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| 1 | Treatment of sepsis: What is the antibiotic choice in bacteremia due to carbapenem resistant Enterobacteriaceae?显示文摘Sepsis is one of the major challenges of today. Although gram-positive bacteria related infections are more prevalent in hospital setting, the highest mortality rate is associated with gram-negative microorganisms especially Enterobacteriaceae. Enterobacteriaceae, including Escherichia coli, Klebsiella spp., Proteus spp., Enterobacter spp. and Serratia spp. Resistance to β-lactams in Enterobacteriaceae is primarily attributed to the production of B-lactamase enzymes with subsequent antibiotic hydrolysis and to a lesser extent by alteration of efflux pump or porins expression. Carbapenem resistant Enterobacteriaceae(CRE) and Acinetobacter baumannii are the most notorious pathogens due to the high incidence of morbidity and mortality especially in the immunocompromised patients in the intensive care unit. The most appropriate antimicrobial therapy to treat CRE is still controversial. Combination therapy is preferred over monotherapy due to its broad-spectrum coverage of micro-organisms, due to its synergetic effect and to prevent development of further resistance. Current suggested therapies for CRE resistance as well as promising antibiotics that are currently under investigation for winning the war against the emerging CRE resistance are reviewed and discussed. | Fatema Alhashem Nicolette Leonie Tiren-Verbeet Emine Alp Mehmet Doganay | 2017 | World Journal of Clinical Cases2017，5，8： | 6 |
| 2 | Host genetic factors affecting hepatitis B infection outcomes:Insights from genome-wide association studies显示文摘The clinical outcome of hepatitis B virus(HBV) infection depends on the success or failure of the immune responses to HBV,and varies widely among individuals,ranging from asymptomatic self-limited infection,inactive carrier state,chronic hepatitis,cirrhosis,hepatocellular carcinoma,to liver failure,depending on the success or failure of immune response to HBV.Genome-wide association studies(GWAS) identified key genetic factors influencing the pathogenesis of HBV-related traits.In this review,we discuss GWAS for persistence of HBV infection,antibody response to hepatitis B vaccine,and HBV-related advanced liver diseases.HBV persistence is associated with multiple genes with diverse roles in immune mechanisms.The strongest associations are found within the classical human leukocyte antigen(HLA) genes,highlighting the central role of antigen presentation in the immune response to HBV.Associated variants affect both epitope binding specificities and expression levels of HLA molecules.Several other susceptibility genes regulate the magnitude of adaptive immune responses,determining immunity vs tolerance.HBV persistence and nonresponse to vaccine share the same risk variants,implying overlapping genetic bases.On the other hand,the risk variants for HBV-related advanced liver diseases are largely different,suggesting different host-virus dynamics in acute vs chronic HBV infections.The findings of these GWAS are likely to pave the way for developing more effective preventive and therapeutic interventions by personalizing the management of HBV infection. | Izzet Mehmet Akcay Seyma Katrinli Kamil Ozdil Gizem Dinler Doganay Levent Doganay | 2018 | World Journal of Gastroenterology2018，24，30： | 6 |
| 3 | Effect of Helicobacter pylori eradication on serum ghrelin and obestatin levels显示文摘AIM: To investigate changes in serum ghrelin and obestatin levels before and after Helicobacter pylori (H. pylori ) eradication. METHODS: A total of 92 patients presenting with symptoms of dyspepsia were enrolled in the study. Upper endoscopy was performed on all patients and used to diagnose H. pylori infection according to the presence of characteristic histopathological findings; seventy patients were diagnosed with H. pylori infection and the remaining 22 non-infected patients were classified as healthy controls. H. pylori eradication was accomplished by administering the classical triple therapy drug regimen, consisting of lansoprazole 30 mg bid , amoxicillin 1 g bid , and clarithromycin 500 mg tid for 14 d. The eradication of H. pylori was assessed with C14-urea breath test, which was performed at eight weeks after treatment. Levels of serum active ghrelin and obestatin were assessed at beginning of the study (prior to treatment) and after eight weeks. The levels were comparatively analyzed between the H. pylori negative control group, the H. pylori eradicated group, and the H. pylori non-eradicated group. RESULTS: A total of 92 patients, 50 females and 42 males with a mean age of 38.2 ± 11.9 years (range: 19-64), were analyzed. H. pylori eradication success was achieved in 74.3% (52/70) of H. pylori positive patients. The initial levels of ghrelin in the H. pylori positive and control cases were 63.6 ± 19.8 pg/mL and 65.1 ± 19.2 pg/mL (P=0.78), respectively, and initial obestatin levels were 771±427 pg/mL and 830 ± 296 pg/mL (P=0.19), respectively. The difference between the initial levels and the week 8 levels of ghrelin and obestatin in the control group was insignificant [4.5% (P=0.30) and -0.9% (P=0.65), respectively]. The difference between the initial and week 8 levels of ghrelin and obestatin in the H. pylori non-eradicated group were also insignificant [0.9% (P=0.64) and 5.3% (P=0.32), respectively]. The H. pylori eradicated group had a greater change in obestatin levels when compared to the control and the non-eradicated groups (148 ± 381 pg/mL vs -12±138 pg/mL and -72.8±203 pg/mL, respectively, P=0.015), while decreases in ghrelin levels were insignificant (-7.2 pg/mL vs -1.4 pg/mL and -1.9 pg/mL, respectively, P=0.52). The ghrelin/obestatin ratio for the initial and week 8 levels changed significantly in only the H. pylori eradicated group (0.11 vs 0.08, respectively, P=0.015). For overweight patients (as designated by body mass index), we observed significant increases in obestatin levels in the eradicated group as compared to non-eradicated group (201 ± 458 pg/mL vs -5 ± 81 pg/mL, respectively, P=0.02). In the H. pylori-eradicated group, the levels did not differ between the sexes for ghrelin (-6.3 ± 26.9 pg/mL vs -8.0 ± 24.0 pg/mL, respectively, P=0.97) or obestatin (210 ± 390 pg/mL vs 96 ± 372 pg/mL, respectively, P=0.23).CONCLUSION: Serum levels of ghrelin decreased while obestatin levels increased in H. pylori eradicated subjects, especially in overweight and male patients. | Celal Ulasoglu Banu Isbilen Levent Doganay Filiz Ozen Safak Kiziltas Ilyas Tuncer | 2013 | World Journal of Gastroenterology2013，19，15： | 5 |
| 4 | Association of human leukocyte antigen DQB1 and DRB1 alleles with chronic hepatitis B显示文摘AIM: To investigate the effect of human leukocyte antigen(HLA) DRB1 and DQB1 alleles on the inactive and advanced stages of chronic hepatitis B.METHODS: Patient records at a single institution's hepatology clinic were reviewed. Demographic data, laboratory results, endoscopy results, virological parameters, biopsy scores and treatment statuses were recorded. In total, 355 patients were eligible for thestudy, of whom 226(63.7%) were male. Overall, 82(23.1%) were hepatitis B early antigen(HBeAg) positive, 87(24.5%) had cirrhosis, and 66(18.6%) had inactive disease. The presence of DQB1 and DRB1 alleles was determined by polymerase chain reaction with sequence-specific primers. The distribution of the genotyped alleles among patients with cirrhosis and patients with chronic active hepatitis was analyzed.RESULTS: The most frequent HLA DQB1 allele was DQB1*03:01(48.2%), and the most frequent HLA DRB1 allele was DRB1*13/14(51.8%). DQB1*05:01 was more frequent in patients with active disease than in inactive patients(27% vs 9.1%; P = 0.002, Pc = 0.026). DRB1*07 was rare in patients with cirrhosis compared with non-cirrhotics(3.4% vs 16%; P = 0.002, Pc = 0.022). Older age(P < 0.001) and male gender(P = 0.008) were the other factors that affected the presence of cirrhosis. In a multivariate logistic regression analysis, DRB1*07 remained a significant negative predictor of cirrhosis(P = 0.015). A bioinformatics analysis revealed that a polymorphic amino acid sequence in DRB1*07 may alter interaction with the T-cell recognition site.CONCLUSION: This study demonstrates that HLA alleles may influence cirrhosis development and disease activity in Turkish chronic hepatitis B patients. | Levent Doganay Arta Fejzullahu Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Ilyas Tuncer Gizem Dinler Doganay | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 5 | Assessment of endothelial function in patients with nonalcoholic fatty liver disease显示文摘 | Yasar Colak Ebubekir Senates Atakan Yesil Yusuf Yilmaz Oguzhan Ozturk Levent Doganay Ender Coskunpinar Ozlem Timirci Kahraman Banu Mesci Celal Ulasoglu Ilyas Tuncer | 2013 | Endocrine2013，，1： | 2 |
| 6 | A risk score for conversion from laparoscopic to open cholecystectomy显示文摘 | NA Kama M Kologlu M Doganay | 2001 | The American Journal of Surgery2001，181，： | 1 |
| 7 | Risk factors resulting in conversion of laparoscopic cholecystectomy to open surgery显示文摘 | Kama N A Doganay M Dolapci M | 2001 | Surg Endosc2001，15，9： | 1 |
| 8 | Acute abdomen due to a foreign body in the nrinary bladder in an adolescent显示文摘 | Dogangy M Metin E Doganay M | 2011 | Jour nal Emergency Medicine2011，40，4： | 1 |
| 9 | Infection con- troll practice in countries with bruited resources显示文摘 | ALP E LEBLEBICIOGLU H DOGANAY M | 2011 | Ann Clin Mi- crobiol Antimicrob2011，10，1： | 1 |
| 10 | Comparison of serum NO,TNF-alpha,IL-1beta,Sil-2R,IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus显示文摘 | Doganay S Everek lioglu C Er H | 2002 | Eye2002，16，： | 1 |
| 11 | Sensitivity and specificity of left ventricular ejection fraction by echocardiographic automated border detection: comparison with radionuclide ventriculography显示文摘 | Lucariello R J Sun Y Doganay G | 1997 | Clin Cardiol1997，20，： | 1 |
| 12 | A risk score for conversion from laparoscopic to open cholecystec to my显示文摘 | Kama NA Kologlu M Doganay M | 2001 | Am J Surg2001，181，6： | 1 |
| 13 | Comparison of serum NO,TNF-alpha,IL-1beta,Sil-2R,IL-6 and IL-8 levels with grades of retinopathy in patients with diabetes mellitus显示文摘 | Doganay S Everek liogli C Er H | 2002 | Eye2002，16，： | 1 |
| 14 | Current therapeutic strategy in spinal brucellosis显示文摘 | Alp E Doganay M | 2008 | Infect Dis2008，，12： | 1 |
| 15 | Effects of 1-name and timolol on aqueous IL-1 β,IL-6,IL-8,TNF-α and NO levels after Nd:YAG laser iridotomy in rabbits显示文摘 | Er H Doganay S Evereklioglu C Cekmen M Daglioglu MC Isci N | 2002 | Eur J Ophthalmol2002，12，4： | 1 |
| 16 | Comparison of peritoneal tumor imaging using conventional MR imaging and diffusion-weighted MR imaging with different b values显示文摘 | Bozkurt M Doganay S Kantarci M | 2011 | Eur J Radiol2011，80，2： | 1 |
| 17 | The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs显示文摘 | Levent Doganay Ilyas Tuncer Seyma Katrinli Feruze Yilmaz Enc Oguzhan Ozturk Yasar Colak Celal Ulasoglu Gizem Dinler | 2012 | Clinics and Research in Hepatology and Gastroenterology2012，，： | 1 |
| 18 | Physiological-dose steroid therapy in sepsis 显示文摘 | Yildiz 0 Doganay M Aygen B | 2002 | Crit Care2002，6，3： | 1 |
| 19 | The effect of resveratrol in experimental cataract model formed by sodium selenite 显示文摘 | Doganay S Borazan N Iraz M | 2006 | Curr Eye Res2006，31，2： | 1 |
| 20 | Arisk score for conversion from laparoscopic to open chlecystectomy 显示文摘 | NA Kama M Doganay | 2001 | The American Journal of Surgery2001，181，： | 1 |
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