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    题名 作者 年代 出处 被引量
1曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M 2001中国疼痛医学杂志2001,7,1:2
2Histopathology of pressure ulcers as a result of sequential computer-controlled pressure sessions in a fuzzy rat model显示文摘Salcido R Donofrio J C Fisher S B 1994Adv Wound Care1994,7,24:1
3Caspases activation in equine influenza virus induced apoptotic cell death 显示文摘 Holland RE Donofrio JC McCoy MH Tudor LR Chambers TM 2002Vet Microbiol2002,84,4:1
4An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers显示文摘Salcido R Fisher S B Donofrio J C 1995J Rehabil Res Dev1995,32,2:1
5Susceptibility of bovine mesenchymal stem ceils to bovine herpesvirus 4显示文摘DONOFRIO G COLLEONI S GALLI C 2005J Virol Methods2005,127,2:1
6An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers显示文摘Salcido R Fisher S B Donofrio J C 1995J Reha- bil Res Dev1995,32,2:1
7Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function显示文摘Donofrio G Herath S Sartori C 2007Reproduction2007,134,1:1
8Impact of congenital heart disease on fetal brain development and injury显示文摘Donofrio MT Duplessis AJ Limperopoulos C 0,,05:1
9Cell type specificity and host genetic polymorphisms influence antibody-dependent enhancement of dengue virus infection显示文摘Boonnak K Dambach K M Donofrio G C 2011J Virol2011,85,:1
10Double immunization strategy with a BoHV-4-vectorialized secreted chimeric peptide BVDV-E2/BoHV-I-gD显示文摘Donofrio G Sartori C Franceschi V 2008Vaccine2008,26,48:1
11Caspase activation in equine influenza virus induced apoptotic cell death显示文摘Lin C Holland R E Jr Donofrio J C 2002Vet Microbial2002,84,4:1
12Bovine herpesvirus 4 is tropic for bovine endometrial cells and modulates endocrine function显示文摘Donofrio G Herath S Sartori C 2007Reproduction2007,134,1:1
13Interaction of a green recombinant bovine herpesvirus 4 with in vitro-produced bovine embryos显示文摘Donofrio G Galli C Lazzari G 2003Veterinary Research Communications2003,27,5:1
14Magnetic resonance and echocardiographic imaging of pulmonary artery size throughout stages of fontan reconstruction显示文摘Fogel MA Donofrio MT Ramaciotti C 1994Circulation1994,90,6:1
15Diagnosis of equine influenza by the polymerase chain reaction 显示文摘James C Donofrio A Donald J 1994J Vet Diagn Invest1994,6,:1
16An animal model and computer-controlled surface pressure delivery system for the production of pressure ulcers显示文摘Salcido R Fisher S B Donofrio J C 1995J Rehabil Res Dev1995,32,2:1
17Impact of con-genital heart disease on fetal brain development and injury显示文摘Donofrio MT Duplessis AJ Limperopoulos C 0,,05:1
18Skin per- fusion responses to surface pressure-induced ischemia: implication for the developing pressure ulcer显示文摘Herrman E C Knapp C F Donofrio J C 1999J Reha- bil Res Dev1999,36,2:1
19The concentration of P-enolpyruvate carboxykinase protein in murine tis-sues in diabetes of chemical and genetic origin显示文摘VENEZIALE C M DONOFRIO J C NISHIMURA H 0,,23:1
20The R2R3-MYB transcription factors MYB14 and MYB15 regulate stilbene biosynthesis in Vitis vinifera显示文摘HOLL J VANNOZZI A CZEMMEL S DONOFRIO C WALKER A R RAUSCH T LUCCHIN M BOSS P K DRY I B BOGSA J 2013Plant Cell2013,25,10:1
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