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| 1 | 人肿瘤细胞核苷酸切除修复蛋白表达与抗癌药耐药的相关性(英文)显示文摘背景与目的:核苷酸切除修复(Nucleotideexcisionrepair,NER)是真核细胞中的DNA修复多酶系统,它可能与人肿瘤细胞对抗癌药的耐药有关。本实验将探讨NER蛋白(XPA,XPB,XPD和ERCC1)的表达与人肿瘤细胞耐药的关系。方法:采用westernblot检测美国国家癌症研究所(NationalCancerInstitute,NCI)用于抗癌药筛选的60株人肿瘤细胞的ERCC1,XPA,XPBXPD表达,并与170种抗癌药物的细胞毒试验结果进行相关性分析。结果:ERCC1,XPB和XPD的蛋白表达与抗癌药物敏感性呈负相关,在170种抗癌药物中分别有13,17和32种的耐药性与上述蛋白水平相关性显著或非常显著(P<0.05)。而XPA的表达与药物敏感性无明显正/负相关。根据已确定的6种药物作用机理分析,肿瘤细胞XPD表达与其对烷化剂类抗癌药耐药相关性显著。结论:本实验结果肿瘤细胞的XPD蛋白表达与烷化剂类抗癌药的耐药相关,提示XPD在肿瘤细胞耐药过程中起重要作用。 | 陈忠平 Areti MALAPETSA Anne MONKS Timothy G. MYERS Gérard MOHR Eaward A. SAUSVILLE Dominic A. SCUDIERO Lawrence C. PANASCI | 2002 | 癌症2002，21，3： | 12 |
| 2 | Up to what temperature is petroleum satble? New insights from a 5200 free radical reaction model显示文摘 | Domine F Bounaceur R Scacchi G | 2002 | Organic Geochemistry2002，33，： | 1 |
| 3 | Effect of capsaicin and dihydrocapsaicin on in vitro blood coagulation and platelet aggregation显示文摘 | Murray J A Kiran D K A Dominic P G | 2009 | Thrombosis Research2009，124，6： | 1 |
| 4 | A new distance between two bodies of evidence显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，2，2： | 1 |
| 5 | A new dis-tance between two bodies of evidence显示文摘 | JOUSSELME A L DOMINIC G BOSSE E | 2001 | Information Fu-sion2001，2，2： | 1 |
| 6 | A new distance between two bodies of evidence 显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，2，： | 1 |
| 7 | A study of turbomachinery components machining and repairing methodologies 显示文摘 | YILMAZ 0 DOMINIC N NABIL G | 2005 | Aircraft Engineering and Aerospace Technology2005，77，6： | 1 |
| 8 | A new distance between two bodies of evidence显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，，2： | 1 |
| 9 | A new distance between two bodies of evidence 显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，2，2： | 1 |
| 10 | Extracting topographic su-ucture from digital elevation data for geographical information system analysis显示文摘 | JENSON S K DOMIN G J O | 1988 | Photogrammetric Engineering and Remote Sensing1988，54，11： | 1 |
| 11 | A new distance between two bodies of evidence显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，2，2： | 1 |
| 12 | To- wards iron-catalysed suzuki biaryl cross-coupling:Un- usual reactivity of 2-halobenzyl halides 显示文摘 | Robin B B Timothy G Dominic R P | 2015 | Synthe- sis2015，47，12： | 1 |
| 13 | Advanced network monitoring application based on mobile/intelligent technology显示文摘 | Damianos G Dominic G Mohammed G | 2000 | Computer Communication Journal2000，23，8： | 1 |
| 14 | A new distance between two bodies of evidence显示文摘 | Jousselme A L Dominic G Bosse E | 2001 | Information Fusion2001，2，2： | 1 |
| 15 | A new distance between two bodies evidence显示文摘 | Jousselme A L Dominic G bosse E | 2001 | Information Fusion2001，2，2： | 1 |
| 16 | 400 Gbit/s (10 channel×40 Gbit/s) DWDM photonic integrated circuits显示文摘 | NAGARAJAN R KATO M DOMINIC V G | 2005 | Electronics Letters2005，41，6： | 1 |
| 17 | Genistein inhibitsglutamate-induced apoptotic processes in primary neuronal cellcultures : An involvement of aryl hydrocarbon receptor andestrogen receptor/glycogen synthase kinase-3 (3 intracellularsignaling pathway显示文摘 | Kajta M Domin H Grynkiewicz G | 2007 | Neuroscience2007，145，2： | 1 |
| 18 | A new distance between two bodies of evidence 显示文摘 | Anne -Laure J Dominic G Eloi B | 2001 | Information Fusion2001，2，2： | 1 |
| 19 | Synthesis and structure-activity relationship study of cytotoxic germanicane and lupane-type 3β-O-monodesmosidic saponins starting from betulin显示文摘 | DOMINIC T CHARLES G JEAN L | 2007 | Bioorganic & Medicinal Chemistry2007，15，： | 1 |
| 20 | Impa- cat of free-falling wedge with water:syn-chronized visual-ization, pressure and acceleration measurement 显示文摘 | Simon G L Dominic A H Stephen R Turnock | 2010 | Fluid Dynamics Research2010，42，3： | 1 |
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