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| 1 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 2 | Animal models of ex vivo lung perfusion as a platform for transplantation research显示文摘Ex vivo lung perfusion(EVLP) is a powerful experimental model for isolated lung research. EVLP allows for the lungs to be manipulated and characterized in an external environment so that the effect of specific ventilation/perfusion variables can be studied independent of other confounding physiologic contributions. At the same time,EVLP allows for normal organ level function and real-time monitoring of pulmonary physiology and mechanics. As a result,this technique provides uniqueadvantages over in vivo and in vitro models. Small and large animal models of EVLP have been developed and each of these models has their strengths and weaknesses. In this manuscript,we provide insight into the relative strengths of each model and describe how the development of advanced EVLP protocols is leading to a novel experimental platform that can be used to answer critical questions in pulmonary physiology and transplant medicine. | Kevin Nelson Christopher Bobba Samir Ghadiali Don Hayes Jr Sylvester M Black Bryan A Whitson | 2014 | World Journal of Experimental Medicine2014，4，2： | 2 |
| 3 | Monocyte-derived Wnt5a regulates inflammatory ymphangiogenesis显示文摘 | Roberto Sessa Don Yuen Stephanie Wan Michael Rosner Preethi Padmanaban Shaokui Ge April Smith Russell Fletcher Ariane Baudhuin-Kessel Terry P Yamaguchi Richard A Lang LuChen | 2016 | Cell Research2016，26，2： | 2 |
| 4 | 互动式整合营销传播:统合IMC、新媒介以及数据库营销的力量显示文摘自上世纪九十年代中期开始,整合营销传播理论传入中国,掀起了一股IMC热潮,为市场营销、广告公关的理论和实践带来了强大的推动力.然而,近年来,有关整合营销传播的研究渐趋消沉.究其原因,主要有二:一,学界和业界对IMC概念和理论本身并未透彻理解;二,对有关IMC新的研究动态和成果未予以足够重视.2002年,舒尔茨教授等人提出了'互动式整合营销传播'的新概念.2003年,舒尔茨和威斯康新大学的James W.Peltier、内华达大学的John A.Schibrowsky三位教授又在上发表了一篇名为的论文,通过模型和案例系统阐述了'互动式整合营销传播'的概念,代表了IMC理论研究的最新成果,对国内的有关研究具有重要的借鉴意义.限于篇幅,本刊在发表时删去了文中的案例研究部分. | James W Peltier John A Schibrowsky Don E Schultz 陈欢 | 2004 | 新闻大学2004，，8： | 2 |
| 5 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 6 | Cerebellar neurodegeneration in the absence of microRNAs显示文摘 | Schaefer A O\'Carroll DON Tan CL | 2007 | Journal of Experimental Medicine2007，204，7： | 1 |
| 7 | Heterosis and correlation analysis of the vegetative components and ajmalicine content in the roots of the medicinal plant-Catharanthus roseus 显示文摘 | Don G Levy A Milo J | 1983 | Euphytica1983，32，2： | 1 |
| 8 | Hard transparent domes and windows from magnesium aluminate spinel显示文摘 | Anthony A DiGiovanni Larry Fehrenbacher Don W Roy | 2005 | Proceedings of SPIE2005，5786，： | 1 |
| 9 | A review of indicators of climate change for use in Ireland 显示文摘 | DON'NELLY A JONES M B SWEENEY J | 2004 | International Journal of Biometeorology2004，49，1： | 1 |
| 10 | Age specific differences in pediatric obstructive sleep apnea显示文摘 | Don D M Geller K A Koempel J A | 2009 | Int J Pediatr Otorhinolaryn Gol2009，73，7： | 1 |
| 11 | The geography of parameter space: an investigation into spatial nonstationarity 显示文摘 | FOTHERINGHAM A S CHARLTON M E BRUNS- DON C | 1996 | International Journal of GIS1996，，10： | 1 |
| 12 | Cyclin G2 As- sociates with protein phosphatase 2A catalytic and regulatory B subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest 显示文摘 | Bennin D A Don A S A Brake T | 2002 | J Biol Chem2002，277，27： | 1 |
| 13 | Noise effects on cen-troid tracker aimpolnt estimation 显示文摘 | Don R Van Rheeden Richard A Jones | 1998 | IEEE Transactions on Aerospace and Eelctronic System1998，24，2： | 1 |
| 14 | Human papidoman virus type6 viua- like particle,and able to activiate the Ras,Map kinase pathway and in- duce cell proliferation显示文摘 | Payne E Bowles MR Don A | 2001 | J Viirol2001，75，9： | 1 |
| 15 | Facet joint orientation in spondylolysis and isthmic spondylolisthesis显示文摘 | Don A S Robertson P A | 2008 | J Spinal Disord Tech2008，21，2： | 1 |
| 16 | Deter-mination of relative sensitivity factors for trace element analysis of solar cell silicon by fast-flow glow discharge mass spectrometry 显示文摘 | Di Sabatino M Dons A L Hinrichs J Amberg L | 2011 | Spectrochimica Acta Part B : Atomic Spectroscopy2011，66，2： | 1 |
| 17 | Continuous detoxification,transformation and degradation of nitrophenol in upflow anaerobic sludge blanket(UASB)reactors显示文摘 | Don]on B A Bazo-Flares E Lettiga G | 1996 | Biotechnology and Bioengineeting1996，51，： | 1 |
| 18 | Children' s lnternet searching on complex problems : Performance and process analysis 显示文摘 | Schaehter J Chung G K Don' A | 1998 | Journal of the American Society for Information Science1998，49，9： | 1 |
| 19 | Polycystic ovary syndrome and the differential diagnosis of hyperandrogenism显示文摘 | Meek CL Bravis V Don A | 2013 | The Obstetrician and Gynaecologist2013，15，3： | 1 |
| 20 | Impact of tropicalland-use change on soil organic carbon stocks-ameta-analysis 显示文摘 | Don A Schumacher J Freibauer A | 2011 | Global Change Biology2011，17，4： | 1 |
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