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| 1 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 2 | Constraining the stepwise migration of the eastern Tibetan Plateau margin by apatite fission track thermochronology显示文摘Granites sampled from Garzê-Litang thrust, Longmen Shan thrust, Garzê and Litang strike-slip faults in the eastern Tibetan Plateau have been analyzed with apatite fission track thermochronological method in this study. The measured fission track apparent ages, combined with the simulated annealing mod- eling of the thermal history, have been used to reconstruct the thermal evolutionary histories of the samples and interpret the active history of the thrusts and faults in these areas. Thermal history mod- eling shows that earlier tectonic cooling occurred in the Garzê-Litang thrust in Miocene (~20―16 Ma) whereas the later cooling occurred mainly in the Longmen Shan thrust since ~5 Ma. Our study sug- gests that the margin of eastern Tibetan Plateau was extended by stages: through strike-slip faults deformations and related thrusts, the upper crust formed the Garzê-Litang margin in the Miocene epoch and then moved to the Longmen Shan margin since ~5 Ma. During this process, the deformations of different phases in the eastern Tibetan Plateau were absorbed by the thrusts within them and conse- quently the tectonic events of long-distance slip and extrusion up to hundreds of kilometers have not been found. | LAI QingZhou DING Lin WANG HongWei YUE YaHui CAI FuLong | 2007 | Science China Earth Sciences2007，50，2： | 24 |
| 3 | LHD1,an Allele of DTH8/Ghd8,Controls Late Heading Date in Common Wild Rice (Oryza rufipogon)显示文摘Flowering at suitable time is very important for plants to adapt to complicated environments and produce their seeds successfully for reproduction.In rice (Oryza rufipogon Griff.) photoperiod regulation is one of the important factors for controlling heading date.Common wild rice,the ancestor of cultivated rice,exhibits a late heading date and a more sensitive photoperiodic response than cultivated rice.Here,through map-based cloning,we identified a major quantitative trait loci (QTL) LHD1 (Late Heading Date 1),an allele of DTH8/Ghd8,which controls the late heading date of wild rice and encodes a putative HAP3/NF-YB/CBF-A subunit of the CCAAT-box-binding transcription factor.Sequence analysis revealed that several variants in the coding region of LHD1 were correlated with a late heading date,and a further complementary study successfully rescued the phenotype.These results suggest that a functional site for LHD1 could be among those variants present in the coding region.We also found that LHD1 could down-regulate the expression of several floral transition activators such as Ehd1,Hd3a and RFT1 under long-day conditions,but not under short-day conditions.This indicates that LHD1 may delay flowering by repressing the expression of Ehd1,Hd3a and RFT1 under long-day conditions. | Xiaodong Dai Younian Ding Lubin Tan Yongcai Fu Fengxia Liu Zuofeng Zhu Xianyou Sun Xuewen Sun Ping Gu Hongwei Cai Chuanqing Sun | 2012 | Journal of Integrative Plant Biology2012，54，10： | 23 |
| 4 | Trends in cancer mortality in China from 2004 to 2018:A nationwide longitudinal study显示文摘Background:The long-term trend in cancer death in a rapidly developing country provides information for cancer prophylaxis.Here,we aimed to identify the trends in cancer mortality in China during the 2004-2018 period.Methods:Using raw data from the national mortality surveillance system of China,we assessed the mortalities of all cancer and site-specific cancers during the 2004-2018 period.The participants were divided into three age groups:≥65 years,40-64 years,and≤39 years.Changing trends in cancer death by gender,residency,and tumor location were estimated using fitting joinpoint models to log-transformed crude mortality rates(CMRs)and age-standardizedmortality rates(ASMRs).Results:Cancer death accounted for 24% of all-cause of death in China during 2014-2018.The CMR of all cancer was 150.0 per 100,000 persons.Cancer was the leading cause of death in the population<65 years.The six major cancer types(lung/bronchus cancer,liver cancer,stomach cancer,esophagus cancer,colorectal cancer,and pancreas cancer)accounted for 75.85% of all cancer deaths.The CMR of all cancer increased while the ASMR decreased during 2014-2018(P<0.001).Lung/bronchus cancer and liver cancer were the leading causes of cancer death in the population<65 years,accounting for 45.31%(CMR)and 44.35%(ASMR)of all cancer death,respectively.The ASMR of liver cancer was higher in the 40-64 years population than in the≥65 years population,in contrast to the other five major cancers.The ASMRs of liver cancer,stomach cancer,and esophagus cancer decreased although they were higher in rural residents than in urban residents;the ASMRs of lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents although they were higher in urban residents than in rural residents during 2014-2018.Conclusion:Although the ASMR of all cancer decreased in China during 2004-2018,lung/bronchus cancer and liver cancer remained the leading causes of cancer-related premature death.Lung/bronchus cancer,colorectal cancer,and pancreas cancer increased in rural residents. | Dongming Jiang Lijuan Zhang Wenbin Liu Yibo Ding Jianhua Yin Rongbing Ren Qi Li Yifan Chen Jiaying Shen Xiaojie Tan Hongwei Zhang Guangwen Cao | 2021 | Cancer Communications2021，41，10： | 23 |
| 5 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 6 | Effective gene editing by high-fidelity base editor 2 in mouse zygotes显示文摘通过相应再结合的指向的点 mutagenesis 广泛地在基因研究被使用了并且为在病人修理引起疾病的变化保持可观的诺言。然而,象 mosaicism 那样的问题和低 mutagenesis 效率继续提出挑战到如此的途径的临床的申请。最近,一个基础编辑器() 在 cytidine (C) 脱氨基酶上造的系统和 CRISPR/Cas9 技术在植物,酵母,和人的房间为指向的点 mutagenesis 作为一个其他的方法被开发。然而,基础编辑器高效地在 deamination 窗口中把 C 变换成 thymidine (T) 是否指向了在鼠标胚胎的基础编辑,仍然保持不清楚是可行的。在这份报告,我们产生了基础编辑的一个修改高保真版本 2 (HF2-BE2 ) ,并且调查了它在老鼠胚胎编辑功效的底。我们发现 HF2-BE2 能高效地把 C 变换成 T,与直到在老鼠胚胎的 100% biallelic 变化效率。不同于 BE3, HF2-BE2 能在目标和非目标海滨上把 C 变换成 T,扩展基础编辑器的编辑范围。令人惊讶地,我们发现 HF2-BE2 能也使脱去氨基对 gRNA 有约束力的区域近似的 C。一起拿,我们的工作表明由基础编辑,和下划线在鼠标产生点变化的可行性小心地优化编辑系统以便消除近似地点的 deamination 的底的需要。 | Puping Liang Hongwei Sun Ying Sun Xiya Zhang Xiaowei Xie Jinran Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2017 | Protein & Cell2017，8，8： | 17 |
| 7 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 8 | Study of Manganese Promoter on a Precipitated Iron-Based Catalyst for Fischer-Tropsch Synthesis显示文摘猛抛的基于铁的 Fischer-Tropsch 合成(英尺) 上的锰(Mn ) 加入的效果催化剂用 N2 物理吸附被调查,空气微分热分析(DTA ) , H2 规划温度的减小(TPR ) ,和 M ? ssbauer 光谱学。催化剂的英尺表演在一个泥浆阶段反应堆被测试。描述结果显示 Mn 增加了催化剂的表面区域,并且改进了 -Fe2O3 的分散并且由于 Mn 和 Fe-Mn 相互作用的高分散效果减少了它的雏晶尺寸。Fe-Mn 相互作用也压制了 -Fe2O3 的减小到 Fe3O4,稳定了 FeO 阶段,并且(或) 减少在 H2 和 syngas 减小的催化剂的 carburization 度处理。另外,合并了 Mn 减少起始的催化剂活动,但是因为 Mn 制止了铁碳化物的氧化到 Fe3O4,改进了催化剂稳定性,并且改进了催化剂的进一步的 carburization。锰压制了 CH4 的形成并且增加了选择点亮石蜡(C=2 4 ) ,但是它在选择上有小效果到重(C5+) 烃。所有这些结果显示强壮的 Fe-Mn 相互作用作为一个电子倡导者压制了 Mn 的 chemisorptive 效果,到某程度,在猛抛的铁锰催化剂系统。 | Zhichao Tao Yong fang Chenghua Zhang Tingzhen Li Mingyue Ding Hongwei Xiang Yongwang Li | 2007 | Journal of Natural Gas Chemistry2007，16，3： | 10 |
| 9 | Mechanisms of Qi-blood circulation and Qi deficiency syndrome in view of blood and interstitial fluid circulation显示文摘OBJECTIVE: Based on comparison between fundamental theories of Traditional Chinese Medicine (TCM) and Western Medicine (WM) and modern scientific research on meridians, we find that 'Qi' in TCM is closely related to tissue fluid. In this study, the essence of Qi is explored in the view of circulation of blood and interstitial fluid. METHODS: Because the concept of Qi is complicated, Qi deficiency syndrome (QDS) is chosen to probe the relationship between of Qi deficiency and Qi-blood circulation (QBC). We analyze Qi-blood theory in terms of WM, set up a hemodynamic model to describe QBC, and review clinical research on QDS in the view of blood-interstitial fluid circulation. RESULTS: QDS is caused by imbalances of substance exchanges between blood and interstitial fluid, leading to an increase in the interstitial liquid volume or a decrease in nutrients and retention ofmetabolic wastes in interstitial fluid. CONCLUSION: This study describes the essence of Qi, providing support for further research on theories of Qiand Qi-blood circulation inTCM. | Wei Yao Hongwei Yang Guanghong Ding | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 8 |
| 10 | The Chinese Hα Solar Explorer(CHASE) mission: An overview显示文摘The Chinese Hα Solar Explorer(CHASE), dubbed “Xihe”—Goddess of the Sun, was launched on October 14, 2021 as the first solar space mission of China National Space Administration(CNSA). The CHASE mission is designed to test a newly developed satellite platform and to acquire the spectroscopic observations in the Hα waveband. The Hα Imaging Spectrograph(HIS)is the scientific payload of the CHASE satellite. It consists of two observational modes: raster scanning mode and continuum imaging mode. The raster scanning mode obtains full-Sun or region-of-interest spectral images from 6559.7 to 6565.9 ? and from 6567.8 to 6570.6 ? with 0.024 ? pixel spectral resolution and 1 min temporal resolution. The continuum imaging mode obtains photospheric images in continuum around 6689 ? with the full width at half maximum of 13.4 ?. The CHASE mission will advance our understanding of the dynamics of solar activity in the photosphere and chromosphere. In this paper, we present an overview of the CHASE mission including the scientific objectives, HIS instrument overview, data calibration flow, and first results of on-orbit observations. | Chuan Li Cheng Fang Zhen Li MingDe Ding PengFei Chen Ye Qiu Wei You Yuan Yuan MinJie An HongJiang Tao XianSheng Li Zhe Chen Qiang Liu Gui Mei Liang Yang Wei Zhang WeiQiang Cheng JianXin Chen ChangYa Chen Qiang Gu QingLong Huang MingXing Liu ChengShan Han HongWei Xin ChangZheng Chen YiWei Ni WenBo Wang ShiHao Rao HaiTang Li Xi Lu Wei Wang Jun Lin YiXian Jiang LingJie Meng Jian Zhao | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，8： | 7 |
| 11 | by a cascade optical field modulation strategy facilitating selective multispectral narrow-band near-infrared photodetection显示文摘Since selective detection of multiple narrow spectral bands in the near-infrared(NIR)region still poses a fundamental challenge,we have,in this work,developed NIR photodetectors(PDs)using photon upconversion nanocrystals(UCNCs)combined with perovskite films.To conquer the relatively high pumping threshold of UCNCs,we designed a novel cascade optical field modulation strategy to boost upconversion luminescence(UCL)by cascading the superlensing effect of dielectric microlens arrays and the plasmonic effect of gold nanorods,which readily leads to a UCL enhancement by more than four orders of magnitude under weak light irradiation.By accommodating multiple optically active lanthanide ions in a core-shell-shell hierarchical architecture,developed PDs on top of this structure can detect three well-separated narrow bands in the NIR region,i.e.,those centered at 808,980,and 1540 nm.Due to the large UCL enhancement,the obtained PDs demonstrate extremely high responsivities of 30.73,23.15,and 12.20 AW^(−1) and detectivities of 5.36,3.45,and 1.91×10^(11) Jones for 808,980,and 1540 nm light detection,respectively,together with short response times in the range of 80-120 ms.Moreover,we demonstrate for the first time that the response to the excitation modulation frequency of a PD can be employed to discriminate the incident light wavelength.We believe that our work provides novel insight for developing NIR PDs and that it can spur the development of other applications using upconversion nanotechnology. | Yanan Ji Wen Xu Nan Ding Haitao Yang Hongwei Song Qingyun Liu Hans Agren Jerker Widengren Haichun Liu | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 12 | Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma显示文摘Background:We previously showed that the expression of follistatin-like protein 1(FSTL1)was significantly down-regulated in metastatic clear-cell renal cell carcinoma(ccRCC).In this study,we aimed to characterize the role of FSTL1 in the development of ccRCC.Methods:The effects of FSTL1 on cell activity and cell cycle were investigated in ccRCC cell lines with altered FSTL1 expression.Gene expression microarray assays were performed to identify the major signaling pathways affected by FSTL1 knockdown.The expression of FSTL1 in ccRCC and its effect on postoperative prognosis were estimated in a cohort with 89 patients.Results:FSTL1 knockdown promoted anchorage-independent growth,migration,invasion,and cell cycle of ccRCC cell lines,whereas FSTL1 overexpression attenuated cell migration.FSTL1 knockdown up-regulated nuclear factor-κB(NF-κB)and hypoxia-inducible factor(HIF)signaling pathways,increased epithelial-to-mesenchymal transition,up-regulated interleukin-6 expression,and promoted tumor necrosis factor-α-induced degradation of NF-κB inhibitor(IκBα)in ccRCC cell lines.FSTL1 immunostaining was selectively positive in epithelial cytoplasm in the loop of Henle,and positive rate of FSTL1 was significantly lower in ccRCC tissues than in adjacent renal tissues(P<0.001).The mul-tivariate Cox regression analysis showed that the intratumoral FSTL1 expression conferred a favorable independent prognosis with a hazard ratio of 0.325(95%confidence interval 0.118-0.894).HIF-2αexpression was negatively cor-related with FSTL1 expression in ccRCC specimens(r=−0.229,P=0.044).Intratumoral expression of HIF-2α,rather than HIF-1α,significantly predicted an unfavorable prognosis in ccRCC(log-rank,P=0.038).Conclusions:FSTL1 plays a tumor suppression role possibly via repressing the NF-κB and HIF-2αsignaling pathways.To increase FSTL1 expression might be a candidate therapeutic strategy for metastatic ccRCC. | Yan Liu Xiaojie Tan Wenbin Liu Xi Chen Xiaomei Hou Dan Shen Yibo Ding Jianhua Yin Ling Wang Hongwei Zhang Yongwei Yu Jianguo Hou Timothy C.Thompson Guangwen Cao | 2018 | Cancer Communications2018，38，1： | 5 |
| 13 | A novel approach for designing efficient broadband photodetectors expanding from deep ultraviolet to near infrared显示文摘Broadband photodetection(PD)covering the deep ultraviolet to near-infrared(200–1000 nm)range is significant and desirable for various optoelectronic designs.Herein,we employ ultraviolet(UV)luminescent concentrators(LC),iodinebased perovskite quantum dots(PQDs),and organic bulk heterojunction(BHJ)as the UV,visible,and near-infrared(NIR)photosensitive layers,respectively,to construct a broadband heterojunction PD.Firstly,experimental and theoretical results reveal that optoelectronic properties and stability of CsPbI3 PQDs are significantly improved through Er3+doping,owing to the reduced defect density,improved charge mobility,increased formation energy,tolerance factor,etc.The narrow bandgap of CsPbI3:Er3+PQDs serves as a visible photosensitive layer of PD.Secondly,considering the matchable energy bandgap,the BHJ(BTP-4Cl:PBDB-TF)is selected as to NIR absorption layer to fabricate the hybrid structure with CsPbI3:Er3+PQDs.Thirdly,UV LC converts the UV light(200–400 nm)to visible light(400–700 nm),which is further absorbed by CsPbI3:Er3+PQDs.In contrast with other perovskites PDs and commercial Si PDs,our PD presents a relatively wide response range and high detectivity especially in UV and NIR regions(two orders of magnitude increase that of commercial Si PDs).Furthermore,the PD also demonstrates significantly enhanced air-and UV-stability,and the photocurrent of the device maintains 81.5%of the original one after 5000 cycles.This work highlights a new attempt for designing broadband PDs,which has application potential in optoelectronic devices. | Nan Ding Yanjie Wu Wen Xu Jiekai Lyu Yue Wang Lu Zi Long Shao Rui Sun Nan Wang Sen Liu Donglei Zhou Xue Bai Ji Zhou Hongwei Song | 2022 | Light(Science & Applications)2022，11，5： | 5 |
| 14 | Crashworthiness Analysis on Alternative Square Honeycomb Structure under Axial Loading显示文摘Hexagonal metal honeycomb is widely used in energy absorption field for its special construction. However, many other metal honeycomb structures also show good energy absorption characteristics. Currently, most of the researches focus on hexagonal honeycomb, while few are performed into different honeycomb structures. Therefore, a new alternative square honeycomb is developed to expand the non-hexagonal metal honeycomb applications in the energy absorption fields with the aim of designing low mass and low volume energy absorbers. The finite element model of alternative square honeycomb is built to analyze its specific energy absorption property. As the diversity of honeycomb structure, the parameterized metal honeycomb finite element analysis program is conducted based on PCL language. That program can automatically create finite element model. Numerical results show that with the same foil thickness and cell length of metal honeycomb, the alternative square has better specific energy absorption than hexagonal honeycomb. Using response surface method, the mathematical formulas of honeycomb crashworthiness properties are obtained and optimization is done to get the maximum specific energy absorption property honeycomb. Optimal results demonstrate that to absorb same energy, alternative square honeycomb can save 10% volume of buffer structure than hexagonal honeycomb can do. This research is significant in providing technical support in the extended application of different honeycomb used as crashworthiness structures, and is absolutely essential in low volume and low mass energy absorber design. | LI Meng DENG Zongquan GUO Hongwei LIU Rongqiang DING Beichen | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 5 |
| 15 | Study of temperature and precipitation change in upstream mountain area of the Hexi inland river basin since 1960s显示文摘All rivers in the Hexi inland region of Gansu Province, China, originate from the northern slope of the Qilian Mountains. They are located in the southern portion of the region and respectively belong to the three large river systems from east to west, the Shiyang, Heihe and Shule river basins. These rivers are supplied by precipitation, snowmelt and ice-melt runoff from the Qilian Mountain area. Therefore, changes of precipitation and temperature in the upstream watersheds of these rivers have an important effect on changes of mountainous runoff and reasonable utilization of water resources in this region. For this reason, the Qilian Mountain area, upstream watersheds and runoff forming areas of these rivers are chosen as the study area. The change characteristics and variation trend of temperature and precipitation in this area under the backdrop of global warming are analyzed based on observational data of relational weather and hydrologic stations in the area. Results show that temperatures in the upriver mountain areas of these three large river basins have been increasing, although the increasing degree is differentially affected by global warming. The rising extent of annual and seasonal temperatures in the upstream mountain area of the Shule river basin located in the western Qilian Mountains, were all largest over the past 50 years. Precipitation in the upstream mountain areas of Hexi region' three river basins located respectively in the western, middle and eastern Qilian Mountains have been presenting an increasing trend to varying degrees as a whole for more than 50 years. This means that climate in the upstream mountain areas of Hexi region' three river basins are becoming increasingly warmer and moister over the past 50 years, which will be very good for the ecological environment and agricultural production in the region. | YongChao Lan HongLang Xiao XingLin Hu HongWei Ding SongBing Zou ChengFang La Jie Song | 2012 | Research in Cold and Arid Regions2012，4，6： | 4 |
| 16 | N-Type Mg_(3)Sb_(2-x)Bi_(x) Alloys as Promising Thermoelectric Materials显示文摘N-type Mg_(3)Sb_(2-x)Bi_(x) alloys have been extensively studied in recent years due to their significantly enhanced thermoelectric figure of merit(zT),thus promoting them as potential candidates for waste heat recovery and cooling applications.In this review,the effects resulting from alloying Mg_(3)Bi_(2) with Mg_(3)Sb_(2),including narrowed bandgap,decreased effective mass,and increased carrier mobility,are summarized.Subsequently,defect-controlled electrical properties in n-type Mg_(3)Sb_(2-x)Bi_(x) are revealed.On one hand,manipulation of intrinsic and extrinsic defects can achieve optimal carrier concentration.On the other hand,Mg vacancies dominate carrier-scattering mechanisms(ionized impurity scattering and grain boundary scattering).Both aspects are discussed for Mg_(3)Sb_(2-x)Bi_(x) thermoelectric materials.Finally,we review the present status of,and future outlook for,these materials in power generation and cooling applications. | Hongjing Shang Zhongxin Liang Congcong Xu Jun Mao Hongwei Gu Fazhu Ding Zhifeng Ren | 2020 | Research2020，，1： | 4 |
| 17 | Performance Analysis and Prediction of Double-Server Polling System Based on BP Neural Network显示文摘To solve the poor performance of the single-server polling system in high traffic and the complex analysis of the multi-server polling system,a synchronous double-server polling system is proposed,and its performance is analyzed using a Backpropagation(BP)neural network prediction algorithm.Experimental data are processed and analyzed,and a three-layer multiinput single-output BP network model is constructed to predict the performance of the polling system under different arrival rates of information packets.In the prediction stage,first,the data are processed and the average queue length under different information arrival rates is used to form a sequence.Subsequently,a multiinput single-output BP neural network is constructed for prediction.Experimental results show that the algorithm can accurately predict the performance of the double-server polling system,thereby facilitating research regarding polling systems. | YANG Zhijun MAO Lei GAN Jianhou DING Hongwei | 2020 | Chinese Journal of Electronics2020，29，6： | 4 |
| 18 | Partial oxidation of simulated hot coke oven gas to syngas over Ru-Ni/Mg(Al)O catalyst in a ceramic membrane reactor显示文摘Hydrogen amplification from simulated hot coke oven gas(HCOG) was investigated in a BaCo 0.7 Fe 0.2 Nb 0.1 O 3 δ(BCFNO) membrane reactor combined with a Ru-Ni/Mg(Al) O catalyst by the partial oxidation of hydrocarbon compounds under atmospheric pressure. Under optimized reaction conditions,the dense oxygen permeable membrane had an oxygen permeation flux around 13.3 ml/(cm 2 min) . By reforming of the toluene and methane,the amount of H 2 in the reaction effluent gas was about 2 times more than that of original H2 in simulated HCOG. The Ru-Ni/Mg(Al) O catalyst used in the membrane reactor possessed good catalytic activity and resistance to coking. After the activity test,a small amount of whisker carbon was observed on the used catalyst,and most of them could be removed in the hydrogen-rich atmosphere,implying that the carbon deposition formed on the catalyst might be a reversible process. | Hongwei Cheng Xionggang Lu Xu Liu Yuwen Zhang Weizhong Ding | 2009 | Journal of Natural Gas Chemistry2009，18，4： | 4 |
| 19 | HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia显示文摘Dear Editor,β-Thalassemia is a common severe genetic disease caused by mutations in HBB and affects approximately 1.5% of the global population (Origa, 2017). In southern China, the carrier rate of β-thalassemia is as high as 6.43%, creating a high socio-economic burden (Xiong et al., 2010). In adult humans, there are three types of hemoglobin: HbA1 (~97%), HbA2 (~2%) and HbF (~1%). HbA1 (α2β2) is composed of two a-globin and two β-globi n sub units en coded by HBA and HBB, respectively;HbF (α2β2)is made up of two α-globin subunits and two β-globin sub units en coded by HBG. Mutations in the coding region or regulatory region of HBB are involved in β-thalassemia pathogenesis. Except for some rare dominant mutations, most HBB mutations are recessive (Origa, 2017). Depending on the mutation type, the β-globin level will either be reduced or completely depleted, resulting in α-globin accumulation and precipitation. These α-globin precipitates lead to red blood cell death, resulting in anemia and tissue damage, and even death in thalassemia major patients. Blood transfusions can help slow disease progression but lead to iron overload, ultimately resulting in iron toxicity. Bone marrow transfer is the only cure in the clinic and is available only to a small percentage of patients with human leukocyte antigervmatched donors. Recently, gene therapy and gene editing therapy have shown great promise in curing β-thalassemia (Glaser et al., 2015;Thompson et al., 2018). However, no appropriate animal models are available for evaluating the safety and efficacy of such advanced therapeutic strategies in vivo.β-thalassemia mice are the sole animal model available for research. However, substantial differences have been reported between the types and expressi on patter ns of human and mouse globins (McColl and Vadolas, 2016). Moreover, mice contain no fetal globin gene equivalent, and homozygous mutations of HBB in mouse for early models of β-thalassemia major or Cooley anemia are all embryonic lethal (Huo et al., 2009). Recently, significant phenotype and physiology differences have been reported between SIRT6- null mice and the non-human primate model (Zhang et al., 2018). Thus, an appropriate non-human primate model is needed for human β-thalassemia studies and treatments. | Yan Huang Chenhui Ding Puping Liang Duanduan Li Yu Tang Wei Meng Hongwei Sun Hongyu Lu Yu Chen Xueying Chen Qunshan Huang Jianpei Fang Canquan Zhou Shihua Yang Junjiu Huang | 2019 | Protein & Cell2019，10，7： | 4 |
| 20 | Characteristics of a Two-Class Polling System Model显示文摘Polling system models have a wide range of important applications including time-sharing computer systems,industrial control,communications,and computer networks.In this paper,we propose a two-class prioritybased polling system that uses gated and exhaustive services to achieve the priority-based scheme.This model is set up according to the method of the imbedded Markov chain theory and the generation function and explicitly analyzes key system performance characteristics including mean queue length,cyclic time,and throughput.Theoretical and simulation results are identical and demonstrate the efficiency of the model. | Zhijun Yang Hongwei Ding | 2014 | Tsinghua Science and Technology2014，19，5： | 3 |
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