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| 1 | Clinical impact of immunomonitoring in the treatment of inflammatory bowel disease显示文摘Despite improvement in outcomes, loss of response(LOR) to tumor necrosis factor-alpha (TNFα) therapies is a big concern in the management of inflammatory bowel disease. LOR is associated with flares of disease, increased hospitalisation rates, need for surgical interventions, and decline in quality of life. LOR may be multifactorial, but immunogenicity makes a significant contribution. Traditionally doses of anti-TNFα have been adjusted based on clinical response, using a standard approach. Immunomonitoring involves the measurement of anti-TNFα trough and antibody levels. It takes into account the underlying pharmacokinetics of anti-TNFα therapies. Expanding on this a treat to target approach may be used, where doses are intensified, or tailored to the individual based on the measurement of anti-TNFα trough and antibody levels. This review looks at the history, evolution, and clinical impact that immunomonitoring is having in the treatment of inflammatory bowel disease. It will focus on the role of immunomonitoring in helping to achieve long lasting deep remission and mucosal healing. It will explore the different options in terms of best measuring trough and antibody levels, explore possible advantages of immunomonitoring, and discuss its role in best optimising response, at induction, during the maintenance phase of treatment, as well as a role in withdrawing or switching therapy. | Donal Tighe Deirdre Mc Namara | 2017 | World Journal of Gastroenterology2017，23，3： | 6 |
| 2 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 3 | Positive Solutions to Singular Boundary Value Problems with Sign Changing Nonlinearities on the Half-Line via Upper and Lower Solutions显示文摘This paper presents a lower and upper solution technique for singular second order boundaryvalue problems on the half line. | Bao Qiang YAN Donal O'REGAN Ravi P. AGARWAL | 2007 | Acta Mathematica Sinica,English Series2007，23，8： | 5 |
| 4 | Chronic pancreatitis:A diagnostic dilemma显示文摘Typical clinical symptoms of chronic pancreatitis are vague and non-specific and therefore diagnostic tests are required, none of which provide absolute diagnostic certainly, especially in the early stages of disease. Recently-published guidelines bring much needed structure to the diagnostic work-up of patients with suspected chronic pancreatitis. In addition, novel diagnostic modalities bring promise for the future. The assessment and diagnosis of pancreatic exocrine insufficiency remains challenging and this review contests the accepted perspective that steatorrhea only occurs with > 90% destruction of the gland. | Sinead N Duggan Hazel M NíChonchubhair Oladapo Lawal Donal B O’Connor Kevin C Conlon | 2016 | World Journal of Gastroenterology2016，22，7： | 4 |
| 5 | Total hepatectomy and liver transplantation as a two-stage procedure for fulminant hepatic failure: A safe procedure in exceptional circumstances显示文摘AIM: To evaluate the outcomes of two-stage liver transplant at a single institution, between 1993 and March 2015.METHODS: We reviewed our institutional experience with emergency hepatectomy followed by transplantation for fulminant liver failure over a twenty-year period. A retrospective review of a prospectively maintained liver transplant database was undertaken at a national liver transplant centre. Demographic data, clinical presentation, preoperative investigations, cardiocirculatory parameters, operative and postoperative data were recorded.RESULTS: In the study period, six two-stage liver transplants were undertaken. Indications for transplantation included acute paracetamol poisoning(n = 3), fulminant hepatitis A(n = 1), trauma(n = 1) and exertional heat stroke(n = 1). Anhepatic time ranged from 330 to 2640 min. All patients demonstrated systemic inflammatory response syndrome in the first post-operative week and the incidence of sepsis was high at 50%. There was one mortality, secondary to cardiac arrest 12 h following re-perfusion. Two patients required re-transplantation secondary to arterial thrombosis. At a median follow-up of 112 mo, 5 of 6 patients are alive and without evidence of graft dysfunciton.CONCLUSION: Two-stage liver transplantation represents a safe and potentially life-saving treatment for carefully selected exceptional cases of fulminant hepatic failure. | Rebeca Sanabria Mateos Niamh M Hogan Dimitri Dorcaratto Helen Heneghan Venkatesh Udupa Donal Maguire Justin Geoghegan Emir Hoti | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 6 | Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types:implications for cell cycle regulation and cell adhesion maintenance显示文摘Background: Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have significant implications for prognosis. In this study, we examined the pan-cancer prognostic significance of oxygen-sensing genes from the 2-oxoglutarate-dependent oxygenase family. Methods: A multi-cohort, retrospective study of transcriptional profiles of 20,752 samples of 25 types of cancer was performed to identify pan-cancer prognostic signatures of 2-oxoglutarate-dependent oxygenase gene family (a family of oxygen-dependent enzymes consisting of 61 genes). We defined minimal prognostic gene sets using three independent pancreatic cancer cohorts (n = 681). We identified two signatures, each consisting of 5 genes. The ability of the signa-tures in predicting survival was tested using Cox regression and receiver operating characteristic (ROC) curve analyses. Results: Signature 1 (KDM8, KDM6B, P4HTM, ALKBH4, ALKBH7) and signature 2 (KDM3A, P4HA1, ASPH, PLOD1, PLOD2) were associated with good and poor prognosis. Signature 1 was prognostic in 8 cohorts representing 6 cancer types (n = 2627): bladder urothelial carcinoma (P = 0.039), renal papillary cell carcinoma (P = 0.013), liver cancer (P = 0.033 and P = 0.025), lung adenocarcinoma (P = 0.014), pancreatic adenocarcinoma (P < 0.001 and P = 0.040), and uterine corpus endometrial carcinoma (P < 0.001). Signature 2 was prognostic in 12 cohorts representing 9 cancer types (n = 4134): bladder urothelial carcinoma (P = 0.039), cervical squamous cell carcinoma and endocervical adenocar-cinoma (P = 0.035), head and neck squamous cell carcinoma (P = 0.038), renal clear cell carcinoma (P = 0.012), renal papillary cell carcinoma (P = 0.002), liver cancer (P < 0.001, P < 0.001), lung adenocarcinoma (P = 0.011), pancreatic adenocarcinoma (P = 0.002, P = 0.018, P < 0.001), and gastric adenocarcinoma (P = 0.004). Multivariate Cox regression confirmed independent clinical relevance of the signatures in these cancers. ROC curve analyses confirmed superior performance of the signatures to current tumor staging benchmarks. KDM8 was a potential tumor suppressor down- regulated in liver and pancreatic cancers and an independent prognostic factor. KDM8 expression was negatively correlated with that of cell cycle regulators. Low KDM8 expression in tumors was associated with loss of cell adhesion phenotype through HNF4A signaling. Conclusion: Two pan-cancer prognostic signatures of oxygen-sensing genes were identified. These genes can be used for risk stratification in ten diverse cancer types to reveal aggressive tumor subtypes. | Wai Hoong Chang Donall Forde Alvina G.Lai | 2019 | Cancer Communications2019，39，1： | 3 |
| 7 | An Upper and Lower Solution Theory for the Problem(G′(y))′+f(t,y)=0 on Finite and Infinite Intervals显示文摘A new upper and lower solution theory is presented for the second order problem(G'(y))'+f(t,y)=0 on finite and infinite intervals.The theory on finite intervals is based on a Leray-Schauderalternative,whereas the theory on infinite intervals is based on results on the finite interval and adiagonalization process. | Ravi P.AGARWAL Donal O'REGAN Svatoslav STANEK | 2006 | Acta Mathematica Sinica,English Series2006，22，3： | 2 |
| 8 | 一个分数阶方程组积分边值问题的正解(英文)显示文摘本文研究一个分数阶方程组积分边值问题.利用不动点指数方法,采用非负凹凸函数刻画非线性项间的耦合行为,并借助单调有界原理,获得该问题正解的存在性结果,并构造了近似解的迭代序列,推广和完善了已有的一些结果. | 程伟 徐家发 Donal O’Regan | 2018 | 应用数学2018，31，2： | 2 |
| 9 | Unlocking quality in endoscopic mucosal resection显示文摘A review of the development of the key performance metrics of endoscopic mucosal resection(EMR),learning from the experience of the establishment of widespread colonoscopy quality measurements.Potential future performance markers for both colonoscopy and EMR are also evaluated to ensure continued high quality performance is maintained with a focus service framework and predictors of patient outcome. | Eoin Keating Jan Leyden Donal B O'Connor Conor Lahiff | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 2 |
| 10 | Prognostic significance of detection of microscopic peritoneal disease in colorectal cancer: A systematic review显示文摘 | Helen M. Mohan Donal B. O’Connor James M. O’Riordan Des C. Winter | 2013 | Surgical Oncology2013，，： | 2 |
| 11 | Assessment of longitu- dinal and radial ventricular dyssynehrony in isehemic and no- nischemic chronic systolic heart failure: a two-dimensional e- chocardiographic speckle-tracking strain study 显示文摘 | Donal E Toumoux F Leclercq C | 2008 | J Am Soc Echocardiogr2008，21，1： | 1 |
| 12 | Mapping hydraulic fractures using a borehole-to-sur- face electrical resisitivity method 显示文摘 | Wang Tsili Stodt John A Stierman Donals J | 1991 | Geoexplora-tion1991，28，34： | 1 |
| 13 | Interrater reliability of APACHEⅡscores for medical-surgical intensive care patients:a prospective blinded study显示文摘 | Kho M E Mc Donale E Stratford P W | 2007 | Am J Crit Care2007，16，4： | 1 |
| 14 | Propofol or sevoflurane for laryngeal mask airway insertion显示文摘 | Mary E Molloy F Donal J | 1999 | Can J Anuesth1999，46，： | 1 |
| 15 | Longitudinalstrain is a marker of microvascular obstruction and infarctsize in patients with acute ST-segment elevation myocardialinfarction 显示文摘 | BlfeRE L I DONAL E 2 TERRIEN G1 | 2014 | PLoS One2014，9，86： | 1 |
| 16 | Inert anodes for the Hall-Heroult cell: the ultimate materials challenge显示文摘 | Sadoway Donal R | 2001 | JOM2001，，4： | 1 |
| 17 | Usefulness of Doppler assessment of pulmonary vein and left atrial appendage flow following pulmonary vein isolation of chronic atrial fibrillation in predicting recovery of left atrial function显示文摘 | Donal E Grimm RA Yamada H | 2005 | Am J Cardiol2005，95，： | 1 |
| 18 | Shivering and neuraxi-al anesthesia显示文摘 | LARRY J CROWLEY DONAL J BUGGY | 2008 | Regional Anesthesia and Pain Medicine2008，133，3： | 1 |
| 19 | Left atrial function assessed by transthoracic echocardiography in pa- tients treated by ablation for a lone paroxysmal atrial fibrilla- tion显示文摘 | DONAL E OLLIVIER R VEILLARD D | 2010 | Eur J Echocardiogr2010，11，10： | 1 |
| 20 | The left atrial appendage,a small,blind-ended structure:a review of its echocardiographic evaluation and its clinical role显示文摘 | Donal E Yamada H Leclercq C | 2005 | Chest2005，128，： | 1 |
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