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| 1 | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity显示文摘Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases. | Qin Chen Peiliang Shi Yufang Wang Dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao | 2019 | Journal of Molecular Cell Biology2019，11，6： | 22 |
| 2 | A novel superhard tungsten nitride predicted by machine-learning accelerated crystal structure search显示文摘Transition metal nitrides have been suggested to have both high hardness and good thermal stability with large potential application value,but so far stable superhard transition metal nitrides have not been synthesized.Here,with our newly developed machine-learning accelerated crystal structure searching method,we designed a superhard tungsten nitride,h-WN_6,which can be synthesized at pressure around65 GPa and quenchable to ambient pressure.This h-WN_6is constructed with single-bonded armchair-like N_6rings and presents ionic-like features,which can be formulated as W^(2.4+)N_6^(2.4à).It has a band gap of1.6 e V at 0 GPa and exhibits an abnormal gap broadening behavior under pressure.Excitingly,this h-WN_6is found to be the hardest among transition metal nitrides known so far(Vickers hardness around57 GPa)and also has a very high melting temperature(around 1,900 K).Additionally,the good gravimetric(3.1 k J/g)and volumetric(28.0 k J/cm^3)energy densities make this nitrogen-rich compound a potential high-energy-density material.These predictions support the designing rules and may stimulate future experiments to synthesize superhard and high-energy-density material. | Kang Xia Hao Gao Cong Liu Jianan Yuan Jian Sun Hui-Tian Wang Dingyu Xing | 2018 | Science Bulletin2018，63，13： | 11 |
| 3 | Photopolymerization-based additive manufacturing of ceramics:A systematic review显示文摘Conversion of inorganic-organic frameworks (ceramic precursors and ceramic-polymer mixtures) into solid mass ceramic structures based on photopolymerization process is currently receiving plentiful attention in the field of additive manufacturing (3D printing).Various techniques(e.g.,stereolithography,digital light processing,and two-photon polymerization) that are compatible with this strategy have so far been widely investigated.This is due to their cost-viability,flexibility,and ability to design and manufacture complex geometric structures.Different platforms related to these techniques have been developed too,in order to meet up with modem technology demand.Most relevant to this review are the challenges faced by the researchers in using these 3D printing techniques for the fabrication of ceramic structures.These challenges often range from shape shrinkage,mass loss,poor densification,cracking,weak mechanical performance to undesirable surface roughness of the final ceramic structures.This is due to the brittle nature of ceramic materials.Based on the summary and discussion on the current progress of material-technique correlation available,here we show the significance of material composition and printing processes in addressing these challenges.The use of appropriate solid loading,solvent,and preceramic polymers in forming slurries is suggested as steps in the right direction.Techniques are indicated as another factor playing vital roles and their selection and development are suggested as plausible ways to remove these barriers. | Sefiu Abolaji RASAKI Dingyu XIONG Shufeng XIONG Fang SU Muhammad IDREES Zhangwei CHEN | 2021 | Journal of Advanced Ceramics2021，10，3： | 8 |
| 4 | Fractal desulfurization kinetics of high-sulfur coal显示文摘The pore structure characteristics of high-sulfur coal from Wansheng in Chongqing have been studied by a nitrogen adsorption method (BET). The effects of grinding and pre-treating with nitric acid on the inorganic sulfur content of coal have been investigated. Organic sulfur in coal pretreated with nitric acid was desulfurized by using propylene-glycol-KOH (PG-KOH). Fractal kinetic properties of these two desulfurization procedures were investigated by using fractal geometric theory. The results show that both the specific surface area and pore volume increased with the decrease in particle diameter. The microspore surface of coal had fractal characteristics; the fractal dimension was 2.48. The sulfur content decreased with the decrease in particle diameter by grinding. After pretreatment with nitric acid, the desulfurization ratio (DFR) of inorganic sulfur increased to over 99% and the DFR of total sulfur to over 70%. The desulfurization procedure of inorganic sulfur had fractal kinetic characteristics; its reactive fractal dimension was 2.94. The organic sulfur desulfurization procedure by PG-KOH was also tallied with fractal kinetic properties; the reactive fractal dimension was 2.57. The effect of temperature on the desulfurization ratio of organic sulfur can be described with an Arrhenius empirical equation. The rate constant, pre-exponential factor and the activation energy of the reaction increased with the decrease in particle diameter. | Xu Longjun Peng Tiefeng Zhang Dingyue Zhang Fukaia | 2012 | International Journal of Mining Science and Technology2012，22，1： | 7 |
| 5 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6suquu90xk0kqb6q00.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 6 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 7 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 8 | Recovery of the free field in noisy environment by using the spherical wave superposition method显示文摘To remove the scattering effect of the disturbing sound on the target source when implementing nearfield acoustic holography in a non-free field,a free field recovery technique based on the spherical wave superposition method is proposed.In the method,the sound field separation technique based on the spherical wave superposition method is first used to separate the incoming and outgoing fields,and a further step for separating the radiated and scattered fields is performed by utilizing the surface admittance of the target source as the boundary conc1ition.The technique makes it possible to correctly identify noise sources in a non-free sound feld.The basic principle of the technique is described firstly,a method for choosing the optimal number of spherical wave expansion terms is given,and two numerical simulations are used to demonstrate the validity of this technique.It is shown that,for the lower frequency,the scattering effect can be neglected,and the radiated field of the target source can be obtained by the sound field separation technique,however,as the increasing of the frequcncy,the scattering effcct cannot be neglected,and the frec field recovery technique has to be used to obtain the radiated field of the target source. | BI Chuanxing HU Dingyu XU Liang ZHANG Yongbin | 2014 | Chinese Journal of Acoustics2014，33，1： | 5 |
| 9 | Coexistence of plastic and partially diffusive phases in a helium-methane compound显示文摘Helium and methane are major components of gian icy planets and are abundant in the universe.However,helium is the most inert element in the periodic table and methane is one of the most hydrophobic molecules,thus whether they can react with each other is of fundamental importance.Here,our crystal structure searches and first-principles calculations predict that a He3CH4 compound is stable over a wide range of pressures from 55 to 155 GPa and a HeCH4 com pound becomes stable around 105 GPa.As nice examples of pure van der Waals crystals;the insertion of helium atoms changes the original packing of pure methane molecules and also largely hinders the polymerization of methane at higher pressures.After analyzing the diffusive properties during the melting of He3CH4 at high pressure and high temperature,in addition to a plastic methane phase,we have discovered an unusual phase which exhibits coexistence of diffusive helium and plastic methane.In addition,the range of the diffusive behavior within the helium-methane phase diagram is found to be much narrower compared to that of previously predicted helium-water compounds.This may be due to the weaker van der Waals interactions between methane molecules compared to those in helium-water compounds;and that the helium-methane compound melts more easily. | Hao Gao Cong Liu Andreas Hermann Richard J.Needs Chris J.Pickard Hui-Tian Wang Dingyu Xing Jian Sun | 2020 | National Science Review2020，7，10： | 4 |
| 10 | Effect of Cd on GSH and GSH-related enzymes of Chlamydomonas sp.ICE-L existing in Antarctic ice显示文摘Glutathione(GSH) and GSH-related enzymes play a great role in protecting organisms from oxidative damage. The GSH level and GSH-related enzymes activities were investigated as well as the growth yield and malonyldialdehyde(MDA) content in the Antarctic ice microalga Chlamydomonas sp. ICE-L exposure to the different cadmium concentration in this paper. The results showed that the higher concentration Cd inhibited the growth of ICE-L significantly and Cd would induce formation of MDA. At the same time, it is clear that GSH level, glutathione peroxidases(GPx) activity and glutathione S\|transferases(GST), activity were higher in ICE-L exposed to Cd than the control. But GR activity dropped notably when ICE-L were cultured in the medium containing Cd. Increase of GSH level, GPx and GST activities acclimate to oxidative stress induced by Cd and protect Antarctic ice microalga Chlamydomonas sp. ICE-L from toxicity caused by Cd exposure. These parameters may be used to assess the biological impact of Cd in the Antarctic pole region environment. | DINGYu MIAOJin-lai LIGuang-you WANGQuan-fu KANGuang-feng WANGGuo-dong | 2005 | Journal of Environmental Sciences2005，17，4： | 3 |
| 11 | RETRACTED ARTICLE:Human H9N2 Avian Influenza Infection:Epidemiological and Clinical Characterization of 16 Cases in China显示文摘The authors are retracting this paper owing to errors in the reported data.The paper claimed that 16 patient cases were infected with H9N2 virus.However,when the authors recently further investigated all the thirteen sera samples,no anti-H9N2 antibodies were found by the haemagglutination inhibition assay.Moreover,re-sequencing of the remaining five throat swabs showed all five samples were H1N1 virus. | Xuan Dong Jiasong Xiong Chaolin Huang Jie Xiang Wenjuan Wu Nanshan Chen Danning Wen Chao Tu Xueli Qiao Liang Kang Zhongzi Yao Dingyu Zhang Quanjiao Chen | 2021 | Virologica Sinica2021，36，3： | 3 |
| 12 | The NPR1-WRKY46-WRKY6 signaling cascade mediates probenazole/salicylic acid-elicited leaf senescence in Arabidopsis thaliana显示文摘Endogenous salicylic acid(SA) regulates leaf senescence, but the underlying mechanism remains largely unexplored. The exogenous application of SA to living plants is not efficient for inducing leaf senescence. By taking advantage of probenazole(PBZ)-inducedbiosynthesisof endogenous SA, we previously established a chemical inducible leaf senescence system that depends on SA biosynthesis and its core signaling receptor NPR1 in Arabidopsis thaliana. Here,using this system, we identified WRKY46 and WRKY6 as key components of the transcriptional machinery downstream of NPR1 signaling. Upon PBZ treatment, the wrky46 mutant exhibited significantly delayed leaf senescence. We demonstrate that NPR1 is essential for PBZ/SA-induced WRKY46 activation, whereas WRKY46 in turn enhances NPR1 expression. WRKY46 interacts with NPR1 in the nucleus, binding to the W-box of the WRKY6 promoter to induce its expression in response to SA signaling. Dysfunction of WRKY6 abolished PBZ-induced leaf senescence, while overexpression of WRKY6 was sufficient to accelerate leaf senescence even under normal growth conditions, suggesting that WRKY6 may serve as an integration node of multiple leaf senescence signaling pathways. Taken together,these findings reveal that the NPR1-WRKY46-WRKY6 signaling cascade plays a critical role in PBZ/SA-mediated leaf senescence in Arabidopsis. | Dingyu Zhang Zheng Zhu Jiong Gao Xin Zhou Shuai Zhu Xiaoyan Wang Xiaolei Wang Guodong Ren Benke Kuai | 2021 | Journal of Integrative Plant Biology2021，63，5： | 3 |
| 13 | COVID-19-associated monocytic encephalitis(CAME):histological and proteomic evidence from autopsy显示文摘Severe neurological symptoms are associated with Coronavirus disease 2019(COVID-19).However,the morphologic features,pathological nature and their potential mechanisms in patient brains have not been revealed despite evidence of neurotropic infection.In this study,neuropathological damages and infiltrating inflammatory cells were quantitatively evaluated by immunohistochemical staining,ultrastructural examination under electron microscopy,and an image threshold method,in postmortem brains from nine critically ill COVID-19 patients and nine age-matched cadavers of healthy individuals.Differentially expressed proteins were identified by quantitative proteomic assays.Histopathological findings included neurophagocytosis,microglia nodules,satellite phenomena,extensive edema,focal hemorrhage,and infarction,as well as infiltrating mononuclear cells.Immunostaining of COVID-19 brains revealed extensive activation of both microglia and astrocytes,severe damage of the blood-brain barrier(BBB)and various degrees of perivascular infiltration by predominantly CD14+/CD16+/CD141+/CCR7+/CD11c+monocytes and occasionally CD4+/CD8+T lymphocytes.Quantitative proteomic assays combined with bioinformatics analysis identified upregulated proteins predominantly involved in immune responses,autophagy and cellular metabolism in COVID-19 patient brains compared with control brains.Proteins involved in brain development,neuroprotection,and extracellular matrix proteins of the basement membrane were downregulated,potentially caused by the activation of transforming growth factorβreceptor and vascular endothelial growth factor signaling pathways.Thus,our results define histopathological and molecular profiles of COVID-19-associated monocytic encephalitis(CAME)and suggest potential therapeutic targets. | Pei-Pei Zhang Zhi-Cheng He Xiao-Hong Yao Rui Tang Jie Ma Tao Luo Chuhong Zhu Tian-Ran Li Xindong Liu Dingyu Zhang Shuyang Zhang Yi-Fang Ping Ling Leng Xiu-Wu Bian | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 3 |
| 14 | VIRAL DYNAMICS IN A DISTRIBUTED TIME DELAYED HCV PATHOGENESIS MODEL显示文摘 | SHIFEI WANG DINGYU ZOU | 2012 | International Journal of Biomathematics2012，5，6： | 2 |
| 15 | High-pressure phases of Weyl semimetals NbP, NbAs, TaP,and TaAs显示文摘In this study, we used the crystal structure search method and first-principles calculations to systematically explore the highpressure phase diagrams of the TaAs family(NbP, NbAs, TaP, and TaAs). Our calculation results show that NbAs and TaAs have similar phase diagrams, the same structural phase transition sequence I4_1 md→P6 m2→P2_1/c→Pm3 m, and slightly different transition pressures. The phase transition sequence of NbP and TaP differs somewhat from that of NbAs and TaAs, in which new structures emerge, such as the Cmcm structure in NbP and the Pmmn structure in TaP. Interestingly, we found that in the electronic structure of the high-pressure phase P6 m2-NbAs, there are coexistingWeyl points and triple degenerate points, similar to those found in high-pressure P6 m2-TaAs. | ZhaoPeng Guo PengChao Lu Tong Chen JueFei Wu Jian Sun DingYu Xing | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 2 |
| 16 | Modified Grey Model Predictor Design Using Optimal Fractional-order Accumulation Calculus显示文摘The major advantage of grey system theory is that both incomplete information and unclear problems can be processed precisely. Considering that the modeling of grey model(GM) depends on the preprocessing of the original data,the fractional-order accumulation calculus could be used to do preprocessing. In this paper, the residual sequence represented by Fourier series is used to ameliorate performance of the fractionalorder accumulation GM(1,1) and improve the accuracy of predictor. The state space model of optimally modified GM(1,1)predictor is given and genetic algorithm(GA) is used to find the smallest relative error during the modeling step. Furthermore,the fractional form of continuous GM(1,1) is given to enlarge the content of prediction model. The simulation results illustrated that the fractional-order calculus could be used to depict the GM precisely with more degrees of freedom. Meanwhile, the ranges of the parameters and model application could be enlarged with better performance. The method of modified GM predictor using optimal fractional-order accumulation calculus is expected to be widely used in data processing, model theory, prediction control and related fields. | Yang Yang Dingyu Xue | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 2 |
| 17 | An equivalent source method for recovering and reconstructing the target sound field in a non-free field显示文摘In a non-free field,the existence of disturbing sources would destroy the free-field condition required by near-field acoustic holography,and confuse the identification of target source due to the scattering effect caused by disturbing sound falling on the target source.To totally remove the influence of disturbing source,a method for recovering and reconstructing the target sound field in a non-free field was proposed based on the equivalent source method and the pressure-velocity measurement.In the proposed method,the sound field separation technique was firstly used to separate the mixed sound field into the outgoing field coming from the target source and the incoming field coming from the disturbing source.Then the scattered component contained in the outgoing field was calculated by using the disturbing sound and the surface impedance of the target source.Finally,the sound field radiated by the target source in a free field was obtained by subtracting the scattered component from the outgoing field and was further used to reconstruct the sound field of the target source.The proposed method was numerically and experimentally testified and the results of both the simulation and the experiment demonstrated the validity of the proposed method. | HU Dingyu LI Zaiwei FANG Yu | 2017 | Chinese Journal of Acoustics2017，36，2： | 2 |
| 18 | Digital medical education empowered by intelligent fabric space显示文摘Medical education plays an important role in promoting the development of global medical science.Nevertheless,the intrinsic gap existing between institutional medical teaching and practical clinical tasks causes low education efficiency and students’weak initiative.Recent developments of sensing fabric and embedded computing,along with the advances in artificial intelligence(AI)and digital twin technology are paving the way for the transformation of medical research towards digitization.In this work,we present an intelligent fabric space based on novel functional fabric materials and digital twin networking enabled by 5G and internet of things(IoT)technologies.In this space,medical students can learn knowledge with collaborative mapping of the digital and real world,cyber-physical interaction and real-time tactile feedback.And the proposed service system will evaluate and feedback students’operational behaviors to improve their experimental skills.We provide four typical applications of intelligent fabric space for medical education,including medical education training,health and behavior tracking,operation playback and reproduction,as well as medical knowledge popularization.The proposed intelligent fabric space has the potential to promote innovative technologies for training cutting-edge medical students by effective and efficient ways. | Min Chen Rui Wang Rui Wang Yingting Zhou Zicheng He Xiaojuan Liu Muyao He Jiaxi Wang Chaolin Huang Huamin Zhou Ping Hong Chong Hou Ning Zhou Dingyu Zhang Guangming Tao | 2022 | National Science Open2022，1，1： | 2 |
| 19 | Closed-form solutions to fractional-order linear differential equations显示文摘The definitions and properties of widely used fractional-order derivatives are summarized in this paper.The characteristic polynomials of the fractional-order systems are pseudo-polynomials whose powers of the complex variable are non-integers.This kind of systems can be approximated by high-order integer-order systems,and can be analyzed and designed by the sophisticated integer-order systems methodology.A new closed-form algorithm for fractional-order linear differential equations is proposed based on the definitions of fractional-order derivatives,and the effectiveness of the algorithm is illustrated through examples. | Chunna ZHAO Dingyu XUE | 2008 | Frontiers of Electrical and Electronic Engineering in China2008，3，2： | 2 |
| 20 | 显示文摘 | HUZong-Qiu(胡宗球) DINGYu(丁瑜) JIABing(加兵) | | WujiHuaxueXuebao0，，： | 1 |
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