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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis显示文摘Trichomoniasis is the most common, sexually transmitted infection. It is caused by the flagellated protozoan parasite Trichomonas vaginalis. Symptoms include vaginitis and infections have been associated with preterm delivery, low birth weight and increased infant mortality, as well as predisposing to HIV/AIDS and cervical cancer. Trichomoniasis has the highest prevalence and incidence of any sexually transmitted infection. The 5-nitroimidazole drugs, of which metronidazole is the most prescribed, are the only approved,effective drugs to treat trichomoniasis. Resistance against metronidazole is frequently reported and crossresistance among the family of 5-nitroimidazole drugs is common, leaving no alternative for treatment, with some cases remaining unresolved. The mechanism of metronidazole resistance in T. vaginalis from treatment failures is not well understood, unlike resistance which is developed in the laboratory under increasing metronidazole pressure. In the latter situation, hydrogenosomal function which is involved in activation of the prodrug, metronidazole, is down-regulated. Reversion to sensitivity is incomplete after removal of drug pressure in the highly resistant parasites while clinically resistant strains, so far analysed, maintain their resistance levels in the absence of drug pressure. Although anaerobic resistance has been regarded as a laboratory induced phenomenon, it clearly has been demonstrated in clinical isolates. Pursuit of both approaches will allow dissection of the underlying mechanisms. Many alternative drugs and treatments have been tested in vivo in cases of refractory trichomoniasis, as well as in vitro with some successes including the broad spectrum anti-parasitic drug nitazoxanide. Drug resistance incidence in T. vaginalis appears to be on the increase and improved surveillance of treatment failures is urged. | REBECCALDUNNE LINDAADUNN PETERUPCROFT PETERJO‘DONOGHUE JACQUE-LINEAUPCROFT | 2003 | Cell Research2003，13，4： | 4 |
| 3 | Highly Fluorescent Dye-Doped Silica Nanoparticles Increase Flow Cytometry Sensitivity for Cancer Cell Monitoring显示文摘Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor cells.Current diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled antibodies.However,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell surface.To solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard methods.Our NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their matrix.We have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow cytometry.The NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated molecules.By virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow cytometry.Moreover,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties. | M.-Carmen Estévez Meghan B.OʼDonoghue Xiaolan Chen Weihong Tan | 2009 | Nano Research2009，2，6： | 3 |
| 4 | 运动表现分析:过去、现在与未来显示文摘对运动表现分析的发展历程、现状、未来进行研究发现,运动表现分析起源于标记分析,历经一个多世纪的实践与研究完成了由方法向方法论的转型,进入21世纪后逐渐发展成为运动科学(Sports Science)的一个新兴分支学科。在运动表现分析实践中采用定性、定量以及两者相结合的方法对“人的运动”进行直接描述和分析,分析手段主要包括标记分析和移动分析,通常需要从方法和学科2个层面来理解其定义。技术和战术表现评估、信效度分析、负荷监控以及学科交叉研究是近年来运动表现分析领域的研究热点。运动表现分析相关专业的设立以及运动表现分析师这一新职业的出现有力地推动了运动训练的科学化。当前,运动表现分析的理论基础、技术手段、人才培养和学科影响力等方面还面临挑战,未来其理论体系将趋向完善,向分析智能化、服务对象大众化和人才培养专业化等方向发展。 | 易清 黎涌明 张铭鑫 崔一雄 刘天彪 张绍良 龚炳南 黄展煜 周长敬 MiguelÁngel Gómez Ruano Daniel Memmert Peter O'Donoghue 刘鸿优 | 2023 | 上海体育学院学报2023，47，2： | 3 |
| 5 | 清管保证管线畅通:对管线除蜡的清管频率评估显示文摘针对目前输油管道结蜡情况严重 ,通过不同的方式和模型对管线中清蜡的频率进行研究。输油管线结蜡严重 ,不但影响生产 ,而且成本损耗较大 ,给正常管道输油造成困难。介绍并分析了清管器旁通模型 ,给出了实例分析介绍。虽然这种清蜡方式很有效 ,但是在实际应用当中还存在一定的局限性。 | Aidan O'Donoghue 黎兴文 杨贵模 石金华 | 2004 | 国外油田工程2004，20，11： | 3 |
| 6 | Anxiety in patients undergoing percutaneous coronary interventions显示文摘 | Renée Trotter Robyn Gallagher Judith Donoghue | 2011 | Heart & Lung - The Journal of Acute and Critical Care2011，，3： | 2 |
| 7 | bcl‐2 protein expression is associated with better prognosis in colorectal cancer显示文摘 | Leahy Mulcahy O’Donoghue Parfrey | 2001 | Histopathology2001，，4： | 2 |
| 8 | The effects of Thailand's Great Flood of 2011 on river sediment discharge in the upper Chao Phraya River basin, Thailand显示文摘严重充满在泰国发生在 2011 季风季节期间那是在过去的 50 的最重的泛滥;年。在泰国的北部分上的降雨,特别在 7 月 8 月期间 2011,比一般水准高是 150% 。在泛滥的经期期间,河在 1.4-5 时间的范围增加的四条主要 Chao Phraya 河支流(砰,王,日子,和 Nan 河) 流动平均分泌物。这研究在泰国在上面的 Chao Phraya 河盆检验了四条主要的河的河沉积分泌物。四条河被认为沉积供应的主要来源到 Chao Phraya 河口。砰,王,日子,和 Nan 河的河调查在 2011 年 10 月被执行(在大洪水期间) 并且 2012 年 10 月(在洪水以后的一年) 。调查数据包括了河十字节,流动速度,推迟的沉积集中,和床负担每条河里的运输。这些数据的分析显示沉积运输在泛滥 2011 期间为四条主要的河评估的那个总数比在 60 上的平均沉积分泌物高是 2.3-5.6 时间;年。2011 的洪水显著地包括比例影响了沉积特征推迟并且每条河里的床沉积负担不过以不同方法。沉积的率每为戏剧性地在 2011 洪水,但是泛滥期间增加的砰和王河统一分泌物搬运在日子和 Nan 河的沉积特征上的有的最小的效果。每条河里的沉积分泌物在 2011 引起了泛滥的总数的数量在 0.3 和 1.6 之间变化了;阿迪蒂奥纳尔利山,这些河里的床负担运输在 0% 推迟的沉积和 26% 解除的 ~ 之间变化了。 | Butsawan Bidorn Seree Chanyotha Stephen A. Kish Joseph F. Donoghue Komkrit Bidorn Ruetaitip Mama | 2015 | International Journal of Sediment Research2015，30，4： | 2 |
| 9 | Cryptosporidium and cryptosporidiosis in man and animals显示文摘 | Peter J. O'Donoghue | 1995 | International Journal for Parasitology1995，，2： | 2 |
| 10 | A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9显示文摘 | Mary Donoghue Frank Hsieh Elizabeth Baronas Kevin Godbout Michael Gosselin Nancy Stagliano Michael Donovan Betty Woolf Keith Robison Raju Jeyaseelan Roger E. Breitbart Susan Acton | 2000 | Circulation Research: Journal of the American Heart Association2000，，5： | 2 |
| 11 | Long-term potention of horizontal connections providees a mechanism to reorganize cortical motor maps 显示文摘 | Donoghue JP | 1994 | J Neurophysiol1994，71，6： | 1 |
| 12 | A novel angiotensinconverting enzyme-related earboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E | 2000 | Circ Res2000，87，5： | 1 |
| 13 | A novel angiotensin-converting enzyme-related carboxypep- tidase ( ACE2 ) converts angiotensin I to angiotensin 1-9显示文摘 | Donoghue M Hsieh F Baronas E et a/ | 2000 | Cir Res2000，87，5： | 1 |
| 14 | Cochlear never aplasia:its importance in cochlear implantation显示文摘 | Maxwell AP Mason SM O'Donoghue GM | 1999 | AM J Otal1999，20，3： | 1 |
| 15 | Iodination of Annexin V for Imaing Apoptosis显示文摘 | Russell JO Donoghue JA Finn R | 2002 | J Nucl Med2002，43，： | 1 |
| 16 | Strategies for selective targeting of Auger electron emitters to tumor cells显示文摘 | O'Donoghue JA | 1996 | J Nucl Med1996，，： | 1 |
| 17 | Outgroup analysis and parsimony显示文摘 | Maddison W P Donoghue M J Maddison D R | 1984 | Systematic Zoology1984，33，： | 1 |
| 18 | The Small-world Dynamics of Tree Networks and Data Mining in Phyloinformatics显示文摘 | Piel W H Sanderson M J Donoghue M J | 2003 | Bioinformatics2003，19，9： | 1 |
| 19 | Mouse cytomegalovirus infection induces antibodies which cross - react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis 显示文摘 | Lawson CM O' Donoghue HL Reed WD | 1992 | Immunology1992，75，3： | 1 |
| 20 | Lipoprotein-asso- ciated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TI- MI 22 ( PRavastatin Or atorVastatin Evaluation and Infection Therapy- Thrombolysis In Myocardial Infarction) trial 显示文摘 | O' Donoghue M Morrow DA Sabatine MS | 2006 | Circulation2006，113，14： | 1 |
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