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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers 显示文摘 | Donato MT Viitala P Rodriguez-Antona C | 2000 | Drug Metab Dispos2000，28，11： | 1 |
| 3 | Steroid signaling activation and intracellular localization of sex steroid receptors显示文摘 | Giraldi T Giovannelli P Di Donato M | 2010 | J Cell Commun Signal2010，4，4： | 1 |
| 4 | Correspondence between left ventricular 17 myocardial segments and coronary anatomy obtained by multi - detector com- puted tomography: an ex vivo contribution显示文摘 | Donato P Coelho P Santos C er al | 2012 | Surg Radiol Anat2012，34，9： | 1 |
| 5 | Pharmacodynamic poten- tiation of antiepileptic drugs' effects by some HMG-CoA reductase in- hibitors against audiogenie seizures in DBA/2 mice 显示文摘 | Russo E Donato di Paola E Gareri P | 2013 | Pharmacol Res2013，70，1： | 1 |
| 6 | Chronic cough in children:signs of serious disease and investigations显示文摘 | Donato L Gaugler C Weiss L Krieger P Debry C | 2001 | Arch Pediatr2001，8，3： | 1 |
| 7 | The rutin/fl- cyclodextrin interactions in fully aqueous solution:Spec- troscopic studies and biological assays 显示文摘 | Calabr5 M L Tommasini S Donato P | 2005 | J Pharm Bi- omed Anal2005，36，： | 1 |
| 8 | Occurrences at the mineral-bacteria interface during the oxidation of arsenopyrite by Thiobacillusferrooxidans 显示文摘 | Monroy M G Mustin C Donato P | 1995 | Biotechnology and Bioengineering1995，46，： | 1 |
| 9 | Joining of SiC/SiCf ceramic matrix composites for fusion reactor blanket applications显示文摘 | COLOMBO P RICCARDI B DONATO A | 2000 | Journal of Nuclear Materials2000，278，： | 1 |
| 10 | Plant-derived vaccines and antibodies:potential and limitations-expression of single-chain antibodies in transgenic plants显示文摘 | Galeffi P Lombardi A Donato M | 2005 | Vaccine2005，23，15： | 1 |
| 11 | A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma 显示文摘 | Donato F Boffetta P Puoti M | 1998 | Int J Cancer1998，75，3： | 1 |
| 12 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 13 | Effect of early versus late administration of human recombinant erythropoietin on transfusion requirements in premature infants:results of a randomized,placebo controlled,multi-center trial显示文摘 | Donato H Vain N Rendo P | 2000 | Pediatrics2000，105，5： | 1 |
| 14 | Four new trihydroxylated sterols from the sponge Spongionella gracilis显示文摘 | Vincenzo P Donato S | 1987 | J Nat Prod1987，50，5： | 1 |
| 15 | Joining of SiC/SiCf Ceramic Matrix Composites for Fusion Reactor Blanket Applieations 显示文摘 | Colombo P Riccardi B Donato A | 2000 | Journal of Nuclear Materials2000，278，23： | 1 |
| 16 | Joining of SiC/SiCf ceramic matrix composites for fusion reactor blanket applications显示文摘 | COLOMBO P RICCARDI B DONATO A | 2000 | J Nucl Mater2000，278，23： | 1 |
| 17 | Radiofrequency ablation of hepatocellular carcinoma: long- term experience with expandable needle electrodes 显示文摘 | Cabassa P Donato F Simeone F | 2006 | AJR Am J Roentgenol2006，186，5： | 1 |
| 18 | The rutin/β- cyclodextrin interactions in fully aqueous solution:spectroscopic studies and biological assays显示文摘 | Calabro M L Tommasini S Donato P | 2005 | J Pharm Biomed Anal2005，36，5： | 1 |
| 19 | Structural plasticity upon learning:regulation and functions显示文摘 | Caroni P Donato F Muller D | | 0，，07： | 1 |
| 20 | The rutin/beta-cyclodextrin interactions in fully aqueous solution:spectroscopic studies and biological assays显示文摘 | CALABRO M L TOMMASINI S DONATO P | 2005 | Journal of Pharmaceutical and Biomedical Analysis2005，36，5： | 1 |
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