I^2 = 44.3%).CONCLUSION There is an overall higher rate of adverse events related to ERCP in patients with cirrhosis, especially hemorrhage and PEP. A thorough risk/benefit assessment should be performed prior to undertaking ERCP in patients with cirrhosis. | Shailender Singh Mashiana Amaninder Singh Dhaliwal Harlan Sayles Banreet Dhindsa Ji Won Yoo Qing Wu shailender singh Ali A Siddiqui Gordon Ohning Mohit Girotra Douglas G Adler | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，11： | 6 |
| 3 | Determination of extractable and bound condensed tannin concentrations in forage plants, protein concentrate meals and cereal grains显示文摘 | Terrill T H Rowan A M Douglas G B | 1992 | Journal of the Science of Food and Agriculture1992，58，3： | 1 |
| 4 | Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and re- generation显示文摘 | All Z A Rinze R Douglas G | 2013 | Circulation2013，128，111： | 1 |
| 5 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 6 | Environmentalstability of selected petroleum hydrocarbon source and weatheringratios显示文摘 | Douglas G S Bence A E Prince R C | 1996 | Environmental Science&Technology1996，30，7： | 1 |
| 7 | On the generation of trajectories for multiple UAVs in environments with obstacles显示文摘 | Armando A N Douglas G M Mado F M | 2010 | J of Intelligent and Robotic Systems Archive2010，57，4： | 1 |
| 8 | Multicriteria optimization with a multiobjective golden section line search显示文摘 | Douglas A G V Ricardo H C T Rodney R S | 2012 | Mathematical Programming2012，131，12： | 1 |
| 9 | Laser desorption ionization ofpolycyclic aromatic hydrocarbons from glass surfaces with ion mobility spectrometry analysis显示文摘 | Young D Douglas K M Eiceman G A | | 0，，： | 1 |
| 10 | Temporal expression of ECE-1, ET-1,ET-3, ETA and ETB receptor mRNAs after balloon angioplasty in the rat 显示文摘 | DOUGLAS S A FEUERSTEIN G Z | 1995 | J Cardiovasc Pharmacol1995，26，： | 1 |
| 11 | Developing and Implementing Supply Partnerships 显示文摘 | Douglas M L Margaret A E John T G | 1996 | The International Journal of Logistics Management1996，7，2： | 1 |
| 12 | Exaggerated heart rate oscillations during two meditation techniques 显示文摘 | Peng C-K and Mietus J E and Liu Y and Khalsa G and Douglas P S and Benson H and Goldberger A L | 1999 | Int J Cardiol:1999，70，： | 1 |
| 13 | Expression of cell cycle control proteins in primary colorectal tumors does not always predict expression in lymph node metastases显示文摘 | McKay Joy J Douglas Val G | 2000 | Clin Cancer Res2000，6，3： | 1 |
| 14 | Sulfur: Role in genesis of petroleum显示文摘 | Douglas A G Mair B J | 1965 | Science1965，147，29： | 1 |
| 15 | Diamondoid hydrocmbons Appli- cation in the chemical fingerprinting of natural gas condensate and gasoline显示文摘 | Stout S A Douglas G S | 2004 | Environmental Forensics2004，5，4： | 1 |
| 16 | Glucosinolate metabolism and its control 显示文摘 | DOUGLAS G C STEFFEN A | 2006 | Trends Plant Sci2006，11，2： | 1 |
| 17 | Saturated hydrocarbon biomarkers in oils of Late Precambrian age from Eastern Siberia显示文摘 | Fowler M G Douglas A G | 1987 | Organic Geochemistry1987，11，3： | 1 |
| 18 | Modifiable Factors Associated With Improved Cardiac Arrest Survival in a Multicenter Basic Life Support/Defibrillation System: OPALS Study Phase I Results显示文摘 | Ian G Stiell George A Wells Valerie J DeMaio Daniel W Spaite Brian J Field Douglas P Munkley Marion B Lyver Lorraine G Luinstra Roxanne Ward | 1999 | Annals of Emergency Medicine1999，，： | 1 |
| 19 | Electroantennogram response of alfalfa seed chalcid, Bruchophagus roddi (Hymenoptera: Eurytomidae) to host-and nonhost-plant volatiles 显示文摘 | Douglas M In James A K Ronald G R | 1992 | Journal of Chemical Ecology1992，18，3： | 1 |
| 20 | The recognition of bio degraded petroleum-derived aromatic hydrocarbons in recent ma- rine sediments显示文摘 | Jones D M Douglas A G Parkes R J | 1983 | Marine Pollution Bulletin1983，14，： | 1 |
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