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| 1 | 卫生经济学评价报告标准共识2022(CHEERS 2022):卫生经济学评价报告指导意见更新版显示文摘卫生经济学评价是对备选行动方案的成本和结果的比较分析。2013年发表的《卫生经济学评价报告标准共识》(CHEERS)提出了卫生经济学评价的特点,确保结果正确阐释,以支持决策制订。2013版CHEERS旨在指导研究报告撰写者准确报告卫生干预和对照措施、背景、过程、结果等评价细节,使审稿人理解文章内容,帮助读者使用研究结果。本版共识将取代2013版共识,其更加适用于各类卫生经济学评价,结合学科发展和方法更新的需要,更注重患者、公众等相关利益方的参与。本共识适用多种个体或人群健康干预措施(简单或复杂)在不同政策场景的应用分析,包括医疗服务、公共卫生、教育、社会服务等。本文概要介绍了CHEERS 2022共识中包含的28个检查项及每一个检查项的相关建议。CHEERS 2022共识主要用于指导研究人员撰写拟投递同行评议学术期刊的卫生经济学评价文章,亦可用于期刊编辑和审稿专家对待发表文章的评价。熟悉了解本共识要求,还有助于研究人员规划评价研究。随着决策透明度要求提高,本共识可支持卫生技术评估机构建立评价报告标准。 | Don Husereau Michael Drummond Federico Augustovski Esther de Bekker-Grob Andrew H Briggs Chris Carswell Lisa Caulley Nathorn Chaiyakunapruk Dan Greenberg Elizabeth Loder Josephine Mauskopf C Daniel Mullins Stavros Petrou Raoh-Fang Pwu Sophie Staniszewska on behalf of CHEERSISPOR Good Research Practices Task Force 肖月(译) 邱英鹏(译) 史黎炜(译) 张治国(译) 张歆(译) 王海银(译) 翟铁民(译) | 2022 | 英国医学杂志中文版2022，25，8： | 31 |
| 2 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 3 | A NEW ANIMAL MODEL OF ERYTHROCYTE SENESCENCE: THE ALTERRATION OF SURFACE CHARGE AND THE RHEOLOGGICAL PROPERTIES OF ERRYTHROCYTE DRUING ITS LIFE SPAN显示文摘Based on Mohandas' work, a new animal model of red blood cell(RBC) synchronous senescence in a near normal physiological conditions was proposed. Using this model,we studied the changes of RBC surface charge with the aging process. The results showed that its surface charge decreased with RBC agingprocess. Nevertheless,the regulation of the changes was not linear during RBC aging. The indexes of (DI)d and (DI)or describing RBC rheological behaviours duringits aging process were measured with a new Ektacytometry. It is demonstrated thatboth the indexes decreased with RBC aging,but the relationship was not linear. Thecharacteristics of the indexes displayed a common regularity of smaller alterationsin the first half period of RBC life span and greater alterations in the latter periodof RBC life span. It was also shown that the regulation of the changes for each individual index were not alike. The alterations of RBC mechanical properties duringlife span maight result from the influence of RBC shape, the properties of cytoplasm and membrane viscoelasity and the other factors during RBC aging. | Wen Zongyao Song Lichua Lu Zhihong Sun Dagong(Department of Medical Physics, Beijing Medical University, Beijing 100083,China) Yan Zongyi(Department of Mechanics and Engineering SciencePeking University,Beijing 100871,China) Don Huanfu(Department of H | 1998 | Chinese Journal of Biomedical Engineering(English Edition)1998，7，2： | 3 |
| 4 | 卫生经济学评价报告标准共识(CHEERS)声明显示文摘卫生干预的经济学评价对报告提出特殊挑战,有必要统一和更新已有的指南并促进其以一种用户友好的方式使用。卫生经济学评价报告标准共识(CHEERS)声明是对以前的卫生经济学评价指南的继承和更新,并将其转化为与时俱进的实用报告指南,CHEERS声明的主要读者是报告经济学评价结果的研究人员和评估经济学评价结果的编辑和审稿人。对医学编辑的调查确定了需要新的报告指南,基于系统综述创建了可能的条目清单。之后进行了两轮改进的德尔菲专家咨询,这些专家来自学术界、临床医生、企业、政府和编辑。从44个候选条目中确定了24个条目及建议。这些建议包含在一个用户友好的24条目清单里。声明、清单和这个报告可在ISPOR网站的卫生经济学评价指南工作组网站上找到 (www. ispor, org/TaskForces/EeonomicPub (;uidelines. asp )我们希望CHEERS带来更好的报告,最终带来更好的卫生决策,为了便于传播和获取,CHEERS声明刊登在10种卫生经济学和医学期刊上。我们鼓励其他期刊和团体支持CHEERS。作者团队计划在5年后更新清单,卫生经济学评价是用来辅助资源分配决策的,经济学评价被定义为“依照它们的成本和效果对可供选择的行动方案进行比较分析”,所有经济学评价都评估成本,但测量和评估健康干预效果的方法可能有所不同(框图1)。经济学评价已广泛应用于卫生政策,包括干预项目(如疫苗接种、筛检和健康促进)、诊断、治疗(如药物和外科手术)、护理和康复的评估。经济学评价越来越多地用于决策,并且是国际卫生技术评估项目的一个重要组成部分^2。 | Don Husercau Michael Drumrnond Stavrps Petrpi Chris Carswell editor David Moher Dan Greeuberg Federico Argustovski Andrew H Briggs Josephine Mauskopf Elizabeth Loder 杨莉 | 2013 | 英国医学杂志中文版2013，16，3： | 3 |
| 5 | On the symmetric solutions of a linear matrix equation显示文摘 | F J H Don | 1987 | Linear Algebra Appl1987，93，： | 2 |
| 6 | Management practices of hepatitis C virus infected alcoholic hepatitis patients:A survey of physicians显示文摘AIM:To survey gastroenterologists and hepatologists regarding their current views on treating hepatitis C virus(HCV) infected alcoholic hepatitis(AH) patients.METHODS:A sixteen item questionnaire was electronically mailed to gastroenterologists and hepatologists.A reminder was sent after 2 mo to increase the response rate.Participation of respondents was confidential.Accessing secured web site to respond to the questionnaire was considered as informed consent.Responses received on the secured website were downloaded in an excel sheet for data analysis.RESULTS:Analyzing 416 responses to 1556(27% response rate) emails,57% respondents(56% gastroenterologists) reported HCV prevalence > 20% amongst AH patients.Sixty nine percent often treated AH and 46% preferred corticosteroids(CS).Proportion of respondents with consensus(75% or more respondents agreeing on question) on specific management of HCV infected AH were:routine HCV testing(94%),HCV not changing response to CS(80%) or pentoxifylline(91%),no change in approach to treating HCV infected AH(75%).None of respondent variables:age,specialty,annual number of patients seen,and HCV prevalence could predict respondent to be in consensus on any of or all 4 questions.Further,only 4% would choose CS for treating HCV infected AH as opposed to 47% while treating HCV negative AH.CONCLUSION:Gastroenterologists and hepatologists believe that AH patients be routinely checked for HCV.However,there is lack of consensus on choice of drug for treatment and outcome of HCV positive AH patients.Studies are needed to develop guidelines for management of HCV infected AH patients. | Ashwani K Singal Habeeb Salameh Anjna Singal Sarat C Jampana Daniel H Freeman Karl E Anderson Don Brunder | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 2 |
| 7 | Hard carbon nanocomposite films with low stress显示文摘 | TAY B K CHENG Y H DON X Z | 2001 | Dia-mond Relat Mater2001，10，： | 1 |
| 8 | Dynamic response of single pile and soil-pile interaction显示文摘 | DON H | 1996 | Canadian Geotech J1996，33，： | 1 |
| 9 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 10 | Efficient approaches for materialized views selection in a data warehouse显示文摘 | Ming Chuan Hung Man Lin H uang Don Lin Yang Nien Lin H sueh | 2007 | Information Sciences2007，177，： | 1 |
| 11 | Congenital cysts of the iris stroma显示文摘 | Hilda C Earl P Don H | 1993 | Am J Ophthalmol1993，116，： | 1 |
| 12 | Leakage Current Monitoring of Composite Long Rod Insulators显示文摘 | BRIAN P COLIN L DON H | 1994 | Properties and Applications of Diejectric Materials1994，，4： | 1 |
| 13 | Heat shock and the heat shock proteins显示文摘 | Roy H Bur Don | 1986 | Biochem J1986，240，： | 1 |
| 14 | 3D moment forms: their construction and application to object identification and positioning 显示文摘 | Lo C H Don H S | 1989 | IEEE Transactions on Pattern Analysis and Machine Intelligence (S0162- 8828)1989，11，10： | 1 |
| 15 | J Appl Polym Sci显示文摘 | Don T M Yeh C H Bell J P | 1999 | 74(10):2 5101999，74，10： | 1 |
| 16 | Insectresistant chrysanthemum calluses by introduction of a Bacillus thuringiensis crystal protein gene 显示文摘 | Wordragen M F Honee G Dons H J M | 1993 | Transgenic Research1993，2，3： | 1 |
| 17 | Optical performance monitoring with tunable narrowband optical filtering 显示文摘 | Sarah D D Don F H Peter M F | 2005 | Optics Express2005，13，22： | 1 |
| 18 | Somatic embryogenesis and shoot regeneration from excised adventitious roots of the rootstock Rosa hybrida L. ‘Moneyway’显示文摘 | Theo P. M. Salm Caroline J. G. Toorn Charlotte H. H?nisch Hans J. M. Dons | 1996 | Plant Cell Reports1996，，7： | 1 |
| 19 | Nutrition,xylem cavitation and drought resistance in hybrid poplar显示文摘 | HARVEY H P van don DRIESSCHE R | 1997 | Tree Physiology1997，17，： | 1 |
| 20 | The effect of endurance training on serum triiodothyronine kinetics in man:physieal conditioning marked by enhaneed thyroid hormone metabolism显示文摘 | Rone J K Dons R F Reed H L | 1992 | Clin Endoerinol ( Oxf)1992，37，4： | 1 |
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