|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mechanisms and clinical significance of early recurrences of atrial arrhythmias after catheter ablation for atrial fibrillation显示文摘Early recurrence of atrial arrhythmias(ERAA) after ablation is common and strongly predicts late recurrences and ablation failure. However, since arrhythmia may eventually resolve in up to half of patients with ERAA, guidelines do not recommend immediate reintervention for ERAA episodes occurring during a 3-mo postablation blanking period. Certain clinical demographic, electrophysiologic, procedural, and ERAA-related characteristics may predict a higher likelihood of longterm ablation failure. In this review, we aim to discuss potential mechanisms of ERAA, and to summarize the clinical significance, prognostic implications, and treatment options for ERAA. | Jackson J Liang Sanjay Dixit Pasquale Santangeli | 2016 | World Journal of Cardiology2016，8，11： | 18 |
| 2 | Drugging the undruggables: exploring the ubiquitin system for drug development显示文摘 | Xiaodong Huang Vishva M Dixit | 2016 | Cell Research2016，26，4： | 16 |
| 3 | Appendiceal mucocoeles and pseudomyxoma peritonei显示文摘Mucocoele of the appendix occurs when obstruction of the appendiceal lumen results in mucus accumulation and consequent abnormal dilatation. The most impor- tant aetiology, from a surgical perspective, is either mucinous cystadenoma or cystadenocarcinoma. In the latter, a spontaneous or iatrogenic rupture of the mucocoele can lead to mucinous intraperitoneal ascites, a syndrome known as pseudomyxoma peritonei. Optimal management of mucoceles is achieved through accurate preoperative identification and subsequent careful resection. We report two cases and subsequently discuss the clinical presentation of mucocoeles, their association with pseudomyxoma peritonei and an optimal management of both conditions. | Anupam Dixit John HP Robertson Satvinder S Mudan Charles Akle | 2007 | World Journal of Gastroenterology2007，13，16： | 14 |
| 4 | Gall bladder carcinoma: Aggressive malignancy with protean loco-regional and distant spread显示文摘The most common malignancy of biliary tract is gallbladder cancer(GBC) which is the third most common cancer in gastrointestinal tract. It is a lethal disease for most patients in spite of growing awareness and improved diagnostic techniques. GBC has a verypoor prognosis and the 5 year survival rate is < 10%. Although etiology of the carcinoma of the gallbladder is still obscure, various factors have been implicated, cholelithiasis being the most frequent. The incidence of GBC worldwide is based on the gender, geography and ethnicity which suggest that both genetic and environmental factors can cause GBC. The major route of spread of gallbladder cancer(GC) is locoregional rather than distant. It spreads by lymphatic, vascular, neural, intraperitoneal, and intraductal routes. Sonography is usually the most common imaging test to evaluate symptoms of biliary tract disease including suspected GC. With recent advances in imaging modalities like multi-detector computed tomography(CT) scanners, magnetic resonance imaging-positron emission tomography/CT diagnosis of gallbladder cancer has improved. Studies have also targeted molecular and genetic pathways. Treatment options have included extended and radical surgeries and adjuvant chemotherapy. This review article deals in detail with important aspects of carcinoma gallbladder and its manifestations and challenges. Role of various imaging modalities in characterization and accurate staging has been discussed. The loco-regional spread of this aggressive malignancy is dealt explicitly. | Amit Nandan Dhar Dwivedi Shivi Jain Ruhi Dixit | 2015 | World Journal of Clinical Cases2015，3，3： | 14 |
| 5 | Enhanced recovery after surgery protocol enhances early postoperative recovery after pancreaticoduodenectomy显示文摘Background: Enhanced recovery after surgery(ERAS) protocol is a multimodal, multidisciplinary and evidence-based approach to reduce surgical stress and enhance recovery in the postoperative period. This study aimed to analyze the outcome of ERAS protocol in patients after pancreaticoduodenectomy(PD). Methods: A total of 50 consecutive patients with pancreatic/periampullary cancer who underwent PD between January 2016 to August 2017 were included in the study. As per the institute ERAS protocol, nasogastric tube(NGT) was removed on postoperative day(POD) 1 if output was less than 200 mL and oral sips were allowed; oral liquids were allowed on POD2; semisolid diet by POD3; abdominal drain was removed on POD 4 if output was less than 100 mL with no evidence of postoperative pancreatic fistula(POPF); normal diet was allowed on POD5. Discharge criteria on POD6 were afebrile, tolerating oral normal diet, pain free and no surgery related complications(defined as per the ISGPS definitions). Results: NGT was removed on POD1 in 45(90%) patients, abdominal drain removed by POD4 in 41(82%) and 43(86%) patients were discharged on POD6. There was no 30-day postoperative mortality. Three(6%) patients had delayed gastric emptying(DGE). None had postoperative hemorrhage and POPF. Readmission rate was 8%. A significant relation was found between the length of hospital stay(LOS) with age( P < 0.05) and a marginal relation between LOS and postoperative albumin( P = 0.05). Conclusions: ERAS protocol can be safely followed in the perioperative care of patients who undergo PD. Early removal of NGT and allowing oral diet restore bowel function early. ERAS decreases the LOS and postoperative complications. | Ramasamy Mahendran Mallika Tewari Vinod Kumar Dixit Hari Shankar Shukla | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 9 |
| 6 | Single Molecule Analysis of the Arabidopsis FRA1 Kinesin Shows that It Is a Functional Motor Protein with Unusually High Processivity显示文摘Arabidopsis FRA1 kinesin 通过未知机制贡献纤维素 microfibrils 的组织。这 kinesin 的外皮的本地化在分裂期间期间提起它搬运房间的可能性沿着直接或间接地影响纤维素 microfibril patterning 的外皮的微导管的墙相关的货物。决定 FRA1 是否是真马达蛋白质,我们联合了体积生物化学的试金和单个分子荧光成像到分析 recombinant,包含马达的标注 GFP 的 FRA1 和卷卷领域的马达性质(指定了为 FRA1 (707 ) GFP ) 。我们发现 FRA1 (707 ) GFP 以一种 ATP 依赖的方式绑在微导管并且它的 ATPase 活动被微导管的存在戏剧性地刺激。用单个分子研究,我们在大约 0.4ms1 的速度沿着微导管轨道 processively 发现那 FRA1 (707 ) GFP 行动。另外,我们发现 FRA1 (707 ) GFP 是一台微导管 plus-end-directed 马达并且它是沿着微导管移动一更暗淡。有趣地,我们的单个分子分析证明 FRA1 (707 ) GFP 的 processivity 是至少两次常规 kinesin 的 processivity,迄今为止使 FRA1 成为大多数 processive kinesin。一起,我们 FRA1 是有潜力沿着外皮的微导管驾驶货物的长途的运输的真正的马达蛋白质的数据表演。 | Chuanmei Zhu Ram Dixit | 2011 | Molecular Plant2011，4，5： | 7 |
| 7 | Changes in cultivated land patterns and driving forces in the Three Gorges Reservoir area, China, from 1992 to 2015显示文摘Changes of cultivated land patterns caused by major water conservation projects are rarely reported. We selected the Three Gorges Reservoir area in China to study the change in area and landscape pattern of the cultivated land in the head,central, and tail areas of the reservoir that took place between 1992 and 2015;we then studied the spatial distribution of the cultivated land in the three parts of the reservoir;finally, we studied the driving forces behind the changes in the cultivated land. The results derived are as follows.(1) During the construction of the Three Gorges Project(TGP, 1992–2015), the area of cultivated land around the reservoir decreased by30.23 million ha. This reduction occurred in phases:the most severe change in cultivated land occurred during the later stage of the project(2002–2010);only 0.62 million ha of cultivated land did not change between 1992 and 2015.(2) Spatial pattern analysis showed that the cultivated land in the three parts of the reservoir changed from a northern distribution to a southern distribution;thus, the area of cultivated land in the north decreased over the time period. The area of cultivated land in the head and tail areas decreased by varying degrees, while it increased in the central area over the 23 years, indicating that the change in cultivated land showed regional differences.(3) The TGP, the policy of reverting farmland to forest,and urbanization were the main driving factors for the change of cultivated land, but there were differences in their impacts at different stages.(4) According to the patch dynamics of the land cover change, the degree of change gradually intensified during the early and later stages of the project and then stabilized during the operational period. Our research provides scientific support for the protection of cultivated land resources and food security in the reservoir area and for the coordination of social and economic development, which is of great significance to sustainable development in the reservoir area. | ZHANG Yu-xin WANG Yu-kuan FU Bin LI Ming LU Ya-feng DIXIT Amod Mani CHAUDHARY Suresh WANG Shan | 2020 | Journal of Mountain Science2020，17，1： | 7 |
| 8 | 仙茅:对健康有众多益处的黑金(英文)显示文摘仙茅(石蒜科)是一种濒临灭绝的多年生草本植物,是印度本土药,作为强有力的适应原和春药在印度传统药物中占有重要位置。它也是多种印度传统药物处方的重要组成部分,被认为具有促进性欲、刺激免疫、保护肝脏、抗氧化、抗癌和治疗糖尿病等作用。已有报道,从仙茅中提取出多种化学成分,如植物黏胶,酚苷、皂苷和脂肪族化合物等。仙茅也是中医和日本汉方医学中各种草药处方的重要成分。本文对仙茅的多种生物活性和其不同化学成分的作用进行了综述。 | Nagendra Singh Chauhan Vikas Sharma Mayank Thakur Vinod Kumar Dixit | 2010 | 中西医结合学报2010，8，7： | 6 |
| 9 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 10 | 共用阿片类和苯二氮类药物与药物过量之间的关系:一项回顾性分析显示文摘目标确定同时使用苯二氮类药物和阿片类药物的趋势,确定这些趋势对阿片类药物过量导致的住院和急诊就诊的影响,提出修改建议。参与者:在研究期间,18~64岁的私人投保人连续参加医疗和药房福利健康计划的病人,并且至少接受过一张阿片类药物的处方。干预:同时使用苯二氮类药物/阿片类药物,定义为每种药物处方所涵盖的时间段内至少有一天重叠。主要观察结局指标:使用苯二氮类药物的阿片类药物使用者的年度百分比;每年发生的急诊就诊和阿片类药物过量住院事件。结果:阿片类药物使用者中在2001年使用苯二氮卓类药物的有9%,2013年增加到17%(相对增加80%)。这种增加主要是间断性阿片类药物使用者的增加,而非长期的阿片类药物使用者。与未使用苯二氮卓类药物的阿片类药物使用者相比,同时使用这两种药物与急诊室留观或阿片类药物过量住院相关的风险增加(校正比值比2.14,95%置信区间2.05-2.24;P<0.001)。间断性阿片类药物使用者的急诊室或住院病人阿片类药物过量的校正比值比为1.42(1.33-1.51;P<0.001),长期阿片类药物使用者为1.81(1.67-1.96;P<0.001)。如果这种关联是因果关系,那么消除同时使用两种药物的情况可以减少阿片类药物使用和阿片类药物过量住院病人因急诊就诊的风险,估计有15%(95%置信区间14-16)。结论:从2001年到2013年,在美国大量私人保险病人样本中,苯二氮类药物和阿片类药物的并用显着增加,并且导致总体人群阿片类药物过量使用的风险。 | Sun EC Dixit A Humphreys K 李楠琦 | 2018 | 中国疼痛医学杂志2018，24，6： | 5 |
| 11 | Pseudomonas fluorescens-like bacteria from the stomach:A microbiological and molecular study显示文摘AIM:To characterize oxidase-and urease-producing bacterial isolates,grown aerobically,that originated from antral biopsies of patients suffering from acid peptic diseases.METHODS:A total of 258 antral biopsy specimens were subjected to isolation of bacteria followed by tests for oxidase and urease production,acid tolerance and aerobic growth.The selected isolates were further characterized by molecular techniques viz.amplifications for 16S rRNA using universal eubacterial and HSP60 gene specific primers.The amplicons were subjected to restriction analysis and partial sequencing.A phylogenetic tree was generated using unweighted pair group method with arithmetic mean(UPGMA) from evolutionary distance computed with bootstrap test of phylogeny.Assessment of acidity tolerance of bacteria isolated from antrum was performed using hydrochloric acid from 10-7 mol/L to 10-1 mol/L.RESULTS:Of the 258 antral biopsy specimens collected from patients,179(69.4%) were positive for urease production by rapid urease test and 31%(80/258) yielded typical Helicobacter pylori(H.pylori) after 5-7 d of incubation under a microaerophilic environment.A total of 240(93%) antral biopsies yielded homogeneous semi-translucent and small colonies after overnight incubation.The partial 16S rRNA sequences revealed that the isolates had 99% similarity with Pseudomonas species.A phylogenetic tree on the basis of 16S rRNA sequences denoted that JQ927226 and JQ927227 were likely to be related to Pseudomonas fluorescens(P.fluorescens).On the basis ofHSP60 sequences applied to the UPGMA phylogenetic tree,it was observed that isolated strains in an aerobic environment were likely to be P.fluorescens,and HSP60 sequences had more discriminatory potential rather than 16S rRNA sequences.Interestingly,this bacterium was acid tolerant for hours at low pH.Further,a total of 250(96.9%) genomic DNA samples of 258 biopsy specimens and DNA from 240 bacterial isolates were positive for the 613 bp amplicons by targeting P.fluorescens-specific conserved putative outer membrane protein gene sequences.CONCLUSION:This study indicates that bacterial isolates from antral biopsies grown aerobically were P.fluorescens,and thus acid-tolerant bacteria other than H.pylori can also colonize the stomach and may be implicated in pathogenesis/protection. | Saurabh Kumar Patel Chandra Bhan Pratap Ajay Kumar Verma Ashok Kumar Jain Vinod Kumar Dixit Gopal Nath | 2013 | World Journal of Gastroenterology2013，19，7： | 4 |
| 12 | Ebola virus disease: past, present and future显示文摘Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate(up to 90%) accompanying with the disease. Ebola haemorrhagic fever(EHF) is an infectious disease of animal that can be transmitted to both human and non-human primates. The first epidemic of EHF occurred in 1976 in the Democratic Republic of the Congo. The incubation period of ebola is less than 21 days. Ebola virus infections are depicted by immune suppression and a systemic inflammatory response that leads to damage of the vascular, coagulation and immune systems, causing multi-organ failure and shock. Five genetically distinct members of the Filoviridae family responsible for EHF are as follows: Zaire ebolavirus, Sudan ebolavirus, C?te d'Ivoire ebolavirus, Bundibugyo ebolavirus and Reston ebolavirus. The ongoing 2014 West Africa ebola epidemic has been considered as the most serious panic in the medical field with respect to both the number of human cases and death toll. The natural host for ebola virus is unknown, thus it is not possible to carry out programs to regulate or abolish virus from transmission to people. The ebola virus infection provides little chance to develop acquired immunity causing rapid progression of the disease. It is pertinent to mention that at present, there is no antiviral therapy or vaccine that is helpful against ebola virus infection in humans. The impediment of EHF necessitates much better understanding of the epidemiology of the disease, particularly the role of wildlife, as well as bats, in the spread of ebola virus to humans. | Harish Rajak Deepak Kumar Jain Avineesh Singh Ajay Kumar Sharma Anshuman Dixit | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 4 |
| 13 | Predicting accurate cathode properties of layered oxide materials using the SCAN meta-GGA density functional显示文摘Layered lithium intercalating transition metal oxides are promising cathode materials for Li-ion batteries.Here,we scrutinize the recently developed strongly constrained and appropriately normed(SCAN)density functional method to study structural,magnetic,and electrochemical properties of prototype cathode materials LiNiO_(2),LiCoO_(2),and LiMnO_(2) at different Li-intercalation limits.We show that SCAN outperforms earlier popular functional combinations,providing results in considerably better agreement with experiment without the use of Hubbard parameters,and dispersion corrections are found to have a small effect.In particular,SCAN fares better than Perdew–Burke–Ernzerhof(PBE)functional for the prediction of band-gaps and absolute voltages,better than PBE+U for the electronic density of states and voltage profiles,and better than both PBE and PBE+U for electron densities and in operando lattice parameters.This overall better performance of SCAN may be ascribed to improved treatment of localized states and a better description of short-range dispersion interactions. | Arup Chakraborty Mudit Dixit Doron Aurbach Dan T.Major | 2018 | npj Computational Materials2018，，1： | 4 |
| 14 | Achievements and prospects of grass pea(Lathyrus sativus L.) improvement for sustainable food production显示文摘Grass pea offers an attractive choice for sustainable food production, owing to its intrinsic properties including limited water requirement and drought tolerance. However, low productivity and the presence of a neurotoxin(ODAP) have posed major obstacles to its genetic improvement. Also, biotechnological investments remain limited and the genome is complex and not well understood. Strategies that allow identification of genotypes with reduced ODAP content, coupling of low ODAP content with enhanced yield, and effective seed detoxification methods merit immediate attention. Breeder-friendly genomic tools are being increasingly made available to improve the efficiency of breeding protocols. To this end, the application of next-generation sequencing has provided a means of leveraging the repertoire of genomic resources for this somewhat neglected crop. In this review, we describe progress achieved in Lathyrus genetic improvement. We also explore potential opportunities in Lathyrus research and identify urgent research needs. | Girish Prasad Dixit Ashok Kumar Parihar Abhishek Bohra Narendra Pratap Singh | 2016 | The Crop Journal2016，4，5： | 3 |
| 15 | Effect of Chlorophytum Borivilianum Santapau and Fernandes on Sexual Dysfunction in Hyperglycemic Male Rats显示文摘Objective:To investigate the effects of Chlorophytum borivilianum(CB) on sexual dysfunction, loss of body weight,and lack of libido in hyperglycemic rats induced with streptozotocin or alloxan.Methods: Wistar strain male albino rats were divided into five groups of six animals each:the control group(2% polyvinylpyrollidone solution),the streptozotocin control group(50 mg/kg),the alloxan control group(100 mg/kg), the streptozotocin + CB treated group(200 mg/kg),and the alloxan + CB treated group(200 mg/kg... | Mayank Thakur Shilpi Bhargava Werner Praznik Renate Loeppert Vinod K Dixit | 2009 | Chinese Journal of Integrative Medicine2009，15，6： | 3 |
| 16 | Death receptors:signaling and modulation显示文摘 | Ashkenazi A Dixit VM | | 0，，： | 3 |
| 17 | Particulate matter emissions and gaseous air toxic pollutants from commercial meat cooking operations显示文摘This study assessed the effectiveness of three novel control technologies for particulate matter(PM) and volatile organic compound(VOC) removal from commercial meat cooking operations. All experiments were conducted using standardized procedures at University of California, Riverside's commercial test cooking facility. PM mass emissions collected using South Coast Air Quality Management District(SCAQMD) Method 5.1, as well as a dilution tunnel-based PM method showed statistically significantly reductions for each control technology when compared to baseline testing(i.e., without a catalyst). Overall, particle number emissions decreased with the use of control technologies, with the exception of control technology 2(CT2), which is a grease removal technology based on boundary layer momentum transfer(BLMT) theory. Particle size distributions were unimodal with CT2 resulting in higher particle number populations at lower particle diameters. Organic carbon was the dominant PM component(> 99%) for all experiments. Formaldehyde and acetaldehyde were the most abundant carbonyl compounds and showed reductions with the application of the control technologies. Some reductions in mono-aromatic VOCs were also observed with CT2 and the electrostatic precipitator(ESP) CT3 compared to the baseline testing. | Nicholas Gysel William A.Welch Chia-Li Chen Poornima Dixit David R.Cocker Ⅲ Georgios Karavalakis | 2018 | Journal of Environmental Sciences2018，30，3： | 3 |
| 18 | Impact of climatic factors on vegetation dynamics in the upper Yangtze River basin in China显示文摘It is necessary to understand vegetation dynamics and their climatic controls for sustainable ecosystem management.This study examines the vegetation dynamics and the effect of climate change on vegetation growth in the pristine conditions of 58 woodland National Nature Reserves(NNRs)located in the upper Yangtze River basin(UYRB)in China which are little influenced by human activities.Changes in the normalized difference vegetation index(NDVI),precipitation,and temperature in the selected NNRs were observed and analyzed for the period between 1999 and 2015.The relationship between time-lag effect of climate and changes in the NDVI were assessed using Pearson correlations.The results showed three major trends.1)The NDVI increased during the study period;this indicates an increase in the amount of green vegetation,especially due to the warmer climate during the growing season.The NDVIs in March and September were significantly affected by the temperature of the previous months.Spring temperatures increased significantly(P<0.05)and there was a delay between climatic factors and their effect on vegetation,which depended on the previous season.In particular,the spring temperature had a delayed effect on the NDVI in summer.2)The way in which vegetation responds to climatic factors varied significantly across the seasons.Temperature had a greater effect on the NDVI in spring and summer and the effect was greater at higher altitudes.A similar trend was observed for precipitation,except for altitudes of 1000–2000 m.3)Temperature had a greater effect on the NDVI in spring and autumn at higher altitudes.The same trend was observed for precipitation in summer.These findings suggest that the vegetation found in NNRs in the upper reaches of the Yangtze River was in good condition between 1999 and 2015 and that the growth and development of vegetation in the region has not been adversely affected by climate change.This demonstrates the effectiveness of nature reserves in protecting regional ecology and minimizing anthropogenic effects. | ZHANG Yu-xin WANG Yu-kuan FU Bin DIXIT Amod Mani CHAUDHARY Suresh WANG Shan | 2020 | Journal of Mountain Science2020，17，5： | 3 |
| 19 | Evaluation and analysis of cutting speed, wire wear ratio, and dimensional deviation of wire electric discharge machining of super alloy Udimet-L605 using support vector machine and grey relational analysis显示文摘 | Somvir Singh Nain Dixit Garg Sanjeev Kumar | 2018 | Advances in Manufacturing2018，6，2： | 3 |
| 20 | Structure–property correlations in Al 7050 and Al 7055 high-strength aluminum alloys显示文摘 | M. Dixit R.S. Mishra K.K. Sankaran | 2007 | Materials Science & Engineering A2007，，1： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员