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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cells Progress of mesenchymal stem cell therapy for neural and retinal diseases显示文摘Complex circuitry and limited regenerative power make central nervous system(CNS)disorders the most challenging and difficult for functional repair.With elusive disease mechanisms,traditional surgical and medical interventions merely slow down the progression of the neurodegenerative diseases.However,the number of neurons still diminishes in many patients.Recently,stem cell therapy has been proposed as a viable option.Mesenchymal stem cells(MSCs),a widely-studied human adult stem cell population,have been discovered for more than 20 years.MSCs have been found all over the body and can be conveniently obtained from different accessible tissues:bone marrow,blood,and adipose and dental tissue.MSCs have high proliferative and differentiation abilities,providing an inexhaustible source of neurons and glia for cell replacement therapy.Moreover,MSCs also show neuroprotective effects without any genetic modification or reprogramming.In addition,the extraordinary immunomodulatory properties of MSCs enable autologous and heterologous transplantation.These qualities heighten the clinical applicability of MSCs when dealing with the pathologies of CNS disorders.Here,we summarize the latest progress of MSC experimental research as well as human clinical trials for neural and retinal diseases.This review article will focus on multiple sclerosis,spinal cord injury,autism,glaucoma,retinitis pigmentosa and age-related macular degeneration. | Tsz Kin Ng Veronica R Fortino Daniel Pelaez Herman S Cheung | 2014 | World Journal of Stem Cells2014，6，2： | 13 |
| 3 | A Model and Methodology for Hardware-software Codesign显示文摘 | Donald E T Jay K A Herman S | 1993 | IEEE Design & Test of Computers1993，10，3： | 2 |
| 4 | Nanosecond-to-femtosecond laser-induced breakdown in dielectrics显示文摘 | STUART B C FEIT M D HERMAN S | 1996 | Phys Rew B1996，53，： | 2 |
| 5 | Perifolliculitis capitis abscedens et suffodiens显示文摘 | Herman A David M Pitlik S | 1992 | Int J Dermatol1992，31，10： | 2 |
| 6 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 7 | Methylation-specitlc PCR:a novel PCR assay for methylation status of CpG islands显示文摘 | Herman JG Graff JR Myohanen S | 1996 | Proc Natl Acad Sci USA1996，93，18： | 1 |
| 8 | Methylation-special PCR:a novel PCR assasy for methylation status of CpG islands显示文摘 | HERMAN J G GRAFF J R MYOHANEN S | 1996 | Proc Natl Acad Sci USA1996，93，： | 1 |
| 9 | Methylation-specific PCR:a novel PCR assay for methylation status of CpG islands显示文摘 | Herman JG Graff JR Myohanen S | 1996 | Proc Natl Acad Sci USA1996，93，18： | 1 |
| 10 | Methylation-specific PCR: a novel PCR assay for methylation status of CpG island显示文摘 | Herman J G Graff R Myohanen S | 1996 | Proc Natl Acad Sci USA1996，93，18： | 1 |
| 11 | Novel transglutaminase-1 muta- tions and genotyp-phenotype investigations of 104 patients with autoso- mal recessive congenital ichthyosis in the USA 显示文摘 | Farasat S Wei MH Herman M | 2009 | J Med Genet2009，46，2： | 1 |
| 12 | Elder abuse education in primary care residency programs:a cluster group analysis elder abuse education in primary care residency programs:a cluster group analysis显示文摘 | Wagenaar D Rosenbaum R Herman S | | 0，，07： | 1 |
| 13 | The effect of a confining unit on the geochemical evolution of ground water in the Upper Floridan aquifer system显示文摘 | Wicks C M Herman J S | 1994 | Journal of Hydrology1994，153，1： | 1 |
| 14 | Ovine pla- cental laetogen specifically binds to endometrial glands of the ovine uterus 显示文摘 | NOEL S HERMAN A JOHNSON G A | 2003 | Biol Reprod2003，68，： | 1 |
| 15 | Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands显示文摘 | Herman J G Graft J R Myohanen S | 1996 | Proceedings of the National Academy of Sciences of the United States of America1996，93，18： | 1 |
| 16 | Nanosecond-tofemtosecond laser-induced breakdown in dielectrics显示文摘 | STUART B C FEIT M D HERMAN S | 1996 | Phys Rev B1996，53，4： | 1 |
| 17 | Immunohistochemical characterization of human retinoblastomas in situ with multiple markers显示文摘 | Perentes E Herbort CP Rubinstein LJ Herman MM Uffer S Donoso LA | 1987 | Am J Ophthalmol1987，103，5： | 1 |
| 18 | Rapid solidification and microstructure development during plasma spray deposition显示文摘 | SAMPATH S HERMAN H | 1996 | Journal of Thermal Spray Technology1996，5，： | 1 |
| 19 | DNA hypermethylation in tumorigenesis:epigenetics joins genetics显示文摘 | Baylin S B Herman J G | | 0，，04： | 1 |
| 20 | The chemical evolution of a travertine-depositing stream:Geochemical processes and mass transfer reactions显示文摘 | Lorah M M Herman J S | 1988 | Water Resources Research1988，24，9： | 1 |
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