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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Effects of AT1 receptor antagonist,Iosartan,on rat hepatic fibrosis induced by CCl_4显示文摘AIM To investigate effect of losartan,an AT1receptor antagonist,on hepatic fibrosis induced byCCl;and to determine whether or not AT1receptors are expressed on hepatic stellate cells,METHODS AND RESULTS Fifty male Sprague-Dawley rats,weighing(180±20)g,wererandomized into five groups(control group,modelgroup,and three losartan treated groups),inwhich all rats were given the subcutaneousinjection of 40% CCl4(every 3 days for 6 weeks)except for rats of control group.Rats of losartan-treated groups were treated with losartan(20 mg/kg,10 mg/kg,5 mg/kg,daily gavage),After 6weeks liver tissue and serum samples of all ratswere examined.Serum hyaluronic acid(HA),procollagen typeⅢ(PCⅢ)were detected byradioimmunoassays,van Giesion collagen stainingwas used to evaluate the extracellular matrix of ratswith liver fibrosis.The expression of AT1receptors,transforming growth factor-beta(TGF-β),and alpha-smooth muscle actin(a-SMA)inliver tissue were determined byimmunohistochemical techniques.Compared withmodel group,serum ALT and AST of losartan-treated groups were significantly reduced(t=4.20,P<0.01 and t=4.57,P<0.01).Serum HAand PCⅢalso had significant differences(t=3.53,P<0.01 and t=2.20,P<0.05).Thedegree of fibrosis was improved by losartan and correlated with the expressions of AT1 receptors,TGF-β,and α-SMA in liver tissue.CONCLUSION AT1 receptor antagonist,losartan,could limit the progression of the hepatic fibrosisinduced by CCl4.The mechanism may be related tothe decrease in the expression of AT1 receptorsand TGF-β,ameliorating the injury of hepatocytes;activation of local renin-angiotensin system mightrelate to hepatic fibrosis;and during progressionof fibrosis,activated hepatic stellate cells mightexpress AT1 receptors. | Hong Shan Wei Ding Guo Li Han Ming Lu Yu Tao Zhan Zhi Rong Wang Xin Huang Jing Zhang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，4： | 42 |
| 3 | Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.)显示文摘Gibberellin (GA) 2-oxidase plays a key role in the GA catabolic pathway through 2β-hydroxylation.In the present study,we isolated a CaMV 35S-enhancer activation tagged mutant,H032.This mutant exhibited a dominant dwarf and GA-deficient phenotype,with a final stature that was less than half of its wild-type counterpart.The endogenous bioactive GAs are markedly decreased in the H032 mutant,and application of bioactive GAs (GA3 or GA4) can reverse the dwarf phenotype.The integrated T-DNA was detected 12.8 kb upstream of the OsGA2ox6 in the H032 genome by TAIL-PCR.An increased level of OsGA2ox6 mRNA was detected at a high level in the H032 mutant,which might be due to the enhancer role of the CaMV 35S promoter.RNAi and ectopic expression analysis of OsGA2ox6 indicated that the dwarf trait and the decreased levels of bioactive GAs in the H032 mutant were a result of the up-regulation of the OsGA2ox6 gene.BLASTP analysis revealed that OsGA2ox6 belongs to the class III of GA 2-oxidases,which is a novel type of GA2ox that uses C20-GAs (GA12 and/or GA53) as the substrates.Interestingly,we found that a GA biosynthesis inhibitor,paclobutrazol,positively regulated the OsGA2ox6 gene.Unlike the over-expression of OsGA2ox1,which led to a high rate of seed abortion,the H032 mutant retained normal flowering and seed production.These results indicate that OsGA2ox6 mainly affects plant stature,and the dominant dwarf trait of the H032 mutant can be used as an efficient dwarf resource in rice breeding. | Jian Huang Ding Tang Yi Shen Baoxiang Qin Lilan Hong Aiqing You Ming Li Xin Wang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，1： | 36 |
| 4 | Recent developments and applications on high-performance cast magnesium rare-earth alloys显示文摘During the past decades,with the increasing demands in lightweight structural materials,Mg alloys with low density and high performance have been extensively investigated and partly applied in some industries.Especially when rare earth(RE)elements are added as major alloying elements to Mg alloys,the alloy strength and creep resistance are greatly improved,which have promoted several series of Mg-RE alloys.This paper reviews the progress and developments of high-performance Mg-RE alloys in recent years with emphasis on cast alloys.The main contents include the alloy design,melt purification,grain refinement,castability,novel liquid casting and semisolid forming approaches,and the industrial applications or trials made of Mg-RE alloys.The review will provide insights for future developments of new alloys,techniques and applications of Mg alloys. | Guohua Wu Cunlong Wang Ming Sun Wenjiang Ding | 2021 | Journal of Magnesium and Alloys2021，9，1： | 35 |
| 5 | Network Pharmacology Evaluation Method Guidance-Draft显示文摘Foreword Note:Some of the document contents may involve certain patents,the identification of which is not the responsibility of the institution that releases the document.Main drafting organizations:Tsinghua University,Specialty Committee of Network Pharmacology of World Federation of Chinese Medicine Societies(WFCMS). | Shao Li Yi-Tao Chen Qing-Yang Ding Jian-Ye Dai Xian-Chun Duan Yuan-Jia Hu Xin-Xing Lai Qing-Fei Liu Ming Niu Rong-Wu Xiang Zheng Xiang Hai-Yu Xu Xin Wang Hong-Jun Yang Kuo Yang Ming Yang Hai-Yang Yu Bo Zhang Peng Zhang Qian-Ru Zhang Hui-Hui Zhao Jing Zhao | 2021 | World Journal of Traditional Chinese Medicine2021，7，1： | 32 |
| 6 | The regulatory role of AT 1 receptor on activated HSCs in hepat,c fibrogenesis,effects of RAS inhibitors on hepatic fibrosis induced by CCl_4显示文摘AIM To assess the effect of ACE inhibitor andAng Ⅱ type Ⅰ(AT1)receptor antagonist inpreventing hepatic fibrosis caused by CCl4administration in rats;to investigate whether ornot there are expression of AT 1 receptors onhepatic stellate cells;and to observe the effectof Ang Ⅱ on proliferation and ECM synthesis ofcultured HSCs.METHODS Studies were conducted in maleSprague-Dawley rats.Except for thehepatofibrotic model group and the controlgroup,in three treated groups,either enalapril(5 mg/kg),or Iosartan(10 mg/kg),or enalapril+Iosartan were given to the fibrotic rats bydaily gavage,and saline vehicle was given tomodel and normal control rats.After 6 weeks,liver fibrosis was assessed directly by hepaticmorphometric analysis,which has beenconsidered the gold standard for thequantification of fibrosis.The expressions of AT1 receptors and(α-mooth muscle actin,α-SMA)in liver tissue or isolated hepatic stellate cells(HSCs)were detected by immunohistochemicaltechniques.The effect of Ang Ⅱ on HSCproliferation was determined by MTT method.Effect of Ang Ⅱ on collagen synthesis of HSCswas determined by 3H-proline incorporation.RESULTS Contrasted to the fibrosis in rats ofthe model group,groups of rats treated with either enalapril or Iosartan,or a combination oftwo drugs showed a limited expansion of theinterstitium(4.23±3.70 vs 11.22±4.79,P<0.05),but no difference was observedamong three treated groups(5.38±3.43,4.96±2.96,4.23±2.70,P>0.05).Expression of AT 1receptors was found in fibrotic interstitium offibrotic rats,whereas in normal control rats theywere limited to vasculature only to a very slightdegree.AT 1 receptors were also expressed onactivated HSCs in the culture.At concentrationsfrom 10-9to 10-5mol/L,Ang Ⅱ stimulated HSCproliferation in culture in a dose-dependentmanner.Increasing Ang Ⅱ concentrationsproduced corresponding increases in 3H-prolineincorporation.Differences among groups were significant.CONCLUSION Angiotensin-converting enzyme inhibitors and AT I blocker may slow the progression of hepatic fibrosis; activated HSCs express AT 1 receptors, and Ang Ⅱ can stimulate the proliferation and collagen synthesis of HSCs in a dose-dependent manner; and activation of RAS may be related to hepatic fibrogenesis induced by CCI4. | Hong Shan Wei Han Ming Lu Ding Guo Li Yu Tao Zhan Zhi Rong Wang Xin Huang Ji Lin Cheng Qin Fang Xu Department of Gastroenterology,Xinhua Hospital,Shanghai Second Medical University,Shanghai 200092,China | 2000 | World Journal of Gastroenterology2000，6，6： | 27 |
| 7 | Tillage and straw mulching impacts on grain yield and water use efficiency of spring maize in Northern Huang–Huai–Hai Valley显示文摘A two-year field experiment(2012–2013) was conducted to investigate the effects of two tillage methods and five maize straw mulching patterns on the yield, water consumption,and water use efficiency(WUE) of spring maize(Zea mays L.) in the northern Huang–Huai–Hai valley of China. Compared to rotary tillage, subsoil tillage resulted in decreases in water consumption by 6.3–7.8% and increases in maize yield by 644.5–673.9 kg ha-1, soil water content by 2.9–3.0%, and WUE by 12.7–15.2%. Chopped straw mulching led to higher yield,soil water content, and WUE as well as lower water consumption than prostrate whole straw mulching. Mulching with 50% chopped straw had the largest positive effects on maize yield, soil water content, and WUE among the five mulching treatments. Tillage had greater influence on maize yield than straw mulching, whereas straw mulching had greater influence on soil water content, water consumption, and WUE than tillage. These results suggest that 50% chopped straw mulching with subsoil tillage is beneficial in spring maize production aiming at high yield and high WUE in the Huang–Huai–Hai valley. | Zhiqiang Tao Congfeng Li Jingjing Li Zaisong Ding Jie Xu Xuefang Sun Peilu Zhou Ming Zhao | 2015 | The Crop Journal2015，3，5： | 26 |
| 8 | Relationship between depth of anesthesia and effect-site concentration of propofol during induction with the target-controlled infusion technique in elderly patients显示文摘在那里的背景是很少研究估计 propofol 的效果地点集中是否能在控制目标的注入(TCI ) 期间预言麻药深度在 eldedy 病人感应。这研究试图在 eldedy patients.Methods 在 TCI 正式就职期间评估在 propofol 的效果地点集中和麻醉的深度之间的关系有麻醉学者( ASA )的一个美国社会的 90 个病人( 60-80 年) 1-3 的物理地位,经历在一般麻醉下面安排了腹、胸的外科随机被分配进三个组,组 S1 , S2 和 S3 (在每个组的 30 个病人)之一。在组 S1 的病人与 4.0 g/ml 的目标血浆集中收到了 propofol;在组 S2 的病人与起始的目标血浆收到了 propofol 3 分钟以后被提起到 4.0 g/ml 的 2.0 g/ml 的集中;在组 S3 的病人收到了 3 步的一个灌输的计划;从是的 2.0 g/ml 的目标血浆集中开始由 1 g/ml 增加了 stepwised 直到 4.0 g/ml 的目标血浆集中被完成,在二步之间的间隔是 3 分钟。当一个观察员对 1 的机警 / 镇静(OAA/S ) 分数的评价被完成时, remifentanil (4.0 ng/ml 的效果地点集中(Ce )) 和 rocuronium 0.9 mg/kg 被管理。气管的 intubation 被开始在 rocuronium 以后的 2 分钟注射。propofol Ce,血压(BP ) ,心率(HR ) ,和 bispectral 索引(二度) 的变化被记录。结果当 1 的一个 OAA/S 分数被完成时, propofol 的 Ce 是(1.7ed .Results 八个病人((3.1 ?? 肀?? | LIU Shao-hua WEI Wei DING Guan-nan KE Jing-dong HONG Fang-xiao TIAN Ming | 2009 | Chinese Medical Journal2009，，8： | 24 |
| 9 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 10 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 11 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 12 | 计划生育工作人员咨询服务状况调查显示文摘目的:了解计划生育工作人员的咨询服务状况及可能的影响因素,为下一步在该人群中开展咨询培训提供依据。方法:通过结构式问卷,调查了来自于全国31个省、市、自治区和直辖市的271名计划生育工作人员,对他们的咨询服务状况及可能的影响因素进行分析。结果:271名调查对象中,255人曾为服务对象提供过咨询服务。咨询服务相关知识得分最高为100.0分,中位数为76.9分;咨询服务知识得分单因素分析显示,不同年龄组、不同文化程度对象之间的差别有统计学意义(P<0.05);多分类反应变量多元Logistic回归分析显示,文化程度越高,研究对象的咨询服务知识得分越高。结论:计划生育工作人员咨询服务的总体状况良好,但研究对象的年龄,文化程度等因素可能对他们的咨询服务产生影响。建议加强咨询培训的针对性,提高计划生育工作人员的整体素质。 | 武俊青 王瑞平 李玉艳 姜综敏 史远明 吴尚纯 Melbourne FrankHovell Ming JI Ding DING | 2007 | 生殖与避孕2007，27，9： | 17 |
| 13 | TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy显示文摘 | Chengyan Wang Xuming Tang Xiaomeng Sun Zhenchuan Miao Yaxin Lv Yanlei Yang Huidan Zhang Pengbo Zhang Yang Liu LiyingDu Yang Gao Ming Yin Mingxiao Ding Hongkui Deng | 2012 | Cell Research2012，22，1： | 17 |
| 14 | Asymptomatic patients of chronic obstructive pulmonary disease in China显示文摘背景长期的妨碍的肺的疾病(COPD ) 让可变自然历史和并非所有个人跟随一样的功课。这研究试图在 China.Methods 从基于人口的调查识别无征状的 COPD 病人的流行和特征多级式的簇采样策略从七不同省 / 城市在一张人口被使用。所有居民(超过 40 岁) 与一张标准化问询表被会见, spirometry.Post-bronchodilator 在 1 秒(FEV1 ) 强迫了吐气的体积 /forced 不到 70% 的重要能力(FVC ) 被定义为 COPD 的诊断标准。屏蔽的所有 COPD 病人根据长期的呼吸症状的存在或缺席被划分成征兆的组和无征状的组。Socio 人口统计,个人和暴露变量被收集,在从 25 627 采样与 COPD 被诊断的 1668 个病人之中的 analyzed.Results 使遭到,(35.3%) 589 是无征状的。年龄,性别,身体团索引(BMI ) ,农村、城市的分布,吸烟习惯和教育层次在二个组是类似的。64.7% 无征状的病人的一个总数没有 comorbidities。心血管的疾病和肺癌症比无征状的 group.Asymptomatic COPD 组多半是更少在厨房,呼吸疾病的家庭历史和周期性的童年咳嗽里与差的通风介绍的在征兆的 COPD 病人之中是更普通的。无征状的 COPD 病人有的显著地更高的 FEV1 (73.1% 对 61.0%) , FVC (91.9% 对 82.0%) ,和 FEV1/FVC (62.9%vs.58.7%) 的更高的比率(所有 P < 0.001 ) 比征兆的组。更无征状的病人是 underdiagnosed (91.9%vs.54.3% , P < 0.001 ) 比征兆的 patients.Conclusions,这大基于人口的调查在中国证实了无征状的 COPD 病人的高流行。屏蔽测试的呼吸量测定法的更多的使用可能对 COPD 的早察觉重要。 | LU Ming YAO Wan-zhen ZHONG Nan-shan ZHOU Yu-min WANG Chen CHEN Ping KANG Jian HUANG Shao-guang CHEN Bao-yuan WANG Chang-zheng NI Dian-tao WANG Xiao-ping WANG Da-li LIU Sheng-ming Lv Jia-chun SHEN Ning DING Yan-ling RAN Pi-xin | 2010 | Chinese Medical Journal2010，，12： | 17 |
| 15 | Sequencing of PCR amplified HBV DNA pre-c and c regions in 2.2.15 cells and antiviral action by targeted antisense oligonucleotide directed against sequence显示文摘INTRODUCTIONManystudieshaveshownthatantisenseoligonucleotides(ASONs)canefficientlyinhibitHBVDNAreplicationandexpresioninvitro... | ZHOUG Sen 1, WEN Shou Ming 2, ZHANG Ding Feng 3, WANG Quan Li 4, WANG Seng Qi 4 and REN Hong 3 | 1998 | World Journal of Gastroenterology1998，4，5： | 16 |
| 16 | Maize kernel weight responses to sowing dateassociated variation in weather conditions显示文摘Variation in weather conditions during grain filling has substantial effects on maize kernel weight(KW). The objective of this work was to characterize variation in KW with sowing date-associated weather conditions and examine the relationship between KW, grain filling parameters, and weather factors. Maize was sown on eight sowing dates(SD) at 15–20-day intervals from mid-March to mid-July during 2012 and 2013 in the North China Plain. With sowing date delay, KW increased initially and later declined, and the greatest KW was obtained at SD6 in both years. The increased KW at SD6 was attributed mainly to kernel growth rate(Gmean), and effective grain-filling period(P). Variations in temperature and radiation were the primary factors that influenced KW and grain-filling parameters. When the effective cumulative temperature(AT) and radiation(Ra)during grain filling were 950 °C and 1005.4 MJ m-2, respectively, P and KW were greatest. High temperatures(daily maximum temperature [Tmax] > 30.2 °C) during grain filling under early sowing conditions, or low temperatures(daily minimum temperature [Tmin] < 20.7 °C) under late sowing conditions combined with high diurnal temperature range(Tmax-min> 7.1 °C) decreased kernel growth rate and ultimately final KW. When sowing was performed from May 25 through June 27, higher KW and yield of maize were obtained. We conclude that variations in environmental conditions(temperature and radiation) during grain filling markedly affect growth rate and duration of grain filling and eventually affect kernel weight and yield of maize. | Baoyuan Zhou Yang Yue Xuefang Sun Zaisong Ding Wei Ma Ming Zhao | 2017 | The Crop Journal2017，5，1： | 15 |
| 17 | 新型2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物的合成及生物活性显示文摘通过烯基膦亚胺1与芳基异氰酸酯的aza-Witig反应得到碳二亚胺2,再用2与亲核试剂的成环反应制得10个新型的2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物4.探讨了碳二亚胺2与不同亲核试剂反应的活性并分离得到了一个胍中间体3i. | DING Ming Wu *, TU Hai Yang, LIU Zhao Jie, ZHUANG Nong Bo (Institute of Organic Synthesis, Central China Normal University, Wuhan, 430079) | 1998 | 高等学校化学学报1998，19，6： | 15 |
| 18 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 19 | The ATP-binding Cassette Transporter OsABCG15 is Required for Anther Development and Pollen Fertility in Rice显示文摘植物男性繁殖开发是复杂生物进程,但是内在的机制不好理解。这里,我们描绘了米饭(Oryza sativa L.) 男无菌的异种。基于基于地图的克隆和顺序分析,我们在腺苷 triphosphate (ATP ) 识别了 1,459-bp 删除有约束力的盒子(ABC ) transporter 基因, OsABCG15,引起的反常花药和男绝育。因此,我们说出这变异的 osabcg15。表示分析证明 OsABCG15 从舞台 8 在发展花药明确地被表示(成熟分裂 II 阶段) 上演 10 (迟了的小孢子阶段) 。二基因 CYP704B2 和 WDA1,为花药表皮和花粉 exine 的建立在 very-long-chain 的生合成包含了丰满的酸,是在 osabcg15 异种的 downregulated,建议那 OsABCG15 可以从 tapetal 房间在与 sporopollenin 生合成或 sporopollenin 转移有关的过程玩关键功能到花药小腔。一致地,组织学的分析证明 osabcg15 异种在 postmeiotic tapetum 退化开发了明显的反常,导致年轻小孢子的快速的 degredation。结果建议 OsABCG15 在 exine 形成和花粉开发起一个关键作用,类似于在 Arabidopsis 的 AtABCG26 的相应基因。这个工作是有用的在米饭花药开发理解规章的网络。 | Bai-Xiao Niu Fu-Rong He Ming He Ding Ren Le-Tian Chen Yao-Guang Liu | 2013 | Journal of Integrative Plant Biology2013，55，8： | 14 |
| 20 | Grape Seed Proanthocyanidin Extract Alleviates Arsenic-induced Oxidative Reproductive Toxicity in Male Mice显示文摘Objective To determine the ability of grape seed proanthocyanidin extract(GSPE) in alleviating arsenic-induced reproductive toxicity. Methods Sixty male Kunming mice received the following treatments by gavage: normal saline solution(control); arsenic trioxide(ATO; 4 mg/kg); GSPE(400 mg/kg); ATO+GSPE(100 mg/kg); ATO+GSPE(200 mg/kg) and ATO+GSPE(400 mg/kg). Thereafter, the mice were sacrificed and weighed, and the testis was examined for pathological changes. Nuclear factor(erythroid-derived 2)-like 2(Nrf2), heme oxygenase 1(HO1), glutathione S-transferase(GST), NAD(P)H dehydrogenase, and quinone 1(NQO1) expression in the testis was detected by real-time PCR. Superoxide dismutase(SOD), glutathione(GSH), total antioxidative capability(T-AOC), malondialdehyde(MDA), 8-hydroxydeoxyguanosine(8-OHd G), and reproductive indexes were analyzed. Results ATO-treated mice showed a significantly decreased sperm count and testis somatic index and activity levels of SOD, GSH, and T-AOC than control group. Compared to the ATO-treated group, ATO +GSPE group showed recovery of the measured parameters. Mice treated with ATO+high-dose GSPE showed the highest level of m RNA expression of Nrf2, HO, NQO1, and GST. Conclusion GSPE alleviates oxidative stress damage in mouse testis by activating Nrf2 signaling, thus counteracting arsenic-induced reproductive toxicity. | LI Shu Gang DING Yu Song NIU Qiang XU Shang Zhi PANG Li Juan MA Ru Lin JING Ming Xia FENG Gang Ling LIU Jia Ming GUO Shu Xia | 2015 | Biomedical and Environmental Sciences2015，28，4： | 14 |
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