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| 1 | Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices. | Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 4 | 基于自适应光学的视网膜单细胞光学相干层析成像技术显示文摘 | 屈军乐 Ravi S JONNAL Karen E THORN Donald T MILLER | 2004 | 生物物理学报2004，20，2： | 3 |
| 5 | A Model and Methodology for Hardware-software Codesign显示文摘 | Donald E T Jay K A Herman S | 1993 | IEEE Design & Test of Computers1993，10，3： | 2 |
| 6 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 7 | New font and arrow for national park service guide signs 显示文摘 | PHILIP M DONALD T | 2004 | Transportation Research Record (n 1862)2004，，： | 1 |
| 8 | All Lost-Circulation Materials and Systems Are Not Created Equal显示文摘 | Donald L Whitfill Hemphill T | | SPE0，，： | 1 |
| 9 | The effects of timing jitter in sampling systems显示文摘 | Souders T M Donald R F Charles Hagwood | 1990 | IEEE Transactions on Instrumentation and Measurement1990，39，1： | 1 |
| 10 | Anaerobic ammonium oxi- dation (anammox) in the marine environment 显示文摘 | Dalsgaard T Thamdrup B Donald E C | 2005 | Research in Mi- crobiology2005，156，4： | 1 |
| 11 | A survey on physical delivery versus cash settlement in futures contracts显示文摘 | Donald L Yiu K T | | 0，，： | 1 |
| 12 | Mechanisms of adverse effects of anti-VEGF therapy for cancer 显示文摘 | Kamba T Mc Donald D M | 2007 | Br J Cancer2007，96，12： | 1 |
| 13 | Paleoshoreline evidence for postglacial tilting in Southern Manitoba显示文摘 | Gary E T Donald R C Bruce G B | 1998 | Journal of Paleolin- nology1998，19，： | 1 |
| 14 | Identification of resistance gene analogs linked to a powdery mildew resistance locus in grapevine显示文摘 | Donald T M Pellerone F Adam-Blondon A F | 2002 | Theor Appl Genet2002，104，： | 1 |
| 15 | Reassessment of the unbound concentrations of unconjugated bilirubin in relation to neurotoxicity in vitro显示文摘 | Donald O Lorella P Claudio T | 2003 | Pediatr Res2003，54，： | 1 |
| 16 | Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes显示文摘 | Mc Donald SJ Middleton P Dowswell T | 2014 | Evid Based Child Health2014，9，2： | 1 |
| 17 | Chemical Oxygen Demand Analysis of Waste Water Using Trivalent Mangunese Oxidant with Chloride Removal by Sodium Bismuthate Pretreatment显示文摘 | DONALD G M SCOTT V B WAYNE T B | 2001 | Water Environment Research2001，73，1： | 1 |
| 18 | Identification of resistance gene analogs linked to a powdery mildew resistance locus in grapevine 显示文摘 | Donald T M Pellerone A Adam-Blondon F | 2002 | Theor Appl Genet2002，104，： | 1 |
| 19 | Physical delivery versus cash settlement:an empirical study on the feeder cattle contract显示文摘 | Donald L Yiu K T | | 0，，： | 1 |
| 20 | 查看详情显示文摘 | Elaine M T Donald J L J John H.L Debbie A M Peter B F Karen B | | 0，，： | 1 |
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